Dr. Hongyan Qin

Associate Professor
First Hospital of Lanzhou University, China

Highest Degree
Ph.D. in Pharmacology from Hong Kong Baptist University, China

My URL
https://livedna.org/86.24979

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Area of Interest:

Pharmacology and Toxicology
Pharmacology
Medical Microbiology
Pharmaceutical Analysis
Basic Medical Science

Selected Publications

  1. Wong, H.L.X., H.Y. Qin, S.W. Tsang, X. Zuo and S. Che et al., 2019. Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Commun., 10: 1-14.
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  2. Qin, H.Y., K.H. Zang, X. Zuo, X.A. Wu and Z.X. Bian, 2019. Quercetin attenuates visceral hypersensitivity and 5-hydroxytryptamine availability in postinflammatory irritable bowel syndrome rats: Role of enterochromaffin cells in the colon. J. Med. Food, 22: 663-671.
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  3. Qin, H.Y., J.X. Kou, Z. Rao, G.Q. Zhang, X.H. Wang, L.P. Bai and Y.H. Wei, 2019. N-acetyltransferase activity assay and inhibitory compounds screening by using living human hepatoma heparg cell model. Int. J. Pharmacol., 15: 229-237.
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  4. Chow, C.F.W., S. Che, H.Y. Qin, H.Y. Kwan, Z.X. Bian and H.L.X. Wong, 2019. From psychology to physicality: How nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle, 18: 1824-1829.
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  5. Zhang F, L. Xi, Y. Duan, H. Qin and M. Wei et al., 2018. The ileum-liver farnesoid x receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats. Eur. J. Pharm. Sci., 123: 404-415.
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  6. Rao, Z., F. Zhang, X.Y. Zhang, G.Q. Zhang and Y.R. Ma et al., 2018. Multicomponent determination of traditional Chinese medicine preparation yin‐zhi‐huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells. Biomed. Chromatogr., Vol. 32. 10.1002/bmc.4057.
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  7. Ma, Y.R., Y. Zhou, J. Huang, H.Y. Qin and P. Wang et al., 2018. The urinary excretion of metformin, ceftizoxime and ofloxacin in high serum creatinine rats: Can creatinine predict renal tubular elimination? Life Sci., 196: 110-117.
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  8. Kou, W., H. Qin, S. Hanif and X. Wu, 2018. Nephrotoxicity evaluation on cisplatin combined with 5-HT3 receptor antagonists: A retrospective study. Biomed. Res. Int., Vol. 2018. 10.1155/2018/1024324.
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  9. Zhang, F., H. Qin, Y. Zhao, Y. Wei, L. Xi, Z. Rao and X. Wu., 2017. Effect of cholecystectomy on bile acids as well as relevant enzymes and transporters in mice: Implication for pharmacokinetic changes of rifampicin. Eur. J. Pharm. Sci., 96: 141-153.
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  10. Shi, A.X., Y. Zhou, X.Y. Zhang, Y.S. Zhao, H.Y. Qin, Y.P. Wang and X.A. Wu, 2017. Irinotecan-induced bile acid malabsorption is associated with down-regulation of ileal Asbt (Slc10a2) in mice. Eur. J. Pharm. Sci., 102: 220-229.
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  11. Duan, H., S. Lu, H. Qin, C. Gao and X. Bai et al., 2017. Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. Int. J. Pharm., 516: 214-224.
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  12. Zhou, L., Y. Song, J. Zhao, H. Qin, G. Zhang, Y. Zhou and X.A. Wu, 2016. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp and Oatp1a4 in liver. Pharm. Biol., 54: 931-937.
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  13. Zhang, G., J. Zhu, Y. Zhou, Y. Wei, L. Xi, H. Qin and X.A. Wu, 2016. Hesperidin alleviates oxidative stress and upregulates the multidrug resistance protein 2 in isoniazid and rifampicin‐induced liver injury in rats. J. Biochem. Mol. Toxicol., 30: 342-349.
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  14. Wang, X.D., Z. Rao, H.Y. Qin, G.Q. Zhang and Y.R. Ma et al., 2016. Effect of hesperidin on the pharmacokinetics of CPT‐11 and its active metabolite SN‐38 by regulating hepatic Mrp2 in rats. Biopharm. Drug Dispos., 37: 421-432.
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  15. Ma, Y.R., H.Y. Qin, Y.W. Jin, J. Huang, M. Han, X.D. Wang and X.A. Wu, 2016. Gender-related differences in the expression of organic cation transporter 2 and its role in urinary excretion of metformin in rats. Eur. J. Drug metab. Pharmacokinet., 41: 559-565.
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  16. Ma, Y.R., A.X. Shi, H.Y. Qin, T. Zhang, Y.F. Wu and G.Q. Zhang, 2016. Metoprolol decreases the plasma exposure of metformin via the induction of liver, kidney and muscle uptake in rats. Biopharm. Drug Disposit., 97: 511-521.

  17. Kai-hong, Z., S. Yun-yun, Z. Xiao, R. Zhi and Q. Hong-yan, 2016. Oridonin alleviates visceral hyperalgesia in a rat model of postinflammatory irritable bowel syndrome: Role of colonic enterochromaffin cell and serotonin availability. J. Med. Food, 19: 586.-592.
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  18. Duan, H., S. Lu, C. Gao, X. Bai and H. Qin et al., 2016. Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflammed colon. Colloids Surf. B Biointerfaces, 145: 510-519.
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  19. Zhou, Y., G.Q. Zhang, Z. Rao, Y. Yang and Q. Zhou et al., 2015. Increased brain uptake of venlafaxine loaded solid lipid nanoparticles by overcoming the efflux function and expression of P-gp. Arch. Pharm. Res., 38: 1325-1335.
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  20. Zhang, G., Y. Zhou, Z. Rao, H. Qin and Y. Wei et al., 2015. Effect of yin-zhi-huang on up-regulation of Oatp2, Ntcp, and Mrp2 proteins in estrogen-induced rat cholestasis. Pharm. Biol., 53: 319-325.
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  21. Zang, K.H., Z. Rao, G.Q. Zhang and H.Y. Qin, 2015. Anticolitis activity of chinese herbal formula yupingfeng powder via regulating colonic enterochromaffin cells and serotonin. Indian J. Pharmacol., 47: 632-637.
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  22. Shao, Y.Y., J. Huang, Y.R. Ma, M. Han, K. Ma, H.Y. Qin and X.A. Wu, 2015. Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats. Can. J. Physiol. Pharmacol., 93: 633-639.
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  23. Rao, Z., Y.R., Ma, H.Y. Qin, Y.F. Wang and Y.H. Wei et al., 2015. Development of a LC‐MS/MS method for simultaneous determination of metoprolol and its metabolites, α‐hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: Application to the herb-drug interaction study of metoprolol and breviscapine. Biomed. Chromatogr., 29: 1453-1460.
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  24. Rao, Z., H. Qin, Y. Wei, Y. Zhou, G. Zhang, F. Zhang and X.A. Wu, 2014. Development of a dynamic multiple reaction monitoring method for determination of digoxin and six active components of Ginkgo biloba leaf extract in rat plasma. J. Chromatogr. B, 959: 27-35.
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  25. Qin, H.Y., C.W. Cheng, X.D. Tang and Z.X. Bian, 2014. Impact of psychological stress on irritable bowel syndrome. World J. Gastroenterol., 20: 14126-14131.
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  26. Xiao, H.T., S.W. Tsang, H.Y. Qin, F.F.K. Choi and Z.J. Yang et al., 2013. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J. Ethnopharmacol., 149: 499-505.
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  27. Qin, H.Y., H.T. Xiao, J.C.Y. WU, B.M. Berman, J.J. Sung and Z.X. Bian, 2012. Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats World J. Gastroenterol., 18: 2481-2492.
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  28. Qin, H.Y., H.T. Xiao, F.P. Leung, J.C.Y. Wu and J.J.Y. Sung et al., 2012. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing colonic EC cell hyperplasia and serotonin availability. Evid. Based Complement. Altern. Med., Vol. 2012. 10.1155/2012/239638.
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  29. Qin, H.Y., Wu, J.C., X.D. Tong , J.J.Y. Sung , H.X. Xu and Z.X. Bian, 2011. Systematic review of animal models of post-infectious/post inflammatory irritable. J. Gastroenterol., 46: 164-174.
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  30. Luo, J.L., H.Y. Qin, C.K. Wong, S.Y. Tsang, Y. Huang and Z.X. Bian, 2011. Enhanced excitability and down-regulated voltage-gated potassium channels in colonic drg neurons from neonatal maternal separation rats. J. Pain, 12: 600-609.
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  31. Bian, Z.X., H.Y. Qin, S.L. Tian and S.D. Qi, 2011. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: Differences between proximal and distal colon in rats. Stress: Int. J. Biol. Stress, 14: 448-458.
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  32. Qin, H.Y., J.L. Luo, S.D. Qi, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2010. Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon. Eur. J. Pharmacol., 647: 75-83.
    CrossRef  |  

  33. Wei, Y.H., J.Q. He, H.Y. Qin, X.A. Wu and X.J. Yao, 2009. Determination of ferruginol in rat plasma via high‐performance liquid chromatography and its application in pharmacokinetics study. Biomed. Chromatogr., 23: 1116-1120.
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  34. Zhao, G., W. Du, Y. Wei, H. Qin and X. Wu, 2008. An HPLC method for the determination and pharmacokinetic study of lehmannine in rat plasma. Biomed. Chrom., 22 : 1149-1154.
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  35. Du, W., Y.H. Wei, G. Zhao, H.Y. Qin and X.A. Wu, 2008. Determination of tanshinone i in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. J. Chromatogr. Sci., 46: 730-734.
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Member since September, 2018