Dr. Hans Raj Bhat

Assistant Professor
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India

Highest Degree
Ph.D. in Pharmaceutical Sciences from Dibrugarh University, Dibrugarh, Assam, India

My URL
https://livedna.org/91.36528

Share this Profile

Area of Interest:

Pharmaceutical Sciences
Anti-HIV
Anticancer
Developing Novel Antimalarial Molecules
Developing Novel Heterocyclic Scaffolds

Selected Publications

  1. Singh, S., M.K. Mandal, A. Masih, A. Saha, S.K. Ghosh, H.R. Bhat and U.P. Singh, 2021. 1,3,5‐triazine: a versatile pharmacophore with diverse biological activities. Archiv der Pharmazie, Vol. 354. 10.1002/ardp.202000363.
    CrossRef  |  Direct Link  |  

  2. Pande, A., M. Manchanda, H.R. Bhat, P.S. Bairy, N. Kumar and P. Gahtori, 2021. Molecular insights into a mechanism of resveratrol action using hybrid computational docking/CoMFA and machine learning approach. J. Biomol. Struct. Dyn., 10.1080/07391102.2021.1910572.
    CrossRef  |  Direct Link  |  

  3. Mandal, M.K., S. Ghosh, L. Naesens, H.R. Bhat and U.P. Singh, 2021. Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1,3-thiazolidin-4-one sulfonyl derivatives. Bioorg. Chem., Vol. 114. 10.1016/j.bioorg.2021.105153.
    CrossRef  |  Direct Link  |  

  4. Kashyap, A., A.A.K. Choudhury, A. Saha, N. Adhikari and S.K. Ghosh et al., 2021. Microwave‐assisted synthesis of hybrid paba‐1,3,5‐triazine derivatives as an antimalarial agent. J. Biochem. Mol. Toxicol., Vol. 35. 10.1002/jbt.22860.
    CrossRef  |  Direct Link  |  

  5. Zothantluanga, J.H., H.S. Lalnunpuii, H.R. Bhat and A. Shakya, 2020. Awareness on the possible adverse effects of Garcinia cambogia: a scientific approach. Sci. Vision, 19: 120-133.
    CrossRef  |  Direct Link  |  

  6. Shakya, A., S.K. Chaudhary, H.R. Bhat and S.K. Ghosh, 2020. Acute and sub-chronic toxicity studies of Benincasa hispida (Thunb.) cogniaux fruit extract in rodents. Regul. Toxicol. Pharmacol., Vol. 118. 10.1016/j.yrtph.2020.104785.
    CrossRef  |  Direct Link  |  

  7. Shakya, A., S.K. Chaudary, D. Garabadu, H.R. Bhat, B.B. Kakoti and S.K. Ghosh, 2020. A comprehensive review on preclinical diabetic models. Curr. Diabetes Rev., 16: 104-116.
    CrossRef  |  Direct Link  |  

  8. Masih, A., S. Singh, A.K. Agnihotri, S. Giri and J.K. Shrivastava et al., 2020. Design and development of 1,3,5-triazine-thiadiazole hybrids as potent adenosine A2A receptor (A2AR) antagonist for benefit in parkinson's disease. Neurosci. Lett., Vol. 735. 10.1016/j.neulet.2020.135222.
    CrossRef  |  Direct Link  |  

  9. Masih, A., J.K. Shrivastava, H.R. Bhat and U.P. Singh, 2020. Potent antibacterial activity of dihydydropyrimidine‐1,3,5‐triazines via inhibition of DNA gyrase and antifungal activity with favourable metabolic profile. Chem. Biol. Drug Des., 96: 861-869.
    CrossRef  |  Direct Link  |  

  10. Masih, A., A.K. Agnihotri, J.K. Srivastava, N. Pandey, H.R. Bhat and U.P. Singh, 2020. Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2. J. Biochem. Mol. Toxicol., Vol. 35. 10.1002/jbt.22656.
    CrossRef  |  Direct Link  |  

  11. Masih, A., A.K. Agnihotri, J.K. Srivastava, N. Pandey, H.R. Bhat and U.P. Singh, 2020. Discovery of novel 1,3,5‐triazine as adenosine a 2A receptor antagonist for benefit in parkinson's disease. J. Biochem. Mol. Toxicol., Vol. 35. 10.1002/jbt.22659.
    CrossRef  |  Direct Link  |  

  12. Mandal, M.K., S. Ghosh, H.R. Bhat, L. Naesens and U.P. Singh, 2020. Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents. Bioorg. Chem., 10.1016/j.bioorg.2020.104320.
    CrossRef  |  Direct Link  |  

  13. Gogoi, P., A. Shakya, S.K. Ghosh, N. Gogoi and P. Gahtori et al., 2020. In silico study, synthesis, and evaluation of the antimalarial activity of hybrid dimethoxy pyrazole 1,3,5‐triazine derivatives. J. Biochem. Mol. Toxicol., Vol. 35. 10.1002/jbt.22682.
    CrossRef  |  Direct Link  |  

  14. Das, A., S.K. Ghosh, H.R. Bhat, J. Kalita, A. Kashyap and N. Adhikari, 2020. Docking, synthesis and antimalarial evaluation of hybrid phenyl thiazole 1,3,5-triazine derivatives. Curr. Bioact. Compd.., 16: 639-653.
    CrossRef  |  Direct Link  |  

  15. Das, A., A. Shakya, S.K. Ghosh, U.P. Singh and H.R. Bhat, 2020. A review of phytochemical and pharmacological studies of inula species. Curr. Bioact. Compd.., 16: 557-567.
    CrossRef  |  Direct Link  |  

  16. Adhikari, N., A. Kashyap, A. Shakya, S.K. Ghosh, D.R. Bhattacharyya, H.R. Bhat and U.P. Singh, 2020. Microwave assisted synthesis, docking and antimalarial evaluation of hybrid paba‐substituted 1,3,5‐triazine derivatives. J. Heterocycl. Chem., 57: 2389-2399.
    CrossRef  |  Direct Link  |  

  17. Shakya, A., N. Gogoi, S.K. Chaudhary, H.R. Bhat and S.K. Ghosh, 2019. Development and validation of a high-performance thin-layer chromatography method for the quantification of rutin in the fruit pulp of Benincasa hispida (Thunb.) Cogniaux. JPC J. Planar Chromatogr. Mod. TLC, 32: 371-377.
    CrossRef  |  Direct Link  |  

  18. Shakya, A., H.R. Bhat and S.K. Ghosh, 2019. Assessment of neurobehavioral properties of hydroalcoholic extract of Benincasa hispida (Thunb.) cogn. fruit pulp in mice. J. Bio.ly Active Prod. Nat., 9: 299-310.
    CrossRef  |  Direct Link  |  

  19. Sahu, S., S.K. Ghosh, P. Gahtori, U.P. Singh, D.R. Bhattacharyya and H.R. Bhat, 2019. In silico ADMET study, docking, synthesis and antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor. Pharmacol. Rep., 71: 762-767.
    CrossRef  |  Direct Link  |  

  20. Bhat, H.R., A. Masih, A. Shakya, S.K. Ghosh and U.P. Singh, 2019. Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4‐aminoquinoline‐1,3,5‐triazine derivatives. J. Heterocycl. Chem., 57: 390-399.
    CrossRef  |  Direct Link  |  

  21. Singh, U.P. and H.R. Bhat, 2018. Discovery of 1,3,5-triazine-thiazoles (DDTR-502) as potent A2A antagonist/MAO-B inhibitor for the treatment of parkinson’s disease. Parkinsonism Related Disord., 46: e39-e40.
    CrossRef  |  Direct Link  |  

  22. Shakya, A., H.R. Bhat and S.K. Ghosh, 2018. Update on nitazoxanide: a multifunctional chemotherapeutic agent. Curr. Drug Discovery Technol., 15: 201-213.
    CrossRef  |  Direct Link  |  

  23. Kashyap, A., N. Adhikari, A. Das, A. Shakya, S.K. Ghosh, U.P. Singh and H.R. Bhat, 2018. Review on synthetic chemistry and antibacterial importance of thiazole derivatives. Curr. Drug Discovery Technol., 15: 214-228.
    CrossRef  |  Direct Link  |  

  24. Das, A., S.K. Chaudary, H.R. Bhat and A. Shakya, 2018. Cuphea carthagenensis: a review of its ethnobotany, pharmacology and phytochemistry. Bull. Arunachal For. Res., Vol. 33. .

  25. Srivastava, J.K., G.G. Pillai, H.R. Bhat, A. Verma and U.P. Singh, 2017. Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating epidermal growth factor receptor tyrosine kinase. Sci. Rep., Vol. 7. 10.1038/s41598-017-05934-5.
    CrossRef  |  Direct Link  |  

  26. Singh, U.P., J.K. Shrivastava, A. Verma and H.R. Bhat, 2017. Discovery of 1,3,5-triazine-monastrol based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma. Ann. Oncol., Vol. 28. 10.1093/annonc/mdx089.005.
    CrossRef  |  Direct Link  |  

  27. Singh, U.P., J. Shrivastava and H.R. Bhat, 2017. Novel monastrol derivatives exert potent anti-breast cancer activity via inhibition of ubiquitin conjugating enzyme Rad6B. Eur. J. Cancer, 72: S36-S37.
    CrossRef  |  Direct Link  |  

  28. Singh, U., J. Shrivastava, A. Verma and H. Bhat, 2017. AB0075 targeting immune and non-immuno synovitis by 1,3,5-TRIAZINE-THIAZOLE via dual inhibition of NF-KB and EGFR-TKS for possible benefit in rheumatoid arthritis. Abstracts Accepted Publication, Vol. 76. 10.1136/annrheumdis-2017-eular.5612.
    CrossRef  |  Direct Link  |  

  29. Singh, U. and H. Bhat, 2017. PUB081 discovery of 1,3,5-triazine based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma. J. Thoracic Oncol., 12: S1494-S1495.
    CrossRef  |  Direct Link  |  

  30. Singh, U.P., J.K. Srivastava and H.R. Bhat, 2016. 161P discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against non-small cell lung cancer (NSCLC). Ann. Oncol., Vol. 27. 10.1016/s0923-7534(21)00319-7.
    CrossRef  |  Direct Link  |  

  31. Srivastava, J.K., P. Dubey, S. Singh, H.R. Bhat, M.K. Kumawat and U.P. Singh, 2015. Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes. RSC Adv., 5: 14095-14102.
    CrossRef  |  Direct Link  |  

  32. Srivastava, J.K., N.T. Awatade, H.R. Bhat, A. Kmit and K. Mendes et al., 2015. Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity. RSC Adv., 5: 88710-88718.
    CrossRef  |  Direct Link  |  

  33. Pathak, P., A. Thakur, H.R. Bhat and U.P. Singh, 2015. Hybrid 4-Aminoquinoline-1,3,5-triazine derivatives: Design, synthesis, characterization, and antibacterial evaluation. J. Heterocyclic Chem., 52: 1108-1113.
    CrossRef  |  Direct Link  |  

  34. Bhat, H.R., U.P. Singh, P. Gahtori, S.K. Ghosh, K. Gogoi, A. Prakash and R.K. Singh, 2015. Synthesis, docking, in vitro and in vivo antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives against wild and mutant malaria parasites. Chem. Biol. Drug Des., 86: 265-271.
    CrossRef  |  Direct Link  |  

  35. Bhat, H.R., U.P. Singh, A. Thakur, S.K. Ghosh, K. Gogoi, A. Prakash and R.K. Singh, 2015. Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives. Exp. Parasitol., 157: 59-67.
    CrossRef  |  Direct Link  |  

  36. Singh, B., H.R. Bhat, M.K. Kumawat and U.P. Singh, 2014. Structure-guided discovery of 1,3,5-triazine–pyrazole conjugates as antibacterial and antibiofilm agent against pathogens causing human diseases with favorable metabolic fate. Bioorg. Med. Chem. Lett., 24: 3321-3325.
    CrossRef  |  Direct Link  |  

  37. Yadav, P.S., V. Kumar, U.P. Singh, H.R. Bhat and B. Mazumder, 2013. Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol. Saudi Pharm. J., 21: 77-84.
    CrossRef  |  Direct Link  |  

  38. Singh, U.P., H.R. Bhat and R.K. Singh, 2013. Ceric Ammonium Nitrate (CAN) catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium. Comptes Rendus Chimie, 16: 462-468.
    CrossRef  |  Direct Link  |  

  39. Kumar, S., H.R. Bhat, M.K. Kumawat and U.P. Singh, 2013. Design and one-pot synthesis of hybrid thiazolidin-4-one-1,3,5-triazines as potent antibacterial agents against human disease-causing pathogens. New J. Chem., 37: 581-584.
    CrossRef  |  Direct Link  |  

  40. Bhat, H.R., U.P. Singh, P. Gahtori, S.K. Ghosh, K. Gogoi, A. Prakash and R.K. Singh, 2013. Antimalarial activity and docking studies of novel bi-functional hybrids derived from 4-aminoquinoline and 1,3,5-triazine against wild and mutant malaria parasites as pf-DHFR inhibitor. RSC Adv., 3: 2942-2952.
    CrossRef  |  Direct Link  |  

  41. Bhat, H.R., U.P. Singh, P. Gahtori, S.K. Ghosh, K. Gogoi, A. Prakash and R.K. Singh, 2013. 4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies. New J. Chem., 37: 2654-2662.
    CrossRef  |  Direct Link  |  

  42. Bhat, H.R., P.K. Pandey, S.K. Ghosh and U.P. Singh, 2013. Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route. Med. Chem. Res., 22: 5056-5065.
    CrossRef  |  Direct Link  |  

  43. Singh, U.P., H.R. Bhat and P. Gahtori, 2012. Antifungal activity, SAR and physicochemical correlation of some thiazole-1,3,5-triazine derivatives. J. Mycol. Méd., 22: 134-141.
    CrossRef  |  Direct Link  |  

  44. Ghosh, S.K., A. Saha, B. Hazarika, U.P. Singh, H.R. Bhat and P. Gahtori, 2012. Design, facile synthesis, antibacterial activity and structure-activity relationship of novel di- and tri-substituted 1,3,5-Triazines. Lett. Drug Des. Discovery, 9: 329-335.
    CrossRef  |  Direct Link  |  

  45. Gahtori, P., S.K. Ghosh, B. Singh, U.P. Singh, H.R. Bhat and A. Uppal, 2012. Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines. Saudi Pharm. J., 20: 35-43.
    CrossRef  |  Direct Link  |  

  46. Dubey, V., M. Pathak, H.R. Bhat and U.P. Singh, 2012. Design, facile synthesis, and antibacterial activity of hybrid 1,3,4-thiadiazole-1,3,5-triazine derivatives tethered via -S- Bridge. Chem. Biol. Drug Des., 80: 598-604.
    CrossRef  |  Direct Link  |  

  47. Bhat, H.R., S.K. Gupta and U.P. Singh, 2012. Discovery of potent, novel antibacterial hybrid conjugates from 4-aminoquinoline and 1,3,5-triazine: Design, synthesis and antibacterial evaluation. RSC Adv., 2: 12690-12695.
    CrossRef  |  Direct Link  |  

  48. Bhat, H.R., S.K. Ghosh, A. Prakash, K. Gogoi and U.P. Singh, 2012. In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives. Lett. Appl. Microbiol., 54: 483-486.
    CrossRef  |  Direct Link  |  

  49. Singh, U.P., R.K. Singh, H.R. Bhat, Y.P. Subhashchandra, V. Kumar, M.K. Kumawat and P. Gahtori, 2011. Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives. Med. Chem. Res., 20: 1603-1610.
    CrossRef  |  Direct Link  |  
Member since August, 2021