Dr. Ying Huang

Researcher
Western University of Health Sciences, USA

Highest Degree
Ph.D. in Human Cancer Genetics from The Ohio State University, USA

My URL
https://livedna.org/86.1386

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Area of Interest:

Pharmacology and Toxicology
Pharmacogenomics
Drug Transporter
Chemoprevention
Chemoresistance

Selected Publications

  1. Wang, Z, R. Ravula, M. Cao, M. Chow and Y. Huang, 2010. Transporter-mediated multidrug resistance and its modulation by chinese medicines and other herbal products. Curr. Drug Discov. Technol., 7: 54-66.
    CrossRef  |  PubMed  |  

  2. Wang, S., S. Penchala, S. Prabhu, J. Wang and H.Y. Molecular, 2010. Molecular basis of traditional chinese medicine in cancer chemoprevention. Curr. Drug Discov. Technol., 7: 67-75.
    PubMed  |  Direct Link  |  

  3. Pham, A.N., P.E. Blower, O. Alvarado, R. Ravula, P. Gout and Y. Huang, 2010. Pharmacogenomic approach reveals a role for the xc- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. J. Pharmacol. Exp. Ther., 332: 949-958.
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  4. Liao, G., C. Wen, K. Irizarry, Y. Huang and K. Mitsouras et al., 2010. Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development. Brain Res., 1325: 128-140.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Chow, M.S. and Y. Huang, 2010. Utilizing chinese medicines to improve cancer therapy-fiction or reality?. Curr. Drug Discov. Technol., 7: 1-1.
    CrossRef  |  PubMed  |  

  6. Pham, A.N., J. Wang, J. Fang, Z. Gao and Y. Zhang et al., 2009. Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins. Pharmaceut. Res., 26: 936-945.
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  7. Harirforoosh, S., L. Fleckenstein, P. Mahajan, O.I. Aruoma, Y. Huang and M. Moridani, 2009. The importance of including topics related to pharmacogenetics, pharmacogenomics and medical genetics in the pharmacy curriculum. Am. J. Pharmac. Educ., 73: 2-3.
    PubMed  |  

  8. Gao, X., L. Lin and Y. Huang, 2009. Application of model selection technique in chemogenomic data analysis. Statist. Anal. Data Mining, 2: 186-191.
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  9. Lin, Z., X. Zhang, J. Tuo, Y. Guo and B. Green et al., 2008. A variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat., 29: 113-122.
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  10. Huang, Y., S. Penchala, A. Pham and J. Wang, 2008. Genetic variations and gene expression of transporters in drug disposition and response. Expert Opin. Drug Metabolism Toxicol., 4: 237-254.
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  11. Wang, J. and Y. Huang, 2007. Pharmacogenomics of sex difference in chemotherapeutic toxicity. Current Drug Discovery Technol., 4: 59-68.
    CrossRef  |  PubMed  |  

  12. Liu, R., P.E. Blower, A. Pham, J. Fang and Z. Dai et al., 2007. Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Mol. Pharmacol., 72: 1637-1646.
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  13. Huang, Y., P.E. Blower, R. Liu, Z. Dai and A. Pham et al., 2007. Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1. Pharmaceut. Res., 24: 1702-1712.
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  14. Huang, Y., 2007. Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev., 26: 183-201.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Dai, Z., Y. Huang, W. Sadee and P.E. Blower, 2007. Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-. J. Med. Chem., 50: 1896-1906.
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  16. Huang, Y. and W. Sadee, 2006. Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. Cancer Lett., 239: 168-182.
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  17. Dai, Z., C. Barbacioru, Y. Huang and W. Sadee, 2006. Prediction of anticancer drug potency from expression of genes involved in growth factor signaling. Pharmaceut. Res., 23: 336-349.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Cao, X., L. Fang, S. Gibbs, Y. Huang and Z. Dai et al., 2006. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol., 59: 495-505.
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  19. Xiao, J.J., Y. Huang, Z. Dai, Z. Liu and J. Chen et al., 2005. Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. J. Pharmacol. Exper. Therapeutics, 314: 467-475.
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  20. Xiao, J., A.B. Foraker, P.W. Swaan, S. Liu and Y. Huang et al., 2005. Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1. J. Pharmacol. Exp. Therapeutics, 313: 268-276.
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  21. Prasad, M.L., N.S. Pellegata, Y. Huang, H.N. Nagaraja, A. de la Chapelle and R.T. Kloos, 2005. Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod. Pathol., 18: 48-57.
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  22. Huang, Y., Z. Dai, C Barbacioru and W. Sadee, 2005. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res., 65: 7446-7454.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Huang, Y., P.E. Blower, C. Yang, C. Barbacioru and Z. Dai et al., 2005. Correlating gene expression with chemical scaffolds of cytotoxic agents: Ellipticines as substrates and inhibitors of MDR1. The Pharmacogenomics J., 5: 112-125.
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  24. Frank, N.Y., A. Margaryan, Y. Huang, A.M. Waaga-Gasser and M. Gasser et al., 2005. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res., 65: 4320-4333.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Prasad, M., Y. Huang, N.S. Pellegata, A. de la Chapelle and RT. Kloos, 2004. Hashimoto's thyroiditis with papillary thyroid carcinoma (PTC)-like nuclear alterations express molecular markers of PTC. Histopathology, 45: 39-46.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Prasad, M., N.S. Pellegata, R.T. Kloos, C. Barbacioru, Y. Huang and A. de la Chapelle, 2004. CITED1 protein expression suggests papillary thyroid carcinoma in high-throughput tissue microarray-based study. Thyroid, 14: 169-175.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. Huang, Y., P. Anderle, K.J. Bussey, C. Barbacioru and U. Shankavaram et al., 2004. Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res., 64: 4294-4301.
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  28. Dai, Z., Y. Huang and W. Sadee, 2004. Growth factor signaling and resistance to cancer chemotherapy. Curr. Topics Med. Chem., 4: 1347-1356.
    PubMed  |  Direct Link  |  

  29. Anderle, P., Y. Huang and W. Sadee, 2004. Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays. Eur. J. Pharmaceut. Sci., 21: 17-24.
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  30. Aldred, M.A., Y. Huang, S. Liyanarachchi, N.S. Pellegata and O. Gimm et al., 2004. Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes. J. Clinical Oncol., 22: 3531-3539.
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  31. Huang, Y., A. de la Chapelle and N.S. Pellegata, 2003. Hypermethylation, but not LOH, is associated with the Low Expression of MT1G and CRABP1 in Papillary Thyroid Carcinoma. Intl. J. Cancer, 104: 735-744.
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  32. Huang, Y. and W. Sadee, 2003. Drug sensitivity and resistance genes in cancer chemotherapy: A chemogenomics approach. Drug Discovery Today, 8: 356-363.
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  33. Mailman, M.D., T. Hemingway, R.L. Darsey, C.E. Glasure and Y. Huang et al., 2001. Hybrids monosomal for human chromosome 5 reveal the presence of a Spinal Muscular Atrophy (SMA) carrier with two SMN1 copies on one chromosome. Human Genetics., 108: 109-115.
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  34. Huang, Y., M. Prasad, W.J. Lemon, H. Hampel and F.A. Wright et al., 2001. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc. Natl. Acad. Sci. USA., 98: 15044-15049.
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Member since June, 2010