Dr. Zhikang Qian

Staff Scientist
Washington University School of Medicine, USA

Highest Degree
Ph.D. in Biochemistry and Molecular Biology from Fudan University, Shanghai, China

My URL
https://livedna.org/86.532

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Area of Interest:

Biomedical Sciences
Infectious Disease
Molecular Biology
Microbiology
Virology

Selected Publications

  1. Qian, Z., V. Leung-Pineda, B. Xuan, H. Piwnica-Worms and D. Yu, 2010. Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog, 6: e1000814-e1000814.
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  2. Xuan, B., Z. Qian, E. Torigoi and D. Yu, 2009. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J. Virol., 83: 3463-3474.
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  3. Qian, Z., B. Xuan, T.T. Hong and D. Yu, 2008. The full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments. J. Virol., 82: 3452-3465.
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  4. Terhune, S., E. Torigoi, N. Moorman, M. Silva and Z. Qian et al., 2007. Human cytomegalovirus UL38 protein blocks apoptosis. J. Virol., 81: 3109-3123.
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  5. Xuan, B., Z. Qian, J. Hong and W. Huang, 2006. EsiRNAs inhibit hepatitis B virus replication in mice model more efficiently than synthesized siRNAs. Virus Res., 118: 150-155.
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  6. Xuan, B., Z. Qian, C. Tan, T. Min and S. Shen et al., 2005. esiRNAs purified with chromatography suppress homologous gene expression with high efficiency and specificity. Mol. Biotechnol., 31: 203-209.
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  7. Xu, J., L. Li, Z. Qian, J. Hong and S. Shen et al., 2005. Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter. Biochem. Biophys. Res. Commun., 329: 538-543.
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  8. Qian, Z., B.Q. Xuan, T.S. Min, J.F. Xu and L. Li et al., 2005. Cost-effective method of siRNA preparation and its application to inhibit hepatitis B virus replication in HepG2 cells. World J. Gastroenterol., 11: 1297-1302.
    PubMed  |  Direct Link  |  

  9. Qian, Z., B. Xuan, J. Hong, Z. Hao and L. Wang et al., 2005. Expression and purification of the carboxyl terminus domain of Schizosaccharomyces pombe Dicer in Escherichia coli. Protein Peptide Lett., 12: 311-314.
    PubMed  |  Direct Link  |  

  10. Hong, J., Z. Qian, S. Shen, T. Min and C. Tan et al., 2005. High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse. Biochem. J., 390: 675-679.
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  11. Wu, M., Z. Qian, P. Jiang, T. Min and C. Sun et al., 2003. Cloning of an alkaline lipase gene from Penicillium cyclopium and its expression in Escherichia coli. Lipids, 38: 191-199.
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Member since June, 2010