Dr. Xiukun Lin

Professor
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Highest Degree
Ph.D. in Pharmacology from Peking Union Medical College, China

My URL
https://livedna.org/86.17076

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Area of Interest:

Pharmacology and Toxicology
Bioactive Compounds
Alternative Medicine
Natural Products
Cancer Biology

Selected Publications

  1. Yuan, R., H. Xu, X. Liu, Y. Tian and C. Li et al., 2016. Zinc-doped copper oxide nanocomposites inhibit the growth of human cancer cells through reactive oxygen species-mediated NF-κB activations. ACS Applied Mater. Interfaces, 8: 31806-31812.
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  2. Xu, H., T. Yang, X. Liu, Y. Tian and X. Chen et al., 2016. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism. Life Sci., 144: 138-147.
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  3. Wang, X., H. Xu, X. Chen, Y. Tian, F. Wang and X. Lin, 2016. Cloning, expression and cytotoxicity of granulin A, a novel polypeptide contained in human progranulin. Biosci. Trends, 10: 181-187.
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  4. Rytblat, I., N. Wu, H. Xu, A. Gedanken and X. Lin, 2016. In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents. Nano Res., 9: 1609-1617.
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  5. Lin, X., A.A. Farooqi, M.Z. Qureshi, M.A. Romero, S. Tabassum and M. Ismail, 2016. Prostate cancer stem cells: Viewing signaling cascades at a finer resolution. Arch. Immunol. Ther. Exp., 64: 217-223.
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  6. Chen, X., H. Xu, B. Li, F. Wang, X. Chen, D. Kong and X. Lin, 2016. Preparation and antitumor activity of CS5931, a novel polypeptide from sea squirt Ciona savignyi. Mar. Drugs, Vol. 14. 10.3390/md14030047.
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  7. Zhu, S., J. Wang, B. Xie, Z. Luo, X. Lin and D.J. Liao, 2015. Culture at a higher temperature mildly inhibits cancer cell growth but enhances chemotherapeutic effects by inhibiting cell-cell collaboration. PLoS ONE, Vol. 10. 10.1371/journal.pone.0137042.
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  8. Xu, H., X. Zhao, X. Liu, P. Xu, K. Zhang and X. Lin, 2015. Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway. Drug Des. Dev. Ther., 9: 2735-2744.
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  9. Wu, N., J. Liu, X. Zhao, Z. Yan and B. Jiang et al., 2015. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumor Biol., 36: 9667-9676.
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  10. Qi, X., G. Liu, L. Qiu, X. Lin and M. Liu, 2015. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems. Biomed. Pharmacother., 75: 58-66.
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  11. Liu, M., X. Zhao, L. Xiao, G. Liu and H. Liu et al., 2015. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm. Biol., 53: 1-9.
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  12. Lin, X., A.A. Farooqi and M. Ismail, 2015. Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells. Drug Des. Dev. Ther., 9: 1797-1804.
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  13. Zheng, L., Y. Yi, J. Liu, X. Lin and K. Yang et al., 2014. Isolation and characterization of marine Brevibacillus sp.S-1 collected from South China sea and a novel antitumor peptide produced by the strain. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111270.
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  14. Liu, M., G. Wang, L. Xiao, X. Xu, X. Liu, P. Xu and X. Lin, 2014. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules. Mar. Drugs, 12: 3838-3851.
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  15. Liu, J., N. Wu, L. Ma, M. Liu, G. Liu, Y. Zhang and X. Lin, 2014. Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms. PLoS ONE, Vol. 9. 10.1371/journal.pone.0091606.
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  16. Liu, J., L. Zheng, N. Wu, L. Ma, J. Zhong, G. Liu and X. Lin, 2014. Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway. J. Agric. Food Chem., 62: 5528-5537.
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  17. Liu, J., L. Zheng, L. Ma, B. Wang and Y. Zhao et al., 2014. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J. Nutr. Biochem., 25: 1154-1160.
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  18. Liu, J., L. Zheng, J. Zhong, N. Wu, G. Liu and X. Lin, 2014. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways. Oncol. Rep., 32: 567-572.
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  19. Liu, J., L. Ma, N. Wu, G. Liu, L. Zheng and X. Lin, 2014. Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway. Mar. Drugs, 12: 5072-5088.
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  20. Liu, H., J.C. Schmitz, J. Wei, S. Cao and J.H. Beumer et al., 2014. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol. Res. Featuring Preclin. Clin. Cancer Ther., 21: 247-259.
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  21. Liu, G., M. Liu, J. Wei and X. Lin, 2014. CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Mar. Drugs, 12: 1530-1544.
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  22. Zheng, L., X. Lin, N. Wu, M. Liu and Y. Zheng et al., 2013. Targeting cellular apoptotic pathway with peptides from marine organisms. Biochim. Biophys. Acta (BBA)-Rev. Cancer, 1836: 42-48.
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  23. Zhao, J., J. Wei, M. Liu, L. Xiao and N. Wu et al., 2013. Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi. Biochimie, 95: 1611-1619.
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  24. Xiao, L., H. Liu, N. Wu, M. Liu, J. Wei, Y. Zhang and X. Lin, 2013. Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China. World J. Microbiol. Biotechnol., 29: 11-17.
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  25. Wu, N., X. Lin, X. Zhao, L. Zheng and L. Xiao et al., 2013. MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. Br. J. Cancer, 109: 2853-2863.
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  26. Wang, H., J. Wei, N. Wu, M. Liu and C. Wang et al., 2013. Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs. Pharm. Biol., 51: 145-151.
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  27. Liu, H., L. Xiao, J. Wei, J.C. Schmitz and M. Liu et al., 2013. Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China. World J. Microbiol. Biotechnol., 29: 1271-1278.
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  28. Zhao, X., N. Wu, L. Ding, M. Liu, H. Liu and X. Lin, 2012. Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment. FEBS Lett., 586: 1220-1225.
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  29. Wu, N., L. Xiao, X. Zhao, J. Zhao and J. Wang et al., 2012. miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2. FEBS Lett., 586: 3831-3839.
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  30. Wei, J., H. Liu, M. Liu, N. Wu and J. Zhao et al., 2012. Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells. Oncol. Rep., 28: 1339-1345.
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  31. Wang, C., M. Liu, L. Cheng, J. Wei, N. Wu, L. Zheng and X. Lin, 2012. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma. Exp. Biol. Med., 237: 442-450.
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  32. Tang, D., H. Zhu, J. Wu, H. Chen and Y. Zhang et al., 2012. Silencing myostatin gene by RNAi in sheep embryos. J. Biotechnol., 158: 69-74.
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  33. Liu, M., X. Zhao, J. Zhao, L. Xiao and H. Liu et al., 2012. Induction of apoptosis, G0/G1 phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus. Mar. Drugs, 10: 2596-2607.
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  34. Liu, M., W. Zhang, J. Wei, L. Qiu and X. Lin, 2012. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro. Toxicol. Lett., 211: 126-134.
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  35. Cheng, L., C. Wang, H. Liu, F. Wang and L. Zheng et al., 2012. A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells. Clin. Colorectal Cancer, 11: 207-214.
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  36. Wu, N., X. Zhao, M. Liu, H. Liu and W. Yao et al., 2011. Role of microRNA-26b in glioma development and its mediated regulation on EphA2. PLoS ONE, Vol. 6. 10.1371/journal.pone.0016264.
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  37. Wang, C.C., H.Z. Liu, M. Liu, Y.Y. Zhang, T.T. Li and X.K. Lin, 2011. Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila. Molecules, 16: 2796-2801.
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  38. Liu, M., W. Zhang, J. Wei and X. Lin, 2011. Synthesis and α-glucosidase inhibitory mechanisms of bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor. Mar. Drugs, 9: 1554-1565.
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  39. Liu, M., P.E. Hansen and X. Lin, 2011. Bromophenols in marine algae and their bioactivities. Mar. Drugs, 9: 1273-1292.
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  40. Cheng, L., M. Liu, C. Wang, H. Liu, Y. Zhang and X. Lin, 2011. CI431, an aqueous compound from Ciona intestinalis L., induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. Evid.-Based Complement. Altern. Med., Vol. 2011. 10.1155/2011/292873.
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  41. Zhao, X., M. Liu, N. Wu, L. Ding, H. Liu and X. Lin, 2010. Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro. Protein Expression Purif., 72: 262-266.
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  42. Zhang, Y., S. Yang, M. Liu, C. Song and N. Wu et al., 2010. Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos. PLoS ONE, Vol. 5. 10.1371/journal.pone.0010618.
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  43. Liu, M., W. Zhang, L. Qiu and X. Lin, 2010. Synthesis of butyl-isobutyl-phthalate and its interaction with α-glucosidase in vitro. J. Biochem., 149: 27-33.
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  44. Lin, X., M. Liu, C. Hu and D.J. Liao, 2010. Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources. Curr. Drug Targets, 11: 708-715.
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  45. Chen, L., G. Wang, T. Bu, Y. Zhang, Y. Wang, M. Liu and X. Lin, 2010. Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of moderately halophilic bacteria isolated from the Weihai Solar Saltern (China). World J. Microbiol. Biotechnol., 26: 879-888.
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  46. Bu, T., M. Liu, L. Zheng, Y. Guo and X. Lin, 2010. α-glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid. Phytother. Res., 24: 1588-1591.
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  47. Yang, S.L., S. Yan, R.L. Niu and X. Lin, 2009. VEGF gene silencing by cytomegalovirus promoter driven ShRNA expression vector results in vascular development defects in Zebrafish. Russian J. Genet., 45: 1040-1046.
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  48. Ning, X., J. Zhao, Y. Zhang, S. Cao, M. Liu, P. Ling and X. Lin, 2009. A novel anti-tumor protein extracted from Meretrix meretrix Linnaeus induces cell death by increasing cell permeability and inhibiting tubulin polymerization. Int. J. Oncol., 35: 805-812.
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  49. Zheng, L., Z. Wang, R.L. Niu, C.X. Hu and X. Lin, 2007. A novel peptide from shark cartilage with potent antiangiogenesis activity. Cancer Biol. Ther., 6: 775-780.

  50. Wang, Z., L.H. Zheng, S.L. Yang, R.L. Niu, E. Chu and X. Lin, 2007. N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro. Biochem. Biophys. Res. Commun., 357: 26-31.
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  51. Thakur, A., K. Rahman, J. Wu, X. Lin and H. Nassar et al., 2007. Aberrant expression of X-linked genes RbAp46, Rsk4 and Cldn2 in breast cancer. Mol. Cancer Res., 5: 171-181.
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  52. Du, C., R. Niu, E. Chu, P. Zhang and X. Lin, 2006. Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio. J. Biochem., 139: 913-920.
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Member since September, 2017