Dr. B. Ashokkumar

Associate Professor
Madurai Kamaraj University, India

Highest Degree
Ph.D. in Genetic Engineering and Biotechnology from Madurai Kamaraj University, India

My URL
https://livedna.org/91.19099

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Area of Interest:

Molecular Sciences
Microbial Diagnosis
Bioremediation
Biotechnology
Metabolism

Selected Publications

  1. Shakambari, G., B. Ashokkumar and P. Varalakshmi, 2019. L-asparaginase: A promising biocatalyst for industrial and clinical applications. Biocatal. Agric. Biotechnol., 17: 213-224.
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  2. Selvarasu, P., T. Khamrang, M. Velusamy, S. Karthi, B. Ashokkumar and M. Ramasamy, 2019. Coordination geometry induced optical imaging of L-cysteine in cancer cells using imidazopyridine-based copper(II) complexes. Dalton Trans., 48: 1489-1503.
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  3. Kumar, R.S., G. Shakambari, B. Ashokkumar and P. Varalakshmi, 2019. Inhibition of advanced glycation end products formation and inflammation in C. elegans: Studies of potential of Lyngbya sp. against expression of stress related genes and live cell imaging. Biocatal. Agric. Biotechnol., 17: 233-241.
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  4. Karpagam, R., K. Rani, S. Gunaseelan, B. Ashokkumar and P. Varalakshmi, 2019. Transcript analysis of hydrogenase A in an indigenous microalga, Coelastrella sp. M-60. Biocatal. Agric. Biotechnol., 17: 571-575.
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  5. Govindarajan, D., C. Chatterjee, G. Shakambari, K.V.P. Jayakumar and B. Ashokkumar, 2019. Oxidative stress response, epigenetic and behavioral alterations in Caenorhabditis elegans exposed to organophosphorus pesticide quinalphos. Biocatal. Agric. Biotechnol., 17: 702-709.
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  6. Udhayabanu, T., S. Karthi, A. Mahesh, P. Varalakshmi, A. Manole, H. Houlden and B. Ashokkumar, 2018. Adaptive regulation of riboflavin transport in heart: Effect of dietary riboflavin deficiency in cardiovascular pathogenesis. Mol. Cell Biochem., 440: 147-156.
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  7. Shakambari, G., R.S. Kumar, B. Ashokkumar, V. Ganesh, V.S. Vasantha and P. Varalakshmi, 2018. Cloning and expression of L-asparaginase from Bacillus tequilensis PV9W and therapeutic efficacy of solid lipid particle formulations against cancer. Nat. Sci. Rep., Vol. 8, No. 18013. 10.1038/s41598-018-36161-1.
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  8. Salpietro, V., S. Efthymiou, A. Manole1, B. Maurya and S. Wiethoff et al., 2018. A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. Human Mutation, 39: 187-192.
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  9. Kumar, R.S., G. Shakambari, B. Ashokkumar, D.j. Nelson, S.A. John and P. Varalakshmi, 2018. Nitrogen-doped graphene quantum dot-combined sodium 10-amino-2-methoxyundecanoate: Studies of proinflammatory gene expression and live cell imaging.ACS Omega, 3: 11982–11992. ACS Omega, 3: 11982-11992.
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  10. Karpagam, R., K. Jawaharraj, B. Ashokkumar, J. Sridhar and P. Varalakshmi, 2018. Unraveling the lipid and pigment biosynthesis in Coelastrella sp. M-60: Genomics-enabled transcript profiling. Algal Res., 29: 277-289.
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  11. Kalpana, R., M.J. Angelaalincy, K.B. Viswanath, V.S. Vasantha, B. Ashokkumar, V. Ganesh and P. Varalakshmi, 2018. Exopolysaccharide from Bacillus cereus VK1: Enhancement, characterization and its potential application in heavy metal removal. Colloids Surfaces B: Biointerfaces, 171: 327-334.
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  12. Gowda, V.K., T. Udhayabanu, P. Varalakshmi, V.M. Srinivasan and B. Ashokkumar, 2018. Fazio-londe syndrome in siblings from India with different phenotypes. Brain Dev., 40: 582-586.
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  13. Angelaalincy, M.J., R.N. Krishnaraj, G. Shakambari, B. Ashokkumar, S. Kathiresan, P. Varalakshmi, 2018. Biofilm engineering approaches for improving the performance of microbial fuel cells and bioelectrochemical systems. Front. Energy Res., 6: 1-12.
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  14. Vijayakumar, S., B. Vaseeharan, B. Malaikozhundan, N. Gobi and S. Ravichandran et al., 2017. A novel antimicrobial therapy for the control of Aeromonas hydrophila infection in aquaculture using marine polysaccharide coated gold nanoparticle. Microbial. Pathogenesis, 110: 140-151.
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  15. Udhayabanu, T., K. Gandhimathi, P. Varalakshmi and B. Ashokkumar, 2017. Functional Genomics of Riboflavin Transport: Genes and Regulatory Mechanisms. In: Current Developments in Biotechnology and Bioengineering, Book 2: Functional Genomics and Metabolic Engineering, Gunasekaran, P. and S. Noronha (Eds.)., Elsevier Publishers, UK., pp: 79-102.

  16. Udhayabanu, T., A. Manole, M. Rajeshwari, P. Varalakshmi, H. Houlden and B. Ashokkumar, 2017. Riboflavin responsive mitochondrial dysfunction in neurodegenerative diseases. J. Clin. Med., Vol. 6. 10.3390/jcm6050052.
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  17. Ramkumar, S.S., N. Sivakumar, G. Selvakumar, T. Selvankumar, C. Sudhakar, B. Ashokkumar and S. Karthi, 2017. Green synthesized silver nanoparticles from Garcinia imberti bourd and their impact on root canal pathogens and HepG2 cell lines. RSC Adv., 7: 34548-34555.
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  18. Manole, A., Z. Jaunmuktane I. Hargreaves, A. Pandraud and V. Salpietro et al., 2017. Mitochondrial impairment and rescue in riboflavin responsive neuropathy. Biorxiv, 10.1101/110890.
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  19. Maheshwaran, D., T. Nagendraraj, P. Manimaran, B. Ashokkumar, M. Kumar and R. Mayilmurugan, 2017. A highly selective and efficient copper (II)-"turn‐on" fluorescence imaging probe for l‐cysteine. Eur. J. Inorg. Chem., 2017: 1007-1016.
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  20. Karthi, S., M. Rajeshwari, A. Francis, M. Saravanan and P. Varalakshmi et al., 2017. 3'-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and glycogen storage disease type-Ia risk. Clin. Chim. Acta, 471: 46-54.
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  21. Jawaharraj, K., R. Karpagam, B. Ashokkumar, S. Kathiresan, I.M.G. Moorthy, M. Arumugam and P. Varalakshmi, 2017. Improved biomass and lipid production in Synechocystis sp. NN using industrial wastes and nano-catalyst coupled transesterification for biodiesel production. Bioresour. Technol., 242: 128-132.
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  22. Iswarya, A., B. Vaseeharan, M. Anjugam, B. Ashokkumar and M. Govindarajan et al., 2017. Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule β-1, 3-glucan binding protein: Toxicity on HepG2 liver cancer cells and bacterial pathogens. Colloids Surfaces B: Biointerfaces, 158: 257-269.
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  23. Angelaalincy, M., N. Senthilkumar, R. Karpagam, G.G. Kumar, B. Ashokkumar and P. Varalakshmi, 2017. Enhanced extracellular polysaccharide production and self-sustainable electricity generation for PAMFCs by Scenedesmus sp. SB1. ACS Omega, 2: 3754-3765.
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  24. Udhayabanu, T., V.S. Subramanian, T. Teafatiller, V.K. Gowda and V.S. Raghavan et al., 2016. SLC52A2 [p. P141T] and SLC52A3 [p. N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Clin. Chim. Acta, 462: 210-214.
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  25. Shakambari, G., A.K. Birendranarayan, M.J.A. Lincy, S.K. Rai and Q.T. Ahamed et al., 2016. Hemocompatible glutaminase free L-asparaginase from marine Bacillus tequilensis PV9W with anticancer potential modulating p53 expression. RSC Adv., 6: 25943-25951.
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  26. Pramanik, A., A.K. Kole, R.N. Krishnaraj, S. Biswas and C.S. Tiwary et al., 2016. A novel technique of synthesis of highly fluorescent carbon nanoparticles from broth constituent and in-vivo bioimaging of C. elegans. J. Fluorescence, 26: 1541-1548.
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  27. Nisha, K.N., J. Sridhar, P. Varalakshmi and B. Ashokkumar, 2016. Draft genome sequence of Paracoccus sp. MKU1, a new bacterial strain isolated from an industrial effluent with potential for bioremediation. J. Genomics, 4: 13-15.
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  28. Manimaran, P., V.S. Subramanian, S. Karthi, K. Gandhimathi and P. Varalakshmi et al., 2016. Novel nonsense mutation (p. Ile411Metfs* 12) in the SLC19A2 gene causing Thiamine Responsive Megaloblastic Anemia in an Indian patient. Clin. Chim. Acta, 452: 44-49.
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  29. Jawaharraj, K., R. Karpagam, B. Ashokkumar, C.N. Pratheeba and P. Varalakshmi, 2016. Enhancement of biodiesel potential in cyanobacteria: using agro-industrial wastes for fuel production, properties and acetyl CoA carboxylase D (accD) gene expression of Synechocystis sp. NN. Renewable Energy, 98: 72-77.
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  30. Ashokkumar, B., N.D. Vaziri and H.M. Said, 2016. Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: Cellular and molecular mechanisms. Am. J. Physiol.-Renal Physiol., 291: F796-F805.
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  31. Shakambari, G., B.M. Sumi, B. Ashokkumar, P. Palanivelu and P. Varalakshmi, 2015. Industrial effluent as a substrate for glutaminase free L-asparaginase production from Pseudomonas plecoglossicida strain RS1; media optimization, enzyme purification and its characterization. RSC Adv., 5: 48729-48738.
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  32. Shakambari, G., B. Ashokkumar and P. Varalakshmi, 2015. Phlorotannins from Brown Algae: Inhibition of advanced glycation end products formation in high glucose induced Caenorhabditis elegans. Indian J. Exp. Biol., 53: 371-379.

  33. Nisha, K.N., V. Devi, P. Varalakshmi and B. Ashokkumar, 2015. Biodegradation and utilization of dimethylformamide by biofilm forming Paracoccus sp. strains MKU1 and MKU2. Bioresour. Technol., 188: 9-13.
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  34. Lincy, M.J.A., B. Ashokkumar, M. Vasantha and P. Varalakshmi, 2015. Microbial Fuel Cells: Apromising Alternative Energy Source. In: Bioenergy: Opportunities and Challenges, Krishnaraj, R.N. and J.S. Yu (Eds.)., Apple Academy Press, USA., pp: 61-85.

  35. Karuppasamy, K., P. Srinivasan, B. Ashokkumar, R. Tiwari, K. Kanagarajadurai and R. Prasad, 2015. Partial loss of self-resistance to daunorubicin in drrD mutant of Streptomyces peucetius. Biochem. Eng. J., 102: 98-107.
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  36. Karthi, S., P. Manimaran, K. Gandhimathi, R. Ganesh, P. Varalakshmi and B. Ashokkumar, 2015. Glucose-6-phosphatase (G6PC1) promoter polymorphism associated with glycogen storage disease type 1a among the Indian population. RSC Adv., 5: 65297-65302.
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  37. Karpagam, R., R. Preeti, B. Ashokkumar and P. Varalakshmi, 2015. Enhancement of lipid production and fatty acid profiling in Chlamydomonas reinhardtii, CC1010 for biodiesel production. Ecotoxicol. Environ. Safety, 121: 253-257.
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  38. Karpagam, R., K.J. Raj, B. Ashokkumar and P. Varalakshmi, 2015. Characterization and fatty acid profiling in two fresh water microalgae for biodiesel production: Lipid enhancement methods and media optimization using response surface methodology. Bioresour. Technol., 188: 177-184.
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  39. Jawaharraj, K., R. Karpagam, B. Ashokkumar, S. Kathiresan and P. Varalakshmi, 2015. Green renewable energy production from Myxosarcina sp.: Media optimization and assessment of biodiesel fuel properties. RSC Adv., 5: 51149-51157.
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  40. Gandhimathi, K., S. Karthi, P. Manimaran, P. Varalakshmi and B. Ashokkumar, 2015. Riboflavin transporter-2 (rft-2) of Caenorhabditis elegans: Adaptive and developmental regulation. J. Biosci., 40: 257-268.
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  41. Sivakumar, N., G. Selvakumar, P. Varalakshmi and B. Ashokkumar, 2014. Lactobacillus sp. a potent probiotic for disease free shrimp aquaculture. Int. J. Recent Scient. Res., 5: 1031-1045.
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  42. Saravanan, N., B. Ashokkumar, N. Sivakumar and P. Varalakshmi, 2014. Biosorption of Malachite Green (Azo Dye) by Oscillatoria chlorine: Kinetics, Equilibrium Isotherm and FTIR Studies. In: Plants and Microbes, Goyal, P. (Ed.)., SBW Publishers, New Delhi, India, pp: 134-148.

  43. Karpagam, R., R. Preeti, K.J. Raj, S. Saranya, B. Ashokkumar and P. Varalakshmi, 2014. Fatty acid biosynthesis from a new isolate Meyerella sp. N4: Molecular characterization, nutrient starvation and fatty acid profiling for lipid enhancement. Energy Fuels, 29: 143-149.
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  44. Agalya, S., T. Dinakaran, K. Vijayanand, S.D. Kumar, B.A. Kumar, N. Sivakumar and P. Varalakshmim, 2014. Optimization of Medium for the Production of Inulinase from Enterobacter aerogenes by Response Surface Methodology. In: Plants and Microbes, Goyal, P. (Ed.)., SBW Publishers, New Delhi, India, pp: 203-216.

  45. Sivakumar, N., B. Ashokkumar and P. Varalakshmi, 2013. Cyanobacteria in Diverse Environment: A Prolific Source for Bioactive Metabolites. In: Biodiversity: Issues, Impacts, Remediation and Significances, Williams, C. (Ed.)., VLMS Publishers, New Delhi, India.

  46. Babu, S.V., B. Ashokkumar, N. Sivakumar, P. Sudhakarsamy and P. Varalakshmi, 2013. Indole-3-acetic acid from filamentous cyanobacteria: Screening, strain identification and production. J. Scient. Ind. Res., 72: 581-584.
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  47. Krishnaraj, R.N., S.V. Babu, B. Ashokkumar, P. Malliga and P. Varalakshmi, 2012. Antioxidant property of fresh and marine water cyanobacterial extracts in Swiss mice. J. Biopesticides, 5: 250-254.
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  48. Vimalarasan, A., N. Pratheeba, B. Ashokkumar, N. Sivakumar and P. Varalakshmi, 2011. Production of biodiesel from cyanobacteria (Oscillatoria annae) by alkali and enzyme mediated transesterification. J. Scient. Ind. Res., 70: 959-967.
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  49. Said, H.M., L. Mee, V.T. Sekar, B. Ashokkumar and S.J. Pandol, 2010. Mechanism and regulation of folate uptake by pancreatic acinar cells: Effect of chronic alcohol consumption. Am. J. Physiol.-Gastrointestinal Liver Physiol., 298: G985-G993.
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  50. Austin, M.U., W.S. Liau, K. Balamurugan, B. Ashokkumar, H.M. Said and C.W. LaMunyon, 2010. Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans. BMC Dev. Biol., Vol. 10. 10.1186/1471-213X-10-46.
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  51. Ashokkumar, B., S.M. Nabokina, T.Y. Ma and H.M. Said, 2009. Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. Am. J. Physiology-Gastrointestinal Liver Physiol., 297: 480-487.
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  52. Ashokkumar, B., J.S. Kumar, G.A. Hecht and H.M. Said, 2009. Enteropathogenic Escherichia coli inhibits intestinal vitamin B1 (thiamin) uptake: Studies with human-derived intestinal epithelial Caco-2 cells. Am. J. Physiology-Gastrointestinal Liver Physiol., 297: 825-833.
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  53. Balamurugan, K., B. Ashokkumar, M. Moussaif, J.Y. Sze and H.M. Said, 2007. Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. Am. J. Physiol.-Cell Physiol., 293: C670-C681.
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  54. Ashokkumar, B., Z.M. Mohammed, N.D. Vaziri and H.M. Said, 2007. Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am. J. Clin. Nutr., 86: 159-166.
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  55. Senthilkumar, S.R., B. Ashokkumar, K.C. Raj and P. Gunasekaran, 2005. Optimization of medium composition for alkali-stable xylanase production by Aspergillus fischeri Fxn 1 in solid-state fermentation using central composite rotary design. Bioresour. Technol., 96: 1380-1386.
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  56. Ashokkumar, B., S.R. Senthilkumar and P. Gunasekaran, 2005. Purification and Characterization of β-Fructofuranosidases from Aspergillus niger in Submerged and Solid-state Fermentation. In: Current Topic on Bioprocesses in Food Industry, Lachore, C., A. Pandey, C.G. Dussap (Eds.)., Asiatech Publishers, UK., pp: 156-170.

  57. Senthilkumar, S.R., B. Ashokkumar, K.C. Raj and P. Gunasekaran, 2004. Purification and characterization of a low molecular weight endoxylanase from solid-state cultures of alkali-tolerant Aspergillus fischeri. Biotechnol. Lett., 26: 1283-1287.
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  58. Ashokkumar, B., S.R. Senthilkumar and P. Gunasekaran, 2004. Derepressed 2-deoxyglucose resistant mutants of Aspergillus niger with altered hexokinase and acid phosphatase activity in hyperproduction of β-fructofuranosidase. Applied Biochem. Biotechnol., 118: 89-96.
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  59. Alagesan, P., B. Ashokkumar, J. Muthukrishnan and P. Gunasekaran, 2003. Isolation and characterization of gut bacteria of millipede, Xenobolus carnifex (Fabricius). Indian J. Microbiol., 43: 111-113.
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  60. Rajendran, P., B. Ashokkumar, J. Muthukrishnan and P. Gunasekaran, 2002. Toxicity assessment of nickel using Aspergillus niger and its removal from an industrial effluent. Applied Biochem. Biotechnol., 102: 201-206.
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  61. Ashokkumar, B. and P. Gunasekaran, 2002. β-Fructofuranosidase production by 2-deoxyglucose resistant mutants of Aspergillus niger in submerged and solid-state fermentation. Indian J. Exp. Biol., 40: 1032-1037.
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  62. Ashokkumar, B., N. Kayalvizhi and P. Gunasekaran, 2001. Optimization of media for β-fructofuranosidase production by Aspergillus niger in submerged and solid state fermentation. Process Biochem., 37: 331-338.
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