Dr. Bahar Tunctan

Professor
Department of Pharmacology, Mersin University, Turkiye

Highest Degree
Ph.D. in Pharmacology from Gazi University, Turkiye

My URL
https://livedna.org/90.16197

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Area of Interest:

Pharmacology and Toxicology
Nitrosative Stress
Oxidative Stress
Protein Kinases
Septic Shock

Selected Publications

  1. Dolunay, A., S.P. Senol, M. Temiz-Resitoglu, D.S. Guden, A.N. Sari, S. Sahan-Firat and B. Tunctan, 2017. Inhibition of NLRP3 inflammasome prevents LPS-induced inflammatory hyperalgesia in mice: Contribution of NF-κB, caspase-1/11, ASC, NOX and NOS isoforms. Inflammation, 40: 366-386.
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  2. Senol, S.P., M. Temiz, D.S. Guden, C. Cecen and A.N. Sari et al., 2016. Contribution of PPARα/β/γ, AP-1, importin-α3 and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia and inflammation in a rat model of septic shock. Inflammation Res., 65: 367-387.
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  3. Senol, S.P., E.N. Tiftik, S. Unal, A. Akdeniz, B. Tasdelen and B. Tunctan, 2016. Quality of life, clinical effectiveness, and satisfaction in patients with beta thalassemia major and sickle cell anemia receiving deferasirox chelation therapy. J. Basic Clin. Pharm., 7: 49-59.

  4. Senol, S.P. and B. Tunctan, 2016. Myocardial and renal ischemia/reperfusion injury and experimental models. Turkiye Klinikleri J. Pharm. Sci., 5: 93-109.

  5. Senol, S.P. and B. Tunctan, 2015. The role of peroxisome proliferator-activated receptors in the pathogenesis of insulin resistance and septic shock. Clin. Exp. Health Sci., 5: 247-258.

  6. Guden, D.S., M. Temiz and B. Tunctan, 2015. Sahan-F rat, the role of endothelin-1 in the pathogenesis of sepsis and septic shock. Clin. Exp. Health Sci., 5: 178-190.

  7. Unsal, D., M. Temiz, B. Tunctan and S. Sahan-Firat, 2014. Signal transduction of zymosan and spleen tyrosine kinase. Clin. Exp. Health Sci., 4: 148-157.

  8. Sari, A.N., M. Kacan, D. Unsal, S.S. Firat and C.K. Buharalioglu et al., 2014. Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats. Eur. J. Pharmacol., 723: 234-245.
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  9. Sari, A.N., B. Korkmaz, M.S. Serin, M. Kacan and D. Unsal et al., 2014. Effects of 5, 14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223 and miR-297 levels in a rat model of septic shock. Inflammation Res., 63: 741-756.
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  10. Kucuk, M.U., N. Sucu, S.S. Firat, B.N. Aytacoglu and O. Vezir et al., 2014. Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts. Eur. J. Clin. Pharmacol., 70: 1443-1451.
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  11. Guden, D.S. and B. Tunctan, 2014. The role of endothelin-1 in the pathogenesis of diabetes. Clin. Exp. Health Sci., 4: 158-167.

  12. Battal, D., I. Cok, I. Unlusayin, A. Aktas and B. Tunctan, 2014. Determination of urinary levels of Bisphenol A in a Turkish population. Environ. Monitoring Assess., 186: 8443-8452.
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  13. Battal, D., I. Cok, I. Unlusayin and B. Tunctan, 2014. Development and validation of an LC‐MS/MS method for simultaneous quantitative analysis of free and conjugated bisphenol A in human urine. Biomed. Chromatography, 28: 686-693.
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  14. Tunctan, B., B. Korkmaz, A.N. Sari, M. Kacan and D. Unsal et al., 2013. Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1 and gp91 phox to the protective effect of 5, 14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia and inflammation in a rat model of septic shock. Nitric Oxide, 33: 18-41.
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  15. Tunctan, B., B. Korkmaz, A.N. Sari, M. Kacan and D. Unsal et al., 2013. 5, 14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway and proinflammatory cytokine formation. Prostaglandins Other Lipid Mediat., 102-103: 31-41.
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  16. Tunctan, B., A.N. Sari, M. Kacan, D. Unsal and C.K. Buharalioglu et al., 2013. NS-398 reverses hypotension in endotoxemic rats: Contribution of eicosanoids, NO and peroxynitrite. Prostaglandins Lipid Mediators, 104: 93-108.
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  17. Tunctan, B., 2013. 20-HETE mimetics or inhibitors in the treatment of cancer patients with sepsis and septic shock. Int. J. Cancer Stud. Res., 2: 101-108.

  18. Tunctan, B., B. Korkmaz, A.N. Sari, M. Kacan and D. Unsal et al., 2012. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide and 20-hydroxyeicosatetraenoic acid. Anti-Inflammatory Anti-Allergy Agents Med. Chem., 11: 121-150.
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  19. Sahan-Firat, S., N. Canacankatan, B. Korkmaz, H. Yildirim and L. Tamer et al., 2012. Increased production of nitric oxide mediates selective organ-specific effects of endotoxin on oxidative stress. Anti-Inflammatory Anti-Allergy Agents Med. Chem., 11: 161-172.

  20. Korkmaz, B., T. Cuez, C.K. Buharalioglu, A.T. Demiryurek, S. Sahan-Firat, A. Nihal Sari and B. Tunctan, 2012. Contribution of MEK1/ERK1/2/iNOS pathway to oxidative stress and decreased caspase-3 activity in endotoxemic rats. Anti-Inflammatory Anti-Allergy Agents Med. Chem., 11: 243-252.
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  21. Canacankatan, N., N. Sucu, B. Aytacoglu, O.E. Gul and A. Gorur et al., 2012. Affirmative effects of iloprost on apoptosis during ischemia-reperfusion injury in kidney as a distant organ. Renal Failure, 34: 111-118.
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  22. Korkmaz, B., K. Buharalioglu, S. Sahan-Firat, T. Cuez, A.T. Demiryurek and B. Tunctan, 2011. Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats. Nitric Oxide, 24: 160-172.

  23. Buharalioglu, C.K., B. Korkmaz, T. Cuez, S. Sahan‐Firat, A.N. Sari, K.U. Malik and B. Tunctan, 2011. Piroxicam reverses endotoxin‐induced hypotension in rats: Contribution of vasoactive eicosanoids and nitric oxide. Basic Clin. Pharmacol. Toxicol., 109: 186-194.
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  24. Tunctan, B., B. Korkmaz, T. Cuez, C.K. Buharalioglu, S. Sahan‐Firat, J. Falck and K.U. Malik, 2010. Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase‐2 inhibitor, NS‐398, on endotoxin‐induced hypotension in rats. Basic Clin. Pharmacol. Toxicol., 107: 877-882.
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  25. Sari, A.N., S. Sahan-Firat and B. Tunctan, 2010. Rho kinase and cardiovascular diseases. Mersin Univ. J. Health Sci., 3: 1-7.

  26. Cuez, T., B. Korkmaz, C.K. Buharalioglu, S. Sahan‐Firat, J. Falck, K.U. Malik and B. Tunctan, 2010. A synthetic analogue of 20‐HETE, 5, 14‐HEDGE, reverses endotoxin‐induced hypotension via increased 20‐HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats. Basic Clin. Pharmacol. Toxicol., 106: 378-388.
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  27. Sahan-Firat, S., N. Canacankatan, B. Korkmaz, H. Yildirim, L. Tamer, A.N. Sari and B. Tunctan, 2009. Effect of inhibition of inducible nitric oxide synthase on the increased oxidative stress in the liver of endotoxemic rats. Mersin Univ. J. Health Sci., 1: 28-35.

  28. Tunctan, B., F.A. Yaghini, A. Estes and K.U. Malik, 2008. Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production. Arch. Pharm. Res., 31: 856-865.
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  29. Tunctan, B., B. Korkmaz, C.K. Buharalioglu, S.S. Firat and S. Anjaiah et al., 2008. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock, 30: 329-335.
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  30. Uludag, O., B. Tunctan, O. Uludag, B. Tunctan, S. Altug, H. Zengil and N. Abacioglu, 2007. Twenty‐four‐hour variation of l‐arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model. Chronobiol. Int., 24: 413-424.
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  31. Tunctan, B., B. Korkmaz, Z.N. Dogruer, L. Tamer, U. Atik and C.K. Buharalioglu, 2007. Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats. Pharmacol. Res., 56: 56-64.
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  32. Gunaydin, B., B. Sancak, S. Candan, M. Sariahmetoglu and G. Ozcagli et al., 2007. Temporal variation of oxidant stress in critically ill patients. Minerva Anestesiol., 73: 261-266.
    Direct Link  |  

  33. Tunctan, B., S. Altug, O. Uludag and N. Abacioglu, 2006. Contribution of nitric oxide and tumor necrosis factor-a to the effect of indomethacin on the endotoxin-induced mortality. FABAD J. Pharm. Sci., 30: 1-6.

  34. Tunctan, B., F.A. Yaghini, A. Estes and K.U. Malik, 2006. Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats. Nitric Oxide, 14: 51-57.
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  35. Tunctan, B., E. Ozveren, B. Korkmaz, C.K. Buharalioglu, L. Tamer, U. Degirmenci and U. Atik, 2006. Nitric oxide reverses endotoxin-induced inflammatory hyperalgesia via inhibition of prostacyclin production in mice. Pharmacol. Res., 53: 177-192.
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  36. Tunctan, B., B. Korkmaz, H. Yildirim, L. Tamer, U. Atik and C.K. Buharalioglu, 2006. Reversal of endotoxin-induced hypotension by inhibition of inducible nitric oxide synthase activity is associated with improved oxidative status in rat heart, aorta and mesenteric artery. Turk. J. Med. Sci., 36: 71-80.

  37. Ozveren, E., B. Korkmaz, C.K. Buharalioglu and B. Tunctan, 2006. Involvement of calcium/calmodulin-dependent protein kinase II to endotoxin-induced vascular hyporeactivity in rat superior mesenteric artery. Pharmacol. Res., 54: 208-218.

  38. Korkmaz, B., E. Ozveren, C.K. Buharalioglu and B. Tunctan, 2006. Extracellular signal-regulated kinase (ERK1/2) contributes to endotoxin-induced hyporeactivity via nitric oxide and prostacyclin production in rat aorta. Pharmacology, 78: 123-128.
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  39. Altug, S., O. Uludag, B. Tunctan, I. Cakici, H. Zengil and N. Abacioglu, 2006. Biological time‐dependent difference in effect of peroxynitrite demonstrated by the mouse hot plate pain model. Chronobiol. Int., 23: 583-591.
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  40. Tunctan, B., B. Korkmaz, H. Yildirim, L. Tamer, U. Atik and C.K. Buharalioglu, 2005. Increased production of nitric oxide contributes to renal oxidative stress in endotoxemic rat. Am. J. Infect. Dis., 1: 111-115.

  41. Tunctan, B., 2005. Nitric oxide decreases eicosanoid production via activation of guanylyl cyclase and polyADP-ribose synthase in endotoxin-stimulated whole blood, kidney and heart. Turk. J. Pharm. Sci., 2: 137-154.
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  42. Tunctan, B. and C.K. Buharalioglu, 2005. Pharmacological terminology dictionary. Sendrom III, 3: 3-44.

  43. Tunctan, B., D. Aykanat, B. Korkmaz, E. Ozveren and C.K. Buharalioglu, 2004. Euthanasia methods for experimental animals. J. Mersin Univ. Faculty Med., 1: 44-54.

  44. Tunctan, B. and S. Altug, 2004. The use of nitric oxide synthase inhibitors in inflammatory diseases: A novel class of anti-inflammatory agents. Curr. Med. Chem. Anti-Inflammatory Anti-Allergy Agents, 3: 271-301.

  45. Kiziltepe, U., B. Tunctan, Z.B. Eyileten, M. Sirlak and M. Arikbuku et al., 2004. Efficiency of L-arginine supplemented cardioplegia and non-cardiopegic in ischaemic hearts. Int. J. Cardiol., 97: 93-100.

  46. Tunctan, B., S. Altug, O. Uludag, B. Demirkay and N. Abacioglu, 2003. Effects of cyclooxygenase inhibitors on the nitric oxide synthase activity in a mice model of sepsis. Pharmacol. Res., 38: 37-48.

  47. Kiziltepe, U., R. Tasoz, A. Aral, B. Tunctan and Z.B. Eyileten et al., 2003. Efficiency of L-arginine cardioplegia and L-arginine supplemented non-cardiopegic blood in preventing of controlled reperfusions. Med. Network Cardiol., 10: 33-40.

  48. Yurdakul, A.S., H.C. Calisir and B. Tunctan, 2002. Comparison of second controller medications in addition to inhaled corticosteroid in patients with moderate asthma. Respiratory Med., 96: 322-329.

  49. Tunctan, B., Y. Weigl, A. Dotan, L. Peleg, H. Zengil, I. Ashkenazi and N. Abacıoglu, 2002. Circadian variation of nitric oxide synthase activity in mouse tissue. Chronobiol. Int., 19: 393-404.
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  50. Tasoz, R., U. Kiziltepe, Z.B. Eyileten, B. Tunctan and M. Sirlak et al., 2002. Myocardial nitric oxide metabolism and possible treatment options in open thoracic surgery. Med. Network Cardiol., 9: 345-351.

  51. Abacioglu, N., R. Ozmen, I. Cakici, B. Tunctan and I. Kanzik, 2001. Role of L-arginine/nitric oxide pathway in the antinociceptive activities of morphine and mepyramine in mice. Arzneimittelforschung, 51: 977-983.
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  52. Abacioglu, N., B. Tunctan, I. Cakici, E. Akbulut, O. Uludag and I. Kanzik, 2001. The role of L-arginine/nitric oxide pathway in the antinociceptive activity of pyridoxine in mouse. Arzneimittelforschung, 51: 832-838.

  53. Tunctan, B., S. Altug, O. Uludag and N. Abacioglu, 2000. Time-dependent variations in serum nitrite, 6-keto-prostaglandin F1α and thromboxane B2 levels induced by lipopolysaccharide in mice. Biol. Rhythm Res., 31: 499-513.
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  54. Tunctan, B., S. Altug , O. Uludag and N. Abacioglu, 2000. Effects of Econazole on Receptor-Operated and Depolarization-Induced Contractions in Rat Isolated Aorta. Life Sci., 67: 2393-2401.
    PubMed  |  Direct Link  |  

  55. Tunctan, B., 2000. Role of nitric oxide synthase inhibitors in septic shock teatment. J. Drug Treatment, 13: 298-307.

  56. Hosgor-Basgut, B., E. Basgut, G. Soyak, B. Tunxtan, I. Cakici and I. Kanzik, 2000. Peroxynitrite produces relaxations on the rat anococcygeus muscle. Life Sci., 67: 3123-3127.
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  57. Abacıoglu, N., B. Tunctan, E. Akbulut and I. Cakıcı, 2000. Participation of the components of L-arginine/nitric oxide/cGMP cascade by chemically-induced abdominal constriction in the mouse. Life Sci., 67: 1127-1137.

  58. Abacioglu, N., S. Demir, I. Cakici, B. Tunctan and I. Kanzik, 2000. Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse. Arzneimittelforschung, 50: 554-558.
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  59. Uludag, O., B. Tunctan, H.Z. Guney, C. Uluoglu, S. Altug, H. Zengil and N. Abacioglu, 1999. Temporal variation in serum nitrite levels in rats and mice. Chronobiol. Int., 16: 527-532.
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  60. Tunctan, B., I. Cakici, N. Abacioglu and I. Kanzik, 1998. Epithelium-dependent responses of bradykinin in a co-axial bioassay system. Gen. Pharmacol., 30: 477-482.

  61. Tunctan, B., H. Okur, C.H. Calisir, H. Abacioglu, I. Cakici, I. Kanzik and N. Abacioglu, 1998. Comparison of nitric oxide production by monocyte/macrophages in healthy subjects and patients with active pulmonary tuberculosis. Pharmacol. Res., 37: 219-226.
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  62. Tunctan, B. and S. Altu, 1998. Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice. Pharmacol. Res., 38: 405-411.
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  63. Tunctan, B. and N. Abacioglu, 1998. Measurement of nitric oxide in biological samples, Diazotization method. FABAD J. Pharm. Sci., 23: 161-170.

  64. Guney, H.Z., C.Z. Gorgun, B. Tunctan, O. Uludag, U. Hodoglugil, N. Abacioglu and H. Zengil, 1998. Circadian-rhythm-dependent effects of L-NG-nitroarginine methyl ester (L-NAME) on morphine-induced analgesia. Chronobiol. Int., 15: 283-289.
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  65. Cakici, I., H.Y. Ulug, S. Inci, B. Tunctan, N. Abacioglu, I. Kanzik and B. Sener, 1997. Antinociceptive effect of some amaryllidaceae plants in mice. J. Pharm. Pharmacol., 49: 828-830.
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  66. Cakici, I., N. Mataraci, S. Ersoy, B. Tunctan, N. Abacioglu and I. Kanzik, 1995. Effects of platelet‐activating factor antagonists WEB 2086 and BN 50730 on digoxin‐induced arrhythmias. Basic Clin. Pharmacol. Toxicol., 76: 343-347.
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  67. Cakici, I., C. Hurmoglu, B. Tunctan, N. Abacioglu, I. Kanzik and B. Sener, 1994. Hypoglycaemic effect of Momordica charantia extracts in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. J. Ethnopharmacol., 44: 117-121.
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  68. Tunctan, B., I. Cakici, N. Abacioglu and I. Kanzik, 1993. Epithelium-derived relaxant factors and bronchial hypereactivity. J. Pharm. Sci., 18: 71-76.

  69. Cakici, I., B. Tunctan, N. Abacioglu and I. Kanzik, 1993. Epithelium-dependent responses of serotonin in a co-axial bioassay system. Eur. J. Pharmacol., 236: 97-105.
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  70. Abacioglu, N., A. Bediz, I. Cakici, B. Tunctan and I. Kanzik, 1993. Antinociceptive effects of H1-and H2-antihistaminics in mice. General Pharmacol.: Vascular Syst., 24: 1173-1176.
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