Dr. Xiaoxu Zhou
Research FellowBrown University, USA
Highest Degree
M.D. in Clinical Medicine from Harbin Medical University, China
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Area of Interest:
Selected Publications
- Yan, W., D. Li and X. Zhou, 2017. Pravastatin attenuates the action of the ETS domain‐containing protein ELK1 to prevent atherosclerosis in apolipoprotein E‐knockout mice via modulation of extracellular signal‐regulated kinase 1/2 signal pathway. Clin. Exp. Pharmacol. Physiol., 44: 344-352.
CrossRef | Direct Link | - Xiong, C., X. Zang, X. Zhou, L. Liu and M.V. Masucci et al., 2017. Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion. Oncotarget, 8: 31238-31253.
CrossRef | Direct Link | - Zhou, X., X. Zang, M. Ponnusamy, M.V. Masucci and E. Tolbert et al., 2016. Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining smad7 and phosphatase and tensin homolog expression.` J. Am. Soc. Nephrol., 27 : 2092-2108.
- Yan, Y., L. Ma, X. Zhou, M. Ponnusamy, J. Tang, M.A. Zhuang and S. Zhuang, 2016. Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis. Kidney Int., 89: 68-81.
CrossRef | Direct Link | - Xiong, C., M.V. Masucci, X. Zhou, N. Liu, X. Zang, E. Tolbert and S. Zhuang, 2016. Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis. Oncotarget, 7: 69291-69308.
CrossRef | Direct Link | - Yan, Y., J. Bai, X. Zhou, J. Tang, C. Jiang, E. Tolbert and S. Zhuang, 2015. P2X7 receptor inhibition protects against ischemic acute kidney injury in mice. Am. J. Physiol. Cell Physiol., 308: C463-C472.
CrossRef | Direct Link | - Ponnusamy, M., M.A. Zhuang, X. Zhou, E. Tolbert, G. Bayliss, T.C. Zhao and S. Zhuang, 2015. Activation of Sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J. Pharmacol. Exp. Ther., 354: 142-151.
CrossRef | Direct Link | - Ponnusamy, M., X. Zhou, Y. Yan, J. Tang, E. Tolbert, T.C. Zhao and S. Zhuang, 2014. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J. Pharmacol. Exp. Ther., 350: 243-256.
CrossRef | Direct Link | - Zhou, X., D. Li, M.B. Resnick, J. Wands and W. Cao, 2013. NADPH oxidase NOX5-S and nuclear factor κB1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells. Mol. Pharmacol., 83: 978-990.
CrossRef | Direct Link | - Zhou, X., D. Li, M.B. Resnick, J. Behar, J. Wands and W. Cao, 2011. Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells. J. Pharmacol. Exp. Therapeut., 339: 218-227.
CrossRef | Direct Link | - An, Y., H. Xin, W. Yan and X. Zhou, 2011. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice. Exp. Toxicol. Pathol., 63: 215-219.
CrossRef | Direct Link | - Zhou, X.X., P.J. Gao and B.G. Sun, 2009. Pravastatin attenuates interferon‐γ action via modulation of stat1 to prevent aortic atherosclerosis in apolipoprotein e‐knockout mice. Clin. Exp. Pharmacol. Physiol., 36: 373-379.
CrossRef | Direct Link | - Zhou, X.X., P.J. Gao, B.G. Sun and Z. Jian-jun, 2008. ANTI- oxidative mechanisms of pravastatin preventing aortic atherosclerosis in apoe knockout mice: Role of p38 mapk pathway. J. Shanghai Second Med. Univ., 2: 135-141.
- Zhou, X., D. Li, W. Yan and W. Li, 2008. Pravastatin prevents aortic atherosclerosis via modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to attenuate Interleukin-6 (IL-6) action in ApoE knockout mice. Int. J. Mol. Sci., 9: 2253-2264.
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