Dr. Yu Zhang
Research ScientistHarvard Medical School, USA
Highest Degree
Ph.D. in Molecular and Cellular Biology from Novartis Research Foundation Basel, Switzerland
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Area of Interest:
Selected Publications
- Zhang, Y., M. Gostissa, D.G. Hildebrand, M.S. Becker and C. Boboila et al., 2010. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv. Immunol., 106: 93-133.
CrossRef | PubMed | Direct Link | - Zha, S., C. Guo, C. Boboila, V. Oksenych and H.L. Cheng et al., 2010. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature, 469: 250-254.
CrossRef | PubMed | Direct Link | - Yamaguchi, T., F. Cubizolles, Y. Zhang, N. Reichert, H. Kohler, C. Seiser and P. Matthias, 2010. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev., 24: 455-469.
CrossRef | PubMed | Direct Link | - Grausenburger, R., I. Bilic, N. Boucheron, G. Zupkovitz and L. El-Housseiny et al., 2010. Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased th2 cytokine production. J. Immunol., 185: 3489-3497.
CrossRef | PubMed | Direct Link | - Brunmeir, R., S. Lagger, E. Simboeck, A. Sawicka and G. Egger et al., 2010. Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. PLoS Genet., 6: e1000927-e1000927.
CrossRef | PubMed | Direct Link | - Chakraborty, T., T. Perlot, R. Subrahmanyam, A. Jani and P.H. Goff et al., 2009. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. J. Exp. Med., 206: 1019-1027.
CrossRef | PubMed | - Zhang, Y., S. Kwon, T. Yamaguchi, F. Cubizolles and S. Rousseaux et al., 2008. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol. Cell Biol., 28: 1688-1701.
CrossRef | PubMed | Direct Link | - Li, G., F.W. Alt, H.L. Cheng, J.W. Brush and P.H. Goff et al., 2008. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol. Cell, 31: 631-640.
CrossRef | PubMed | Direct Link | - Kwon, S.H., Y. Zhang and P. Matthias, 2007. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev., 21: 3381-3394.
CrossRef | PubMed | Direct Link | - Boyault, C., Y. Zhang, S. Fritah, C. Caron and B. Gilquin et al., 2007. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev., 21: 2172-2181.
CrossRef | PubMed | Direct Link | - Zhang, Y. B. Gilquin, S. Khochbin and P. Matthias, 2006. Two catalytic domains are required for protein deacetylation. J. Biol. Chem., 281: 2401-2404.
CrossRef | PubMed | Direct Link | - Yan, C.T., D. Kaushal, M. Murphy, Y. Zhang and A. Datta et al., 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc. Natl. Acad. Sci. USA., 103: 7378-7383.
CrossRef | PubMed | Direct Link | - Boyault, C., B. Gilquin, Y. Zhang, V. Rybin and E. Garman et al., 2006. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J., 25: 3357-3366.
CrossRef | PubMed | Direct Link | - Li, N., Y. Zhang, M.J. Naylor, F. Schatzmann and F. Maurer et al., 2005. Β1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J., 24: 1942-1953.
CrossRef | PubMed | Direct Link | - Zhang, Y., N. Li, C. Caron, G. Matthias, D. Hess, S. Khochbin and P. Matthias, 2003. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J., 22: 1168-1179.
CrossRef | PubMed | Direct Link | - He, Z., J. Bai and Y. Zhang, 1999. Effect of DNA methylation on protein-DNA interaction of HL-60 cells. Sci. China Series C: Life Sci., 42: 55-62.
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