Dr. Sanghapal D. Sawant

Senior Principal Scientist
Organic Chemistry Division (OCD), CSIR-National Chemical Laboratory, Pune, India

Highest Degree
PostDoc. in Chemical Biology from Kyoto University, Japan

My URL
https://livedna.org/91.13973

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Biography

Sanghapal D. Sawant is currently working as a Senior Principal Scientist at CSIR-IIIM, Jammu and he is designated as Professor of AcSIR, Dr. Sawant obtained his Ph.D. jointly from the CSIR-Indian Institute of Integrative Medicine, Jammu, and SRTM University, Nanded. He has a wide experience of about 17 years and expertise in synthetic organic chemistry and medicinal chemistry.

Area of Interest:

Chemistry
Medicinal Chemistry
Organic Chemistry
Drug Discovery
Asymmetric Synthesis

Selected Publications

  1. Kour, D., M. Ali, P. Khajuria, K. Sharma and P. Ghosh et al., 2023. Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice. Front. Pharmacol., Vol. 14. 10.3389/fphar.2023.1123734.
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  2. Hudwekar, A.D., P. Kotwal, M.I. Dar, S. Balgotra and A. Dogra et al., 2023. Pyrazolopyrimidinone based selective inhibitors of PDE5 for the treatment of erectile dysfunction. Chem. Biodivers., Vol. 20. 10.1002/cbdv.202200707.
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  3. Gour, A., D. Kour, R. Pandian, M. Bhardwaj, S.D. Sawant, A. Kumar and U. Nandi, 2023. Ellagic acid exerts dual action to curb the pathophysiological manifestations of sickle cell disease and attenuate the hydroxyurea-induced myelosuppression in Berkeley mice. ACS Pharmacol. Transl. Sci., 6: 868-877.
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  4. Verma, P.K. and S.D. Sawant, 2022. Unravelling reaction selectivities via bio-inspired porphyrinoid tetradentate frameworks. Coord. Chem. Rev., Vol. 450. 10.1016/j.ccr.2021.214239.
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  5. Sharma, A., H. Kour, J. Kour, Kamal and S.D. Sawant, 2022. Visible-light-promoted iron-catalyzed C-H functionalization of 1,4-naphthoquinones via oxidative coupling with sulfoximines. Chem. Commun., 58: 11312-11315.
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  6. Mahajan, S. and S.D. Sawant, 2022. Iodine/TBHP-mediated one-pot multicomponent protocol for tandem C-N and C-S bond formation to access sulfenylimidazo[1,5-a]pyridines via C-H functionalization. J. Org. Chem., 87: 11387-11398.
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  7. Kour, J., P. Khajuria, P.K. Verma, N. Kapoor, A. Kumar and S.D. Sawant, 2022. Selective synthesis of bis-heterocycles via mono- and di-selenylation of pyrazoles and other heteroarenes. ACS Omega, 7: 13000-13009.
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  8. Kour, J., P. Khajuria, A. Sharma and S.D. Sawant, 2022. TBAX/oxone-mediated halogenation of pyrazoles and other heterocycles: An entry to important cross-coupling reactions. Chem. Asian J., 10.1002/asia.202200778.
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  9. Kour, H., A. Sharma, J. Kour, M. Ahmed and S.D. Sawant, 2022. Green approach for N-H functionalization of sulfoximines: An access to sulfoximinated-oxime conjugates. Eur. J. Org. Chem., Vol. 2022. 10.1002/ejoc.202201375.
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  10. Khan, S.U., A.S. Pathania, A. Wani, K. Fatima and M.J. Mintoo, 2022. Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor. Sci. Rep., Vol. 12. 10.1038/s41598-022-07955-1.
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  11. Behera, C., J. Kour, N. Banjare, P.K. Verma, G. Chashoo, S.D. Sawant and P.N. Gupta, 2022. Mechanistic investigation of synergistic interaction of tocopherol succinate with a quinoline-based inhibitor of mammalian target of rapamycin. J. Pharm. Pharmacol., 74: 605-617.
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  12. Bag, D. and S.D. Sawant, 2022. Gold(I)-catalyzed cycloisomerization–indole addition cascade: Synthesis of 3(2H)-furanone-incorporated unsymmetrical 3,3′- bis(indolyl)methanes. Org. Lett., 24: 4930-4934.
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  13. Kour, J., V. Venkateswarlu, P.K. Verma, Y. Hussain and G. Dubey et al., 2020. Oxone-DMSO triggered methylene insertion and C(sp2)-C(sp3)-H-C(sp2) bond formation to access functional bis-heterocycles. J. Org. Chem., 85: 4951-4962.
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  14. Balgotra, S., P.K. Verma, R.A. Vishwakarma and S.D. Sawant, 2020. Catalytic advances in direct functionalizations using arylated hydrazines as the building blocks. Catal. Rev., 62: 406-479.
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  15. Bag, D., S. Mahajan and S.D. Sawant, 2020. Transition-metal-catalyzed carbohalogenative 1,2-difunctionalization of c-c multiple bonds. Adv. Synth. Catal., 362: 3948-3970.
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  16. Bag, D., P.K. Verma and S.D. Sawant, 2020. Chiral transient directing group strategies in asymmetric synthesis. Chem. Asian J., 15: 3225-3238.
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  17. Bag, D., H. Kour and S.D. Sawant, 2020. Photo-induced 1,2-carbohalofunctionalization of C–C multiple bonds via ATRA pathway. Org. Biomol. Chem., 18: 8278-8293.
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  18. Verma, P.K., R.A. Vishwakarma and S.D. Sawant, 2019. Reaction medium as the installing reservoir for key functionalities in the molecules. Asian J. Org. Chem., 8: 777-801.
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  19. Hudwekar, A.D., P.K. Verma, J. Kour, S. Balgotra and S.D. Sawant, 2019. Transition metal-free oxidative coupling of primary amines in polyethylene glycol at room temperature: Synthesis of imines, azobenzenes, benzothiazoles, and disulfides. Eur. J. Org. Chem., 2019: 1242-1250.
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  20. Dar, M.I., S. Jan, G.L. Reddy, R. Wani and M. Syed et al., 2019. Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384. Cell. Signalling, Vol. 65. 10.1016/j.cellsig.2019.109425.
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  21. Venkateswarlu, V., J. Kour, K.A.A. Kumar, P.K. Verma and G.L. Reddy et al., 2018. Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: Synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles. RSC Adv., 8: 26523-26527.
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  22. Srinivas, M., A.S. Pathania, P. Mahajan, P.K. Verma and S.S. Chobe et al., 2018. Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity. Bioorg. Med. Chem. Lett., 28: 1005-1010.
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  23. Balgotra, S., P.K. Verma, J. Kour, S. Gupta, R.A. Vishwakarma and S.D. Sawant, 2018. A novel approach to access aryl iodides and disulfides via dehydrazination of arylhydrazines and arylsulfonylhydrazides. ChemistrySelect, 3: 2800-2804.
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  24. Saneja, A., D. Nayak, M. Srinivas, A. Kumar and V. Khare et al., 2017. Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. Eur. J. Pharmaceut. Sci., 97: 79-91.
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  25. Hudwekar, A.D., G.L. Reddy, P.K. Verma, S. Gupta, R.A. Vishwakarma and S.D. Sawant, 2017. Transition metal-free single step approach for arylated pyrazolopyrimidinones and quinazolinones using benzylamines/benzylalcohols/benzaldehydes. ChemistrySelect, 2: 4963-4968.
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  26. Venkateswarlu, V., S. Balgotra, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. Metal-free chemoselective ortho-C (sp2)-F bond hydroxylation and N-trifluoroacylation of fluoroarylamines for domino synthesis of 2-(N-Trifluoroacyl) aminophenols. Synlett, 26: 1258-1262.

  27. Venkateswarlu, V., K.A. Kumar, S. Gupta, D. Singh, R.A. Vishwakarma and S.D. Sawant, 2015. DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: A metal-free approach for one-pot esterification. Org. Biomol. Chem., 13: 7973-7978.
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  28. Venkateswarlu, V., A.S. Pathania, K.A. Kumar, P. Mahajan and A. Nargotra et al., 2015. 4-(N-Phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines as inhibitors of mammalian target of rapamycin. Bioorg. Med. Chem., 23: 4237-4247.
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  29. Sawant, S.D., G.L. Reddy, M.I. Dar, M. Srinivas and G. Gupta et al., 2015. Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. Bioorg. Med. Chem., 23: 2121-2128.
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  30. Raghupathy, R., A.A. Anilkumar, A. Polley, P.P. Singh and M. Yadav et al., 2015. Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins. Cell, 161: 581-594.
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  31. Munagala, G., K.R. Yempalla, S. Singh, S. Sharma and N.P. Kalia et al., 2015. Synthesis of new generation triazolyl-and isoxazolyl-containing 6-nitro-2, 3-dihydroimidazooxazoles as anti-TB agents: In vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation. Org. Biomol. Chemistry, 13: 3610-3624.
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  32. Kumar, S., S.K. Guru, V. Venkateswarlu, F.A. Malik, R. Vishwakarma, D.S. Sawant and S. Bhushan, 2015. A novel quinoline based second-generation mTOR inhibitor that induces apoptosis and disrupts PI3K-Akt-mTOR signaling in human Leukemia HL-60 cells. Anti-Cancer Agents Med. Chem., 15: 1297-1304.
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  33. Kumar, K.A., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach to carboxylic acids by oxidation of Alkyl, Aryl, or Heteroaryl Alkyl ketones or arylalkynes. Synthesis, 47: 3161-3168.

  34. Gul, T., H.M. Balkhi, G.L. Reddy, S.D. Sawant, A. Hamid and E. Haq, 2015. Effect of combination of Suberoylanilide hydroxamic acid and O2', O3', O5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine on various obesity related markers in 3T3-L1 pre-adipocytic cell line. Int. J. Biol. Pharmaceut. Res., 6: 831-838.
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  35. Balgotra, S., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. Direct C-N bond cleavage of N-vinyl or N-allyl arylamines: A metal-free strategy for N-devinylation and N-deallylation. Tetrahedron Lett., 56: 4289-4292.
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  36. 6. Srinivas, M., A.D. Hudwekar, V. Venkateswarlu, G.L. Reddy, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach for transamidation of amides with amines in aqueous media. Tetrahedron Lett., 56: 4775-4779.
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  37. Yadav, M., R. Raghupathy, V. Saikam, S. Dara and P.P. Singh et al., 2014. Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors. Org. Biomol. Chem., 12: 1163-1179.
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  38. Venkateswarlu, V., K.A. Kumar, S. Balgotra, G.L. Reddy, M. Srinivas, R.A. Vishwakarma and S.D. Sawant, 2014. C-H Oxygenation and N‐trifluoroacylation of arylamines under metal‐free conditions: A convenient approach to 2‐aminophenols and N‐trifluoroacyl‐ortho‐aminophenols. Chem.: A Eur. J., 20: 664-6645.

  39. Sawant, S.D., A.D. Hudwekar, K.A.A Kumar, V. Venkateswarlu, P.P. Singh and R.A. Vishwakarma, 2014. Ligand- and base-free synthesis of phenols by rapid oxidation of arylboronic acids using iron(III) oxide. Tetrahedron Lett., 55: 811-814.

  40. Reddy, G.L., S.K. Guru, M. Srinivas, A.S. Pathania and P. Mahajan et al., 2014. Synthesis of 5-substituted-1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. Eur. J. Med. Chem., 80: 201-208.
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  41. Sawant, S.D., M. Srinivas, K.A. Kumar, G.L. Reddy and P.P. Singh et al., 2013. Ligand-free C-N bond formation in aqueous medium using a reusable Cu-Mn bimetallic catalyst. Tetrahedron Lett., 54: 5351-5354.
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  42. Khazir, J., P.P. Singh, D.M. Reddy, I. Hyder and S. Shafi et al., 2013. Synthesis and anticancer activity of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of α-santonin. Eur. J. Med. Chem., 63: 279-289.
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  43. Bharate, S.B., S.D. Sawant, P.P. Singh and R.A. Vishwakarma, 2013. Kinase inhibitors from marine origin. Chem. Rev., 113: 6761-6815.

  44. Singh, P.P., T. Thatikonda, K.A. Kumar, S.D. Sawant and B. Singh et al., 2012. Cu-Mn spinel oxide catalyzed regioselective halogenation of phenols and N-Heteroarenes. J. Org. Chem., 77: 5823-5828.
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  45. Singh, P.P., S. Gudup, H. Aruri, U. Singh and S. Ambala et al., 2012. New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction. Org. Biomol. Chem., 10: 1587-1597.
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  46. Sawant, S.D., M. Srinivas, G.L. Reddy, V.V. Rao, P.P. Singh and R.A. Vishwakarma, 2012. One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives. Tetrahedron Lett., 53: 6195-6198.
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  47. Singh, P.P., S. Gudup, S. Ambala, U. Singh and S. Dadhwal et al., 2011. Iron oxide mediated direct C-H arylation/alkylation at α-position of cyclic aliphatic ethers. Chem. Commun., 47: 5852-5854.

  48. Saikam, V., R. Raghupathy, M. Yadav, V. Gannedi and P.P. Singh et al., 2011. Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors. Tetrahedron Lett., 52: 4277-4279.
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  49. Reddy, D.M., N.A. Qazi, S.D. Sawant, A.H. Bandey and J. Srinivas et al., 2011. Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. Eur. J. Med. Chem., 46: 3210-3217.
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  50. Sawant, S.D., P.P. Singh, N.A. Qazi and H.S. Kumar, 2007. Addition of allylindium bromide to nitrile oxides in aqueous media: Convenient synthesis of 5-methylisoxazolines. Chem. Lett., 36: 296-297.
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  51. Singh, P.P., P.B. Reddy, S.D. Sawant, S. Koul, S.C. Taneja and H.S. Kumar, 2006. Domino synthesis of indenols and alkyl-indene ethers under modified Vilsmeier conditions. Tetrahedron Lett., 47: 7241-7243.
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  52. Reddy, P.B., P.P. Singh, S.D. Sawant, S. Koul, S.C. Taneja and H.M.S. Kumar, 2006. Microwave promoted novel synthesis of indenols catalyzed by SiO2 in dry media. Arkivoc, 13: 142-146.
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  53. Kumar, H.M.S., P. Chakravarthy, S.D. Sawant, P.P. Singh, M. Shesha Rao and J.S. Yadav, 2005. Catalytic transfer hydrogenation reactions of PEG-bound succinyl esters. Tetrahedron Lett., 46: 3591-3593.
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