Dr. Peng George Wang

Professor
Georgia State University, USA


Highest Degree
Ph.D. in Bioorganic Chemistry from University of California, USA

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Area of Interest:

Chemistry
Microbial Glycobiology
Glycochemistry
Carbohydrate Chemistry
Glycomics

Selected Publications

  1. Wu, B., R. Woodward, L.Q. Wen, X. Wang, G.H. Zhao and P.G. Wang, 2013. Synthesis of a comprehensive polyprenol library for the evaluation of bacterial enzyme lipid substrate specificity. Eur. J. Organic Chem., 36: 8162-8173.
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  2. Li, Z., T. Li, S. Dai, X. Xie and X. Ma et al., 2013. New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of gaucher disease. ChemBioChem, 14: 1239-1247.
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  3. Fang, J., M. Xue, G. Gu, X.W. Liu and P.G. Wang, 2013. A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168. Bioorg. Med. Chem. Lett., 23: 4303-4307.
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  4. Li, Z., L. Cai, M. Wei and P.G. Wang, 2012. One-Pot four-enzyme synthesis of ketoses with fructose 1,6-bisphosphate aldolases from Staphylococcus carnosus and rabbit muscle. Carbohydr. Res., 357: 143-146.
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  5. Hou, J., X. Liu, J. Shen, G. Zhao and P.G. Wang, 2012. The impact of click chemistry in medicinal chemistry. Expert Opin. Drug Discov., 7: 489-501.
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  6. Han, W., B. Wu, L. Li, G. Zhao and R. Woodward et al., 2012. Defining function of lipopolysaccharide O-antigen ligase WaaL using chemoenzymatically synthesized substrates. J. Biol. Chem., 287: 5357-5365.
    CrossRef  |  PubMed  |  

  7. Ban, L., N. Pettit, L. Li, A.D. Stuparu and L. Cai et al., 2012. Discovery of glycosyltransferases using carbohydrate arrays and mass spectrometry. Nat. Chem. Biol., 8: 769-773.
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  8. Zhou, Z., C. Zhang, C. Xia, W. Chen and H. Zhu et al., 2011. Enhanced antitumor effects by chemical modified IGb3 analogues. Mol. Cancer Ther., 10: 1375-1384.
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  9. Zhou, G., X. Liu, D. Su, L. Li, M. Xiao and P.G. Wang, 2011. Large scale enzymatic synthesis of oligosaccharides and a novel purification process. Bioorg. Med. Chem. Lett., 21: 311-314.
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  10. Zhang, W., C. Xia, J. Nadas, W. Chen, L. Gu and P.G. Wang, 2011. Introduction of aromatic group on 4'-OH of α-GalCer manipulated NKT cell cytokine production. Bioorg. Med. Chem., 19: 2767-2776.
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  11. Wu, B.,W.P. Zhang, Z.H. Li, L. Gu, X. Wang and P.G. Wang, 2011. Concise synthesis of 5-methoxy-6-hydroxy-6-methylchromone-7-O- and 5-Hydroxy-2-methylchromone-7-O-rutinosides. Investigation of their cytotoxic activities against several human tumor cell lines. J. Org. Chem., 76: 2265-2268.
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  12. Pettit, N., L. Cai, W.Q.Han, L. Zha, W. Guan and P.G. Wang, 2011. C2-Carbon isostere of N-acetylglucosamine as substrate for bacterial polysaccharide remodeling. Am. J. Biomed. Sci., 3: 107-115.
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  13. Li, Z., L. Cai, Q. Qi, T.J. Styslinger, G. Zhao and P.G. Wang, 2011. Synthesis of rare sugars with L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8. Bioorg. Med. Chem. Lett., 21: 5084-5087.
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  14. Li, Z., L. Cai, Q. Qi and P.G. Wang, 2011. Enzymatic synthesis of D-sorbose and D-psicose with aldolase RhaD: Effect of acceptor configuration on enzyme stereoselectivity. Bioorg. Med. Chem. Lett., 21: 7081-7084.
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  15. Li, Y.H., H. Yu, Y. Chen, K. Lau and L. Cai et al., 2011. Substrate promiscuity of N-acetylhexosamine 1-kinases. Molecules, 16: 6396-6407.
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  16. Guan, W., L. Ban, L. Cai, L. Li and W. Chen et al., 2011. Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitides β1,3-N-acetylglucosaminyltransferase LgtA. Bioorg. Med. Chem. Lett., 21: 5025-5028.
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  17. Facciotti, F., M. Cavallari, C. Angenieux, L.F. Garcia-Alles and F. Signorino-Gelo et al., 2011. Fine tuning by human CD1e of lipid-specific immune responses. Proc. Natl. Acad. Sci., 108: 14228-14233.
    CrossRef  |  PubMed  |  

  18. Chen, W., L. Gu, W. Zhang, E. Motari, L. Cai, T.J. Styslinger and P.G. Wang, 2011. L-Rhamnose antigen: A promising alternative to α-Gal for cancer immunotherapies. ACS Chem. Biol., 6: 185-191.
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  19. Cai, L., L. Ban, W. Guan, M. Mrksich and P.G. Wang, 2011. Enzymatic synthesis and properties of uridine-5'-O-(2-thiodiphospho)-N-acetylglucosamine. Carbohydr. Res., 346: 1576-1580.
    CrossRef  |  PubMed  |  

  20. Bhatt, V.S., W. Guan, M. Xue, H. Yuan and P.G. Wang, 2011. Insights into role of the hydrogen bond networks in substrate recognition by UDP-GalNAc 4-epimerases. Biochem. Biophys. Res. Commun., 412: 232-237.
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  21. Bhatt, V.S., S. Zaldivar-Lopez, D.R. Harris, C.G. Couto, P.G. Wang and A.F. Palmer, 2011. Structure of Greyhound hemoglobin: Origin of high oxygen affinity. Acta Crystallographica D Biol. Crystallographica, 67: 395-402.
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  22. Bhatt, V.S., C.Y. Guo, W. Guan, G. Zhao, W. Yi, Z.J. Liu and P.G. Wang, 2011. Altered architecture of substrate binding region defines the unique specificity of UDP-GalNac 4-epimerases. Protein Sci., 20: 856-866.
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  23. Zhao, G., W. Guan, L. Cai and P.G. Wang, 2010. Enzymatic route to preparative-scale synthesis of UDP-GlcNAc/GalNAc, their analogues and GDP-fucose. Nat. Protoc., 5: 636-646.
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  24. Zhang, L., K. Lau, J. Cheng, H. Yu and Y.H. Li et al., 2010. Helicobacter hepaticus Hh0072 gene encodes a novel α1-3-fucosyltransferase belonging to CAZy GT11 family. Glycobiology, 20: 1077-1088.

  25. Yu, H., V. Thon, K. Lau, L. Cai and Y. Chen et al., 2010. Highly Efficient Chemoenzymatic Synthesis of β1-3-Linked Galactosides. Chem. Commun., 46: 7507-7509.

  26. Woodward, R., W. Yi, L. Li, G. Zhao and H. Eguchi et al., 2010. In vitro bacterial polysaccharide biosynthesis: Defining the functions of Wzy and Wzz. Nat. Chem. Biol., 6: 418-423.
    CrossRef  |  PubMed  |  

  27. Wang, J., V. Dang, W. Zhao, D. Lu and Rivera et al., 2010. Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion. Bioorg. Med. Chem., 18: 922-929.
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  28. Pettit, N., T. Styslinger, Z. Mei, W. Han, G. Zhao and P.G. Wang, 2010. Characterization of WbiQ: An α1,2-fucosyltransferase from Escherichia coli O127:K63(B8) and synthesis of H-type 3 blood group antigen. Biochem. Biophys. Res. Commun., 402: 190-195.
    CrossRef  |  PubMed  |  

  29. Li, L., R. Woodward, Y. Ding, X.W. Liu and W. Yi et al., 2010. Overexpression and topology of bacterial oligosaccharyltransferase PglB. Biochem. Biophys. Res. Commun., 394: 1069-1074.
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  30. Han, W., L. Li, N. Pettit, W. Yi and R. Woodward et al., 2010. In vitro reconstitution of Escherichia coli O86 O antigen repeating unit. Methods Mol. Biol., 600: 93-110.
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  31. Guan, W., L. Cai and P.G. Wang, 2010. Highly efficient synthesis of UDP-GalNAc/GlcNAc analogues with promiscuous recombinant human UDP-GalNAc Pyrophosphorylase AGX1. Chem. Eur. J., 16: 13343-13345.
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  32. Chen, W., C. Xia, L. Cai and P.G. Wang, 2010. Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation. Bioorg. Med. Chem. Lett., 20: 3859-3862.
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  33. Cai, L., W. Guan, W. Chen and P.G. Wang, 2010. Chemoenzymatic synthesis of uridine 5'-diphospho-2-acetonyl-2-deoxy-alpha-D-glucose as C(2)-carbon isostere of UDP-GlcNAc. J. Org. Chem., 75: 3492-3494.
    CrossRef  |  PubMed  |  

  34. Yi, W., X.W. Liu, Y. Li, J.J. Li and C.F. Xia et al., 2009. Remodeling bacterial polysaccharides by metabolic pathway engineering. Proc. Natl. Acad. Sci., 106: 4207-4212.

  35. Xia, C.F., W.P. Zhang, Y. Zhang, R.L. Woodward, J.H. Wang and P.G. Wang, 2009. Facile synthesis of biotin-labelled α-galactosylceramide as antigen for invariant natural killer T cells. Tetrahedron, 65: 6390-6395.
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  36. Xia, C., W. Zhang, Y. Zhang, W. Chen and J. Nadas et al., 2009. The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer t cells. ChemMedChem, 4: 1810-1815.
    CrossRef  |  PubMed  |  

  37. Thapa, P., G. Zhang, C. Xia, A. Gelbard and W.W. Overwijk et al., 2009. Nanoparticle formulated α-galactosylceramide activates NKT cells without inducing anergy. Vaccine, 27: 3484-3488.
    CrossRef  |  PubMed  |  

  38. Paquette, L.A., G. Moura-Letts and P.G. Wang, 2009. From D-glucose to enantiomeically pure cycloctanoses. The glycosidase inhibitory capacity of medium-ring carbasugars. J. Org. Chem., 74: 2099-2107.

  39. Nadas, J., C. Li and P.G. Wang, 2009. Computational structure activity relationship studies on the CD1d/Glycolipid/TCR complex using AMBER and AUTODOCK. J. Chem. Inform. Model., 49: 410-423.
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  40. Motari, E., X. Zheng, X. Su, Y. Liu, M. Kvaratskhelia, M Freitas and P.G. Wang, 2009. Analysis of recombinant CD24 glycans by MALDI-TOF-MS reveals prevalence of sialyl-T antigen. Am. J. Biomed. Sci., 1: 1-11.
    PubMed  |  

  41. Liu, X.W., C. Xia, L. Li, W.Y. Guan and N. Pettit et al., 2009. Characterization and synthetic application of a novel beta1,3-galactosyltransferase from Escherichia coli O55:H7. Bioorg. Med. Chem., 17: 4910-4915.
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  42. Guan, W., L. Cai, J. Fang, B. Wu and P.G. Wang, 2009. Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU). Chem. Commun., 45: 6976-6978.
    CrossRef  |  PubMed  |  

  43. Florence, W.C., C. Xia, L.E. Gordy, W. Chen and Y. Zhang et al., 2009. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J., 28: 3579-3590.
    CrossRef  |  PubMed  |  

  44. Chen, W., R. Woodward and P.G. Wang, 2009. Targeting wall techoic acid biosynthesis: An in vivo based high-throughput screen for small molecule inhibitors. ACS Chem. Biol., 4: 893-894.
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  45. Cai, L., W. Guan, W. Wang, W. Zhao and M. Kitaoka et al., 2009. Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives. Bioorg.Med. Chem. Lett., 19: 5433-5435.
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  46. Cai, L., W. Guan, M. Kitaoka, J. Shen, C.F. Xia, W. Chen and P.G. Wang, 2009. A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase. Chem. Commun., 20: 2944-2946.
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  47. Zhang, Y., V.S. Bhatt, G. Sun, P.G. Wang and A.F. Palmer, 2008. Site-Selective glycosylation of hemoglobin on Cys β-93. Bioconjug. Chem., 19: 2221-2230.
    CrossRef  |  PubMed  |  

  48. Zhang, Y., S. Luo, Y. Tang, L. Yu and K.Y. Hou et al., 2008. Carbohydrate-Protein interactions by clicked carbohydrate self-assembled monolayers. Anal. Chem., 78: 2001-2008.
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  49. Zhang, W., X. Zheng, C. Xia, R.S. Perali and Q. Yao et al., 2008. Α-Lactosylceramide as a novel sugar-capped CD1d ligand for natural killer T cells: Biased cytokine profile and therapeutic activities. ChemBioChem, 9: 1423-1430.
    CrossRef  |  PubMed  |  

  50. Yi, W., R.S. Perali, H. Eguchi, E. Motari, R. Woodward and P.G. Wang, 2008. Characterization of a bacterial β-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics. Biochemistry, 47: 1241-1248.
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  51. Yi, W., J. Shen, G. Zhou, J. Li and P.G. Wang, 2008. Bacterial homologue of human blood group A transferase. J. Am. Chem. Soc., 130: 14420-14421.
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  52. Su, D.M., H. Eguchi, W. Yi, L. Li, P.G. Wang and C. Xia, 2008. Enzymatic synthesis of tumor-associated carbohydrate antigen globo-H Hexasaccharide. Org. Lett., 10: 1009-1012.
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  53. Shen, J., R. Woodward, J.P. Kedenburg, X.W. Liu and M. Chen et al., 2008. Novel HDAC inhibitors through click chemistry. J. Med. Chem., 51: 7417-7427.

  54. Pradhan, P., J. Guan, D. Lu, P.G. Wang, L.J. Lee and R.J. Lee, 2008. A facile microfluidic method for production of liposomes. Anticancer Res., 28: 943-948.
    PubMed  |  

  55. Nagy, J.O., Y. Zhang, W. Yi, X. Liu and E. Motari et al., 2008. Glycopolydiacetylene nanoparticles as a chromatic biosensor to detect Shiga-like toxin producing Escherichia coli O157:H7. Bioorg. Med. Chem. Lett., 18: 700-703.
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  56. Liu, Y.H., S.L. Zhou, G.J. Li, B. Yan and S.H. Guo et al., 2008. Highly efficient Bronsted acid-catalyzed cycloisomerizations of alkynes bearing bis(acetoxy) groups to indenyl ketones. Adv. Synth. Catal., 350: 797-801.
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  57. Li, Y., D. Zhou, C. Xia, P.G. Wang and S.B. Levery, 2008. Sensitive quantitation of isoglobotriaosylceramide in the presence of isobaric components using electrospray ionization-ion trap mass spectrometry. Glycobiology, 18: 166-176.
    PubMed  |  

  58. Li, M., X.W. Liu, J. Shao, J. Shen and Q. Jia, et al., 2008. Characterization of a novel α1,2-fucosyltransferase of Escherichia coli O128:B12 and functional investigation of its common motif. Biochemistry, 47: 378-387.
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  59. Li, M., J. Shen, X. Liu, J. Shao, W. Yi, C.S. Chow and P.G. Wang, 2008. Identification of a new α1,2-fucosyltransferase involved in O-antigen biosynthesis of Escherichia coli O86:B7 and formation of H-type 3 blood group antigen. Biochemistry, 47: 11590-11597.
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  60. Li, G.J., E. Wang, H. Chen, H.F. Li, Y.H. Liu and P.G. Wang, 2008. A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps. Tetrahedron, 64: 9033-9043.
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  61. Guo, H., W. Yi, J.K. Song and P.G. Wang, 2008. Current understanding on biosynthesis of microbial polysaccharides. Curr. Top. Med. Chem., 8: 141-151.
    PubMed  |  

  62. Faridmoayer, A., M.A. Fentabil, M.F. Haurat, W. Yi, R. Woodward, P.G. Wang and M.F. Feldman, 2008. Substrate promiscuity of a bacterial oligosaccharyltransferase involved in o-linked protein glycosylation. J. Biol. Chem., 283: 34596-34604.

  63. Cui, H., J. Shen, D. Lu, T. Zhang, W. Zhang, D. Sun, P.G. Wang, 2008. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemother. Pharmacol., 62: 509-515.
    CrossRef  |  PubMed  |  

  64. Yu, L., M. Huang, P.G. Wang and X. Zeng, 2007. Cross-Linked surface-grafted glycopolymer for multivalent recognition of lectin. Anal. Chem., 79: 8979-8986.
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  65. Xia, C., J. Schumann, R. Emmanuel, Y. Zhang and W. Chen et al., 2007. Modification of the ceramide moiety of isoglobotrihexosylceramide on its agonist activity in stimulation of invariant natural killer T cells. J. Med. Chem., 50: 3489-3496.
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  66. Wang, P.G., 2007. Sugars synthesized in a snap. Nat. Chem. Biol., 3: 309-310.
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  67. Tang, K.H., H. Guo, W. Yi, M.D. Tsai and G.P. Wang, 2007. Investigation of conformational states of Wzz and the Wzz.O-antigen complex under near-physiological conditions. Biochemistry, 46: 11744-11752.
    PubMed  |  

  68. Shen, Z., M. Huang, C. Xiao, Y. Zhang, X. Zeng and P.G. Wang, 2007. Nonlabeled quartz crystal microbalance biosensor for bacterial detection using carbohydrate and lectin recognitions. Anal. Chem., 79: 2312-2319.
    PubMed  |  

  69. Lu, D., J. Nadas, G. Zhang, W. Johnson and J.L. Zweier et al., 2007. 4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-Controlled NO-Donors: The next generation of S-Nitrosothiols. J. Am. Chem. Soc., 129: 5503-5514.
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  70. Li, G., S. Zhou, G. Su, Y. Liu and P.G. Wang, 2007. Improved synthesis of aryl-substituted anthracenes and heteroacenes. J. Org. Chem., 72: 9830-9833.
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  71. Huang, M., Z. Shen, Y. Zhang, X. Zeng and P.G. Wang, 2007. Alkanethiol containing glycopolymers: A tool for the detection of lectin binding. Bioorg. Med. Chem. Lett., 17: 5379-5383.
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  72. Guo, H., W. Yi, L. Li and P.G. Wang, 2007. Three UDP-hexose 4-epimerases with overlapping substrate specificity coexist in Escherichia coli O86:B7. Biochem. Biophys. Res. Commun., 356: 604-609.
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  73. Dang, V., J. Wang, S. Feng, C. Buron, F.A. Villamena, P.G. Wang and P. Kuppusamy, 2007. Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems. Bioorg. Med. Chem. Lett., 17: 4062-4065.
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  74. Chen, W., C. Xia, J. Wang, P. Thapa and Y. Li et al., 2007. Synthesis and structure-activity relationship study of isoglobotrihexosylceramide analogues. J. Org. Chem., 72: 9914-9923.
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  75. Zhang, Y., Q. Yao, C. Xia, X. Jiang and P.G. Wang, 2006. Trapping norovirus by Glycosylated hydrogels: A potential oral antiviral drug. ChemMedChem, 1: 1361-1366.
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  76. Zhang, G., L. Fang, L. Zhu, Y. Zhong, P.G. Wang and D. Sun, 2006. Syntheses and biological activities of 3'-Azido disaccharide analogues of daunorubicin against drug-resistant leukemia. J. Med. Chem., 49: 1792-1799.
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  77. Zhang, G., L. Fang, L. Zhu, D. Sun and P.G. Wang, 2006. Syntheses and biological activity of bisdaunorubicins. Bioorg. Med. Chem., 14: 426-434.
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  78. Zhang, C., C. Albermann, X. Fu, N.R. Peters and J.D. Chisholm et al., 2006. RebG-and RebM-catalyzed indolocarbazole diversification. ChemBioChem, 7: 795-804.
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  79. Yi, W., Q. Yao, Y. Zhang, E. Motari, S. Lin and P.G. Wang, 2006. The wbnH gene of Escherichia coli O86:H2 encodes an α-1,3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis. Biochem. Biophys. Res. Commun., 344: 631-639.
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  80. Yi, W., P. Bystricky, Q. Yao, H. Guo and L. Zhu et al., 2006. Two different O-polysaccharides from Escherichia coli O86 are produced by different polymerization of the same O-repeating unit. Carbohydr. Res., 341: 100-108.
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  81. Yi, W., L. Zhu, H. Guo, M. Li, J. Li and P.G. Wang, 2006. Formation of a new O-polysaccharide in Escherichia coli O86 via disruption of a glycosyltransferase gene involved in O-unit assembly. Carbohydr. Res., 341: 2254-2260.
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  82. Yao, Q., J. Song, C. Xia, W. Zhang and P.G. Wang, 2006. Chemoenzymatic syntheses of iGb3 and Gb3. Org. Lett., 8: 911-914.
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  83. Xia, C., Q. Yao, J. Schumann, E. Rossy and W. Chen et al., 2006. Synthesis and biological evaluation of α-galactosylceramide (KRN7000) and isoglobotrihexosylceramide (iGb3). Bioor. Med. Chem. Lett., 16: 2195-2199.
    CrossRef  |  PubMed  |  Direct Link  |  

  84. Xia, C., D. Zhou, C. Liu, Y. Lou, Q. Yao, W. Zhang and P.G. Wang, 2006. Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells. Org. Lett., 8: 5493-5496.
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  85. Wang, P.G., 2006. The charged sialic acid exhibits its power again: A new high-throughput screening technology. Nat. Methods, 3: 589-590.
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  86. Song, J.K., H.C. Zhang, L. Li, Z. Bi and M. Chen et al., 2006. Enzymatic biosynthesis of oligosaccharides and glycoconjugates. Curr. Org. Synth., 3: 159-168.

  87. Nahalka, J., P. Gemeiner, M. Bucko and P.G. Wang, 2006. Bioenergy beads: A tool for regeneration of ATP/NTP in biocatalytic synthesis. Artif. Cells Blood Substit. Immobil. Biotechnol., 34: 515-521.
    PubMed  |  

  88. Li, J., G.P. Wang and H.B. Schlegel, 2006. A computational exploration of some transnitrosation and thiolation reactions involving CH3SNO, CH3ONO and CH3NHNO. Org. Biomol. Chem., 4: 1352-1364.
    PubMed  |  

  89. Jaramillo-Gomez, L.M., A.E. Loaiza, J. Martin, L.A. Rios and P.G. Wang, 2006. Sequenced cyclizations involving intramolecular capture of alkyl-oxyaminyl radicals. Synthesis of heterocyclic compounds. Tetrahedron Lett., 47: 3909-3912.

  90. Huang, G.L., H.C. Zhang and P.G. Wang, 2006. Fabrication and application of neoglycolipid arrays in a microtiter plate. Bioorg. Med. Chem. Lett., 16: 2031-2033.
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  91. Guo, H., L. Li and P.G. Wang, 2006. Biochemical characterization of UDP-GlcNAc/Glc 4-epimerase from Escherichia coli O86:B7. Biochemistry, 45: 13760-13768.
    CrossRef  |  PubMed  |  Direct Link  |  

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