Dr. Fener Chen

Professor
Fudan University, China

Highest Degree
Ph.D. in Organic Chemistry from Sichuan University, China

My URL
https://livedna.org/86.27818

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Area of Interest:

Chemistry
Organic Chemistry
Medicinal Chemistry
Carbohydrate
Crystallography

Selected Publications

  1. Li, Z., Z. Wang, G. Meng, H. Lu, Z. Huang and F. Chen, 2018. Identification of an ene reductase from yeast Kluyveromyces marxianus and application in the asymmetric synthesis of (R)-profen esters. Asian J. Org. Chem., 7: 763-769.
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  2. Jin, K., H. Yin, E. de Clercq, C. Pannecouque, G. Meng and F. Chen, 2018. Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. Eur. J. Med. Chem., 145: 726-734.
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  3. Huang, G., M. Liu, F. Xiong, G. Meng and Y. Tao et al., 2018. Chiral syn-1, 3-diol derivatives via a one-pot diastereoselective carboxylation/bromocyclization of homoallylic alcohols. iScience, 9: 513-520.
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  4. Wu, Y., M.J. Liu, H.Q. Huang, G.X. Huang, F.J. Xiong and F.E. Chen, 2017. Asymmetric synthesis of atorvastatin calcium through intramolecular oxidative oxygen-nucleophilic bromocyclization. Eur. J. Org. Chem., 25: 3681-3688.
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  5. Wang, X., L. Xu, F. Xiong, Y. Wu and F. Chen, 2017. An improved synthesis of (20S)-camptothecin and its analogue via an asymmetric α-hydroxylation with a chiral organocatalyst. Tetrahedron: Asymmetry, 28: 843-848.
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  6. Peng, H. and F.E. Chen, 2017. Recent advances in asymmetric total synthesis of prostaglandins. Org. Biomol. Chem., 15: 6281-6301.
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  7. Xiong, F., H. Wang, L. Yan, S. Han, Y. Tao, Y. Wu and F. Chen, 2016. Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization. Org. Biomol. Chem., 14: 1363-1369.
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  8. Wang, H., L. Yan, F. Xiong, Y. Wu and F. Chen, 2016. New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α,β-unsaturated aldehydes with diketene: A short synthesis of atorvastatin calcium. RSC Adv., 6: 75470-75477.
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  9. Xiong, F., H. Wang, L. Yan, L. Xu, Y. Tao, Y. Wu and F. Chen, 2015. Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction. Org. Biomol. Chem., 13: 9813-9819.
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  10. Wu, H.Q., J. Yao, Q.Q. He, W.X. Chen and F.E. Chen et al., 2015. Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem., 23: 624-631.
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  11. Wang, H., L. Yan, Y. Wu, Y. Lu and F. Chen, 2015. Asymmetric synthesis of vitamin D3 analogues: Organocatalytic desymmetrization approach toward the A-ring precursor of calcifediol. Org. Lett., 17: 5452-5455.
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  12. Wan, Z.Y., Y. Tao, Y.F. Wang, T.Q. Mao and H. Yin et al., 2015. Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem., 23: 4248-4255.
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  13. Wan, Z.Y., J. Yao, Y. Tao, T.Q. Mao and X.L. Wang et al., 2015. Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur. J. Med. Chem., 97: 1-9.
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  14. Wan, Z.Y., J. Yao, T.Q. Mao, X.L. Wang and H.F. Wang et al., 2015. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur. J. Med. Chem., 102: 215-222.
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  15. Chen, W., F. Xiong, Q. Liu, L. Xu, Y. Wu and F. Chen, 2015. Substrate stereocontrol in bromine-induced intermolecular cyclization: Asymmetric synthesis of pitavastatin calcium. Tetrahedron, 71: 4730-4737.
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  16. Meng, G., Y. Liu, A. Zheng, F. Chen and W. Chen et al., 2014. Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors. Eur. J. Med. Chem., 82: 600-611.
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  17. Chen, X., F. Xiong, W. Chen, Q. He and F. Chen, 2014. Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: An organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach. J. Org. Chem., 79: 2723-2728.
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  18. Chen, X., F. Xiong, C. Zheng, J. Li and F. Chen, 2014. Synthetic studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy. Tetrahedron, 70: 5794-5799.
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  19. Chen, X. and F. Chen, 2014. An efficient synthesis of Katsube nitrile: A key building block for Eburnamine-Vincamine alkaloids. Synthesis, 46: 1506-1510.
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  20. Yang, H.J., F.J. Xiong, X.F. Chen and F.E. Chen, 2013. Highly enantioselective thiolysis of prochiral cyclic anhydrides catalyzed by amino alcohol bifunctional organocatalysts and its application to the synthesis of pregabalin. Eur. J. Org. Chem., 21: 4495-4498.
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  21. Wu, H.Q., Z.H. Yan, W.X. Chen, Q.Q. He and F.E. Chen et al., 2013. Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies. Bioorg. Med. Chem., 21: 6477-6483.
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  22. Liu, Q., F.J. Xiong, Q.Q. He and F.E. Chen, 2013. Development of an efficient process for the decomposition of the borate complexes formed during the large-scale synthesis of (S)-1,2,4-butanetriol. Org. Process Res. Dev., 17: 1540-1542.
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  23. Yang, H.J., L. Dai, S.Q. Yang and F.E. Chen, 2012. Direct bifunctional squaramide-catalyzed asymmetric N-nitroso aldol reaction of tertiary β-carbonyl esters. Synlett, 23: 948-950.
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  24. Dai, L., H. Yang, J. Niu and F. Chen, 2012. Enantioselective protonation in the sulfa-Michael addition using chiral squaramides as hydrogen-bonding organocatalysts. Synlett, 2: 314-316.
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  25. Zhao, L., X.D. Ma and F.E. Chen, 2011. Development of two scalable syntheses of 4-amino-5-aminomethyl-2-methylpyrimidine: Key intermediate for vitamin B1. Org. Process Res. Dev., 16: 57-60.
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  26. Zhao, L., F.J. Xiong, W.X. Chen and F.E. Chen, 2011. A novel and enantioselective total synthesis of (20S)-camptothecin via a sharpless asymmetric dihydroxylation strategy. Synthesis, 24: 4045-4049.
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  27. Li, F., Z.H. Wang, L. Zhao and F.E. Chen, 2011. A facile and efficient asymmetric synthesis of florfenicol. Synlett, 19: 2883-2885.
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  28. Chen, F.E., 2011. Drug Discovery and Synthesis Methods. People's Health Press, Beijing, China.

  29. Xiong, F., X.X. Chen, Z.Q. Liu and F.E. Chen, 2010. A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin. Tetrahedron Lett., 51: 3670-3672.
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  30. Xiong, F., X.X. Chen and F.E. Chen, 2010. An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide. Tetrahedron: Asymmetry, 21: 665-669.
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  31. Huang, J.P., X.X. Chen, S.X. Gu, L. Zhao, W.X. Chen and F.E. Chen, 2010. An efficient method for removal of residual palladium from organic solution of faropenem sodium in the Pd(II)-catalyzed cleavage of allyl faropenem. Org. Process Res. Dev., 14: 939-941.
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  32. Dai, L., S.X. Wang and F.E. Chen, 2010. A bifunctional Cinchona alkaloid-squaramide catalyst for the highly enantioselective conjugate addition of thiols to trans-chalcones. Adv. Synth. Catal., 352: 2137-2141.
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  33. Wang, Y.P., F.E. Chen, E. de Clercq, J. Balzarini and C. Pannecouque, 2009. Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur. J. Med. Chem., 44: 1016-1023.
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  34. Wang, S.X. and F.E. Chen, 2009. A novel cost-effective thiourea bifunctional organocatalyst for highly enantioselective alcoholysis of meso-cyclic anhydrides: Enhanced enantioselectivity by configuration inversion. Adv. Synth. Catal., 351: 547-552.
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  35. Yu, X., S. Wang and F. Chen, 2008. Solid-phase synthesis of solanesol. J. Combinatorial Chem., 10: 605-610.
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  36. Huang, J., F. Xiong and F.E. Chen, 2008. Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy. Tetrahedron: Asymmetry, 19: 1436-1443.
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  37. Dai, H.F., W.X. Chen, L. Zhao, F. Xiong, H. Sheng and F.E. Chen, 2008. Synthetic Studies on (+)-biotin, part 11: Application of Cinchona alkaloid-mediated asymmetric alcoholysis of meso-cyclic anhydride in the total synthesis of (+)-biotin. Adv. Synth. Catal., 350: 1635-1641.
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  38. Chen, F.E., B. Xie, P. Zhang, J.F. Zhao, H. Wang and L. Zhao, 2007. An efficient and green oxidation of vicinal diols to aldehydes using polymer-supported (diacetoxyiodo) benzene as the oxidant. Synlett, 4: 619-622.
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  39. Chen, F.E., X.X. Chen, H.F. Dai, Y.Y. Kuang, B. Xie and J.F. Zhao, 2005. Synthetic studies on d-biotin, part 8:[1] An efficient chemoenzymatic approach to the asymmetric total synthesis of d-biotin via a polymer-supported PLE-mediated desymmetrization of meso-symmetic dicarboxylic esters. Adv. Synth. Catal., 347: 549-554.
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  40. Chen, F.E. and J. Huang, 2005. Reserpine: A challenge for total synthesis of natural products. Chem. Rev., 105: 4671-4706.
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  41. Chen, F.E., Y.Y. Kuang, H.F. Dai, L. Lu and M. Huo, 2003. A selective and mild oxidation of primary amines to nitriles with trichloroisocyanuric acid. Synthesis, 17: 2629-2631.
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  42. Chen, F.E., J.L. Yuan, H.F. Dai, Y.Y. Kuang and Y. Chu, 2003. Synthetic studies on d-biotin, part 6: An expeditious and enantiocontrolled approach to the total synthesis of d-biotin via a polymer-supported chiral oxazaborolidine-catalyzed reduction of meso-cyclic imide strategy. Synthesis, 14: 2155-2160.
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  43. Chen, F.E., H.F. Dai, Y.Y. Kuang and H.Q. Jia, 2003. Synthetic studies on d-biotin. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine. Tetrahedron: Asymmetry, 14: 3667-3672.
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  44. Chen, F.E., Y.Y. Li, M. Xu and H.Q. Jia, 2002. Tetrabutylammonium peroxydisulfate in organic synthesis; XIII.[1] A simple and highly efficient one-pot synthesis of nitriles by nickel-catalyzed oxidation of primary alcohols with tetrabutylammonium peroxydisulfate. Synthesis, 13: 1804-1806.
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  45. Chen, F.E., Z.Z. Peng, H. Fu, G. Meng, Y. Cheng and Y.X. Lu, 2000. A novel and efficient method for the oxidative removal of O-benzyl protective groups of carbohydrates by tetrabutylammonium peroxydisulfate. Synlett, 5: 627-628.
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  46. Chen, F.E., Y.D. Huang, H. Fu, Y. Cheng, D.M. Zhang, Y.Y. Li and Z.Z. Peng, 2000. An efficient and enantioselective synthesis of d-biotin. Synthesis, 14: 2004-2008.
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  47. Chen, F.E., 1998. Organic Drug Synthesis Method. Chinese Medical Science and Technology Press, Beijing, China.

  48. Chen, F.E., 1995. Science-based Drug Design. Huazhong University Press, Wuhan, China.
Member since March, 2019