Prof. Dr. Ayse Altintas

Professor
Koc University, Istanbul, Turkiye

Highest Degree
M.D. in Neurology and Algology from Ege University, Turkiye

My URL
https://livedna.org/90.18184

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Area of Interest:

Molecular Sciences
Molecular Biology
Neuroimmunology
Neuroendocrinology
Multiple Sclerosis

Selected Publications

  1. Altintas, A., I. Caliskan, S.S. Ahmed, S. Peker and A.E. Danyeli, 2022. A case of radiologically isolated syndrome developing Balo's concentric sclerosis lesions on long-term follow-up. Neuroimmunol. Rep., Vol. 2. 10.1016/j.nerep.2022.100093.
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  2. Zhou, Y., S.B. Claflin, J. Stankovich, I. van der Mei and S. Simpson et al., 2020. Redefining the multiple sclerosis severity score (MSSS): The effect of sex and onset phenotype. Mult. Scler., 26: 1765-1774.
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  3. Leurs, C.E., H.A.M. Twaalfhoven, B.I. Lissenberg-Witte, V. van Pesch and I. Dujmovic et al., 2020. Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study. Mult. Scler., 26: 912-923.
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  4. Kunchok, A., C. Malpas, P. Nytrova, E.K. Havrdova and R. Alroughani et al., 2020. Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder. Multiple Sclerosis Relat. Disorders, Vol. 38. 10.1016/j.msard.2019.101868.
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  5. Tahrali, I., U.C. Kucuksezer, N. Akdeniz, A. Altintas, U. Uygunoglu, E. Aktas-Cetin and G. Deniz, 2019. CD3-CD56+ NK cells display an inflammatory profile in RR-MS patients. Immunol. Lett., 216: 63-69.
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  6. Fambiatos, A., V. Jokubaitis, D. Horakova, E.K. Havrdova and M. Trojano et al., 2019. Risk of secondary progressive multiple sclerosis: A longitudinal study. Mult. Scler., 26: 79-90.
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  7. Boz, C., M. Terzi, B. Özer, R. Turkoglu and R. Karabudak et al., 2019. Comparative analysis of fingolimod versus teriflunomide in relapsing–remitting multiple sclerosis. Mult. Scler. Relat. Dis., Vol. 19. 10.1016/j.msard.2019.101376.
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  8. Uygunoglu, U., M. Tutuncu, A. Altintas, S. Saip and A. Siva, 2018. Factors predictive of severe multiple sclerosis disease reactivation after fingolimod cessation. Neurologist, 23: 12-16.
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  9. Tahrali, I., U.C. Kucuksezer, A. Altintas, U. Uygunoglu, N. Akdeniz, E. Aktas-Cetin and G. Deniz, 2018. Dysfunction of CD3 − CD16 + CD56 dim and CD3 − CD16 − CD56 bright NK cell subsets in RR-MS patients. Clin. Immunol., 193: 88-97.
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  10. Okhovat, A.A., B. Ansari, S. Rezaali, A. Altintas and A.N. Moghadasi, 2017. Catastrophic presentation of a patient with combined NMOSD and thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: A case report. Acta Neurol. Belgica, 117: 757-759.
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  11. Grond-Ginsbach, C., T. Brandt, M. Kloss, S.S. Aksay and P. Lyrer et al., 2017. Next generation sequencing analysis of patients with familial cervical artery dissection. Eur. Stroke J., 2: 137-143.
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  12. Waters, P., M. Reindl, A. Saiz, K. Schanda and F. Tuller et al., 2016. Multicentre comparison of a diagnostic assay: Aquaporin-4 antibodies in neuromyelitis optica. J. Neurol. Neurosurg. Psychiatry, Vol. 87, No. 9. 10.1136/jnnp-2015-312601.
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  13. Moghadasi, A.N. and A. Altintas, 2016. NMOSD with an unusual cerebral radiologic manifestation. Multiple Sclerosis Relat. Disord., 7: 74-75.
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  14. Kellert, L., M. Kloss, A. Pezzini, S. Debette and D. Leys et al., 2016. Prognostic significance of pulsatile tinnitus in cervical artery dissection. Eur. J. Neurol., 23: 1183-1187.
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  15. Disanto, G., R. Adiutori, R. Dobson, V. Martinelli and G. Dalla Costa et al., 2016. Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. J. Neurol. Neurosurg. Psychiatry, 87: 126-129.
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  16. Altintas, A., A. Gunduz, F. Kantarci and G.G. Celik, 2016. Sciatic neuropathy developed after injection during curettage. Agri, 28: 46-48.
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  17. Alroughani, R., A. Altintas, M. Al Jumah, M. Sahraian and I. Alsharoqi et al., 2016. Pregnancy and the use of disease-modifying therapies in patients with multiple sclerosis: Benefits versus risks. Multiple Sclerosis Int. 10.1155/2016/1034912.
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  18. Kuhle, J., G. Disanto, R. Dobson, R. Adiutori and L. Bianchi et al., 2015. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Multiple Sclerosis J., 21: 1013-1024.
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  19. Kellert, L., M. Kloss, A. Pezzini, T.M. Metso and A.J. Metso et al., 2015. Anemia in young patients with ischaemic stroke. Eur. J. Neurol., 22: 948-953.
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  20. Grond-Ginsbach, C., C. Lichy, S. Debette, D. Leys and A. Pezzini et al., 2015. Cervical Artery Dissection (CeAD) in physicians. Cerebrovasc. Dis., 39: 72-74.
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  21. Altintas, A., R. Karabudak, B.P. Balci, M. Terzi and A. Soysal et al., 2015. Neuromyelitis optica and neuromyelitis optica spectrum disorder patients in Turkish cohort: Demographic, clinical and laboratory features. Neurologist, 20: 61-66.
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  22. Altintas, A., B. Najar, G. Gozubatik-Celik and S.F. Menku, 2015. Pregnancy data in a Turkish multiple sclerosis population. Eur. Neurol., 74: 296-302.
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  23. Kloss, M., C. Grond-Ginsbach, A. Pezzini, T.M. Metso and A.J. Metso et al., 2014. Stroke in first-degree relatives of patients with cervical artery dissection. Eur. J. Neurol., 21: 1102-1107.
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  24. Kalra, S., A. Silman, G. Akman-Demir, S. Bohlega and A. Borhani-Haghighi et al., 2014. Diagnosis and management of Neuro-Behcet's disease: International consensus recommendations. J. Neurol., 261: 1662-1676.
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  25. Debette, S., B.G. Simonetti, S. Schilling, J.J. Martin and M. Kloss et al., 2014. Familial occurrence and heritable connective tissue disorders in cervical artery dissection. Neurology, 83: 2023-2031.
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  26. Collongues, N., R. Marignier, A. Jacob, M.I. Leite and A. Siva et al., 2014. Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset. Multiple Sclerosis J., 20: 1086-1094.
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  27. Cakal, B., U. Uygunoglu, S. Saip, A. Altintas, A. Siva and S. Badur, 2014. BAb and MxA as functional biomarkers in routine clinical laboratories for the determination of anti-IFN-beta antibodies and their bioactivity levels in multiple sclerosis patients. J. Immunoassay Immunochem., 35: 398-411.
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  28. Teunissen, C., T. Menge, A. Altintas, J.C. Alvarez-Cermeno and A. Bertolotto et al., 2013. Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis. Multiple Sclerosis J., 19: 1802-1809.
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  29. Seven, A., M. Aslan, S. Incir and A. Altintas, 2013. Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis: Effect of corticosteroid therapy. Folia Neuropathol., 51: 58-64.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Metso, T.M., T. Tatlisumak, S. Debette, J. Dallongeville and S.T. Engelter et al., 2012. Migraine in cervical artery dissection and ischemic stroke patients. Neurology, 78: 1221-1228.
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  31. Hasiloglu, Z.I., M. Asik, B. Erer, A.S. Dikici, A. Altintas and S. Albayram, 2012. Magnetic resonance imaging of rheumatoid meningitis: A case report and literature review. Rheumatol. Int., 32: 3679-3681.
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  32. Armagan, H., E. Tuzun, S. Icoz, O. Birisik and C. Ulusoy et al., 2012. Long extensive transverse myelitis associated with aquaporin-4 antibody and breast cancer: Favorable response to cancer treatment. J. Spinal Cord Med., 35: 267-269.
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  33. Altintas, A., B. Petek, N. Isik, M. Terzi and F. Bolukbasi et al., 2012. Clinical and radiological characteristics of tumefactive demyelinating lesions: Follow-up study. Multiple Sclerosis J., 18: 1448-1453.
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  34. Debette, S., T. Metso, A. Pezzini, S. Abboud and A. Metso et al., 2011. Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults. Circulation, 123: 1537-1544.
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  35. Albayram, S., M. Asik, Z.I. Hasiloglu, A.S. Dikici, H.E. Erdemli and A. Altintas, 2011. Pathological contrast enhancement of the oculomotor and trigeminal nerves caused by intracranial hypotension syndrome. Headache: J. Head Face Pain, 51: 804-808.
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  36. Radue, E.W., W.H. Stuart, P.A. Calabresi, C. Confavreux and S.L. Galetta et al., 2010. Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis. J. Neurol. Sci., 292: 28-35.
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  37. Petzold, A., A. Altintas, L. Andreoni, A. Bartos and A. Berthele et al., 2010. Neurofilament ELISA validation. J. Immunol. Methods, 352: 23-31.
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  38. Tumani, H., H.P. Hartung, B. Hemmer, C. Teunissen and F. Deisenhammer et al., 2009. Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiol. Dis., 35: 117-127.
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  39. Siva, A., S. Saip, A. Altintas, A. Jacob, B.M. Keegan and O.H. Kantarci, 2009. Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease. Multiple Sclerosis J., 15: 918-927.
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  40. Kocazeybek, B., B. Karatoka, A. Altintas, M. Aslan and S. Saribas et al., 2009. Infection and genotype relationship in multiple sclerosis: Do Chlamydophila pneumoniae and human herpes virus-6 infections together with APO E alleles have a role in the etiopathogenesis of multiple sclerosis? Afr. J. Microbiol. Res., 3: 565-571.
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  41. Hutchinson, M., L. Kappos, P.A. Calabresi, C. Confavreux and G. Giovannoni et al., 2009. The efficacy of natalizumab in patients with relapsing multiple sclerosis: Subgroup analyses of AFFIRM and SENTINEL. J. Neurol., 256: 405-415.
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  42. Havrdova, E., S. Galetta, M. Hutchinson, D. Stefoski and D. Bates et al., 2009. Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study. Lancet Neurol., 8: 254-260.
    CrossRef  |  Direct Link  |  

  43. Debette, S., T.M. Metso, A. Pezzini, S.T. Engelter and D. Leys et al., 2009. CADISP-genetics: An International project searching for genetic risk factors of cervical artery dissections. Int. J. Stroke, 4: 224-230.
    CrossRef  |  Direct Link  |  

  44. Altıntas, A., G. Saruhan-Direskeneli, G. Benbir, M. Demir and S. Purisa, 2009. The role of osteopontin: A shared pathway in the pathogenesis of multiple sclerosis and osteoporosis? J. Neurol. Sci., 276: 41-44.
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  45. Yaman, M., S. Albayram, A. Altintas, S.N. Yeni, N. Karaagac and C. Islak, 2008. A cerebellar demyelinating lesion following treatment of acne with isotretinoin. Clin. Exp. Dermatol., 33: 118-121.
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  46. Lucchinetti, C.F., R.H. Gavrilova, I. Metz, J.E. Parisi and B.W. Scheithauer et al., 2008. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain, 131: 1759-1775.
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  47. Kappos, L., R. Gold, D.H. Miller, D.G. MacManus and E. Havrdova et al., 2008. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet, 372: 1463-1472.
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  48. Rudick, R.A., D. Miller, S. Hass, M. Hutchinson and P.A. Calabresi et al., 2007. Health-related quality of life in multiple sclerosis: Effects of natalizumab. Ann. Neurol., 62: 335-346.
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  49. Mutluay, F.K., R. Demir, S. Ozyilmaz, A.T. Caglar, A. Altintas and H.N. Gurses, 2007. Breathing-enhanced upper extremity exercises for patients with multiple sclerosis. Clin. Rehabil., 21: 595-602.
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  50. Miller, D.H., D. Soon, K.T. Fernando, D.G. MacManus and G.J. Barker et al., 2007. MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS. Neurology, 68: 1390-1401.
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  51. Calabresi, P.A., G. Giovannoni, C. Confavreux, S.L. Galetta and E. Havrdova et al., 2007. The incidence and significance of anti-natalizumab antibodies: Results from AFFIRM and SENTINEL. Neurology, 69: 1391-1403.
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  52. Altintas, A., T. Demir, H.D. Ikitimur and N. Yildirim, 2007. Pulmonary function in multiple sclerosis without any respiratory complaints. Clin. Neurol. Neurosurg., 109: 242-246.
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  53. Uyguner, Z.O., A. Siva, H. Kayserili, S. Saip and A. Altintas et al., 2006. The R110C mutation in Notch3 causes variable clinical features in two Turkish families with CADASIL syndrome. J. Neurol. Sci., 246: 123-130.
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  54. Polman, C.H., P.W. O'Connor, E. Havrdova, M. Hutchinson and L. Kappos et al., 2006. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med., 354: 899-910.
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  55. Phillips, J.T., P.W. O'Connor, E. Havrdova, M. Hutchinson and L. Kappos et al., 2006. Infusion-related hypersensitivity reactions during natalizumab treatment. Neurology, 67: 1717-1718.
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  56. Kaynak, H., A. Altintas, D. Kaynak, O. Uyanik and S. Saip et al., 2006. Fatigue and sleep disturbance in multiple sclerosis. Eur. J. Neurol., 13: 1333-1339.
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  57. Siva, A., A. Altintas and S. Saip, 2005. Neuro-Behcet's Syndrome. In: Clinical Neuroimmunology, Antel, J., G. Birnbaum, H.P. Hartung and A. Vincent (Eds.). Oxford University Press, New York, USA., ISBN-13: 9780198510680, pp: 339-354.

  58. Saip, S., A. Siva, A. Altintas, A. Kiyat, E. Seyahi, V. Hamuryudan and H. Yazici, 2005. Headache in Behcet's syndrome. Headache: J. Head Face Pain, 45: 911-919.
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  59. Siva, A., A. Altintas and S. Saip, 2004. Behcet's syndrome and the nervous system. Curr. Opin. Neurol., 17: 347-357.
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  60. Kantarci, O.H., D.D. Hebrink, S.J. Achenbach, S.J. Pittock and A. Altintas et al., 2004. Association of APOE polymorphisms with disease severity in MS is limited to women. Neurology, 62: 811-814.
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  61. Tuzun, S., A. Altintas, I. Karacan, S. Tangurek, S. Saip and A. Siva, 2003. Bone status in multiple sclerosis: Beyond corticosteroids. Multiple Sclerosis J., 9: 600-604.
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  62. Ozkara, C., A. Altintas, E. Yilmaz, E. Eskazan and G. Erkol et al., 2002. An association between mesial temporal lobe epilepsy with hippocampal sclerosis and human leukocyte antigens. Epilepsia, 43: 236-239.
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  63. Altintas, A., Y. Alici, M. Melikoglu and A. Siva, 2002. Arthritis during interferon beta-1b treatment in multiple sclerosis. Multiple Sclerosis J., 8: 534-536.
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  64. Siva, A., O.H. Kantarci, S. Saip, A. Altintas and V. Hamuryudan et al., 2001. Behcet's disease: Diagnostic and prognostic aspects of neurological involvement. J. Neurol., 248: 95-103.
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  65. Karaarslan, E., A. Altintas, U. Senol, N. Yeni and A. Dincer et al., 2001. Balo's concentric sclerosis: Clinical and radiologic features of five cases. Am. J. Neuroradiol., 22: 1362-1367.
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  66. Karaali-Savrun, F., A. Altintas, S. Saip and A. Siva, 2001. Hepatitis B vaccine related-myelitis? Eur. J. Neurol., 8: 711-715.
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  67. Siva, A. and A. Altintas, 2000. Neuro-Behcet Syndrome. In: Treatment of Neurological Disorders with Intravenous Immunoglobulins, Said, G. (Ed.). Martin Dunitz Ltd., London, UK., ISBN-13: 9781853177583, pp: 115-126.

  68. Kantarci, O., A. Siva, M. Eraksoy, R. Karabudak and N. Sutlas et al., 1998. Survival and predictors of disability in Turkish MS patients. Neurology, 51: 765-772.
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  69. Altintas, A., Z. Cai, L.R. Pease and M. Rodriguez, 1993. Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus. J. Immunol., 151: 2803-2812.
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