Dr. Xin-Min Li

Professor
University of Alberta, Canada

Highest Degree
Ph.D. in Physiology from Norman Bethune University of Medical Sciences, Changchun, China

My URL
https://livedna.org/86.6387

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Area of Interest:

Pharmacology and Toxicology
Physiology
Neurodegeneration
Psychiatric Disorders
Neuropharmacology

Selected Publications

  1. Zhu, S., J. He, R. Zhang, L. Kong, A. Tempier, J. Kong and X.M. Li, 2013. Therapeutic effects of quetiapine on memory deficit and brain β-amyloid plaque pathology in a transgenic mouse model of Alzheimer's disease. Curr. Alzheimer Res., 10: 270-278.
    Direct Link  |  

  2. Tempier, A., J. He, S. Zhu, R. Zhang and L. Kong et al., 2013. Quetiapine modulates conditioned anxiety and alternation behavior in Alzheimer's transgenic mice. Curr. Alzheimer Res., 10: 199-206.
    Direct Link  |  

  3. Chen, X., T. Guan, X. Zhang, C. Li and H. Shang et al., 2013. S-nitrosylated protein disulfide isomerase contributes to mutant SOD1 aggregates in amyotrophic lateral sclerosis. J. Neurochem., 124: 45-58.
    CrossRef  |  

  4. Zhang, Y., H. Zhang, L. Wang, W. Jiang and H. Xu et al., 2012. Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination. Schizphr. Res., 138: 8-17.
    CrossRef  |  

  5. Zhang, R., S. Zhu, H. Zhang, H. Wang and A. Adilijiang et al., 2012. Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia. Brain Res., 1469: 136-143.
    CrossRef  |  

  6. Wang, H., J. He, R. Zhang, S. Zhu and J. Wang et al., 2012. Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease. Behav. Brain Res., 233: 237-243.
    CrossRef  |  

  7. Shi, R., J. Weng, L. Zhao, X.M. Li, T.M. Gao and J. Kong, 2012. Excessive autophagy contributes to neuron death in cerebral ischemia. CNS Neurosci. Ther., 18: 250-260.
    CrossRef  |  

  8. Mei, F., S. Guo, Y. He, L. Wang and H. Wang et al., 2012. Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector t cell proliferation. PLoS One, Vol. 7. 10.1371/journal.pone.0042746.
    CrossRef  |  Direct Link  |  

  9. Chen, X., T. Guan, C. Li, H. Shang, L. Cui, X.M. Li and J. Kong, 2012. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: A role of NO-mediated S-nitrosylation of Protein Disulfide Isomerase (PDI). J. Neuroinflammation, Vol. 9. 10.1186/1742-2094-9-237.
    CrossRef  |  

  10. Chen, X., H. Shang, X. Qiu, N. Fujiwara and L. Cui et al., 2012. Oxidative modification of cysteine 111 promotes disulfide bond-independent aggregation of SOD1. Neurochem. Res., 37: 835-845.
    CrossRef  |  

  11. Bi, X., Y. Zhang, B. Yan, S. Fang and J. He et al., 2012. Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice. J. Neurochem., 123: 14-20.
    CrossRef  |  

  12. Zhang, Z., R. Shi, J. Weng, X. Xu, X.M. Li, T.M. Gao and J. Kong, 2011. The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity. FEBS J., 278: 134-142.
    CrossRef  |  

  13. Wang, Y., Y. Zhang, J. He, H. Zhang and X. Lan et al., 2011. Hyperforin promotes mitochondrial function and development of oligodendrocytes. J. Neurochem., 119: 555-568.
    CrossRef  |  

  14. Tian, L., C. Meng, H. Yan, Q. Zhao and Q. Liu et al., 2011. Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives. PLoS One, Vol. 6. 10.1371/journal.pone.0028794.
    CrossRef  |  

  15. Xu, H., H.J. Yang, B. McConomy, R. Browning and X.M. Li, 2010. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: Effects of antipsychotics. Front. Behav. Neurosci., Vol. 4. 10.3389/fnbeh.2010.00008.
    CrossRef  |  

  16. Wang, H., H. Xu, J. Niu, F. Mei and X.M. Li et al., 2010. Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain. Schizophr. Res., 119: 164-174.
    CrossRef  |  

  17. Niu, J., F. Mei, N. Li, H. Wang, X. Li, J. Kong and L. Xiao, 2010. Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell cultures. Biochem. Cell Biol., 88: 611-620.
    CrossRef  |  

  18. Fang, S., B. Yan, D. Wang, X. Bi and Y. Zhang et al., 2010. Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice. Biochem. Cell. Biol., 88: 655-663.
    CrossRef  |  

  19. Yu, Y., J. He, Y. Zhang, H. Luo and S. Zhu et al., 2009. Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus, 19: 1247-1253.
    CrossRef  |  Direct Link  |  

  20. Yang, H.J., H. Wang, Y. Zhang, L. Xiao and R. Clough et al., 2009. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia. Brain Res., 1270: 121-130.
    CrossRef  |  

  21. Xu, H., H.J. Yang, Y. Zhang, R. Clough, R. Browning and X.M. Li, 2009. Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behav. Neurosci., 123: 418-429.
    CrossRef  |  

  22. He, J., J. Kong, Q.R. Tan and X.M. Li, 2009. Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models. Cell Adh. Migr., 3: 129-137.
    Direct Link  |  

  23. He, J., H. Luo, B. Yan, Y. Yu and H. Wang et al., 2009. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol. Aging, 30: 1205-1216.
    CrossRef  |  

  24. Cao, X., X.M. Li and D.D. Mousseau, 2009. Calcium alters monoamine oxidase-a parameters in human cerebellar and rat glial C6 cell extracts: Possible influence by distinct signalling pathways. Life Sci., 85: 262-268.
    CrossRef  |  

  25. Cao, X., L.W. Rui, P.R. Pennington, J. Chlan-Fourney and Z.J. Jiang et al., 2009. Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-a activity. J. Neurochem., 111: 101-110.
    CrossRef  |  

  26. Bi, S., B. Yan, S. Fang, Y. Yang, J. He, X.M. Li and J. Kong, 2009. Quetiapine regulates neurogenesis in ischemic mice by inhibiting NF-κB p65/p50 expression. Neurol. Res., 31: 159-166.
    CrossRef  |  Direct Link  |  

  27. Zhang, Y., H. Xu, W. Jiang, L. Xiao and B. Yan et al., 2008. Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. Schizophrenia Res., 106: 182-191.
    CrossRef  |  

  28. Xu, H., H. Wang, L. Zhuang, B. Yan and Y. Yu et al., 2008. Demonstration of an anti-oxidative stress mechanism of quetiapine: Implications for the treatment of Alzheimer's disease. FEBS J., 275: 3718-3728.
    CrossRef  |  Direct Link  |  

  29. Xiao, L., H. Xu, Y. Zhang, Z. Wei and J. He et al., 2008. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol. Psychiatry, 13: 697-708.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Lieberman, J.A., F.P. Bymaster, H.Y. Meltzer, A.Y. Deutch and G.E. Duncan et al., 2008. Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation and neuroprotection. Pharmacol. Rev., 60: 358-403.
    CrossRef  |  Direct Link  |  

  31. Zhang, Y., H. Xu, J. He, B. Yan, W. Jiang and X.M. Li, 2007. Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment. Neurosci. Lett., 420: 66-71.
    CrossRef  |  

  32. Yan, B., X. Bi, J. He, Y. Zhang and S. Thakur et al., 2007. Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occulusion in mice. Life Sci., 81: 353-361.
    CrossRef  |  

  33. Yan, B., J. He, H. Xu, Y. Zhang and X. Bi et al., 2007. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav. Brain Res., 182: 36-41.
    CrossRef  |  

  34. Li, X.M. and H. Xu, 2007. In vitro and in vivo evidence for neuroprotective effects of antipsychotic drugs: Implications for the pathophysiology and treatment of schizophrenia. Int. Rev. Neurobiol., 77: 107-142.
    Direct Link  |  

  35. Cao, X., Z. Wei, G.G. Gabriel, X.M. Li and D.D. Mousseau, 2007. Calcium-sensitive regulation of monoamine oxidase-a contributes to the production of peroxyradicals in hippocampal cultures: Implications for Alzheimer disease-related pathology. BMC Neurosci., Vol. 8. 10.1186/1471-2202-8-73.
    CrossRef  |  

  36. Xu, H., Z. Chen, J. He, S. Haimanot and X.M. Li, 2006. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus, 16: 551-559.
    CrossRef  |  

  37. Wei, Z., D.D. Mousseau, Y. Dai, X. Cao and X.M. Li, 2006. Haloperidol induces apoptosis via the sigma2 receptor system and Bcl-XS. J. Pharmacogenomics, 6: 279-288.
    Direct Link  |  

  38. Shao, Z., H. Wang, L.E. Dyck and X.M. Li, 2006. Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells. J. Psychiatry Neurosci., 31: 32-37.
    Direct Link  |  

  39. He, J., Y. Yang, Y. Yu, X. Li and X.M. Li, 2006. The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats. Behav. Brain Res., 172: 39-45.
    Direct Link  |  

  40. He, J., H. Xu, Y. Yang, D. Rajakumar, X. Li and X.M. Li, 2006. The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats. Behav. Brain Res., 168: 236-242.
    CrossRef  |  

  41. Bai, O., H. Xu and X.M. Li, 2006. Haloperidol and atypical antipsychotics share a same action of decreasing p75NTR mRNA levels in PC12 cells. Life Sci., 79: 570-574.
    CrossRef  |  

  42. Wang, H., H. Xu, L. Dyck and X.M. Li, 2005. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide (25-35)-induced oxidative stress and the ensuing apoptosis. J. Neurosci. Res., 81: 572-580.
    CrossRef  |  PubMed  |  

  43. Luo, C., H. Xu and X.M. Li, 2005. Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress. Brain Res., 1063: 32-39.
    CrossRef  |  

  44. Kolla, N., Z. Wei, J.S. Richardson and X.M. Li, 2005. Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxide. J. Psychiatry Neurosci., 30: 196-201.
    PubMed  |  

  45. He, J., Y. Yang, H. Xu, X. Zhang and X.M. Li, 2005. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology, 30: 1511-1520.
    PubMed  |  

  46. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2005. Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by neurotoxic regimen of dl-amphetamine in rats. Behav. Brain Res., 160: 178-187.
    CrossRef  |  PubMed  |  

  47. Chen, Z., H. Xu, S. Haimanot, X. Li and X.M. Li, 2005. Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in hippocampal formations of stressed rats. Neurosci. Lett., 389: 173-177.

  48. Xu, H., J.S. Richardson, C. Luo and X.M. Li, 2004. Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine. Pharmacogenomics J., 4: 322-331.
    CrossRef  |  

  49. Xu, H., J. He, J.S. Richardson and X.M. Li, 2004. The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. J. Neurochem., 91: 1380-1388.
    CrossRef  |  

  50. Luo, C., H. Xu and X.M. Li, 2004. Post-stress changes in BDNF and Bcl-2 immuno-reactivities in hippocampal neurons: Effect of chronic administration of olanzapine. Brain Res., 1025: 194-202.
    CrossRef  |  

  51. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2004. Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats. Brain Res., 1018: 186-192.
    CrossRef  |  

  52. Bai, O., H. Zhang and X.M. Li, 2004. Antipsychotic drugs clozapine and olanzapine upregulate Bcl-2 mRNA and protein in rat frontal cortex and hippocampus. Brain Res., 1010: 81-86.
    CrossRef  |  PubMed  |  

  53. Xu, H., J.S. Richardson and X.M. Li, 2003. Dose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus. Neuropsychopharmacol., 28: 53-62.
    PubMed  |  

  54. Wei, Z., O. Bai, J.S. Richardson, D.D. Mousseau and X.M. Li, 2003. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J. Neurosci. Res., 73: 364-368.
    CrossRef  |  PubMed  |  

  55. Wei, Z., D.D. Mousseau, J.S. Richardson, L.E. Dyck and X.M. Li, 2003. Atypical antipsychotics attenuate neurotoxicity of β-amyloid(25-35) by modulating Bax and Bcl-Xl/s expression and localization. J. Neurosci. Res., 74: 942-947.
    CrossRef  |  PubMed  |  

  56. Qing, H., H. Xu, Z. Wei, K. Gibson and X.M. Li, 2003. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis. Eur. J. Neurosci., 17: 1563-1570.
    CrossRef  |  

  57. Cui, S.S., C.P. Yang, R.C. Bowen, O. Bai, X.M. Li, W. Jiang and W. Zhang, 2003. Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats. Brain Res., 975: 229-236.
    CrossRef  |  PubMed  |  

  58. Bai, O., J. Chlan-Fourney, R. Bowen, D. Keegan and X.M. Li, 2003. Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J. Neurosci. Res., 71: 127-131.
    CrossRef  |  PubMed  |  

  59. Xu, H., H. Qing, W. Lu, D. Keegana, J. Richardson, J. Chlan-Fourney and X.M. Li, 2002. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci. Lett., 321: 65-68.
    CrossRef  |  PubMed  |  

  60. Chlan-Fourney, J., P.C. Ashe, K. Nylen, A.V. Juorio and X.M. Li, 2002. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain Res., 954: 11-20.
    CrossRef  |  PubMed  |  

  61. Bai, O., Z. Wei, W. Lu, R. Bowen, D. Keegan and X.M. Li, 2002. Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res., 69: 278-283.
    CrossRef  |  PubMed  |  

  62. Ashe, P.C., J. Chlan-Fourney, A.V. Juorio and X.M. Li, 2002. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain Res., 956: 126-135.
    CrossRef  |  PubMed  |  

  63. Mohapel, P., X. Zhang, G. Gillespie, J. Chlan-Fourney and D.K. Hannesson et al., 2001. Kindling of claustrum and insular cortex: Comparison to pherirhinal cortex. Eur. J. Neurosci., 13: 1501-1519.
    PubMed  |  

  64. Fang, J., G. McKay, A. Remillard, X.M. Li and K.K. Midha, 2001. In vitro characterization of the metabolism of haloperidol using recombinant cytochrome P450 enzymes and human liver microsomes. Drug Metabol. Dispos., 12: 1-6.
    PubMed  |  
Member since January, 2014