Dr. Xiao Zhen Zhou

Assistant Professor
Harvard Medical School, USA

Highest Degree
M.D. in Medicine from Suzhou University, China

My URL
https://livedna.org/86.13919

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Area of Interest:

Biomedical Sciences
Molecualar Biology
Cancer Research
Infectious Disease
Cell Signaling

Selected Publications

  1. Kondo, A., O. Albayram, X.Z. Zhou and K.P. Lu, 2017. Pin1 knockout mice: A model for the study of tau pathology in Alzheimer's disease. Methods Mol. Biol., 1523: 415-425.
    CrossRef  |  PubMed  |  Direct Link  |  

  2. Zhou, X.Z. and K.P. Lu, 2016. The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nat. Rev. Cancer, 16: 463-478.
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  3. Wei, S., N. Yoshida, G. Finn, S. Kozono and M. Nechama et al., 2016. Pin1-targeted therapy against systemic lupus erythematosus. Arthritis Rheumatol., 68: 2503-2513.
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  4. Wang, J., X.H. Liao, M. Zheng, D. Yang, X.Z. Zhou, H. Liu and K.P. Lu, 2016. The roles of the unique prolyl isomerase Pin1 in cancer-related viral and bacterial infections. Curr. Mol. Med., 16: 793-802.
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  5. Nogues, L., C. Reglero, V. Rivas, A. Salcedo and V. Lafarga et al., 2016. G Protein-coupled Receptor Kinase 2 (GRK2) promotes breast tumorigenesis through a HDAC6-Pin1 axis. EBioMedicine, 13: 132-145.
    CrossRef  |  Direct Link  |  

  6. Min, S.H., X.Z. Zhou and K.P. Lu, 2016. The role of Pin1 in the development and treatment of cancer. Arch. Pharmacal Res., 39: 1609-1620.
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  7. Lu, K.P., A. Kondo, O. Albayram, M.K. Herbert, H. Liu and X.Z. Zhou, 2016. Potential of the antibody against cis-phosphorylated tau in the early diagnosis, treatment and prevention of alzheimer disease and brain injury. JAMA Neurol., 73: 1356-1362.
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  8. Albayram, O., M.K. Herbert, A. Kondo, C.Y. Tsai and S. Baxley et al., 2016. Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration. Cell Biosci., Vol. 6. 10.1186/s13578-016-0124-4.
    CrossRef  |  Direct Link  |  

  9. Wei, S., S. Kozono, L. Kats, M. Nechama and W. Li et al., 2015. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat. Med., 21: 457-466.
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  10. Marsolier, J., M. Perichon, J.D. DeBarry, B.O. Villoutreix and J. Chluba et al., 2015. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature, 520: 378-382.
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  11. Luo, M.L., C. Gong, C.H. Chen, H. Hu and P. Huang et al., 2015. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep., 11: 111-124.
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  12. Kondo, A., K. Shahpasand, R. Mannix, J. Qiu and J. Moncaster et al., 2015. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature, 523: 431-436.
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  13. Hilton, B.A., Z. Li, P.R. Musich, H. Wang and B.M. Cartwright et al., 2015. ATR plays a direct antiapoptotic role at mitochondria, which is regulated by prolyl isomerase Pin1. Mol. Cell, 60: 35-46.
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  14. Driver, J.A., X.Z. Zhou and K.P. Lu, 2015. Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease. Biochimica Biophysica Acta (BBA)-Gen. Subj., 1850: 2069-2076.
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  15. Chen, C.H., W. Li, R. Sultana, M.H. You and A. Kondo et al., 2015. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Neurobiol. Dis., 76: 13-23.
    CrossRef  |  Direct Link  |  

  16. Balastik, M., X.Z. Zhou, M. Alberich-Jorda, R. Weissova and J. Ziak et al., 2015. Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons. Cell Rep., 13: 812-828.
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  17. Luo, M.L., C. Gong, C.H. Chen, D.Y. Lee and H. Hu et al., 2014. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res., 74: 3603-3616.
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  18. Kim, B.M., M.H. You, C.H. Chen, S. Lee and Y. Hong et al., 2014. Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function. Cell Death Dis., Vol. 5. 10.1038/cddis.2014.216.
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  19. Jalouli, M., M.A.C. Dery, V.N. Lafleur, L. Lamalice, X.Z. Zhou, K.P. Lu and D.E. Richard, 2014. The prolyl isomerase Pin1 regulates Hypoxia-Inducible transcription Factor (HIF) activity. Cell. Signall., 26: 1649-1656.
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  20. Driver, J.A., X.Z. Zhou and K.P. Lu, 2014. Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease. Discovery Med., 17: 93-99.
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  21. Pastorino, L., A. Kondo, X.Z. Zhou and K.P. Lu, 2013. Pin1 Protects against Alzheimer's Disease: One Goal, Multiple Mechanism. In: Understanding Alzheimer's Disease, Zerr, I. (Ed.). Chapter 6, InTech Publisher, Rijeka, Croatia, ISBN 978-953-51-1009-5, pp: 109-144.
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  22. Nakamura, K., X.Z. Zhou and K.P. Lu, 2013. Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications. Curr. Mol. Med., 13: 1098-1109.
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  23. Nakamura, K., X.Z. Zhou and K.P. Lu, 2013. Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies. Prion, 7: 117-120.
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  24. Chen, C.H., C.C. Chang, T.H. Lee, M. Luo and P. Huang et al., 2013. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer Res., 73: 3951-3962.
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  25. Wang, J., P.S. Ray, M.S. Sim, X.Z. Zhou and K.P. Lu et al., 2012. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling. Oncogene, 31: 4798-4802.
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  26. Nakamura, K., A. Greenwood, L. Binder, E.H. Bigio and S. Denial et al., 2012. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell, 149: 232-244.
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  27. Ma, S.L., L. Pastorino, X.Z. Zhou and K.P. Lu, 2012. Prolyl isomerase Pin1 promotes Amyloid Precursor Protein (APP) turnover by inhibiting Glycogen Synthase Kinase-3β (GSK3β) activity: Novel mechanism for Pin1 to protect against Alzheimer disease. J. Biol. Chem., 287: 6969-6973.
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  28. Luo, T., J. Yu, J. Nguyen, C.R. Wang and R.G. Bristow et al., 2012. Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical and lung cancers. Proc. Natl. Acad. Sci. USA., 109: 10175-10180.
    CrossRef  |  Direct Link  |  

  29. Finn, G., M.L. Luo, X.Z. Zhou and K.P. Lu, 2012. Pin1: A promising novel diagnostic and therapeutic target that acts on numerous cancer-driving pathways. Adv. Cancer Drug Targets, 1: 146-171.
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  30. Zhou, X.Z., P. Huang, R. Shi, T.H. Lee and G. Lu et al., 2011. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J. Clin. Invest., 121: 1266-1282.
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  31. Zhou, X.Z., 2011. PinX1: A sought-after major tumor suppressor at human chromosome 8p23. Oncotarget, 2: 810-819.
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  32. Soohoo, C.Y., R. Shi, T.H. Lee, P. Huang, K.P. Lu and X.Z. Zhou, 2011. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J. Biol. Chem., 286: 3894-3906.
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  33. Liou, Y.C., X.Z. Zhou and K.P. Lu, 2011. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem. Sci., 36: 501-514.
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  34. Lee, T.H., C.H. Chen, F. Suizu, P. Huang and C. Schiene-Fischer et al., 2011. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol. Cell, 42: 147-159.
    CrossRef  |  Direct Link  |  

  35. Boussetta, T., M.A. Gougerot-Pocidalo, G. Hayem, S. Ciappelloni and H. Raad et al., 2010. The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α-induced priming of the NADPH oxidase in human neutrophils. Blood, 116: 5795-5802.
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  36. Zheng, Y., Y. Xia, D. Hawke, M. Halle and M.L. Tremblay et al., 2009. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol. Cell, 35: 11-25.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Lee, T.H., A. Tun-Kyi, R. Shi, J. Lim and C. Soohoo et al., 2009. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat. Cell Biol., 11: 97-105.
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  38. Fan, G., Y. Fan, N. Gupta, I. Matsuura and F. Liu et al., 2009. Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the Rel proteins in the nuclear factor-κB family. Cancer Res., 69: 4589-4597.
    CrossRef  |  Direct Link  |  

  39. Zhang, Y., S. Daum, D. Wildemann, X.Z. Zhou and M.A. Verdecia et al., 2007. Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem. Biol., 2: 320-328.
    CrossRef  |  Direct Link  |  

  40. Wildemann, D., B.H. Alvarez, G. Stoller, X.Z. Zhou and K.P. Lu et al., 2007. An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors. Biol. Chem., 388: 1103-1111.
    CrossRef  |  Direct Link  |  

  41. Lu, K.P. and X.Z. Zhou, 2007. The prolyl isomerase PIN1: A pivotal new twist in phosphorylation signalling and disease. Nat. Rev. Mol. Cell Biol., 8: 904-916.
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  42. Li, Q.M., C. Tep, T.Y. Yune, X.Z. Zhou, T. Uchida, K.P. Lu and S.O. Yoon, 2007. Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury. J. Neurosci., 27: 8395-8404.
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  43. Wildemann, D., F. Erdmann, B.H. Alvarez, G. Stoller and X.Z. Zhou et al., 2006. Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J. Med. Chem., 49: 2147-2150.
    CrossRef  |  Direct Link  |  

  44. Sultana, R., D. Boyd-Kimball, H.F. Poon, J. Cai and W.M. Pierce et al., 2006. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol. Aging, 27: 918-925.
    CrossRef  |  Direct Link  |  

  45. Pastorino, L., A. Sun, P.J. Lu, X.Z. Zhou and M. Balastik et al., 2006. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production. Nature, 440: 528-534.
    CrossRef  |  Direct Link  |  

  46. Lu, K.P., F. Suizu, X.Z. Zhou, G. Finn, P. Lam and G. Wulf, 2006. Targeting carcinogenesis: A role for the prolyl isomerase Pin1? Mol. Carcinogen., 45: 397-402.
    CrossRef  |  Direct Link  |  

  47. Lee, T.H., K. Perrem, J.W. Harper, K.P. Lu and X.Z. Zhou, 2006. The f-box protein fbx4 targets pin2/trf1 for ubiquitin-mediated degradation and regulates telomere maintenance. J. Biol. Chem., 281: 759-768.
    CrossRef  |  

  48. Chen, S.Y., G. Wulf, X.Z. Zhou, M.A. Rubin, K.P. Lu and S.P. Balk, 2006. Activation of β-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-β-catenin interaction. Mol. Cell. Biol., 26: 929-939.
    CrossRef  |  Direct Link  |  

  49. Dougherty, M.K., J. Muller, D.A. Ritt, M. Zhou and X.Z. Zhou et al., 2005. Regulation of Raf-1 by direct feedback phosphorylation. Mol. Cell, 17: 215-224.
    CrossRef  |  Direct Link  |  

  50. Zhou, X.Z., K. Perrem and K.P. Lu, 2003. Role of Pin2/TRF1 in telomere maintenance and cell cycle control. J. Cell. Biochem., 89: 19-37.
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  51. Xu, Y.X., Y. Hirose, X.Z. Zhou, K.P. Lu and J.L. Manley, 2003. Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev., 17: 2765-2776.
    CrossRef  |  Direct Link  |  

  52. Liou, Y.C., A. Sun, A. Ryo, X.Z. Zhou and Z.X. Yu et al., 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature, 424: 556-561.
    CrossRef  |  Direct Link  |  

  53. Zheng, H., H. You, X.Z. Zhou, S.A. Murray and T. Uchida et al., 2002. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature, 419: 849-853.
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  54. Nakamura, M., X.Z. Zhou, S. Kishi and K.P. Lu, 2002. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett., 514: 193-198.
    CrossRef  |  Direct Link  |  

  55. Lu, P.J., X.Z. Zhou, Y.C. Liou, J.P. Noel and K.P. Lu, 2002. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J. Biol. Chem., 277: 2381-2384.
    CrossRef  |  

  56. Lu, K.P., Y.C. Liou and X.Z. Zhou, 2002. Pinning down proline-directed phosphorylation signaling. Trends Cell Biol., 12: 164-172.
    CrossRef  |  Direct Link  |  

  57. Kops, O., X.Z. Zhou and K.P. Lu, 2002. Pin1 modulates the dephosphorylation of the RNA polymerase II C‐terminal domain by yeast Fcp1. FEBS Lett., 513: 305-311.
    CrossRef  |  Direct Link  |  

  58. Zhou, X.Z. and K.P. Lu, 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell, 107: 347-359.
    CrossRef  |  Direct Link  |  

  59. Nakamura, M., X.Z. Zhou, S. Kishi, I. Kosugi, Y. Tsutsui and K.P. Lu, 2001. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Curr. Biol., 11: 1512-1516.
    CrossRef  |  Direct Link  |  

  60. Nakamura, M., X.Z. Zhou and K.P. Lu, 2001. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr. Biol., 11: 1062-1067.
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  61. Kishi, S., X.Z. Zhou, Y. Ziv, C. Khoo, D.E. Hill, Y. Shiloh and K.P. Lu, 2001. Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks. J. Biol. Chem., 276: 29282-29291.
    CrossRef  |  

  62. Zhou, X.Z., O. Kops, A. Werner, P.J. Lu and M. Shen et al., 2000. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol. Cell, 6: 873-883.
    CrossRef  |  Direct Link  |  

  63. Ott, D.E., L.V. Coren, D.G. Johnson, B.P. Kane and R.C. Sowder et al., 2000. Actin-binding cellular proteins inside human immunodeficiency virus type 1. Virology, 266: 42-51.
    CrossRef  |  Direct Link  |  

  64. Gerez, L., K. Mohrmann, M. va Raak, X.Z. Zhou, K.P. Lu and P. van der Sluijs, 2000. Accumulation of Rab4 in the cyltoplasm and interaction with the prolyl isomerase Pin1 during mitosis. Mol. Biol. Cell, 11: 2201-2211.

  65. Zhou, X.Z., P.J. Lu, G. Wulf and K.P. Lu, 1999. Phosphorylation-dependent prolyl isomerization: A novel signaling regulatory mechanism. Cell. Mol. Life Sci., 56: 788-806.
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  66. Lu, P.J., X.Z. Zhou, M. Shen and K.P. Lu, 1999. Function of WW domains as phosphoserine-or phosphothreonine-binding modules. Science, 283: 1325-1328.
    CrossRef  |  Direct Link  |  

  67. Lu, P.J., G. Wulf, X.Z. Zhou, P. Davies and K.P. Lu, 1999. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature, 399: 784-788.
    CrossRef  |  Direct Link  |  

  68. Varughese, K.I., X.Z. Zhou, J.M. Whiteley and J.A. Hoch, 1998. Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase. Mol. Cell, 2: 485-493.
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  69. Tzeng, Y.L., X.Z. Zhou and J.A. Hoch, 1998. Phosphorylation of the Spo0B response regulator phosphotransferase of the phosphorelay initiating development in Bacillus subtilis. J. Biol. Chem., 273: 23849-23855.
    Direct Link  |  

  70. Schutkowski, M., A. Bernhardt, X.Z. Zhou, M. Shen and U. Reimer et al., 1998. Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition. Biochemistry, 37: 5566-5575.
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  71. Zhou, X.Z., J.M. Whiteley, J.A. Hoch and K.I. Varughese, 1997. Purification and preliminary crystallographic studies on the sporulation response regulatory phosphotransferase protein, Spo0B, from Bacillus subtilis. Prot. Struct. Funct. Bioinform., 27: 597-600.
    CrossRef  |  Direct Link  |  

  72. Yaffe, M.B., M. Schutkowski, M. Shen, X.Z. Zhou and P.T. Stukenberg et al., 1997. Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science, 278: 1957-1960.
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  73. Endo, S., X. Zhou, J. Connor, B. Wang and S. Shenolikar, 1996. Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. Biochemistry, 35: 5220-5228.
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