Dr. Jiwen Zhang

Professor
Chinese Academy of Sciences, China

Highest Degree
Ph.D. in Pharmaceutics from Shenyang Pharmaceutical University, China

My URL
https://livedna.org/86.9770

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Biography

Dr. Jiwen Zhang now serves as the Professor and Principal Investigator in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. He has carried out the interdisciplinary research by establishing cooperation with research team at home and abroad. Aiming at the evaluation of DDS, he has established the Pharmokinetics theory for the sustained and controlled-release systems, putting forward the quantitative method for optimizing the formulation of the sustained and controlled-release systems, and has designed new formulation such as Biomimetic DDS. Pointing at the complexity of the structure of Pharmaceutical Dosage forms, his team utilized primarily the Synchrotron Radiation Light source to establish quantitative methods for characterizing the complex and Dynamic Structure of DDS. He obtained his Ph.D. in Pharmaceutics from Shenyang Pharmaceutical University, China. He is member of editor board in journal such as Acta Pharmaceutica Sinica B, and Asian Journal of Pharmaceutics. He is member of UK-China Advanced Material Research Institute, and International Member of the Advisory Board for Science Bridges China. He is also invited to deliver lectures in number of conferences and workshops. He is the author and coauthor of more than 24 journal papers.

Area of Interest:

Pharmacology and Toxicology
Pharmacokinetics
Drug Delivery System
Dosage Form
Controlled Drug Delivery System

Selected Publications

  1. Wang, M., X. Lu, X. Yin, Y. Tong and W. Peng et al., 2015. Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres. Acta Pharm. Sin. B, 5: 270-276.
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  2. Ren, X., C. Wang, L. Wu, H. Li and L. Chi et al., 2015. Bioactivity assay of porcine relaxin based on cAMP accumulation in THP-1 cells quantified by LC-MS/MS. J. Pharm. Biomed. Anal., 111: 320-323.
    CrossRef  |  Direct Link  |  

  3. Chi, L., R. Liu, T. Guo, M. Wang and Z. Liao et al., 2015. Dramatic improvement of the solubility of pseudolaric acid B by cyclodextrin complexation: Preparation, characterization and validation. Int. J. Pharm., 479: 349-356.
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  4. Yang, S., X. Yin, C. Wang, H. Li and Y. He et al., 2014. Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile. AAPS J., 16: 860-871.
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  5. Wang, C., J. Ge, J. Zhang, T. Guo and L. Chi et al., 2014. Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography. J. Chromatogr. A, 1359: 287-295.
    CrossRef  |  Direct Link  |  

  6. Li, Y., L. Wang, L. Wu, X. Zhang and X. Li et al., 2014. Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population. Acta Pharm. Sin. B, 4: 60-66.
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  7. Li, X., H. Li, Q. Xiao, L. Wang and M. Wang et al., 2014. Two-way effects of surfactants on Pickering emulsions stabilized by the self-assembled microcrystals of α-cyclodextrin and oil. Phys. Chem. Chem. Phys., 16: 14059-14069.
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  8. Zhu, Q., T. Guo, D. Xia, X. Li and C. Zhu et al., 2013. Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: Improved solubility, cellular uptake and intestinal penetration. J. Pharm. Pharmacol., 65: 1107-1117.
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  9. Yin, X., H. Li, Z. Guo, L. Wu and F. Chen et al., 2013. Quantification of swelling and erosion in the controlled release of a poorly water-soluble drug using synchrotron X-ray computed microtomography. AAPS J., 15: 1025-1034.
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  10. Yin, X., H. Li, R. Liu, J. Chen and J. Ji et al., 2013. Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets. J. Pharm. Pharmacol., 65: 953-959.
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  11. Wang, D., H. Li, J. Gu, T. Guo and S. Yang et al., 2013. Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: Simultaneous enhancement of drug solubility and stability in aqueous solutions. J. Pharm. Biomed. Anal., 83: 141-148.
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  12. Liu, R., X. Yin, H. Li, Q. Shao and P. York et al., 2013. Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction. Int. J. Pharm., 445: 125-133.
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  13. Li, H., J. Ge, T. Guo, S. Yang and Z. He et al., 2013. Determination of the kinetic rate constant of cyclodextrin supramolecular systems by high performance affinity chromatography. J. Chromatogr. A., 1305: 139-148.
    CrossRef  |  Direct Link  |  

  14. Khan, S., M. de Matas, J. Zhang and J. Anwar, 2013. Nanocrystal preparation: Low-energy precipitation method revisited. Cryst. Growth Des., 13: 2766-2777.
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  15. Lu, Y., T. Guo, J. Qi, J. Zhang and W. Wu, 2012. Enhanced dissolution and stability of lansoprazole by cyclodextrin inclusion complexation: Preparation, characterization and molecular modeling. AAPS PharmSciTech, 13: 1222-1229.
    CrossRef  |  Direct Link  |  

  16. Li, H., X. Yin, J. Ji, L. Sun and Q. Shao et al., 2012. Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography. Int. J. Pharm., 427: 270-275.
    CrossRef  |  Direct Link  |  

  17. Ge, J., X. Zhang, H. Li, C. Zhang and T. Guo et al., 2012. Characterization of the substituent poly-distribution in hydroxypropyl-β-cyclodextrin by electrospray ionization mass spectrometry and liquid chromatography with evaporative light scattering detection. Asian J. Pharm. Sci., 7: 377-385.
    Direct Link  |  

  18. Chen, B., F. Ye, L. Yu, G. Jia and X. Huang et al., 2012. Development of cell-active N 6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc., 134: 17963-17971.
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  19. Li, H.Y., X.Y. Cui, F. Gao, P. York and Q. Shao et al., 2011. Characterization and mapping of the multi-component release kinetics of a traditional Chinese medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory. Acta Pharm. Sin. B, 1: 106-114.
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  20. Li, H., Z. Chen, X. Xu, X. Sui, T. Guo, W. Liu and J. Zhang, 2011. Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR). Biopharm. Drug Dispos., 32: 333-342.
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  21. Li, H., J. Sun, Y. Wang, X. Sui, L. Sun, J. Zhang and Z. He, 2011. Structure-based in silico model profiles the binding constant of poorly soluble drugs with β-cyclodextrin. Eur. J. Pharm. Sci., 42: 55-64.
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  22. Wu, X., L. Liu, M. Zhang, D. Wu and Y. Wang et al., 2010. Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration. J. Chromatogr. B, 878: 861-867.
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  23. Han, J., S. Jiang, X. Cui, Y. Sun and G. Li et al., 2009. Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal., 50: 171-174.
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Member since August, 2015