Dr. Ke-Wu Zeng

Lecturer
Peking University Health Science Center, China

Highest Degree
Ph.D. in Medicine from Peking University, Beijing, China

My URL
https://livedna.org/86.6456

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Biography

Dr. Ke-Wu Zeng is currently working as Lecturer and Research Assistant at Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China. He obtained his Ph.D. in Combination of Chinese Traditional and Western Medicine from Peking University, China, 2011. His research interest related to Neuropharmacology, NeuroImmunology, Natural Products Pharmacology, and Protein and Molecular Biochemistry. He is having 10 year of research experience. He has published 7 research articles journal.

Area of Interest:

Pharmacology and Toxicology
Neuropharmacology
Neuroinflammation
Immunopharmacology
Neuroprotective Drugs

Selected Publications

  1. Zeng, K.W., Q. Yu, L.X. Liao, F.J. Song, H.N. Lv, Y. Jiang and P.F. Tu, 2015. Anti-neuroinflammatory effect of MC13, a novel coumarin compound from Condiment Murraya, through inhibiting lipopolysaccharide-induced TRAF6-TAK1-NF-κB, p38/ERK MAPKs and Jak2-Stat1/Stat3 pathways. J. Cell. Biochem., (In Press). 10.1002/jcb.25084.
    CrossRef  |  Direct Link  |  

  2. Zeng, K.W., Q. Yu, F.J. Song, L.X. Liao and M.B. Zhao et al., 2015. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur. J. Pharmacol., 748: 18-29.
    CrossRef  |  Direct Link  |  

  3. Zeng, K.W., L.X. Liao, M.B. Zhao, F.J. Song, Q. Yu, Y. Jiang and P.F. Tu, 2015. Protosappanin B protects PC12 cells against oxygen-glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation. Eur. J. Pharmacol., 751: 13-23.
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  4. Zeng, K.W., F.J. Song, N. Li, X. Dong, Y. Jiang and P.F. Tu, 2015. ASC, a bioactive steroidal saponin from Ophitopogin japonicas, inhibits angiogenesis through interruption of Src tyrosine kinase-dependent matrix metalloproteinase pathway. Basic Clin. Pharmacol. Toxicol., 116: 115-123.
    CrossRef  |  Direct Link  |  

  5. Zeng, K.W., S. Wang, X. Dong, Y. Jiang, H.W. Jin and P.F. Tu, 2014. Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events. Toxicol. Applied Pharmacol., 275: 244-256.
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  6. Zeng, K.W., S. Wang, X. Dong, Y. Jiang and P.F. Tu, 2014. Sesquiterpene dimmer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. Phytomedicine, 21: 298-306.

  7. Zeng, K.W., F.J. Song, Y.H. Wang, N. Li and Q. Yu et al., 2014. Induction of hepatoma carcinoma cell apoptosis through activation of the JNK-Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase-ROS self-driven death signal circuit. Cancer Lett., 353: 220-231.
    CrossRef  |  Direct Link  |  

  8. Zeng, K.W., N. Li, X. Dong, Z.Z. Ma and Y. Jiang et al., 2013. Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. Eur. J. Pharmacol., 714: 261-273.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Zeng, K.W., J. Li, X. Dong, Y.H. Wang and Z.Z. Ma et al., 2013. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways. Toxicol. Appl. Pharmacol., 273: 159-171.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Zeng, K.W., T. Zhang, H. Fu, G.X. Liu and X.M. Wang, 2012. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur. J. Pharmacol., 692: 29-37.
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  11. Zeng, K.W., T. Zhang, H. Fu, G.X. Liu and X.M. Wang, 2012. Modified Wu-Zi-Yan-Zong prescription, a traditional Chinese polyherbal formula, suppresses lipopolysaccharide-induced neuroinflammatory processes in rat astrocytes via NF-κB and JNK/p38 MAPK signaling pathways. Phytomed., 19: 122-129.
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  12. Zeng, K.W., M.B. Zhao, Z.Z. Ma, Y. Jiang and P.F. Tu, 2012. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int. Immunopharmacol., 14: 558-569.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Zeng, K.W., H. Fu, G.X. Liu and X.M. Wang, 2012. Aluminum maltolate induces primary rat astrocyte apoptosis via overactivation of the class III PI3K/Beclin 1-dependent autophagy signal. Toxicol. in Vitro, 26: 215-220.
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  14. Zeng, K.W., X.M. Wang, H. Ko, H.C. Kwon and J.W. Cha et al., 2011. Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway. Eur. J. Pharmacol., 672: 45-55.
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  15. Zhou, X., K. Zeng, Q. Wang, X. Yang and K. Wang, 2010. In vitro studies on dissolved substance of cinnabar: Chemical species and biological properties. J. Ethnopharmacol., 131: 196-202.
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  16. Zeng, K.W., X.M. Wang, H. Ko and H.O. Yang, 2010. Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells. J. Ethnopharmacol., 130: 13-18.
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  17. Zeng, K.W., H. Ko, H.O. Yang and X.M. Wang, 2010. Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology, 59: 542-550.
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  18. Zeng, K.W., H. Fu, G.X. Liu and X.M. Wang, 2010. Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-κB and JNK/p38 MAPK pathways. Int. Immunopharmacol., 10: 668-678.
    CrossRef  |  PubMed  |  Direct Link  |  
Member since July, 2015