Dr. Li Wei

Research Scientist
Jilin University, China

Highest Degree
Ph.D. in Pharmacology from Jilin Agricultural University, China

My URL
https://livedna.org/86.22883

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Area of Interest:

Pharmacology and Toxicology
Traditional Chinese Medicine
Biological Activities
Medicinal Plants
Process Control

Selected Publications

  1. Zhou, Y.D., J.G. Hou, G. Yang, S. Jiang and C. Chen et al., 2019. Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. Biomed. Pharm., 109: 2309-2317.
    CrossRef  |  Direct Link  |  

  2. Zeng, Q., L. Wei, T. Jing, W. Cui-zhu, L. Hongqiang, Z. Baisong and L. Jinping, 2019. Effect of ginsenoside Rh2 on renal apoptosis in cisplatin-induced nephrotoxicity in vivo. Phytomedicine, Vol. 61. 10.1016/j.phymed.2019.152862.
    CrossRef  |  Direct Link  |  

  3. Xing, J.J., J.G. Hou, Z.N. Ma, Z. Wang and S. Ren et al., 2019. Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. Cell Proliferation, Vol. 52. 10.1111/cpr.12627.
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  4. Xin, S.Q., Z. Wang, W.N. Hao, X.T. Yan and Q. Xu et al., 2019. Liver protection effect of steamed codonopsis lanceolata on alcohol-induced liver injury in mice and its main components by LC/MS analysis. Int. J. Pharmacol., 15: 394-402.
    CrossRef  |  Direct Link  |  

  5. Mi, X.J., J.G. Hou, S. Jiang, Z. Liu and S. Tang et al., 2019. Maltol mitigates thioacetamide-induced liver fibrosis through TGF-β1-mediated activation of PI3K/Akt signaling pathway. J. Agric. Food Chem., 67: 1392-1401.
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  6. Li, R.Y., W.Z. Zhang, X.T. Yan, J.G. Hou and Z. Wang et al., 2019. Arginyl-fructosyl-glucose, a major maillard reaction product of red ginseng, attenuates cisplatin-induced acute kidney injury by regulating nuclear factor ΚB and phosphatidylinositol 3-kinase/protein kinase B signaling pathways. J. Agric. Food Chem., 67: 5754-5763.
    CrossRef  |  Direct Link  |  

  7. Leng, J., J.G. Hou, C.L. Fu, S. Ren and S. Jiang et al., 2019. Platycodon grandiflorum saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice. J. Funct. Food, 54: 479-488.
    CrossRef  |  Direct Link  |  

  8. Hu, J.N., X.Y. Xu, W. Li, Y.M. Wang, Y. Liu, Z. Wang and Y.P. Wang, 2019. Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J. Ginseng Res., 43: 10-19.
    CrossRef  |  Direct Link  |  

  9. Zhou, Y.D., J.G. Hou, W. Liu, S. Ren and Y.P. Wang et al., 2018. 20 (R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. Int. Immunopharmacol., 59: 21-30.
    CrossRef  |  Direct Link  |  

  10. Zhou, S., Y. Shao, J. Fu, L. Xiang, Y. Zheng and W. Li, 2018. Characterization and quantification of taxifolin related flavonoids in Larix olgensis Henry Var. koreana Nakai extract analysis and its antioxidant activity assay. Int. J. Pharmacol., 14: 534-545.
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  11. Zhao, L.C., Y. Liu, Z. Wang, N. Tang and J. Leng et al., 2018. Liquid chromatography/mass spectrometry analysis and hepatoprotective effect of steamed platycodi radix on acute alcohol-induced liver injury. Int. J. Pharmacol., 14: 952-962.
    CrossRef  |  Direct Link  |  

  12. Zhang, W., J. Hou, X. Yan, J. Leng and R. Li et al., 2018. Platycodon grandiflorum saponins ameliorate cisplatin-induced acute nephrotoxicity through the NF-κB-mediated inflammation and PI3K/Akt/apoptosis signaling pathways. Nutrients, Vol. 10. 10.3390/nu10091328.
    CrossRef  |  Direct Link  |  

  13. Yang, H., W. Li, L. Wang, X. He, H. Sun and J. Zhang, 2018. The proteins from Sika deer antler as potential modulators on cisplatin-induced cytotoxicity in human embryonic kidney 293 cells. Nat. Prod. Res., 32: 1982-1986.
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  14. Yang, G., Z. Wang, S. Ren, X.T. Yan and X.Y. Xu et al., 2018. Hepato-protective effect of ginsenosides from the fruits of panax ginseng against acetaminophen-induced liver damage in mice. Int. J. Pharmacol., 14: 1107-1117.

  15. Yan, X.T., Y.S. Sun, S. Ren, L.C. Zhao and W.C. Liu et al., 2018. Dietary α-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis. Int. J. Mol. Sci., Vol. 19. 10.3390/ijms19051335.
    CrossRef  |  Direct Link  |  

  16. Xu, X.Y., Z. Wang, S. Ren, J. Leng and J.N. Hu et al., 2018. Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways. Phytomedicine, 51: 128-138.
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  17. Wang, Z., Y.F. Li, X.Y. Han, Y.S. Sun and L.X. Zhang et al., 2018. Kidney protection effect of ginsenoside re and its underlying mechanisms on cisplatin-induced kidney injury. Cell. Physiol. Biochem., 48: 2219-2229.
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  18. Qi, Z., Z. Li, W. Li, Y. Liu and C. Wang, 2018. Pseudoginsengenin DQ exhibits therapeutic effects in cisplatin-induced acute kidney injury via sirt1/NF-κB and caspase signaling pathway without compromising its antitumor activity in mice. Molecules, Vol. 23. 10.3390/molecules23113038.
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  19. Mi, X.J., J.G. Hou, Z. Wang, Y. Han and S. Ren et al, 2018. The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways. Sci. Rep., .
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  20. Liu, W., Z. Wang, J.G. Hou, Y.D. Zhou and Y.F. He et al., 2018. The liver protection effects of maltol, a flavoring agent, on carbon tetrachloride-induced acute liver injury in mice via inhibiting apoptosis and inflammatory response. Molecules, Vol. 23. 10.3390/molecules23092120.
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  21. Li, Y.Z., Z.N. Ma, Y.S. Sun, R. Shen and J. Shuang et al., 2018. Schisandra chinensis stems exerts potential protective effects on acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways. Chin. J. Nat. Med., 16: 700-713.

  22. Li, Y.Z., S. Ren, X.T. Yan, H.P. Li and W. Li et al., 2018. Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects. J. Ethnopharmacol., 217: 228-237.
    CrossRef  |  Direct Link  |  

  23. Li, W. and C. Chen, 2018. Response to the comments on caspase-mediated anti-apoptotic effect of ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 66: 1734-1735.
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  24. Leng, J., Z. Wang, C.L. Fu, J. Zhang and S. Ren et al., 2018. NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen‐induced acute hepatotoxicity in mice. Phytother. Res., 32: 2235-2246.
    CrossRef  |  Direct Link  |  

  25. Leng, J., Z. Wang, C.L. Fu, J. Zhang and S. Ren et al., 2018. NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice. Phytother., Res., 10.1002/ptr.6160.
    CrossRef  |  Direct Link  |  

  26. Hou, J., J. Xue, Z. Wang and W. Li, 2018. Ginsenoside Rg3 and Rh2 protect trimethyltin‐induced neurotoxicity via prevention on neuronal apoptosis and neuroinflammation. Phytother. Res., 32: 2531-2540.
    CrossRef  |  Direct Link  |  

  27. Hou, J., J. Xue, X. Zhao, Z. Wang, W. Li, X. Li and Y. Zheng, 2018. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: Synthesis and evaluation on murine H22 cells in vitro and in vivo. Chem. Biol. Drug Des., 91: 951-956.
    CrossRef  |  Direct Link  |  

  28. Fu, C.L., Y. Liu, J. Leng, J. Zhang and Y.F. He et al., 2018. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice. Biomed. Pharm., 107: 867-877.
    CrossRef  |  Direct Link  |  

  29. Chen, B., Z. Liu, Y. Zhang, W. Li and Y. Sun et al., 2018. Application of high-speed counter-current chromatography and HPLC to separate and purify of three polyacetylenes from Platycodon grandiflorum. J. Sep. Sci., 41: 789-796.
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  30. Yang, H., W. Li, L. Wang, W. Li, H. Sun, X. He and J. Zhang, 2017. The protective effects of sika deer antler protein on cisplatin-induced nephrotoxicity. Cell. Physiol. Biochem., 43: 395-404.
    CrossRef  |  Direct Link  |  

  31. Xu, X.Y., J.N. Hu, Z. Liu, R. Zhang and Y.F. He et al., 2017. Saponins (Ginsenosides) from the Leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 65: 3684-3692.
    CrossRef  |  Direct Link  |  

  32. Wang, Z., J.N. Hu, M.H. Yan, J.J. Xing, W.C. Liu and W. Li, 2017. Caspase-mediated anti-apoptotic effect of ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 65: 9226-9236.
    CrossRef  |  Direct Link  |  

  33. Qi, Z.L., Z. Wang, W. Li, J.G. Hou and Y. Liu et al., 2017. Nephroprotective effects of anthocyanin from the fruits of Panax ginseng (GFA) on cisplatin-induced acute kidney injury in mice. Phytother. Res., 31: 1400-1409.
    CrossRef  |  Direct Link  |  

  34. Meng, F., X. Su, W. Li and Y. Zheng, 2017. Ginsenoside Rb3 strengthens the hypoglycemic effect through AMPK for inhibition of hepatic gluconeogenesis. Exp. Ther. Med., 13: 2551-2557.
    CrossRef  |  Direct Link  |  

  35. Ma, Z.N., Z. Liu, Z. Wang, S. Ren and S. Tang et al., 2017. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways. Food Chem. Toxicol., 110: 62-73.
    CrossRef  |  Direct Link  |  

  36. Ma, Z.N., Y.Z. Li, W. Li, X.T. Yan and G. Yang et al., 2017. Nephroprotective effects of saponins from leaves of Panax quinquefolius against cisplatin-induced acute kidney injury. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18071407.
    CrossRef  |  Direct Link  |  

  37. Liu, Z., C.Z. Wang, X.Y. Zhu, J.Y. Wan and J. Zhang et al., 2017. Dynamic changes in neutral and acidic ginsenosides with different cultivation ages and harvest seasons: Identification of chemical characteristics for Panax ginseng quality control. Molecules, Vol. 22. 10.3390/molecules22050734.
    CrossRef  |  Direct Link  |  

  38. Hu, J.N., Z. Liu, Z. Wang, X.D. Li, L.X. Zhang, W. Li and Y.P. Wang, 2017. Ameliorative effects and possible molecular mechanism of action of black ginseng (Panax ginseng) on acetaminophen-mediated liver injury. Molecules, Vol. 22. 10.3390/molecules22040664.
    CrossRef  |  Direct Link  |  

  39. Han, X.Y., J.N. Hu, Z. Wang, S.N. Wei, S.W. Zheng, Y.P. Wang and W. Li, 2017. 5-HMF attenuates liver fibrosis in CCl4-plus-alcohol-induced mice by suppression of oxidative stress. J. Nutr. Sci. Vitaminol., 63: 135-143.
    CrossRef  |  Direct Link  |  

  40. Zheng, S., W. Li, J. Wang, Y. Chen and W. Hou et al., 2016. Platycodin D inhibits B16F10 melanoma metastasis via antiangiogenic activity. RSC Adv., 6: 10606-10614.
    CrossRef  |  Direct Link  |  

  41. Li, W., Y.H. Tian, Y. Liu, Z. Wang, S. Tang, J. Zhang and Y.P. Wang, 2016. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. J. Toxicol. Sci., 41: 417-428.
    CrossRef  |  Direct Link  |  

  42. Li, W., M.H. Yan, Y. Liu, Z. Liu and Z. Wang et al., 2016. Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress and apoptosis. Nutrients, Vol. 8. 10.3390/nu8090566.
    CrossRef  |  Direct Link  |  

  43. He, Y.F., M.L. Nan, Y.W. Zhao, W.Y. Sun, W. Li and Q.C. Zhao, 2016. Design, synthesis and evaluation of antitumor activity of new rotundic acid acylhydrazone derivatives. Zeitschrift fur Naturforschung C, 71: 95-103.
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  44. Cai, E.B., L.M. Yang, C.X. Jia, W.Y. Zhang and Y. Zhao et al., 2016. The synthesis and evaluation of arctigenin amino acid ester derivatives. Chem. Pharm. Bull., 64: 1466-1473.
    CrossRef  |  Direct Link  |  

  45. Wei, S., W. Li, Y. Yu, F. Yao and A. Lixiang et al., 2015. Ginsenoside compound K suppresses the hepatic gluconeogenesis via activating adenosine-5’monophosphate kinase: A study in vitro and in vivo. Life Sci., 139: 8-15.
    CrossRef  |  Direct Link  |  

  46. Sun, Y., W. Li and Z. Liu, 2015. Preparative isolation, quantification and antioxidant activity of dihydrochalcones from Sweet Tea (Lithocarpus polystachyus Rehd.). J. Chromatogr. B, 1002: 372-378.
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  47. Li, W., Z. Wang, J. Gu, L. Chen, W. Hou, Y. Jin and Y. Wang, 2015. Bioconversion of ginsenoside rd to ginsenoside m1 by snailase hydrolysis and its enhancement effect on insulin secretion in vitro. Die Pharmazie-Int. J. Pharm. Sci., 70: 340-346.
    CrossRef  |  Direct Link  |  

  48. Li, W., Y. Liu, Z. Wang, Y. Han and Y.H. Tian et al., 2015. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice. Food Funct., 6: 1418-1427.
    CrossRef  |  Direct Link  |  

  49. Li, W., X.N. Qu, Y. Han, S.W. Zheng, J. Wang and Y.P. Wang, 2015. Ameliorative effect of 5-hydroxymethyl-2-furfural (5-HMF) on acute alcoholic liver oxidative injury in mice. Int. J. Mol. Sci., 16: 2446-2457.

  50. Li, W., X.M. Su, Y. Han, Q. Xu, J. Zhang, Z. Wang and Y.P. Wang, 2015. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. RSC Adv., 5: 101850-101859.
    CrossRef  |  Direct Link  |  

  51. Li, W., Q. Xu, Y.F. He, Y. Liu and S.B. Yang et al., 2015. Anti-tumor effect of steamed Codonopsis lanceolata in H22 tumor-bearing mice and its possible mechanism. Nutrients, 7: 8294-8307.
    CrossRef  |  Direct Link  |  

  52. Jin, Y.P., W. Li, S. Yan and Y.P. Wang, 2015. Characterization of three oleane-type saponins from Panax ginseng. Chem. Nat. Compounds, 51: 1193-1195.
    CrossRef  |  Direct Link  |  

  53. Han, Y., Q. Xu, J.N. Hu, X.Y. Han, W. Li and L.C. Zhao, 2015. Maltol, a food flavoring agent, attenuates acute alcohol-induced oxidative damage in mice. Nutrients, 7: 682-696.
    CrossRef  |  Direct Link  |  

  54. Zhang, B., H. Ye, X.M. Zhu, J.N. Hu and H.Y. Li et al., 2014. Esterification enhanced intestinal absorption of ginsenoside Rh2 in Caco-2 cells without impacts on its protective effects against H2O2-induced cell injury in human umbilical vein endothelial cells (HUVECs). J. Agric. Food Chem., 62: 2096-2103.
    CrossRef  |  Direct Link  |  

  55. San, Z., Y. Fu, W. Li, E. Zhou and Y. Li et al., 2014. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. Int. Immunopharmacol., 19: 342-350.
    CrossRef  |  Direct Link  |  

  56. Guan, F.Y., J. Gu, W. Li, M. Zhang and Y. Ji et al., 2014. Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells. Life Sci., 107: 42-49.
    CrossRef  |  Direct Link  |  

  57. Wang, Z., L.C. Zhao, W. Li, L.X. Zhang, J. Zhang and J. Liang, 2013. Highly efficient biotransformation of polydatin to resveratrol by snailase hydrolysis using response surface methodology optimization. Molecules, 18: 9717-9726.
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  58. Liu, Z., W. Li, X. Li, M. Zhang and L. Chen et al., 2013. Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J. Ethnopharmacol., 145: 233-240.
    CrossRef  |  Direct Link  |  

  59. Li, W., L.L. Shi, L.Q. Han and J. Zhang, 2013. Development and validation of a RP-HPLC method for simultaneous determination of salicin and eight flavonoids in leaves of Salix matsudana Koidz. Acta Chromatogr., 25: 735-743.
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  60. He, Y.F., M.L. Nan, J.M. Sun, Z.J. Meng, W. Li and M. Zhang, 2013. Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Bioorg. Med. Chem. Lett., 23: 2543-2547.
    CrossRef  |  Direct Link  |  

  61. Gu, J., W. Li, D. Xiao, S. Wei and W. Cui et al., 2013. Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2. Fitoterapia, 87: 84-88.
    CrossRef  |  Direct Link  |  

  62. Li, W., Z. Wang, Y.P. Wang, C. Jiang, Q. Liu, Y.S. Sun and Y.N. Zheng, 2012. Pressurised liquid extraction combining LC–DAD–ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulate ‘chachi’(Guangchenpi). Food Chem., 130: 1044-1049.
    CrossRef  |  Direct Link  |  

  63. Li, W., Y.S. Sun, Z. Wang and Y.N. Zheng, 2012. Isolation and purification of saponins from Platycodon grandiflorum by semi-preparative high performance liquid chromatography and lc/esi-ms. J. Liq. Chrom. Relat. Technol., 35: 547-557.
    CrossRef  |  Direct Link  |  

  64. Li, W., M. Zhang, J. Gu, Z.J. Meng and L.C. Zhao et al., 2012. Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia, 83: 192-198.
    CrossRef  |  Direct Link  |  

  65. Li, W., L.C. Zhao, Z. Wang, Y.N. Zheng, J. Liang and H. Wang, 2012. Response surface methodology to optimize enzymatic preparation of deapio-platycodin d and platycodin d from radix platycodi. Int. J. Mol. Sci., 13: 4089-4100.
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  66. Li, W., L.C. Zhao, Y.S. Sun, F.J. Lei, Z. Wang, X.B. Gui and H. Wang, 2012. Optimization of pressurized liquid extraction of three major acetophenones from Cynanchum bungei using a box-behnken design. Int. J. Mol. Sci., 13: 14533-14544.
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  67. Li, W., M. Zhang, Z. Wang, Y.P. Wang, Y.N. Zheng and J. Zhang, 2011. Simultaneous RP-HPLC determination of six platycosides: Application to an enzymatic preparation study. Chromatographia, 74: 777-782.
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  68. Li, W., M. Zhang, Y.N. Zheng, J. Li and Y.P. Wang et al, 2011. Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice. Molecules, 16: 10093-10103.
    CrossRef  |  Direct Link  |  

  69. Li, W., Z. Wang, L. Chen, J. Zhang, L. Han, J. Hou and Y. Zheng, 2010. Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in radix saposhnikoviae. J. Sep. Sci., 33: 2881-2887.
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  70. Li, W., Z. Liu, Z. Wang, L. Chen, Y. Sun, J. Hou and Y. Zheng, 2010. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J. Sep. Sci., 33: 1870-1876.
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  71. Li, W., W. Zhang, L. Xiang, Z. Wang and Y.N. Zheng et al., 2010. Platycoside N: A new oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules, 15: 8702-8708.
    CrossRef  |  Direct Link  |  

  72. Li, W., L. Xiang, J. Zhang, Y.N. Zheng, L.K. Han and M. Saito, 2007. A new triterpenoid saponin from the roots of Platycodon grandiflorum. Chin. Chem. Lett., 18: 306-308.
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