Dr. Zhengliang Leon Wu

Research Scientist
Massachusetts Institute of Technology, USA


Highest Degree
Ph.D. in Molecular Biology from Massachusetts Institute of Technology, USA

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Area of Interest:

Molecular Sciences
Molecular Biology
Cellular Biology
Biochemistry
Bioactive Molecules

Selected Publications

  1. Wu, Z.L., C.M. Ethen, B. Prather, M. Machacek and W.P. Jiang, 2011. Universal phosphatase-coupled glycosyltransferase assay. Glycobiology, 21: 727-733.
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  2. Wu, Z.L., B. Prather, C.M. Ethen, A. Kalyuzhny and W.P. Jiang, 2011. Detection of specific glycosaminoglycans and glycan epitopes by in vitro sulfation using recombinant sulfotransferases. Glycobiology, 21: 625-633.
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  3. Wu, Z.L., 2011. Phosphatase-coupled universal Kinase assay and kinetics for first-order-rate coupling reaction. PLoS One, 6: e23172-e23172.
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  4. Wu, Z.L., C.M. Ethen, S. Larson, B. Prather and W. Jiang, 2010. A versatile polyacrylamide gel electrophoresis based sulfotransferase assay. BMC Biotechnol., 10: 11-11.
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  5. Wu, Z.L., C.M. Ethen, G.E. Hickey and W.P. Jiang, 2009. Active 1918 pandemic flu viral neuraminidase has distinct N-glycan profile and is resistant to trypsin digestion. Biochem. Biophys. Res. Communi., 379: 749-753.
    CrossRef  |  

  6. Wu, Z.L. and M. Lech, 2005. Modification degrees at specific sites on heparan sulfate: an approach for measuring chemical modifications on biological molecules with stable isotope labeling. Biochem. J., 389: 383-388.
    CrossRef  |  

  7. Wu, Z.L. and M. Lech, 2005. Characterizing the non-reducing end structure of heparan sulfate. J. Biol. Chem., 280: 33749-33755.
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  8. Wu, Z.L., M. Lech, D.L. Beeler and R.D. Rosenberg, 2004. Determining the structures of heparan sulfate in the vicinity of specific sulfotransferase recognition sites by mass spectrometry. J. Biol. Chem., 279: 1861-1866.
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  9. Wu, Z.L., L. Zhang, T. Yabe, B. Kuberan, D.L. Beeler, A. Love and R.D. Rosenberg, 2003. The involvement of heparan sulfate in FGF1/FGFR1 signaling complex. J. Biol. Chem., 278: 17121-17129.
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  10. Kuberan, B., M. Lech, D.L. Beeler, Z.L. Wu and R.D. Rosenberg, 2003. Enzymatic synthesis of ATIII-binding heparan sulfate pentasaccharide. Nature Biotechnol., 21: 1343-1346.
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  11. Wu, Z.L., L. Zhang, D.L. Beeler, B. Kuberan and R.D. Rosenberg, 2002. A new strategy for defining critical functional groups on heparan sulfate. FASEB J., 16: 539-545.
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  12. Wu, Z. and J.Y. Chiang, 2001. Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1. Gene, 272: 191-197.
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  13. Wu, Z., K.O. Martin, N.B. Javitt and J.Y. Chiang, 1999. Structure and Functions of Human oxysterol 7a-hydroxylase cDNA and the gene CYP7B1. J. Lipid Res., 40: 2195-2203.
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