Dr. Chandramu Chetty

Research Assistant Professor
University of Illinois, USA

Highest Degree
Ph.D. in Genetics from Osmania University, India

My URL
https://livedna.org/91.1604

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Area of Interest:

Medicine
Cancer Biology
Glioblastoma
Lung Cancer
Radiotherapy

Selected Publications

  1. Gupta, R., G.V. Rao, A.K. Nalla, C. Chetty and J.D. Klopfenstein et al., 2011. Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo. Int. J. Oncol., 38: 973-983.
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  2. Gupta, R., C. Chetty, P. Bhoopathi, S. Lakka, S. Mohanam, J.S. Rao and D.E. Dinh, 2011. Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells. Int. J. Oncol., 38: 733-744.
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  3. Gupta, R., A.K. Nalla, V.R. Gogineni, C. Chetty and P. Bhoopathi et al., 2011. uPAR/Cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma. PLoS One, 6: e17123-e17123.
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  4. Chetty, C., J.S. Rao and S.S. Lakka, 2011. Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma. Pharmacogenomics, 12: 535-546.
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  5. Bhoopathi, P., C. Chetty, V.R. Gogineni, M. Gujrati, D.H. Dinh, J.S. Rao and S.S. Lakka, 2011. MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumours. Gene Ther., 10.1038/gt.2011.14.
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  6. Veeravalli, K.K., C. Chetty, S. Ponnala, C.S. Gondi and S.S. Lakka et al., 2010. MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice. PLoS One, 5: e11583-e11583.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Gondi, C.S., G.V. Rao, C. Chetty, V.R. Dasari and B. Gorantla et al., 2010. Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells. Int. J. Oncol., 36: 1165-1173.
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  8. Chetty, C., S.S. Lakka, P. Bhoopathi, K.K. Veeravalli and D. Fassett et al., 2010. Urokinase Plasminogen Activator Receptor and/or Matrix Metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in Glioblastoma xenograft cells. Mol. Cancer Ther., 9: 2605-2617.
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  9. Chetty, C., P. Bhoopathi, S.S. Lakka and J.S. Rao, 2010. MMP-2 alters VEGF expression via αVβ3 Integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int. J. Cancer, 127: 1081-1095.
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  10. Bhoopathi, P., C. Chetty, M. Gujrati, D.H. Dinh, J.S. Rao and S.L. Lakka, 2010. The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine. Br. J. Cancer, 102: 530-540.
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  11. Chetty, C., P. Bhoopathi, J.S. Rao and S.S. Lakka, 2009. Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells. Int. J. Cancer, 124: 2468-2477.
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  12. Tsung, A.J., O. Kargiotis, C. Chetty, L.S. Lakka and M. Gujrati et al., 2008. Downregulation of matrix metalloproteinase-2 (MMP-2) utilizing adenovirus-mediated transfer of small interfering RNA (siRNA) in a novel spinal metastatic melanoma model. Int J. Oncol., 32: 557-564.
    PubMed  |  Direct Link  |  

  13. Kargiotis, O., C. Chetty, V. Gogineni, C.S. Gondi and S.M. Pulukuri et al., 2008. uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo. Int. J. Oncol., 33: 937-947.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Kargiotis, O., C. Chetty, C.S. Gondi, A.J. Tsung and D.H. Dinh et al., 2008. Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma. Oncogene, 27: 4830-4840.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Chetty, C., S.S. Lakka, P. Bhoopathi, S. Kunigal, R. Geiss and J.S. Rao, 2008. Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. Cancer Res., 68: 4736-4745.
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  16. Bhoopathi, P., C. Chetty, S. Kunigal, V. Vanamala, J.S. Rao and S.L. Lakka, 2008. Blockade of tumor growth due to Matrix Metalloproteinase-9 inhibition is mediated by sequential activation of β1-integrin, ERK, and NF-κB. J. Biol.Chem., 283: 1545-1552.
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  17. Rao, J.S., P. Bhoopathi, C. Chetty, M. Gujrati and S.S. Lakka, 2007. MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16INK4A and mitogen-activated protein kinase pathway. Cancer Res., 67: 4956-4964.
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  18. Chetty, C., P. Bhoopathi, S.S. Lakka and J.S. Rao, 2007. MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. Oncogene, 26: 7675-7683.
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  19. Chetty, C., P. Bhoopathi, P. Joseph, S. Chittivelu, J.S. Rao and S.S. Lakka, 2006. Adenovirus-mediated small interfering RNA against Matrix Metalloproteinase-2 suppresses tumor growth and lung metastasis in mice. Mol. Cancer Ther., 5: 2289-2299.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Rao, J.S., C.S. Gondi, C. Chetty, S. Chittivelu, P.A. Joseph and S.S. Lakka, 2005. Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells. Mol. Cancer Ther., 4: 1399-1408.
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  21. Chandramu, C., R.D. Manohar, D.G.L. Krupadanam and R.V. Dashavantha, 2003. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother. Res., 17: 129-134.
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  22. Chandramu, C., M. Rao and V.D. Reddy, 2003. High frequency induction of multiple shoots from nodal explants of Vitex negundo L. using sodium sulphate. J. Plant Biotechnol., 5: 107-113.
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Member since June, 2010