Dr. Chung-Hsuan Winston Chen

Professor
National Taiwan University, Taiwan

Highest Degree
Ph.D. in Chemistry from University of Chicago, Chicago, USA

My URL
https://livedna.org/886.8728

Share this Profile

Area of Interest:

Chemistry
Novel Mass Spectrometry Development
Cancer Biomarker
Nano-Particle Array Technology
Laser Trapping Raman Spectroscopy

Selected Publications

  1. Lee, H.J., L. Lan, G. Peng, W.C. Chang and M.C. Hsu et al., 2015. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res., 25: 225-236.
    CrossRef  |  Direct Link  |  

  2. Chen, C.H., Y.P. Lin, J.L. Lin, S.T. Li, C.T. Ren, C.Y. Wu and C.H. Chen, 2015. Rapid identification of terminal sialic acid linkage isomers by Pseudo-MS3 mass spectrometry. Israel J. Chem., 55: 412-422.
    CrossRef  |  Direct Link  |  

  3. Wang, C.Y., C.Y. Wu, T.C. Hung, C.H. Wong and C.H. Chen, 2014. Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H. Biochem. Biophys. Res. Commun., 452: 484-489.
    CrossRef  |  Direct Link  |  

  4. Ozdemir, A., J.L. Lin, Y.S. Wang and C.H. Chen, 2014. A deeper look into sonic spray ionization. RSC Adv., 4: 61290-61297.
    CrossRef  |  Direct Link  |  

  5. Lin, T.Y., B.R. Li, S.T. Tsai, C.W. Chen, C.H. Chen, Y.T. Chen and C.Y. Pan, 2014. Improved silicon nanowire field-effect transistors for fast protein-protein interaction screening. Lab Chip, 13: 676-684.
    CrossRef  |  Direct Link  |  

  6. Lee, I.C., T.L. Lo, T.H. Young, Y.C. Li, N.G. Chen, C.H. Chen and Y.C. Chang, 2014. Differentiation of neural stem/progenitor cells using low-intensity ultrasound. Ultrasound Med. Biol., 40: 2195-2206.
    CrossRef  |  Direct Link  |  

  7. Huo, L., C.W. Li, T.H. Huang, Y.C. Lam and W. Xia et al., 2014. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am. J. Transl. Res., 6: 649-663.
    Direct Link  |  

  8. Gillig, K.J. and C.H. Chen, 2014. Increasing the performance of portable ion mobility analyzers: Development of the Periodic Focusing Differential Mobility Analyzer (PFDMA). Mass Spectrom., Vol. 3. 10.5702/massspectrometry.S0032.
    CrossRef  |  Direct Link  |  

  9. Chou, R.H., Y.N. Wang, Y.H. Hsieh, L.Y. Li and W. Xia et al., 2014. EGFR modulates DNA synthesis and repair through tyr phosphorylation of histone H4. Dev. Cell, 30: 224-237.
    CrossRef  |  Direct Link  |  

  10. Zhu, L., N.T. Lin, Z.Y. Xie, S.L. Lee and S.L. Huang et al., 2013. Ruthenium-catalyzed cascade metathetical cyclopolymerization of bisnorbornenes with flexible linkers. Macromolecules, 46: 656-663.
    CrossRef  |  Direct Link  |  

  11. Sudhir, P.R., M.P. Kumari, W.T. Hsu, J. Massiot, C.H. Chen, H.C. Kuo and C.H. Chen, 2013. Quantitative proteomics of protein complexes and their implications for cell reprograming and pluripotency. J. Proteome Res., 12: 5878-5890.
    CrossRef  |  Direct Link  |  

  12. Shen, J., W. Xia, Y.B. Khotskaya, L. Huo and K. Nakanishi et al., 2013. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature, 497: 383-387.
    CrossRef  |  Direct Link  |  

  13. Ozdemir, A., J.L. Lin, K.J. Gillig and C.H. Chen, 2013. Triboelectric spray ionization. J. Mass Spectrom., 48: 154-163.
    CrossRef  |  Direct Link  |  

  14. Ozdemir, A., J.L. Lin, K.J. Gillig and C.H. Chen, 2013. Kelvin spray ionization. Analyst, 138: 6913-6923.
    CrossRef  |  Direct Link  |  

  15. Lai, S.H., K.H. Chang, J.L. Lin, C.L. Wu and C.H. Chen, 2013. Sinapinic acid clusters distribution from monomer to mega Dalton's region in MALDI process. Chem. Phys. Lett., 561: 142-146.
    CrossRef  |  Direct Link  |  

  16. Hung, W.T., S.H. Wang, C.H. Chen, C.H. Chen, J.M. Fang and W.B. Yang, 2013. Tagging N-linked glycan with 2,3-naphthalenediamine for mass spectrometric analysis. J. Chin. Chem. Soc., 60: 955-960.
    CrossRef  |  Direct Link  |  

  17. Huang, T.H., L. Huo, Y.N. Wang, W. Xia and Y. Wei et al., 2013. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell, 23: 796-810.
    CrossRef  |  Direct Link  |  

  18. Hsu, Y.F., J.L. Lin, M.L. Chu, Y.S. Wang and C.H. Chen, 2013. Macromolecular ion accelerator mass spectrometer. Analyst, 138: 7384-7391.
    CrossRef  |  Direct Link  |  

  19. Hsu, Y.F., J.L. Lin, M.L. Chu and C.H. Chen, 2013. Biomolecular dual-ion-trap mass analyzer. Analyst, 138: 4823-4829.
    CrossRef  |  Direct Link  |  

  20. Gillig, K.J. and C.H. Chen, 2013. Critical examination of gas-phase protein conformation/multimer ion formation by electrospray ion mobility-mass spectrometry. Anal. Chem., 85: 2177-2182.
    CrossRef  |  Direct Link  |  

  21. Cheng, L.C., H.M. Chen, T.C. Lai, Y.C. Chan and R.S. Liu et al., 2013. Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells. Nanoscale, 5: 3931-3940.
    CrossRef  |  Direct Link  |  

  22. Chen, N.G., J.L. Lin, C.Y. Wu, K.J. Gillig and A. Ozdemir, 2013. Novel atmospheric biomolecule ionization technologies. J. Anal. Bioanal. Tech., Vol. S2. 10.4172/2155-9872.S2-003.
    CrossRef  |  Direct Link  |  

  23. Chang, K.C., W.C. Chang, Y. Chang, L.Y. Hung and C.H. Lai et al., 2013. Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS ONE, Vol. 8. 10.1371/journal.pone.0079863.
    CrossRef  |  Direct Link  |  

  24. Baginskiy, I., T.C. Lai, L.C. Cheng, Y.C. Chan and K.Y. Yang et al., 2013. Chitosan-modified stable colloidal gold nanostars for the photothermolysis of cancer cells. J. Phys. Chem. C, 117: 2396-2410.
    CrossRef  |  Direct Link  |  

  25. Yu, Y.L., R.H. Chou, C.H. Wu, Y.N. Wang and W.J. Chang et al., 2012. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J. Biol. Chem., 287: 31015-31026.
    CrossRef  |  Direct Link  |  

  26. Wang, Y., Q. Ding, C.J. Yen, W. Xia and J.G. Izzo et al., 2012. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell, 21: 374-387.
    CrossRef  |  Direct Link  |  

  27. Wang, C.Y., T.H. Hsiao, L.H. Chu, Y.L. Lin, J.L. Huang, C.H. Chen and K. Peck, 2012. Unraveling virus identity by detection of depleted probes with capillary electrophoresis. Analytica Chimica Acta, 734: 88-92.
    CrossRef  |  Direct Link  |  

  28. Tsai, S.T., C.C. Tsou, W.Y. Mao, W.C. Chang and H.Y. Han et al., 2012. Label-free quantitative proteomics of CD133-positive liver cancer stem cells. Proteome Sci., Vol. 10. 10.1186/1477-5956-10-69.
    CrossRef  |  Direct Link  |  

  29. Sudhir, P.R., C.H. Chen, M.P. Kumari, M.J. Wang and C.C. Tsou et al., 2012. Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells. Mol. Cell. Proteomics, 11: 901-915.
    CrossRef  |  Direct Link  |  

  30. Liu, M., D.F. Lee, C.T. Chen, C.J. Yen and L.Y. Li et al., 2012. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol. Cell, 45: 171-184.
    CrossRef  |  Direct Link  |  

  31. Lin, H.C., J.L. Lin, H.H. Lin, S.W. Tsai, A.L. Yu, R.L. Chen and C.H. Chen, 2012. High-speed mass measurement of nanoparticle and virus. Anal. Chem., 84: 4965-4969.
    CrossRef  |  Direct Link  |  

  32. Hsu, Y.F., J.L. Lin, S.H. Lai, M.L. Chu, Y.S. Wang and C.H. Chen, 2012. Macromolecular ion accelerator. Anal. Chem., 84: 5765-5769.
    CrossRef  |  Direct Link  |  

  33. Cheng, L.C., J.H. Huang, H.M. Chen, T.C. Lai and K.Y. Yang et al., 2012. Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent. J. Mater. Chem., 22: 2244-2253.
    CrossRef  |  Direct Link  |  

  34. Parab, H.J., J.H. Huang, T.C. Lai, Y.H. Jan and R.S. Liu et al., 2011. Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: Synthesis, characterization, cytotoxicity and cellular uptake. Nanotechnology, Vol. 22, No. 39. 10.1088/0957-4484/22/39/395706.
    CrossRef  |  Direct Link  |  

  35. Lu, I.C., J.L. Lin, S.H. Lai and C.H. Chen, 2011. Frequency-scanning MALDI linear ion trap mass spectrometer for large biomolecular ion detection. Anal. Chem., 83: 8273-8277.
    CrossRef  |  Direct Link  |  

  36. Liu, Y.C., H.Y. Yen, C.Y. Chen, C.H. Chen and P.F. Cheng et al., 2011. Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells. Proc. Natl. Acad. Sci. USA., 108: 11332-11337.
    CrossRef  |  Direct Link  |  

  37. Lin, H.H., Y.C. Li, C.H. Chang, C. Liu, A.L. Yu and C.H. Chen, 2011. Single nuclei Raman spectroscopy for drug evaluation. Anal. Chem., 84: 113-120.
    CrossRef  |  Direct Link  |  

  38. Huang, W.C., Y.J. Chen, L.Y. Li, Y.L. Wei and S.C. Hsu et al., 2011. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J. Biol. Chem., 286: 20558-20568.
    CrossRef  |  Direct Link  |  

  39. Huang, J.H., T.C. Lai, L.C. Cheng, R.S. Liu and C.H. Lee et al., 2011. Modulating cell-uptake behavior of Au-based nanomaterials via quantitative biomolecule modification. J. Mater. Chem., 21: 14821-14829.
    CrossRef  |  Direct Link  |  

  40. Huang, H.P., P.H. Chen, W.L. Hwu, C.Y. Chuang and Y.H. Chien et al., 2011. Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum. Mol. Genet., 20: 4851-4864.
    CrossRef  |  Direct Link  |  

  41. Charkin, O.P., N.M. Klimenko, Y.S. Wang, C.C. Wang, C.H. Chen and S.H. Lin, 2011. Theoretical and experimental study of fullerenol molecules and ions C60(OH)24-n(OL)n and C60(OH)24-n(OL)nL+ successively substituted by alkali metal atoms L (n = 1-24). Russian J. Inorg. Chem., 56: 580-590.
    CrossRef  |  Direct Link  |  

  42. Charkin, O.P., N.M. Klimenko, B.G. Chen, S.H. Lin and C.H. Chen, 2011. Theoretical and experimental study of the structure and stability of multiply Na-substituted glucose and 2,4,6-trihydroxyacetophenone derivatives. Russian J. Inorg. Chem., 56: 61-70.
    CrossRef  |  Direct Link  |  

  43. Chang, Y.L., Y.C. Lee, W.B. Yang and C.H. Chen, 2011. Ionic liquid-assisted electrospray ionization of polysaccharides. J. Mass Spectrom., 46: 367-375.
    CrossRef  |  Direct Link  |  

  44. Chang, Y.L., S.K.S. Liao, Y.C. Chen, W.T. Hung and H.M. Yu et al., 2011. Tagging saccharides for signal enhancement in mass spectrometric analysis. J. Mass Spectrom., 46: 247-255.
    CrossRef  |  Direct Link  |  

  45. Wu, C.I., Y.S. Wang, N.G. Chen, C.Y. Wu and C.H. Chen, 2010. Ultrasound ionization of biomolecules. Rapid Commun. Mass Spectrom., 24: 2569-2574.
    CrossRef  |  Direct Link  |  

  46. Ozdemir, A. and C.H. Chen, 2010. Electrode-assisted desorption electrospray ionization mass spectrometry. J. Mass Spectrom., 45: 1203-1211.
    CrossRef  |  Direct Link  |  

  47. Lu, P.J., P.I. Hsu, C.H. Chen, M. Hsiao and W.C. Chang et al., 2010. Gastric juice acidity in upper gastrointestinal diseases. World J. Gastroenterol., 16: 5496-5501.
    CrossRef  |  Direct Link  |  

  48. Lin, H.C., H.H. Lin, C.Y. Kao, A.L. Yu, W.P. Peng and C.H. Chen, 2010. Quantitative measurement of nano-/microparticle endocytosis by cell mass spectrometry. Angewandte Chemie Int. Edn., 49: 3460-3464.
    CrossRef  |  Direct Link  |  

  49. Lin, C., W.T. Hung, C.H. Chen, J.M. Fang and W.B. Yang, 2010. A new naphthimidazole derivative for saccharide labeling with enhanced sensitivity in mass spectrometry detection. Rapid Commun. Mass Spectrom., 24: 85-94.
    CrossRef  |  Direct Link  |  

  50. Liao, H.Y., C.H. Hsu, S.C. Wang, C.H. Liang and H.Y. Yen et al., 2010. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays. J. Am. Chem. Soc., 132: 14849-14856.
    CrossRef  |  Direct Link  |  

  51. Liang, C.W., Y.T. Lee, C.H. Chen and Y.S. Wang, 2010. Ionizing nonvolatile samples using laser desorption-proton-transfer reaction with cluster reagent ions. Int. J. Mass Spectrom., 291: 61-66.
    CrossRef  |  Direct Link  |  

  52. Huo, L., Y.N. Wang, W. Xia, S.C. Hsu and C.C. Lai et al., 2010. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc. Natl. Acad. Sci. USA., 107: 16125-16130.
    CrossRef  |  Direct Link  |  

  53. Hsu, P.I., C.H. Chen, M. Hsiao, D.C. Wu, C.Y. Lin, K.H. Lai and P.J. Lu, 2010. Diagnosis of gastric malignancy using gastric juice α1-antitrypsin. Cancer Epidemiol. Biomarkers Prev., 19: 405-411.
    CrossRef  |  Direct Link  |  

  54. Chen, C.H., J.L. Lin, M.L. Chu and C.H. Chen, 2010. MALDI ion trap mass spectrometer with charge detector for large biomolecule detection. Anal. Chem., 82: 10125-10128.
    CrossRef  |  Direct Link  |  

  55. Chang, W.C., M.S. Huang, C.J. Yang, W.Y. Wang, T.C. Lai, M. Hsiao and C.H. Chen, 2010. Dermcidin identification from exhaled air for lung cancer diagnosis. Eur. Respir. J., 35: 1182-1185.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Chang, W.C., C.K. Chou, C.C. Tsou, S.H. Li and C.H. Chen et al., 2010. Comparative proteomic analysis of proteins involved in the tumorigenic process of seminal vesicle carcinoma in transgenic mice. Int. J. Proteomics. 10.1155/2010/726968.
    CrossRef  |  Direct Link  |  

  57. Ankamwar, B., T.C. Lai, J.H. Huang, R.S. Liu, M. Hsiao, C.H. Chen and Y.K. Hwu, 2010. Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells. Nanotechnology, Vol. 21, No. 7. 10.1088/0957-4484/21/7/075102.
    CrossRef  |  Direct Link  |  

  58. Yang, J.S., J.L. Yan, C.K. Lin, C.Y. Chen, Z.Y. Xie and C.H. Chen, 2009. Pentiptycene-derived oligo(p-phenyleneethynylene)s: Conformational control, chain-length effects, localization of excitation and intrachain resonance energy transfer. Angewandte Chemie, 121: 10120-10123.
    CrossRef  |  Direct Link  |  

  59. Wang, D.Y., T.S. Teng, Y.C. Wu, Y.C. Lee and K.H. Chen et al., 2009. Silver-nanoparticle-conjugated polypeptide brushes for surface-enhanced raman scattering. J. Phys. Chem. C, 113: 13498-13504.
    CrossRef  |  Direct Link  |  

  60. Parab, H.J., H.M. Chen, T.C. Lai, J.H. Huang and P.H. Chen et al., 2009. Biosensing, cytotoxicity and cellular uptake studies of surface-modified gold nanorods. J. Phys. Chem. C, 113: 7574-7578.
    CrossRef  |  Direct Link  |  

  61. Liang, C.H., C.C. Wang, Y.C. Lin, C.H. Chen, C.H. Wong and C.Y. Wu, 2009. Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions. Anal. Chem., 81: 7750-7756.
    CrossRef  |  Direct Link  |  

  62. Hwang-Verslues, W.W., W.H. Kuo, P.H. Chang, C.C. Pan and H.H. Wang et al., 2009. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS ONE, Vol. 4. 10.1371/journal.pone.0008377.
    CrossRef  |  Direct Link  |  

  63. Hsiao, C.R. and C.H. Chen, 2009. Characterization of DNA chips by nanogold staining. Anal. Biochem., 389: 118-123.
    CrossRef  |  Direct Link  |  

  64. Tseng, S.Y., C.C. Wang, C.W. Lin, C.L. Chen and W.Y. Yu et al., 2008. Glycan arrays on aluminum-coated glass slides. Chem.-Asian J., 3: 1395-1405.
    CrossRef  |  Direct Link  |  

  65. Tsai, S.T., C.H. Chen, Y.T. Lee and Y.S. Wang, 2008. Desorption dynamics of neutral molecules in matrix-assisted laser desorption/ionization. Mol. Phys., 106: 239-247.
    CrossRef  |  Direct Link  |  

  66. Susanto, J., Y.H. Lin, Y.N. Chen, C.R. Shen and Y.T. Yan et al., 2008. Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells. PLoS ONE, Vol. 3. 10.1371/journal.pone.0004023.
    CrossRef  |  Direct Link  |  

  67. Peng, W.P., H.C. Lin, M.L. Chu, H.C. Chang, H.H. Lin, A.L. Yu and C.H. Chen, 2008. Charge monitoring cell mass spectrometry. Anal. Chem., 80: 2524-2530.
    CrossRef  |  Direct Link  |  

  68. Nie, Z., F. Cui, M. Chu, C.H. Chen, H.C. Chang and Y. Cai, 2008. Calibration of a frequency-scan quadrupole ion trap mass spectrometer for microparticle mass analysis. Int. J. Mass Spectrom., 270: 8-15.
    CrossRef  |  Direct Link  |  

  69. Jhan, J.W., W.T. Chang, H.C. Chen, M.F. Wu, Y.T. Lee, C.H. Chen and I. Liau, 2008. Integrated multiple multi-photon imaging and Raman spectroscopy for characterizing structure-constituent correlation of tissues. Opt. Express, 16: 16431-16441.
    CrossRef  |  Direct Link  |  

  70. Jessome, L., N.Y. Hsu, Y.S. Wang and C.H. Chen, 2008. Matrix-assisted laser desorption/ionization mechanism study with dihydroxybenzoic acid isomers as matrices. Rapid Commun. Mass Spectrom., 22: 130-134.
    CrossRef  |  Direct Link  |  

  71. Hung, W.T., S.H. Wang, C.H. Chen and W.B. Yang, 2008. Structure determination of β-glucans from Ganoderma lucidum with Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. Molecules, 13: 1538-1550.
    CrossRef  |  Direct Link  |  

  72. Huang, J.H., H.J. Parab, R.S. Liu, T.C. Lai and M. Hsiao et al., 2008. Investigation of the growth mechanism of iron oxide nanoparticles via a seed-mediated method and its cytotoxicity studies. J. Phys. Chem. C, 112: 15684-15690.
    CrossRef  |  Direct Link  |  

  73. Hsu, N.Y., S.Y. Tseng, C.Y. Wu, C.T. Ren, Y.C. Lee, C.H. Wong and C.H. Chen, 2008. Desorption ionization of biomolecules on metals. Anal. Chem., 80: 5203-5210.
    CrossRef  |  Direct Link  |  

  74. Chen, C.H., 2008. Review of a current role of mass spectrometry for proteome research. Analytica Chimica Acta, 624: 16-36.
    CrossRef  |  Direct Link  |  

  75. Chang, W.C., P.I. Hsu, Y.Y. Chen, M. Hsiao, P.J. Lu and C.H. Chen, 2008. Observation of peptide differences between cancer and control in gastric juice. Proteomics-Clin. Applic., 2: 55-62.
    CrossRef  |  Direct Link  |  

  76. Peng, W.P., H.C. Lin, H.H. Lin, M. Chu and A.L. Yu et al., 2007. Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement. Angewandte Chemie Int. Edn., 46: 3865-3869.
    CrossRef  |  Direct Link  |  

  77. Nie, Z., F. Cui, Y.K. Tzeng, H.C. Chang and M. Chu et al., 2007. High-speed mass analysis of whole erythrocytes by charge-detection quadrupole ion trap mass spectrometry. Anal. Chem., 79: 7401-7407.
    CrossRef  |  Direct Link  |  

  78. Lin, N.T., S.Y. Lin, S.L. Lee, C.H. Chen and C.H. Hsu et al., 2007. From polynorbornene to the complementary polynorbornene by replication. Angewandte Chemie Int. Edn., 46: 4481-4485.
    CrossRef  |  Direct Link  |  

  79. Li, M.H., S.T. Tsai, C.H. Chen, C.W. Chen, Y.T. Lee and Y.S. Wang, 2007. Bipolar ion detector based on sequential conversion reactions. Anal. Chem., 79: 1277-1282.
    CrossRef  |  Direct Link  |  

  80. Hsu, P.I., C.H. Chen, C.S. Hsieh, W.C. Chang and K.H. Lai et al., 2007. α1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res., 13: 876-883.
    CrossRef  |  Direct Link  |  

  81. Hsu, N.Y., W.B. Yang, C.H. Wong, Y.C. Lee, R.T. Lee, Y.S. Wang and C.H. Chen, 2007. Matrix‐assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. Rapid Commun. Mass Spectrom., 21: 2137-2146.
    CrossRef  |  Direct Link  |  

  82. Chang, W.C., L.C.L. Huang, Y.S. Wang, W.P. Peng and H.C. Chang et al., 2007. Matrix-Assisted Laser Desorption/Ionization (MALDI) mechanism revisited. Analytica Chimica Acta, 582: 1-9.
    CrossRef  |  Direct Link  |  

  83. Tsai, S.T., C.W. Chen, L.C.L. Huang, M.C. Huang, C.H. Chen and Y.S. Wang, 2006. Simultaneous mass analysis of positive and negative ions using a dual-polarity time-of-flight mass spectrometer. Anal. Chem., 78: 7729-7734.
    CrossRef  |  Direct Link  |  

  84. Peng, W.P., Y.C. Yang, M.W. Kang, Y.K. Tzeng and Z. Nie et al., 2006. Laser-induced acoustic desorption mass spectrometry of single bioparticles. Angewandte Chemie, 118: 1451-1454.
    CrossRef  |  Direct Link  |  

  85. Chen, C.H., 2005. Mass Spectrometry, High Speed DNA Fragment Sizing. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine, Volume 7, Meyers, R.A. (Ed.). 2nd Edn., Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, ISBN-13: 978-3527305490, pp: 589-619.

  86. Zhu, J.H., C.T. Liu and C.H. Chen, 2004. Effect of iron additions on environmental embrittlement of NiTi-base alloys. Intermetallics, 12: 859-868.
    CrossRef  |  Direct Link  |  

  87. Qiu, X.Y., R.A. Hurt, L.Y. Wu, C.H. Chen, J.M. Tiedje and J.Z. Zhou, 2004. Detection and quantification of copper-denitrifying bacteria by quantitative competitive PCR. J. Microbiol. Methods, 59: 199-210.
    CrossRef  |  Direct Link  |  

  88. Chen, C.H., N.T. Potter and N.I. Taranenko, 2004. Detection of trinucleotide repeat containing genes by Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. Methods Mol. Biol., 217: 91-100.
    CrossRef  |  Direct Link  |  

  89. Liu, Z., N.R. Isola, S.L. Allman and C.H. Chen, 2003. Biotin-enhanced fragmentation for direct deoxyribonucleic acid sequencing using matrix-assisted laser desorption/ionization mass spectrometry. Eur. J. Mass Spectrom., 9: 212-219.
    CrossRef  |  Direct Link  |  

  90. Isola, N.R., Z. Liu, S.L. Allman, N.I. Taranenko, Y. Kong and C.H. Chen, 2003. Matrix-assisted laser desorption/ionization detection of polymerase chain reaction products by utilizing the 5'-3' exonuclease activity of Thermus aquaticus DNA polymerase. Rapid Commun. Mass Spectrom., 17: 532-537.
    CrossRef  |  Direct Link  |  

  91. Taranenko, N.I., R. Hurt, J.Z. Zhou, N.R. Isola, H. Huang, S.H. Lee and C.H. Chen, 2002. Laser desorption mass spectrometry for microbial DNA analysis. J. Microbiol. Methods, 48: 101-106.
    CrossRef  |  Direct Link  |  

  92. Maya, L., C.H. Chen, K.A. Stevenson, E.A. Kenik, S.L. Allman and T.G. Thundat, 2002. Mass spectrometric analysis of water-soluble gold nanoclusters. J. Nanopart. Res., 4: 417-422.
    CrossRef  |  Direct Link  |  

  93. Gupta, R.K., S.V. Dobritsa, C.A. Stiles, M.E. Essington and Z. Liu et al., 2002. Metallohistins: A new class of plant metal-binding proteins. J. Protein Chem., 21: 529-536.
    CrossRef  |  Direct Link  |  

  94. Isola, N.R., S.L. Allman, V.V. Golovlev and C.H. Chen, 2001. MALDI-TOF mass spectrometric method for detection of hybridized DNA oligomers. Anal. Chem., 73: 2126-2131.
    CrossRef  |  Direct Link  |  

  95. Hurt, R.A., X. Qiu, L. Wu, Y. Roh, A.V. Palumbo, J.M. Tiedje and J. Zhou, 2001. Simultaneous recovery of RNA and DNA from soils and sediments. Applied Environ. Microbiol., 67: 4495-4503.
    CrossRef  |  Direct Link  |  

  96. Golovlev, V.V., S.H. Lee, S.L. Allman, N.I. Taranenko, N.R. Isola and C.H. Chen, 2001. Nonresonant MALDI of oligonucleotides: Mechanism of ion desorption. Anal. Chem., 73: 809-812.
    CrossRef  |  Direct Link  |  

  97. Chen, C.H., 2001. Laser desorption mass spectrometry of DNA: Mechanism and applications. Trend Chem. Phys., 8: 1-18.
    Direct Link  |  
Member since April, 2015