Dr. Shaoyong Ke

Research Scientist
National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science , Wuhan , 430064 , People's Republic of China

Highest Degree
Ph.D. in Applied Chemistry from East China University of Science & Technology, China

My URL
https://livedna.org/86.6035

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Area of Interest:

Chemistry
Applied Chemistry
Drug Discovery
Multicomponents Reaction
Organic Chemistry

Selected Publications

  1. Ke, S., T. Xu, Y. Min, Z. Wan, Z. Yang and K. Wang, 2021. Marine alkaloid pityriacitrin and its analogues: Discovery, structures, synthetic methods and biological properties. Mini Rev. Med. Chem., 21: 233-244.
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  2. Song, D., X. Cao, W. Huang and S. Ke, 2020. Design, synthesis and biological evaluation of stilbene derivatives containing a 1,3-benzodioxole moiety. ChemistrySelect, 5: 13563-13568.
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  3. Shi, L., Z. Wu, Y. Zhang, Z. Zhang and W. Fang et al., 2020. Herbicidal secondary metabolites from actinomycetes: Structure diversity, modes of action, and their roles in the development of herbicides. J. Agric. Food Chem., 68: 17-32.
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  4. Huang, D., S. Wang, D. Song, X. Cao, W. Huang and S. Ke, 2020. Discovery of γ-lactam alkaloid derivatives as potential fungicidal agents targeting steroid biosynthesis. J. Agric. Food Chem., 68: 14438-14451.
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  5. Xu, T., L. Shi, Y. Zhang, K. Wang, Z. Yang and S. Ke, 2019. Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues. Eur. J. Med. Chem., 168: 293-300.
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  6. Wang, S., L. Bao, D. Song, J. Wang, X. Cao and S. Ke, 2019. Amino acid-oriented poly-substituted heterocyclic tetramic acid derivatives as potential antifungal agents. Eur. J. Med. Chem., 179: 567-575.
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  7. Ke, S., Z. Zhang, M. Liu, W. Fang and D. Huang et al., 2019. Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone. J. Enzyme Inhib. Med. Chem., 34: 1607-1614.
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  8. Ke, S., Z. Zhang, L. Shi, M. Liu and W. Fang et al., 2019. An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A-D and their derivatives. Org. Biomol. Chem., 17: 3635-3639.
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  9. Huang, D., F. Qiu, Z. Zhang, L. Shi, C. Cao and S. Ke, 2019. Synthesis and antifungal activity of substituted 2-aryl benzimidazoles derivatives. J. Heterocyclic Chem., 56: 2494-2498.
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  10. Ke, S., N. Li, T. Ke, L. Shi and Z. Zhang et al., 2018. Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents. Future Med. Chem., 10: 2589-2605.
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  11. Li, S., H. Li, C. Chen, X. Yue, X. Cao and S. Ke, 2013. Novel aroylhydrazine-amide derivatives bearing pyridine core: synthesis, characterisations and selective colorimetric recognition properties. Supramol. Chem., 25: 384-392.
    CrossRef  |  

  12. Ke, S., Z.G. Zhang, T. Long, Y. Liang and Z.W. Yang, 2013. Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: Design, synthesis, characterization and biological evaluation. Med. Chem. Res., 22: 3621-3628.
    CrossRef  |  

  13. Ke, S., Y. Wei, Z. Yang, K. Wang, Y. Liang and L. Shi, 2013. Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation. Bioorg. Med. Chem. Lett., 23: 5131-5134.
    CrossRef  |  

  14. Ke, S., Y. Wei, L. Shi and Yang Q., Z. Yang, 2013. Synthesis of novel steroid derivatives derived from dehydroepiandrosterone as potential anticancer agents. Anticancer Agents Med. Chem., 13: 1291-1298.
    PubMed  |  

  15. Shi, L., R. Hu, Y. Wei, Y. Liang, Z. Yang and S. Ke, 2012. Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation. Eur. J. Med. Chem., 54: 549-556.
    CrossRef  |  

  16. Li, S., X. Cao, C. Chen and S. Ke, 2012. Novel salicylic acid-oriented thiourea-type receptors as colorimetric chemosensor: Synthesis, characterizations and selective naked-eye recognition properties. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 96: 18-23.
    CrossRef  |  

  17. Ke, S., L. Shi, X. Cao, Q. Yang, Y. Liang and Z. Yang, 2012. Heterocycle-functional gramine analogues: Solvent-and catalyst-free synthesis and their inhibition activities against cell proliferation. Eur. J. Med. Chem., 54: 248-254.
    CrossRef  |  

  18. Ke, S., Y.N. Zhang, W. Shu, Z. Zhang and L. Shi et al., 2011. Structural diversity-guided convenient construction of functionalized polysubstituted butenolides and lactam derivatives. C. R. Chim., 14: 1071-1079.
    CrossRef  |  

  19. Ke, S., X. Cao, Y. Liang, K. Wang and Z. Yang, 2011. Synthesis and biological properties of dihydro-oxadiazine-based heterocyclic derivatives. Mini Rev. Med. Chem., 11: 642-657.
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  20. Cao, X., C. Chen, W. Lu and S. Ke, 2011. Chiralβ-arylalkyl-1 H-1, 2, 4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14α-demethylase from Penicillium digitatum. Pestic. Biochem. Phys., 99: 189-193.
    CrossRef  |  

  21. Ke, S., T.T. Sun, Z.G. Zhang, Y.N. Zhang, Y. Liang, K. Wang and Z. Yang, 2010. Spirodiclofen analogues as potential lipid biosynthesis inhibitors: A convenient synthesis, biological evaluation and structure-activity relationship. Bull. Korean Chem. Soc., 31: 2315-2321.
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  22. Cao, X.F., T.T. Sun and S. Ke, 2010. Progress in the studies on synthesis and biological properties of butenolide and its derivatives. 30 Chin. J. Org. Chem.,: 1113-1125.

  23. Ke, S.Y., X.H. Qian, F.Y. Liu, N. Wang, Q. Yang and Z. Li, 2009. Novel 4 H-1, 3, 4-oxadiazin-5 (6 H)-ones with hydrophobic and long alkyl chains: Design, synthesis and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell. Eur. J. Med. Chem., 44: 2113-2121.
    CrossRef  |  

  24. Ke, S., X. Qian, F. Liu, N. Wang, F. Fan, Z. Li and Q. Yang, 2009. Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis and structure-activity relationship. Eur. J. Med. Chem., 44: 2985-2993.
    CrossRef  |  

  25. Ke, S., F. Liu, N. Wang, Q. Yang and X. Qian, 2009. 1, 3, 4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 19: 332-335.
    CrossRef  |  

  26. Ke, S., Z. Li and X. Qian, 2008. 1, 3, 4-Oxadiazole-3 (2 H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation and role of urea moiety. Bioorg. Med. Chem., 16: 7565-7572.
    CrossRef  |  

  27. Ke, S.Y. and S.J. Xue, 2006. Synthesis and herbicidal activity of N-(o-fluorophenoxyacetyl) thioureas derivatives and related fused heterocyclic compounds. Arkivoc, 10: 63-68.
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  28. Xue, S., S. Ke, L. Yan, Z. Cai and Y. Wei, 2005. A trifluoromethyl substituted organoimido derivative of the hexametalate cluster: Synthesis, crystal structure and bioactivity of [Mo 6 O 17(NAr) 2] 2−(Ar= o-CF 3 C 6 H 4). J. Inorg. Biochem., 99: 2276-2281.
    CrossRef  |  
Member since December, 2013