Dr. Thirumurugan Rathinasabapathy

Lecturer
International Medical University, Malaysia

Highest Degree
PostDoc Fellow in Pharmaceutical Chemistry from The State University of New Jersey, USA

My URL
https://livedna.org/91.12182

Share this Profile

Biography

Dr. Thirumurugan Rathinasabapathy holds a position of Lecturer IV at Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia. He has completed his PhD in Medicinal Chemistry from Birla Institute of Technology & Science, (BITS), Pilani and Post Doctoral Associate at Department of Plant Biology & Pathology, SEBS, Rutgers, The State University of New Jersey, NJ, USA. Previously he was appointed as Research Scientist at Nycomed Pharma Pvt. Ltd., Mumbai, MH, India, Senior Research Associate at GVK Biosciences Pvt. Ltd., Hyderabad, AP, India, Junior Research Scientist at Jubilant Chemsys Ltd., Noida, UP, India, and Research Chemist at Sami Labs Ltd., Peenya, Bangaluru, KA, India. He has completed 4 research projects as principal investigator. His main area of interest focuses on Bioassay guided discovery of Lead molecules from the plant sources for the development of new medicines for neglected diseases, Lead identification, optimization and development of preclinical candidates for the treatment of obesity and T2DM, and Designer Food: Preparation and evaluation of their medicinal properties and also to explore the usage of siddha medicine through this preparation. He has published 23 research articles in journals, 1 patent, 5 book chapters, and 14 abstract in seminars/conferences contributed as author/co-author. He is registered Pharmacist, under the Pharmacy Council of India, and member of American Chemical Society, Royal Society of Chemistry, and Indian Pharmacy Graduates Association. He is also serving as reviewer for Chemical Biology and Drug Design, Bioorganic Medicinal Chemistry, Bioorganic Medicinal Chemistry Letters, and Journal of Pharmacy and Pharmacology.

Area of Interest:

Chemistry
Bioassays
Drug Development
Optimization
Obesity

Selected Publications

  1. Prabu, S.L., T.N.K. Suriyaprakash, K. Ruckmani, R. Thirumurugan, 2015. Biopharmaceutics and Pharmacokinetics. In: Basic Pharmacokinetic Concepts and Some Clinical Applications. Ahmed, T.A. (Ed.). InTech Publications, Croatia., ISBN: 978-953-51-2197-8, pp: 117-135..
    CrossRef  |  Direct Link  |  

  2. Lakshmana Prabu, S., T.N.K. Suriyaprakash, K. Ruckmani and R. Thirumurugan, 2015. Effective Waste Water Treatment and its Management. In: 2015 Toxicity and Waste Management Using Bioremediation. Rathoure, A.K. and V.K. Dhatwalia, (Ed.). IGI Global Publications, United States of America,.
    CrossRef  |  

  3. Lakshmana Prabu, S., T.N.K. Suriyaprakash and R. Thirumurugan, 2015. Cleaning Validation and Its Regulatory Aspects in the Pharmaceutical Industry. In: Developments in Surface Contamination and Cleaning - Cleanliness Validation and Verification. Kohli, R. and K.L. Mittal, (Ed.). Elsevier Publications, US, pp: 129-186.

  4. Prabu, S.L., T.N.K. Suriyaprakash and R. Thirumurugan, 2013. Impact of Microbial Surface Contamination and Effective Environment Monitoring System in Pharmaceutical Manufacturing. In: Developments in Surface Contamination and Cleaning - Contaminant Removal and Monitoring. Kohli, R. and K.L. Mittal, (Ed.). Elsevier Publications, US, pp: 169 -190.

  5. Komarnytsky, S., D. Esposito, T. Rathinasabapathy, A. Poulev and I. Raskin, 2013. Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model. J. Agric. Food Chem., 61: 1841-1849.
    Direct Link  |  

  6. Graziose, R., M.H. Grace, T. Rathinasabapathy, P. Rojas Silva and C. Dekock, et al., 2013. Antiplasmodial activity of cucurbitacin glycosides from datisca glomerata (C. Presl) baill. Phytochem., 87: 78-85.
    Direct Link  |  

  7. Esposito, D., T. Rathinasabapathy, B. Schmidt, M.P. Shakarjian, S. Komarnytsky and I. Raskin, 2013. Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair Regener., 21: 688-696.
    Direct Link  |  

  8. Rathinasabapathy, T, P. Rojas Silva, A. Poulev, S. Komarnytsky and I. Raskin, 2012. Isolation of sesquiterpene lactones from roots of chicorium intybus with leishmanicidal activity. Pharm. Biol., 50: 573-573.

  9. Graziose, R., P. Rojas Silva, T. Rathinasabapathy, C. Dekock and M.H. Grace, et al., 2012. Antiparasitic compounds from cornus florida L. with activities against plasmodium falciparum and leishmania tarentolae. J. Ethnopharmacol., 142: 456-461.
    Direct Link  |  

  10. Graziose, R., T. Rathinasabapathy, C. Lategan, A. Poulev and P.J. Smith, et al., 2011. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from liriodendron tulipifera L. J. Ethnopharmacol., 133: 26-30.
    Direct Link  |  

  11. Esposito, D., T. Rathinasabapathy, A. Poulev, S. Komarnytsky and I. Raskin, 2011. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J. Med. Chem., 54: 4057-4066.
    Direct Link  |  

  12. Esposito, D, T. Rathinasabapathy, A. Poulev, S. Komarnytsky and I. Raskin, 2011. Brassinosteroids increase protein accumulation in skeletal muscle cells. Vitro Cell Dev. Biol. Anim., 47: 38-38.

  13. Sriram, D., P. Yogeeswari, M. Dinakaran and R. Thirumurugan, 2007. Antimycobacterial activity of novel 1-(5-cyclobutyl-1, 3-oxazol-2-yl)-3-(sub) phenyl/pyridylthiourea compounds endowed with high activity toward multidrug-resistant mycobacterium tuberculosis. J. Antimicrob. Chemother., 59: 1194-1196.

  14. Yogeeswari, P., R. Thirumurugan, D. Sriram, L.R.J. Sunil Jit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra and J.P. Stables, 2006. Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA-mediated mechanism. Acta Pharm., 56: 259-272.

  15. Yogeeswari, P., J.V. Ragavendran, R. Thirumurugan, S. Induja, D. Sriram and J.P. Stables, 2006. Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones. Med. Chem., 2: 55-62.
    Direct Link  |  

  16. Yogeeswari, P., D. Sriram, T.R. Bal and R. Thirumurugan, 2006. Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update. Nat. Prod. Res., 20: 497-505.
    Direct Link  |  

  17. Thirumurugan, R., D. Sriram, A. Saxena, J. Stables and P. Yogeeswari, 2006. 2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: Synthesis and pharmacological evaluation. Bioorg. Med. Chem., 14: 3106-3112.
    PubMed  |  

  18. Sriram, D., P. Yogeeswari, R. Thirumurugan and R.K. Pavana, 2006. Discovery of new antitubercular oxazolyl thiosemicarbazones. J. Med. Chem., 49: 3448-3450.
    Direct Link  |  

  19. Yogeeswari, P., D. Sriram, V. Veena, R. Kavya and K. Rakhra et al., 2005. Synthesis of aryl semicarbazones as potential anticonvulsant agents. Biomed. Pharmacother., 59: 51-55.
    PubMed  |  

  20. Yogeeswari, P., D. Sriram, R. Thirumurugan, J.V. Raghavendran, K. Sudhan, R.K. Pavana and J. Stables, 2005. Discovery of N-(2, 6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design. J. Med. Chem., 48: 6202-6211.
    Direct Link  |  

  21. Sriram, D., P. Yogeeswari, R. Thirumurugan and T.R. Bal, 2005. Camptothecin and its analogues: A review on their chemotherapeutic potential. Nat. Prod. Res., 19: 393-412.
    CrossRef  |  

  22. Yogeeswari, P., R. Thirumurugan, R. Kavya, J.S. Samuel, J. Stables and D. Sriram, 2004. 3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity. Eur. J. Med. Chem., 39: 729-734.
    Direct Link  |  

  23. Yogeeswari, P., J.V. Ragavendran, R. Thirumurugan, A. Saxena and D. Sriram, 2004. Ion channels as important targets for antiepileptic drug design. Curr. Drug Targets, 5: 589-602.
    Direct Link  |  

  24. Sriram, D., P. Yogeeswari and R.S. Thirumurugan, 2004. Antituberculous activity of some aryl semicarbazone derivatives. Bioorg. Med. Chem. Lett., 14: 3923-3924.

  25. Yogeeswari, P., D. Sriram, V. Saraswat, J.V. Ragavendran and M.M. Kumar, et al., 2003. Synthesis and anticonvulsant and neurotoxicity evaluation of N 4-phthalimido phenyl (thio) semicarbazides. Eur. J. Pharm. Sci., 20: 341-346.
    Direct Link  |  

  26. Yogeeswari, P., D. Sriram, A. Brahmandam, I. Sridharan, R. Thirumurugan and J.P. Stables, 2003. Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism. Med. Chem. Res., 12: 57-68.
    Direct Link  |  

  27. Thirumurugan, R.S., S. Kavimani and R.S. Srivastava, 2000. Antitumour activity of rhinacanthone against Dalton`s ascitic lymphoma. Biol. Pharm. Bull., 23: 1438-1440.
    CrossRef  |  
Member since June, 2016