Dr. Girish Kumar Gupta

Assistant Professor
M.M. University, India

Highest Degree
Ph.D. in Pharmaceutical Sciences from Maharishi Markandeshwar University, India

My URL
https://livedna.org/91.19187

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Area of Interest:

Pharmacology and Toxicology
Pharmaceutical Sciences
Medicinal Chemistry
Drug Delivery
Drug Design

Selected Publications

  1. Yildirim, H., N. Bayrak, A.F. Tuyun, E.M. Kara, B.O. Celik and G.K. Gupta, 2017. 2,3-Disubstituted-1,4-naphthoquinones containing an arylamine with trifluoromethyl group: Synthesis, biological evaluation and computational study. RSC Adv., 7: 25753-25764.
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  2. Sharma, V.R., G.K. Gupta, A.K. Sharma, N. Batra, D.K. Sharma, A. Joshi and A.K. Sharma, 2017. PI3K/Akt/mTOR intracellular pathway and breast cancer: Factors, mechanism and regulation. Curr. Pharmaceut. Des., 23: 1633-1638.
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  3. Pillai, H., B.S. Yadav, N Chaturvedi., A.T. Jan, G.K. Gupta, M.H. Baig and S.K. Bhure, 2017. Protein modeling and molecular dynamics simulation of cloned regucalcin (RGN) gene from Bubalus bubalis. Comb. Chem. High Throughput Screen., 20: 186-192.
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  4. Kumar, S., Sukhvinder, V. Kumar, G.K. Gupta and V. Beniwal et al., 2017. Antibacterial, tyrosinase and DNA photocleavage studies of some triazolylnucleosides. Nucleosides Nucleotides Nucleic Acids, 36: 543-551.
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  5. Kumar, D., P. Sharma, H. Singh, K. Nepali, G.K. Gupta, S.K. Jain and F. Ntie-Kang, 2017. The value of pyrans as anticancer scaffolds in medicinal chemistry. RSC Adv., 7: 36977-36999.
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  6. El Arbi, M., E. Ketata, A. Neifar, W. Mihoubi and G.K. Gupta et al., 2017. Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia. Mini-Rev. Med. Chem., Vol. 17. 10.2174/1389557517666170208142254.
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  7. Bayrak, N., H. Yildirim, A.F. Tuyun, E.M. Kara and B.O. Celik et al., 2017. Synthesis, computational study and evaluation of in vitro antimicrobial, antibiofilm and anticancer activities of new sulfanyl aminonaphthoquinone derivatives. Lett. Drug Des. Discov., 14: 647-661.
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  8. Rajpoot, M., R. Bhattacharyya, G.K. Gupta and A.K. Sharma, 2016. Drug Designing in Novel Drug Discovery: Trends, Scope and Relevance. In: Chemical Drug Design, Gupta, G.K. and V. Kumar (Eds.). Chapter 2, Walter de Gruyter GmbH, Berlin, Germany, ISBN-13: 9783110368826, pp: 15-30.

  9. Patel, S. and G.K. Gupta, 2016. Mistletoe Lectin: A Promising Cancer Therapeutic. In: Chemical Drug Design, Gupta, G.K. and V. Kumar (Eds.). Chapter 7, Walter de Gruyter GmbH, Berlin, Germany, ISBN-13: 9783110368826, pp: 165-181.

  10. Nain, S., G. Mathur, G.K. Gupta and S. Paliwal, 2016. Structure and Ligand Based Approaches in Drug Designing. In: Chemical Drug Design, Gupta, G.K. and V. Kumar (Eds.). Chapter 3, Walter de Gruyter GmbH, Berlin, Germany, ISBN-13: 9783110368826, pp: 31-52.

  11. Kumar, V., M. Kumar, V. Beniwal, G.K. Gupta, S. Kumar and R. Kataria, 2016. Synthesis of some aroylhydrazones and 2,5-disubstituted-1,3,4-oxadiazoles as DNA photocleaving agents. Med. Chem., 6: 474-485.
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  12. Goyal, K., A. Sharma, R. Arya, R. Sharma, G.K. Gupta and A.K. Sharma, 2016. Double edge sword behavior of carbendazim: A potent fungicide with anti-cancer therapeutic properties. Anti-Cancer Agents Med. Chem., Vol. 16. 10.2174/1871520616666161221113623.
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  13. Bayrak, N., H. Yildirim, A.F. Tuyun, E.M. Kara, B.O. Celik and G.K. Gupta, 2016. Synthesis, biological and computational study of naphthoquinone derivatives containing heteroatoms. J. Chem. Soc. Pak., 38: 1211-1221.
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  14. Ahmad, K., M.K. Khan, M.H. Baig, M. Imran and G.K. Gupta, 2016. Role of Azoles in cancer prevention and treatment: Present and future perspectives. Anti-Cancer Agents Med. Chem., Vol. 16. 10.2174/1871520616666161221112042.
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  15. Ahmad, K., M.H. Baig, G.K. Gupta, M.A. Kamal, N. Pathak and I. Choi, 2016. Identification of common therapeutic targets for selected neurodegenerative disorders: An in silico approach. J. Comput. Sci., 17: 292-306.
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  16. Sharma, A., V. Kumar, R. Khare, G.K. Gupta and V. Beniwal, 2015. Synthesis, docking study and DNA photocleavage activity of some pyrimidinyl hydrazones and 3-(quinolin-3-yl)-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidine derivatives. Med. Chem. Res., 24: 1830-1841.
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  17. Kumar, M., V. Kumar and G.K. Gupta, 2015. Synthesis, antibacterial evaluation and SAR study of some novel 3-aryl/heteroaryl-9-methyl-1,2,4-triazolo-[4,3-a]-quinoline derivatives. Med. Chem. Res., 24: 1857-1868.
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  18. Kaur, K., V. Kumar and G.K. Gupta, 2015. Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review. J. Fluorine Chem., 178: 306-326.
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  19. Gupta, G.K., S. De, A. Franco, A.M. Balu and R. Luque, 2015. Sustainable biomaterials: current trends, challenges and applications. Molecules, Vol. 21, No. 1. 10.3390/molecules21010048.
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  20. Gupta, G.K. and V. Kumar, 2015. Pyranopyrazoles as a new class of FTO inhibitors: A Docking study. Res. J. Chem. Environ., 19: 51-60.

  21. Gupta, G.K. and V. Kumar, 2015. A novel class of COX-II inhibitors: Computational and docking study of pyran-pyrimidine hybrids. Res. J. Chem. Environ., 19: 53-62.

  22. Choudhary, D., G.K. Gupta and S.L. Khokra, 2015. Structure based designing and ADME-T studies of butenolide derivatives as potential agents against receptor ICAM-1: A drug target for cerebral malaria. J. Comput. Sci., 10: 156-165.
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  23. Sharma, A., R. Khare, V. Kumar, G.K. Gupta and V. Beniwal, 2014. 1-(subsituted)-4, 4, 6-trimethyl-3, 4-dihydropyrimidine-2(1H)-Thione: Green synthesis, antibacterial activity and DNA photocleavage activity. Int. J. Pharm. Pharmaceut. Sci., 6: 171-175.
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  24. Saini, R.P., V. Kumar, A.K. Gupta and G.K. Gupta, 2014. Synthesis, characterization and antibacterial activity of a novel heterocyclic Schiff's base and its metal complexes of first transition series. Med. Chem. Res., 23: 690-698.
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  25. Pal, R., V. Kumar, V. Beniwal, G.K. Gupta and A.K. Gupta, 2014. In silico and DNA photocleavage studies of N, N'-bis(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene)malonohydrazide Schiff's base and its metal complexes. Der Pharma Chem., 6: 31-36.
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  26. Pal, R., V. Kumar, A.K. Gupta, V. Beniwal and G.K. Gupta, 2014. Synthesis, characterization and DNA cleavage study of dehydroacetic acid based tridentate Schiff’s base and its metal complexes of first transition series. Med. Chem. Res., 23: 4060-4069.
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  27. Pal, R., V. Kumar, A.K. Gupta, V. Beniwal and G.K. Gupta, 2014. Solvent free synthesis, characterization and DNA photocleavage study of some first transition series metal complexes of cyanoacetohydrazone Schiff's bases. Res. J. Chem. Environ., 18: 40-45.

  28. Kumar, V., K. Kaur, D.N. Karelia, V. Beniwal, G.K. Gupta, A.K. Sharma and A.K. Gupta, 2014. Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones: Antibacterial, DNA photocleavage and anticancer activities. Eur. J. Med. Chem., 81: 267-276.
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  29. Kaur, K., V. Kumar, A.K. Sharma and G.K. Gupta, 2014. Isoxazoline containing natural products as anticancer agents: A review. Eur. J. Med. Chem., 77: 121-133.
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  30. Gupta, G.K., V. Saini, R. Khare and V. Kumar, 2014. 1,4-Diaryl-2-mercaptoimidazoles derivatives as a novel class of antimicrobial agents: Design, synthesis and computational studies. Med. Chem. Res., 23: 4209-4220.
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  31. Gupta, G.K., V. Kumar and K. Kaur, 2014. Imidazole containing natural products as antimicrobial agents: A review. Nat. Prod. J., 4: 73-81.
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  32. Gupta, G.K., K. Kaur, S. Singh and V. Kumar, 2014. Isolation of 4-hydroxythiazoline: A solid phase study in Hantzsch thiazole reaction. Res. J. Chem. Environ., 18: 38-44.

  33. Gupta, G.K., A. Mittal and V. Kumar, 2014. DHA: An excellent source of bioactive heterocycles. Lett. Org. Chem., 11: 273-286.
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  34. Gupta, G.K. and V. Kumar, 2014. Recent approaches towards the synthesis of flavonoids: A review. Res. J. Chem. Environ., 18: 73-83.

  35. Singh, R., N. Kaur, L. Kishore and G.K. Gupta, 2013. Management of diabetic complications: A chemical constituents based approach. J. Ethnopharmacol., 150: 51-70.
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  36. Rani, N., A. Sharma, G.K. Gupta and R. Singh, 2013. Imidazoles as potential antifungal agents: A review. Mini Rev. Med. Chem., 13: 1626-1655.
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  37. Kumar, V., K. Kaur, G.K. Gupta, A.K. Gupta and S. Kumar, 2013. Developments in synthesis of the anti-inflammatory drug, celecoxib: A review. Recent Patents Inflamm. Allergy Drug Discov., 7: 124-134.
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  38. Kumar, V., K. Kaur, G.K. Gupta and A.K. Sharma, 2013. Pyrazole containing natural products: Synthetic preview and biological significance. Eur. J. Med. Chem., 69: 735-753.
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  39. Kumar, V., G.K. Gupta, K. Kaur and R. Singh, 2013. 4-Fluorophenylhydrazones as potential COX-2 inhibitors: A novel, efficient, one pot solid phase synthesis, docking study and pharmacological evaluation. Med. Chem. Res., 22: 5890-5900.
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  40. Goyal, V., G.K. Gupta and A. Kumar, 2013. Authorship patterns and collaborative research trends in the field of chemical sciences. Int. J. Inform. Dissemination Technol., 3: 184-186.
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  41. Chandna, N., S. Kumar, P. Kaushik, D. Kaushik and S.K. Roy et al., 2013. Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors. Bioorg. Med. Chem., 21: 4581-4590.
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  42. Aggarwal, R., V. Kumar, G.K. Gupta and V. Kumar, 2013. Synthesis of some new 3,5-diamino-4-(4′-fluorophenylazo)-1-aryl/heteroarylpyrazoles as antimicrobial agents. Med. Chem. Res., 22: 3566-3573.
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  43. Aggarwal, R., S. Kumar, P. Kaushik, D. Kaushik and G.K. Gupta, 2013. Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles. Eur. J. Med. Chem., 62: 508-514.
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  44. Kumar, A., P. Lohan, D.K. Aneja, G.K. Gupta, D. Kaushik and O. Prakash, 2012. Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles. Eur. J. Med. Chem., 50: 81-89.
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  45. Gupta, G.K., N. Rani and V. Kumar, 2012. Microwave assisted synthesis of imidazoles-A review. Mini-Rev. Org. Chem., 9: 270-284.
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  46. Gupta, G.K., M. Bhatia and R. Singh, 2012. Analgesic activity of Psidium guajava root extracts. Curr. Trends Biotechnol. Chem. Res., 2: 113-117.
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  47. Gupta, G.K. and V. Kumar, 2012. Conformational analysis of some novel aurone analogs of DHA as tyrosine kinase receptor inhibitors. Curr. Trends Biotechnol. Chem. Res., 2: 129-133.
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  48. Gupta, G.K. and A. Kumar, 2012. 3D-QSAR studies of some tetrasubstituted pyrazoles as COX-II inhibitors. Acta Pol. Pharmaceut.-Drug Res., 69: 763-772.
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  49. Kumar, V., N. Rani, G.K. Gupta and V. Kumar, 2011. Biological activities of pyrazoline: A review. Purva Mimaansa: Multi-disciplin. Res. J., 2: 88-99.

  50. Kumar, V., G.K. Gupta and M. Kumar, 2011. PTSA catalyzed solid phase synthesis of some 2-arylbenzothiazoles: An expeditious, mild and greener protocol. Curr. Trends Biotechnol. Chem. Res., 1: 132-136.
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  51. Kumar, V., G.K. Gupta and A.K. Gupta, 2011. An expeditious, efficient and green synthesis of some 2-arylbenzoxazoles catalyzed by PTSA under solvent-free condition. Curr. Trends Biotechnol. Chem. Res., 1: 49-52.
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  52. Kumar, G.G., K. Vikas and K. Vinod, 2011. Pyrazoles as potential anti-obesity agents. Res. J. Chem. Environ., 15: 90-103.

  53. Jain, A., R. Sharma, N. Gahalain, J. Chaudary and G.K. Gupta, 2011. Herbal plants used in diabetic complications: An overview. J. Pharm. Res., 4: 986-988.

  54. Gupta, G.K., J. Chahal and D. Arora, 2011. Psidium guajava Linn: Current research and future prospects. J. Pharm. Res., 4: 42-46.

  55. Gupta, G.K., J. Chahal and M. Bhatia, 2010. Clitorea ternatea (L.): Old and new aspects. J. Pharm. Res., 3: 2610-2614.
Member since October, 2017