Dr. Zhu Dan Yan

Research Scientist
Zhejiang University, China

Highest Degree
M.D. in Pharmacology from Zhejiang University, China

My URL
https://livedna.org/86.6253

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Area of Interest:

Pharmacology and Toxicology
Stem Cell Biology
Tissue Engineering
Drug Regulation
Chinese Traditional Medicine

Selected Publications

  1. Zhou, L.,Y. Huang, Y. Zhang, Q. Zhao, B. Zheng, Y. Lou and D. Zhu, 2013. mGluR5 stimulating Homer-PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species. Exp. Cell Res., 319: 1505-1514.
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  2. Yan, J., Q. Liu, Y. Dou, Y. Hsieh and Y. Liu et al., 2013. Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis. J. Ethnopharmacol., 147: 456-466.
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  3. Zhu, D.Y., L.M. Zhou, Y.Y. Zhang, J.Q. Huang, X. Pan and Y.J. Lou, 2012. Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells. Stem Cells Dev., 21: 2130-2141.
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  4. Wu, J., Z. Pan, Z. Wang, W. Zhu and Y. Shen et al., 2012. Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology, 63: 349-361.
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  5. Liang, X., Y. Mei, X. Huang, G. Shen and D. Zhu et al., 2012. Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells. J. Cell. Biochem., 113: 2884-2894.
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  6. Zhu, D.Y., R. Cui, Y.Y. Zhang, H. Li, L.M. Zhou and Y.J. Lou, 2011. Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis. J. Cell. Biochem., 112: 3343-3353.
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  7. Yang, H., Y. Dou, X. Zheng, Y. Tan and J. Cheng et al., 2011. Cysteinyl leukotrienes synthesis is involved in aristolochic acid -induced apoptosis in renal proximal tubular epithelial cells. Toxicology, 287: 38-45.
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  8. Yan, J., Q. Shi, Z. Chen, R. Zhuang, H. Chen, D. Zhu and Y. Lou, 2011. Skeletal muscle aldolase an overexpression in endotoxemic rats and inhibited by GSNO via potential role for S-nitrosylation In vitro. J Surg. Res., 170: e57-e63.
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  9. Wang, D.Y., Y.Z. Hu, S.S. Kong, Y.P. Yu, D.Y. Zhu and Y.J. Lou, 2011. Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation. Acta Pharmacol. Sin., 32: 425-432.
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  10. Zhu, D.Y., J.Y. Wu, H. Li, J.P. Yan, M.Y. Guo, Y.B. Wo and Y.J. Lou, 2010. PPAR-β facilitating maturation of hepatic-like tissue derived from mouse embryonic stem cells accompanied by mitochondriogenesis and membrane potential retention. J. Cell. Biochem., 109: 498-508.
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  11. Ma, K., Y. Zhang, D. Zhu and Y. Lou, 2009. Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur. J. Pharmacol., 603: 98-107.
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  12. Zhu, D.Y., Y. Du, X. Huang, M.Y. Guo, K.F. Ma, Y.P. Yu, Y.J. Lou, 2008. MAPEG expression in mouse embryonic stem cell-derived hepatic tissue system. Stem Cells Dev., 17: 775-784.
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  13. Wo, Y.B., D.Y. Zhu, Y. Hu, Z.Q. Wang, J. Liu and Y.J. Lou, 2008. Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells. J. Cell. Biochem., 103: 1536-1550.
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  14. Wo, Y., D. Zhu, Y. Yu and Y. Lou, 2008. Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur. J. Pharmacol., 586: 59-66.
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  15. Wang, Z., H. Wang, J. Wu, D. Zhu and X. Zhang et al., 2008. Enhanced co-expression of β-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner. Chem. Biol. Interact., 179: 375-385.
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  16. Ma, K.F., H.Y. Yang, Z. Chen, L.Y. Qi, D.Y. Zhu and Y.J. Lou, 2008. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. World J. Gastroenterol., 14: 2748-2756.
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  17. Ding, L., X.G. Liang, Y. Hu, D.Y. Zhu and Y.J. Lou, 2008. Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev., 17: 751-760.
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  18. Zhu, D.Y., X.N. Zhang and Y. Du, 2007. Directed differentiation of mouse embryonic stem cells into neuronal cells induced by icaritin in vitro. J. Zhejiang Univ. (Med. Sci.), 36: 217-223.
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  19. Zhu, D.Y. and Y.J. Lou, 2007. A method of inducing directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Chinese Pharma. J., 42: 667-671.

  20. Huang, X., D. Zhu and Y. Lou, 2007. A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells. Eur. J. Pharmacol., 564: 26-36.
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  21. Ding, L., X.G. Liang, D.Y. Zhu and Y.J. Lou, 2007. Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biol. Int., 31: 1002-1009.
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  22. Ding, L., X.G. Liang, D.Y. Zhu and Y.J. Lou, 2007. Icariin promotes expression of PGC-1α, PPARα and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacol. Sin., 28: 1541-1549.
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  23. Zhu, D.Y. and Y. Lou, 2006. Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol. Sin., 27: 311-320.
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  24. Yang, B., Q.J. He, D.Y. Zhu, Y.J. Lou and R.Y. Fang, 2006. Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo. Cancer Chemother. Pharmacol., 57: 268-273.
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  25. Zhu, D.Y. and Y.J. Lou, 2005. Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol. Sin., 26: 477-485.
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  26. Zhu, D., L. Qu, X. Zhang and Y. Lou, 2005. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Eur. J. Pharmacol., 514: 99-110.
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Member since January, 2014