Dr. Yanguo Hong

Professor
Fujian Normal University, China

Highest Degree
Ph.D. in Physiology from McGill University, Canada

My URL
https://livedna.org/86.22784

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Area of Interest:

Biomedical Sciences
Physiology Immunology
Physiological Mechanisms
Cellular Biochemistry
Physical Biochemistry

Selected Publications

  1. Zhang, Y., K. Wang, M. Lin, Q. Li and Y. Hong, 2017. Inhibition of morphine tolerance by Mrgc receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats. Eur. J. Pharmacol., 815: 10-17.
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  2. Chen, Y.J., Y.H. Huo and Y. Hong, 2017. [Effects of intrathecal administration of AM22-52 on mechanical allodynia and CCL2 expression in DRG in bone cancer rats]. Sheng Li Xue Bao, 69: 70-76.

  3. Wang, D., Y. Xue, Y. Yan, M. Lin, J. Yang, J. Huang and Y. Hong, 2016. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiol. Dis., 91: 274-283.
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  4. Wang, D., Y. Xue, Y. Chen, L. Ruan and Y. Hong, 2016. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neurosci. Lett., 618: 115-121.
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  5. Wang, D., J. Zeng, Q. Li, J. Huang, R. Couture and Y. Hong, 2016. Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats. Br. J. Pharmacol., 173: 1196-1207.
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  6. Huang, J., J. Wu, H.Z. Yang and Y. Hong, 2016. Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats. Sheng Li Xue Bao, 68: 241-248.

  7. Hu, W., Y. Zhang, Q. Cai, D. Wang and Y. Hong, 2016. Blockade of 5-HT2A receptors at the site of inflammation inhibits activation of spinal dorsal horn neurons in rats. Brain Res. Bull., 124: 85-94.
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  8. Chen, Y., Y. Zhang, Y. Huo, D. Wang and Y. Hong, 2016. Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in rats. Brain Res., 1644: 183-191.
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  9. Wang, D., P. Wang, J. Jiang, Q. Lv, X. Zeng and Y. Hong, 2015. Activation of Mas oncogene-related g protein-coupled receptors inhibits neurochemical alterations in the spinal dorsal horn and dorsal root ganglia associated with inflammatory pain in rats. J. Pharmacol. Exp. Ther., 35: 431-439.
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  10. Zeng, X., M.Y. Lin, D. Wang, Y. Zhang and Y. Hong, 2014. Involvement of adrenomedullin in spinal glial activation following chronic administration of morphine in rats. Eur. J. Pain, 18: 1323-1332.
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  11. Wang, D., Y. Huo, R. Quirion and Y. Hong, 2014. Involvement of adrenomedullin in the attenuation of acute morphine-induced analgesia in rats. Peptides, 54: 67-70.
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  12. Wang, D., R. Couture and Y. Hong, 2014. Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur. J. Pharmacol., 728: 59-66.
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  13. Wang, D., J. Li, P. Chen and Y. Hong, 2014. Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats. Neuroscience, 280: 31-39.
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  14. Huang, H., Q. Li, Y. Hong and D. Wang, 2014. MrgC receptor activation reverses chronic morphine-evoked alterations of glutamate transporters and nNOS in rats. Sheng Li Xue Bao, 66: 449-456.

  15. Wang, D., X. Zhou and Y. Hong, 2013. Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. Eur. J. Pharmacol., 721: 126-132.

  16. Wang, D., T. Chen, X. Zhou, R. Couture and Y. Hong, 2013. Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn. Neuroscience, 253: 455-464.
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  17. Wang, D., L. Ruan, Y. Hong, J.G. Chabot and R. Quirion, 2013. Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats. Exp. Neurol., 239: 111-119.
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  18. Jiang, J., D. Wang, X. Zhou, Y. Huo and T. Chen et al., 2013. Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms. Br. J. Pharmacol., 170: 1027-1040.

  19. Wang, D., T. Chen, Y. Gao, R. Quirion and Y. Hong, 2012. Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT2A receptor antagonist ketanserin in rats. Pharmacol. Biochem. Behav., 101: 379-386.
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  20. Hong, Y., D.L. Hay, R. Quirion and D.R. Poyner, 2012. The pharmacology of Adrenomedullin 2/Intermedin. Br. J. Pharmacol., 166: 110-120.

  21. Chen, T., J. Jiang, D. Wang, Y. Liu and Y. Hong, 2012. Role of bovine adrenal medulla 22 (BAM22) in the pathogenesis of neuropathic pain in rats with spinal nerve ligation. Eur. J. Pharmacol., 685: 24-29.
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  22. Chen, T., D. Wang and Y. Hong, 2012. Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in rats. Neurosci. Lett., 514: 82-85.
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  23. Wang, D., P. Chen, Q. Li, R. Quirion and Y. Hong, 2011. Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms. Behav. Brain Res., 221: 83-90.
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  24. Jiang, J. and Y. Hong, 2011. Bovine adrenal medulla 22 attenuates hyperalgesia in the early phase of complete Freund’s adjuvant-induced inflammation in rats. Sheng Li Xue Bao, 63: 529-535.

  25. Huang, J., Y. Fan, Y. Jia and Y. Hong, 2011. Antagonism of 5-HT2A receptors inhibits the expression of pronociceptive mediator and enhances endogenous opioid mechanism in carrageenan-induced inflammation in rats. Eur. J. Pharmacol., 654: 33-41.
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  26. Wang, D., Y. Gao, H. Ji and Y. Hong, 2010. Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation. Eur. J. Pharmacol., 627: 124-130.
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  27. Hong, Y., D. Wang, J.G. Chabot, W. Ma, P. Chen and R. Quirion, 2010. A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats. J. Neurosci., 30: 12508-12516.
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  28. Dai, F. and Y. Hong, 2010. The Mrg family and pain. Prog. Biochem. Biophys., 37: 467-474.

  29. Chen, P., D. Wang, M. Li, Y. Zhang, R. Quirion and Y. Hong, 2010. Modulation of sensory neuron-specific receptors in the development of morphine tolerance and its neurochemical mechanisms. J. Neurosci. Res., 88: 2952-2963.
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  30. Huang, J., Q. Cai, Y. Chen and Y. Hong, 2009. Treatment with ketanserin produces opioid-mediated hypoalgesia in the late phase of carrageenan-induced inflammatory hyperalgesia in rats. Brain Res., 1303: 39-47.
    CrossRef  |  Direct Link  |  

  31. Hong, Y., Y. Liu, J.G. Chabot, A. Fournier and R. Quirion, 2009. Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats. Pain, 146: 105-113.
    CrossRef  |  Direct Link  |  

  32. Huang, H., Q. Cai, W. Lin and Y. Hong, 2008. Effects of blockade of 5-HT2A receptors in the inflamed site on the expression of nitric oxide synthase in the spinal cord of rats. J. Chinese Pain Med., 14: 96-100.

  33. Chen, T., Z. Hu, R. Quirion and Y. Hong, 2008. Modulation of NMDA receptors by intrathecal sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology, 54: 796-803.

  34. Chen, P., Y. Liu and Y. Hong, 2008. Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats. Eur. J. Pharmacol., 589: 110-113.
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  35. Li, Q. and Y. Hong, 2007. The role of nitric oxide in inflammatory pain. Life Sci., 4: 423-426.

  36. Jiang, J. and Y. Hong, 2007. Effect of bovine adrenal medulla 22 on expression of noxious stimulus-evoked c-Fos in the spinal dorsal horn in morphine tolerant rats. J. Chinese Pain Med., 13: 166-170.

  37. Ji, H. and Y. Hong, 2007. 5-HT2A receptors and pain. Int. J. Pathol. Clin. Med., 27: 56-61.

  38. Hu, Z. and Y. Hong, 2007. Protein kinase C and pain. J. Neuroanat., 23: 436-440.

  39. Cai, Q., J. Jiang, T. Chen and Y. Hong, 2007. Sensory neuron-specific receptor agonist BAM8-22 inhibits the development and expression of tolerance to morphine in rats. Behav. Brain Res., 178: 154-159.
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  40. Cai, M., T. Chen, R. Quirion and Y. Hong, 2007. The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing. Eur. J. Neurosci., 26: 1128-1138.
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  41. Jiang, J., Y. Chen and Y. Hong, 2006. Differential reversal effect of intrathecal bovine adrenal medulla peptide 22 on morphine tolerance in rats. Sheng Li Xue Bao, 58: 529-535.

  42. Jiang, J., J. Huang and Y. Hong, 2006. Bovine adrenal medulla 22 reverses antinociceptive morphine tolerance in the rat. Behav. Brain Res., 168: 167-171.

  43. Hong, Y., H. Ji and H. Wei, 2006. Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. Pain, 124: 27-33.
    CrossRef  |  Direct Link  |  

  44. Chen, X., F. Bing, P. Dai and Y. Hong, 2006. Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. Pharmacol. Biochem. Behav., 84: 8-16.
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  45. Chen, T., Q. Cai and Y. Hong, 2006. Intrathecal sensory neuron-specific receptor agonists BAM8-22 and (Tyr6)-γ2-MSH-6-12 inhibit formalin-evoked nociception and neuronal Fos-like immunoreactivity in the spinal cord of the rat. Neuroscience, 141: 965-975.
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  46. Cai, M. and Y. Hong, 2006. Advance in the study of BAM22. Chinese Clin. Pharmacol. Ther., 11: 1-5.

  47. Zeng, X., Y. Lin and Y. Hong, 2005. c-Fos expression in spinal dorsal horn of rats. J. Fujian Normal Univ. (Nat. Sci.), 21: 95-98.

  48. Wei, H., Y. Chen and Y. Hong, 2005. The contribution of peripheral 5-hydroxytryptamine2A receptor to carrageenan-evoked hyperalgesia, inflammation and spinal Fos protein expression in the rat. Neuroscience, 132: 1073-1082.
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  49. Zeng, X., H. Huang and Y. Hong, 2004. Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn. Brain Res., 1028: 170-179.
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  50. Hong, Y., P. Dai, J. Jiang and X. Zeng, 2004. Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor. Br. J. Pharmacol., 141: 423-430.
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  51. Zhang, Y., Y. Hong, Y. Bounhar, M. Blacker and X. Roucou et al., 2003. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid β peptide cytotoxicity. J. Neurosci., 23: 7385-7394.
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  52. Cao, C.Q., Y.G. Hong, A. Dray and M.N. Perkins, 2001. Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse. Neuroscience, 107: 329-338.
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  53. Cao, C.Q., Y. Hong, A. Dray and M. Perkins, 2001. Spinal δ-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat. Eur. J. Pharmacol., 418: 79-87.
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  54. Kenigsberg, R.L., Y. Hong and Y. Theoret, 1998. Cholinergic cell expression in the developing rat medial septal nucleus in vitro is differentially controlled by GABAA and GABAB receptors. Brain Res., 805: 123-130.
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  55. Kenigsberg, R.L., Y. Hong, H. Yao, N. Lemieux, J. Michaud, C. Tautu and Y. Theoret, 1997. Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1). Am. J. Pathol., 151: 867-881.

  56. Abbott, F.V., Y. Hong and P. Blier, 1997. Persisting sensitization to pain through activation of 5-HT2A receptors. Neuroscience, 77: 575-584.

  57. Hong, Y. and F.V. Abbott, 1996. Contribution of peripheral α1A-adrenoceptors to pain induced by formalin or by α-methyl-5-hydroxytryptamine plus noradrenaline. Eur. J. Pharmacol., 301: 41-48.
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  58. Abbott, F.V., Y. Hong and P. Blier, 1996. Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators. Neuropharmacology, 35: 99-110.
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  59. Abbott, F.V., Y. Hong and K.B.J. Franklin, 1996. The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: A dose-response analysis. Pain, 65: 17-23.
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  60. Hong, Y. and F.V. Abbott, 1995. Peripheral opioid modulation of pain and inflammation in the formalin test. Eur. J. Pharmacol., 277: 21-28.
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  61. Hong, Y., D.F. Cechetto and L.C. Weaver, 1994. Spinal cord regulation of sympathetic activity in intact and spinal rats. Am. J. Physiol., 266: H1485-H1493.

  62. Hong, Y. and A.V. Abbott, 1994. Behavioral effects of intra-plantar injection of inflammatory mediators in the rat. Neuroscience, 63: 827-836.

  63. Hong, Y. and L.C. Weaver, 1993. Distribution of enkephalin-,substance P- and vasoactive intestinal peptide-like immunoreactivities in autonomic nuclei of middle and lower thoracic spinal cord of rat: Relationship with sympathetic preganglionic neurons contributing to the greater splanchnic nerve. Neuroscience, 57: 1121-1133.

  64. Hong, Y. and J.L. Henry, 1992. NMDA receptor antagonists block cardiovascular responses to intrathecal administration of D-baclofen in the rat. Eur. J. Pharmacol., 216: 257-263.
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  65. Hong, Y. and J.L. Henry, 1992. Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat. Brain Res., 591: 62-68.
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  66. Hong, Y. and J.L. Henry, 1992. Glutamate, NMDA and NMDA receptor antagonists: Cardiovascular effects of intrathecal administration in the rat. Brain Res., 569: 38-45.
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  67. Hong, Y. and J.L. Henry, 1991. Phaclofen-reversible effects of GABA in the spinal cord of the rat. Eur. J. Pharmacol., 201: 171-177.
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  68. Hong, Y. and J.L. Henry, 1991. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L-and D-baclofen in the rat. Eur. J. Pharmacol., 196: 267-275.
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  69. Hong, Y. and J.L. Henry, 1991. Cardiovascular responses to intrathecal administration of L-and D-baclofen in the rat. Eur. J. Pharmacol., 192: 55-62.
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  70. Hong, Y. and J.L. Henry, 1990. Spinal mediation of the increases in arterial pressure and heart rate in response to intrathecal administration of bicuculline. Brain Res., 513: 86-93.
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  71. Hong, Y., K. Yashpal and J.L. Henry, 1989. Cardiovascular responses to intrathecal administration of strychnine in the rat. Brain Res., 499: 169-173.
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  72. Hong, Y. and K. Krnjevic, 1989. Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Can. J. Physiol. Pharmacol., 67: 47-53.
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  73. Deng, L., Y. Hong and G. Li, 1985. The experimental study on phasic conduction block. Chinese J. Cardiol., 12: 137-142.

  74. Hong, Y.G., T.L. Dai, Q.Z. Zang and Z.Z. Lu, 1983. Effect of stimulation of somatosensory cortex on nociceptive discharges of parafascicular neurons in rabbit's thalamus. Acta Physiol. Sin., 32: 156-162.
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Member since January, 2018