Dr. Heqing Shen
ProfessorChinese Academy of Science, China
Highest Degree
Ph.D. in Chemistry from Technische Universitat Munchen, Germany
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Biography
Dr. Heqing Shen is currently working as Professor and Supervisor of PhD students at Institute of Urban Environment (IUE), Chinese Academy of Science (CAS). He obtained his PhD in Chemistry from Technische Universitat Munchen, Germany in 2005. His area of research interest related to Human Exposure to the Environmental Pollutants, Health Effects and Risk Assessment, Many concerns on Urban Changing (Urbanization) and Health and Wellbeing. He is also serving as Editorial Board Member of Environment International. He is member of International Society of Exposure Science and member of Urban Health and Wellbeing Program, International Council for Science. He has published 63 articles in journals as author/co-author.
Area of Interest:
Selected Publications
- Wang, X., X. Mu, J. Zhang, Q. Huang and A. Alamdar et al., 2015. Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: A step forward in understanding chronic arsenic toxicity. Metallomics, 7: 544-552.
CrossRef | Direct Link | - Wang, X., J. Zhang, Q. Huang, A. Alamdar, M. Tian, L. Liu and H. Shen, 2015. Serum metabolomics analysis reveals impaired lipid metabolism in rats after oral exposure to benzo(a)pyrene. Mol. BioSyst., 11: 753-759.
CrossRef | Direct Link | - Subhani, M., I. Mustafa, A. Alamdar, I.A. Katsoyiannis and N. Ali et al., 2015. Arsenic levels from different land-use settings in Pakistan: Bio-accumulation and estimation of potential human health risk via dust exposure. Ecotoxicol. Environ. Saf., 115: 187-194.
CrossRef | Direct Link | - Peng, S., L. Liu, X. Zhang, J. Heinrich and J. Zhang et al., 2015. A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk. Environ. Health, Vol. 14. .
Direct Link | - Peng, S., J. Zhang, L. Liu, X. Zhang and Q. Huang et al., 2015. Newborn meconium and urinary metabolome response to maternal gestational diabetes mellitus: A preliminary case-control study. J. Proteome Res., 14: 1799-1809.
CrossRef | Direct Link | - Liu, L., J. She, X. Zhang, J. Zhang and M. Tian et al., 2015. Online background cleanup followed by high-performance liquid chromatography with tandem mass spectrometry for the analysis of perfluorinated compounds in human blood. J. Sep. Sci., 38: 247-253.
CrossRef | Direct Link | - Huang, Q., J. Zhang, L. Luo, X. Wang and X. Wang et al., 2015. Metabolomics reveals disturbed metabolic pathways in human lung epithelial cells exposed to airborne fine particulate matter. Toxicol. Res. 10.1039/C5TX00003C.
CrossRef | Direct Link | - Gong, M., C.J. Weschler, L. Liu, H. Shen, L. Huang, J. Sundell and Y. Zhang, 2015. Phthalate metabolites in urine samples from Beijing children and correlations with phthalate levels in their handwipes. Indoor Air. 10.1111/ina.12179.
CrossRef | Direct Link | - Zhang, J., Z. Huang, M. Chen, Y. Xia, F.L. Martin, W. Hang and H. Shen, 2014. Urinary metabolome identifies signatures of oligozoospermic infertile men. Fertil. Steril., 102: 44-53.e12.
CrossRef | Direct Link | - Zhang, J., X. Mu, Y. Xia, F.L. Martin and W. Hang et al., 2014. Metabolomic analysis reveals a unique urinary pattern in normozoospermic infertile men. J. Proteome Res., 13: 3088-3099.
CrossRef | Direct Link | - Zhang, J., X. Mu, W. Xu, F.L. Martin and A. Alamdar et al., 2014. Exposure to arsenic via drinking water induces 5-hydroxymethylcytosine alteration in rat. Sci. Total Environ., 497: 618-625.
CrossRef | Direct Link | - Zhang, J., H. Shen, W. Xu, Y. Xia and D.B. Barr et al., 2014. Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: A proof-of-concept study in a Chinese male cohort. Environ. Sci. Technol., 48: 12265-12274.
CrossRef | Direct Link | - Zafar, A., S.A.M.A.S. Eqani, N. Bostan, A. Cincinelli and F. Tahir et al., 2014. Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility. Environ. Geochem. Health. 10.1007/s10653-014-9666-8.
CrossRef | Direct Link | - Ye, T., M. Kang, Q. Huang, C. Fang, Y. Chen, H. Shen and S. Dong, 2014. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma). Aquat. Toxicol., 146: 115-126.
CrossRef | Direct Link | - Xu, W. and H. Shen, 2014. Arsenic exposure induced male reproductive effects: A brief review. Chin. Sci. Bull., 59: 238-244.
- Tian, M., H. Bao, F.L. Martin, J. Zhang, L. Liu, Q. Huang and H. Shen, 2014. Association of DNA methylation and mitochondrial DNA copy number with human semen quality. Biol. Reprod., Vol. 91. .
PubMed | - Shen, H., W. Xu, S. Peng, H. Scherb and J. She et al., 2014. Pooling samples for top-down molecular exposomics research: The Environ. Health, Vol. 13. 10.1186/1476-069X-13-8.
CrossRef | Direct Link | - Shen, H., F.L. Martin and Y. Su, 2014. Environmental chemical stressors as epigenome modifiers: A new horizon in assessment of toxicological effects. Chin. Sci. Bull., 59: 349-355.
CrossRef | Direct Link | - Liu, L., T. Xia, X. Zhang, D.B. Barr and A. Alamdar et al., 2014. Biomonitoring of infant exposure to phenolic endocrine disruptors using urine expressed from disposable gel diapers. Anal. Bioanal. Chem., 406: 5049-5054.
CrossRef | Direct Link | - Xia, T., L. Liu, W. Zhang and H. Shen, 2013. Determination of phenolic endocrine disrupting chemicals in human urine by high performance liquid chromatography tandem electrospray ionization mass spectrometry. J. Inst. Anal., 32: 211-217.
- Shen, H., W. Xu, J. Zhang, M. Chen and F.L. Martin et al., 2013. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a Han Chinese population. Environ. Sci. Technol., 47: 8843-8851.
CrossRef | Direct Link | - Peng, S., L. Yan, J. Zhang, Z. Wang, M. Tian and H. Shen, 2013. An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. J. Pharm. Biomed. Anal., 86: 56-64.
CrossRef | Direct Link | - Lin, Y., X. Sun, L. Qiu, J. Wei and Q. Huang et al., 2013. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis., Vol. 4. 10.1038/cddis.2012.206.
CrossRef | - Liao, Y., S. Dong, R. Kiyama, P. Cai, L. Liu and H. Shen, 2013. Flos lonicerae extracts and chlorogenic acid protect human umbilical vein endothelial cells from the toxic damage of perfluorooctane sulphonate. Inflammation, 36: 767-779.
- Huang, Q., J. Zhang, S. Peng, M. Tian, J. Chen and H. Shen, 2013. Effects of water soluble PM2.5 extracts exposure on human lung epithelial cells (A549): A proteomic study. J. Applied Toxicol., 34: 675-684.
CrossRef | Direct Link | - Huang, Q., J. Zhang, F.L. Martin, S. Peng, M. Tian, X. Mu and H. Shen, 2013. Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: A proteomic study. Toxicol. Lett., 223: 211-220.
CrossRef | Direct Link | - Gu, J., P. Zhang, F. Zhang, H. Shen, B. Yang, X. Liang and X. Chu, 2013. Determination of aristolochic acids in rat serum by high performance liquid chromatography-Q-TOF tandem mass spectrometry. Anal. Methods, 5: 718-721.
CrossRef | Direct Link | - Fang, C., Q. Huang, T. Ye, Y. Chen and M. Kang et al., 2013. Embryonic exposure to PFOS induces immunosuppression in the fish larvae of marine medaka. Ecotoxicol. Environ. Saf., 92: 104-111.
CrossRef | Direct Link | - Zhao, B., H. Shen, F. Liu, S. Liu, J. Niu, F. Guo and X. Sun, 2012. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case-control study. J. Expo. Sci. Environ. Epidemiol., 22: 541-548.
CrossRef | Direct Link | - Zhang, J., L. Yan, M. Tian, Q. Huang, S. Peng, S. Dong and H. Shen, 2012. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. J. Pharm. Biomed. Anal., 66: 287-297.
CrossRef | Direct Link | - Zhang, J., L. Yan, C. Pan, L. Lin, X. Zhang and H. Shen, 2012. [Simultaneous analysis of 19 antibiotics in dairy products using ultra-performance liquid chromatography coupled with high resolution time-of-flight mass spectrometry]. Chin. J. Chromatogr., 30: 1031-1036, (In Chinese).
PubMed | - Zhang, J., F. Liu, R. Chen, T. Feng, S. Dong and H. Shen, 2012. Levels of polychlorinated biphenyls and organochlorine pesticides in edible shellfish from Xiamen (China) and estimation of human dietary intake. Food Chem. Toxicol., 50: 4285-4291.
CrossRef | Direct Link | - Xu, W., H. Bao, F. Liu, L. Liu and Y.G. Zhu et al., 2012. Environmental exposure to arsenic may reduce human semen quality: Associations derived from a Chinese cross-sectional study. Environ. Health, Vol. 11. .
Direct Link | - Tian, M., S. Peng, F.L. Martin, J. Zhang and L. Liu et al., 2012. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology, 296: 48-55.
CrossRef | Direct Link | - Shen, H., B. Henkelmann, W.A. Rambeck, R. Mayer, U. Wehr and K.W. Schramm, 2012. The predictive power of the elimination of dioxin-like pollutants from pigs: An in vivo study. Environ. Int., 38: 73-78.
CrossRef | Direct Link | - Shen, H., B. Henkelmann, W.A. Rambeck, R. Mayer, U. Wehr and K.W. Schramm, 2012. Physiologically based persistent organic pollutant accumulation in pig tissues and their edible safety differences: An in vivo study. Food Chem., 132: 1830-1835.
CrossRef | Direct Link | - Peng, S., L. Yan, J. Zhang and H. Shen, 2012. [Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics]. Chin. J. Chromatogr., 30: 123-127, (In Chinese)..
PubMed | - Peng, S., J. Zhang, M. Tian, Z. Wang and H. Shen, 2012. Determination of global DNA methylation in biological samples by liquid chromatography-tandem mass spectrometer. Chin. J. Anal. Chem., 40: 1201-1206.
CrossRef | Direct Link | - Liu, L., T. Xia, L. Guo, L. Cao and B. Zhao et al., 2012. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. J. Expo. Sci. Environ. Epidemiol., 22: 625-631.
CrossRef | Direct Link | - Liu, L., H. Bao, F. Liu, J. Zhang and H. Shen, 2012. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environ. Int., 42: 78-83.
CrossRef | Direct Link | - Liu, F., H.G. Ni, F. Chen, Z.X. Luo, H. Shen, L. Liu and P. Wu, 2012. Metal accumulation in the tissues of grass carps (Ctenopharyngodon idellus) from fresh water around a copper mine in Southeast China. Environ. Monit. Assess., 184: 4289-4299.
CrossRef | Direct Link | - Liao, Y., J. Wang, Q. Huang, C. Fang, R. Kiyama, H. Shen and S. Dong, 2012. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol. In Vitro, 26: 421-428.
CrossRef | Direct Link | - Krysiak‐Baltyn, K., J. Toppari, N.E. Skakkebaek, T.S. Jensen and H.E. Virtanen et al., 2012. Association between chemical pattern in breast milk and congenital cryptorchidism: Modelling of complex human exposures. Int. J. Androl., 35: 294-302.
CrossRef | Direct Link | - Fang, C., X. Wu, Q. Huang, Y. Liao and L. Liu et al., 2012. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat. Toxicol., 106: 9-19.
CrossRef | Direct Link | - Zhao, B., F. Liu, S. Liu, J. Niu, F. Guo, X. Sun and H. Shen, 2011. A case-control study of the association between human exposure to selected chlorinated pesticides and primary hepatocellular carcinoma. Epidemiology, 22: S145-S145.
Direct Link | - Wang, X., Y. Suo, R. Yin, H. Shen and H. Wang, 2011. Ultra-performance liquid chromatography/tandem mass spectrometry for accurate quantification of global DNA methylation in human sperms. J. Chromatogr. B, 879: 1647-1652.
CrossRef | - Voigt, K., R. Brueggemann, H. Scherb, H. Shen and K.W. Schramm, 2010. Evaluating the relationship between chemical exposure and cryptorchidism. Environ. Model. Software, 25: 1801-1812.
CrossRef | Direct Link | - Krysiak‐Baltyn, K., J. Toppari, N.E. Skakkebaek, T.S. Jensen and H.E. Virtanen et al., 2010. Country‐specific chemical signatures of persistent environmental compounds in breast milk. Int. J. Androl., 33: 270-278.
CrossRef | Direct Link | - Cok, I., K.M. Donmez, M. Uner, E. Demirkaya and B. Henkelmann et al., 2009. Polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls levels in human breast milk from different regions of Turkey. Chemosphere, 76: 1563-1571.
CrossRef | Direct Link | - Shen, H., K.M. Main, A.M. Andersson, I.N. Damgaard and H.E. Virtanen et al., 2008. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum. Reprod., 23: 201-210.
PubMed | - Shen, H., B. Henkelmann, W. Levy, A. Zsolnay and P. Weiss et al., 2008. Altitudinal and chiral signature of persistent organochlorine pesticides in air, soil, and spruce needles (Picea abies) of the Alps. Environ. Sci. Technol., 43: 2450-2455.
CrossRef | Direct Link | - Cok, I., M.K. Donmez, M.H. Satiroglu, B. Aydinuraz and B. Henkelmann et al., 2008. Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs in adipose tissue of infertile men. Arch. Environ. Contam. Toxicol., 55: 143-152.
CrossRef | Direct Link | - Shen, H., K.M. Main, H.E. Virtanen, I.N. Damggard and A.M. Haavisto et al., 2007. From mother to child: Investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere, 67: 256-262.
CrossRef | Direct Link | - Simm, M., O. Roots, J. Kotta, A. Lankov, B. Henkelmann, H. Shen and K.W. Schramm, 2006. PCDD/Fs in sprat (Sprattus sprattus balticus) from the gulf of Finland, the Baltic Sea. Chemosphere, 65: 1570-1575.
CrossRef | Direct Link | - Shen, H., H.E. Virtanen, K.M. Main, M. Kaleva and A.M. Andersson et al., 2006. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas. Chemosphere, 62: 390-395.
CrossRef | Direct Link | - Damgaard, I.N., N.E. Skakkebaek, J. Toppari, H.E. Virtanen and H. Shen et al., 2006. Nordic cryptorchidism study group. persistent pesticides in human breast milk and cryptorchidism. Environ. Health. Perspect., 114: 1133-1138.
CrossRef | PubMed | - Shen, H., K.M. Main, M. Kaleva, H. Virtanen and A.M. Haavisto et al., 2005. Prenatal organochlorine pesticides in placentas from Finland: exposure of male infants born during 1997-2001. Placenta, 26: 512-514.