Dr. Sadiq Umar

Research Scientist
University of Illinois at Chicago, USA

Highest Degree
Ph.D. in Autoimmunity from Hamdard University, India

My URL
https://livedna.org/91.3676

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Biography

Dr Sadiq Umar is currently working as Postdoctoral Research Associate. He obtained his PhD degree in the field of Clinical Toxicology Lab, MSc in the field of Toxicology from Hamdard University, New Delhi, India in 2012 & 2007, respectively. His main area of interest includes Autoimmune Disease, Rheumatoid arthritis, Neurodegenerative disease. His area of expertise includes, Rheumatoid arthritis, Stroke, Inflammation, Oxidative stress, Cytokine, Animal model, Multiple sclerosis, Synovial fibroblast. Dr Sadiq Umar published 25 articles in journals as author/co-author.

Area of Interest:

Pharmacology and Toxicology
Autoimmune Disease
Rheumatoid Arthritis
Inflammation
Pharmacy

Selected Publications

  1. Raemdonck, V.K., S. Umar, K. Palasiewicz, S. Volkov and M.V. Volin et al., 2019. CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis. Cell. Mol. Life Sci., 10.1007/s00018-019-03235-w.
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  2. Kim, S.J., H.J. Chang, M.V. Volin, S. Umar and K.V. Raemdonck et al., 2019. Macrophages are the primary effector cells in IL-7-induced arthritis. Cell. Molecular Immunol., 10.1038/s41423-019-0235-z..
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  3. Khan, M.A., N. Khurana, R.S. Ahmed, S. Umar and M.A. Hasnathet al., 2019. Chemokines: A potential therapeutic target to suppress autoimmune arthritis. Curr. Pharm. Des., 10.2174/1381612825666190709205028.
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  4. Ahmad, N., F.J. Ahmad, S. Bedi, S. Sharma, S. Umar and M.A. Ansari, 2019. A novel nanoformulation development of eugenol and their treatment in inflammation and periodontitis. Saudi Pharm. J., 6: 778-790.
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  5. Raemdonck, V.K., S. Umar, Z. Szekanecz, R.K. Zomorrodi and S. Shahrara, 2018. Impact of obesity on autoimmune arthritis and its cardiovascular complications. Autoimmunity Rev., 17: 821-835.
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  6. Haider, S., M.S. Alam, H. Hamid, S. Umar, D. Kumar and S. Nazreen, 2018. Synthesis of novel amide containing schiffs bases of 5-(4-chloro-phenyl)-furan-2-carboxaldehyde: Their in vivo anti-inflammatory, antioxidant and antinociceptive activities with ulcerogenic risk evaluation. J. Rep. Pharm. Sci., 7: 44-63.
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  7. Umar, S., A.M. Tyagi, A.K. Singh and A. Haseeb, 2017. Molecular mechanism of rheumatic diseases and efficacy of current therapies. BioMed Res. Int. 10.1155/2017/2401329.
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  8. Rathore, A., R. Sudhakar, M.J. Ahsan, A. Ali and N. Subbarao et al., 2017. In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings. Bioorg. Chem., 70: 107-117.
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  9. Tantray, M.A., I. Khan, H. Hamid, M.S. Alam and S. Umar et al., 2016. Synthesis of novel oxazolo[4,5-b]pyridine-2-one based 1,2,3-triazoles as glycogen synthase kinase-3β inhibitors with anti-inflammatory potential. Chem. Biol. Drug Des., 87: 918-926.
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  10. Singh, A.K., S. Umar, S. Riegsecker, M. Chourasia and S. Ahmed, 2016. Regulation of transforming growth factor β-activated kinase activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts: Suppression of K63-linked autoubiquitination of tumor necrosis factor receptor-associated factor 6. Arthritis Rheumatol., 68: 347-358.
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  11. Umar, S., O. Hedaya, A.K. Singh and S. Ahmed, 2015. Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol. Applied Pharmacol., 287: 299-305.
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  12. Khan, Y.A., S. Umar and S.M. Abidi, 2015. Somatic antigens of tropical liver flukes ameliorate collagen-induced arthritis in Wistar rats. PLoS ONE, Vol. 10. 10.1371/journal.pone.0126429.
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  13. Boddu, S.H., H. Alsaab, S. Umar, S.P. Bonam, H. Gupta and S. Ahmed, 2015. Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. Int. J. Pharmaceut., 479: 207-211.
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  14. Umar, S., K. Umar, A.H.M.G. Sarwar, A. Khan and N. Ahmad et al., 2014. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine, 21: 847-856.
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  15. Haider, S., M.S. Alam, H. Hamid, S. Shafi and A. Dhulap et al., 2014. Synthesis of novel 2-mercaptobenzoxazole based 1, 2, 3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression. Eur. J. Med. Chem., 81: 204-217.
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  16. Haider, S., M.S. Alam, H. Hamid, A. Dhulap and S. Umar et al., 2014. Design, synthesis and docking studies of 2-benzoxazolinone-based 1, 2, 4-triazoles as proinflammatory cytokine inhibitors. Med. Chem. Res., 23: 4250-4268.
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  17. Ahmad, N., I. Ahmad, S. Umar, Z. Iqbal, M. Samim and F.J. Ahmad, 2014. PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model. Drug Delivery, (In Press). 10.3109/10717544.2014.941076.
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  18. Umar, S., A.H.M.G. Sarwar, K. Umar, N. Ahmad and M. Sajad et al., 2013. Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis. Cell. Immunol., 284: 51-59.
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  19. Umar, S., A. Kumar, M. Sajad, J. Zargan and M.M. Ansari et al., 2013. Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration. Rheumatol. Int., 33: 657-663.
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  20. Sajad, M., J. Zargan, M.A. Zargar, J. Sharma, S. Umar, R. Arora and H.A. Khan, 2013. Quercetin prevents protein nitration and glycolytic block of proliferation in hydrogen peroxide insulted cultured Neuronal Precursor Cells (NPCs): Implications on CNS regeneration. Neurotoxicology, 36: 24-33.
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  21. Ahmad, N., S. Umar, M. Ashafaq, M. Akhtar, Z. Iqbal, M. Samim and F.J. Ahmad, 2013. A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke. Protoplasma, 250: 1327-1338.
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  22. Umar, S., N.K. Mishra, K. Pal, M. Sajad and M.M. Ansari et al., 2012. Protective effect of rutin in attenuation of collagen-induced arthritis in Wistar rat by inhibiting inflammation and oxidative stress. Indian J. Rheumatol., 7: 191-198.
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  23. Umar, S., M. Asif, M. Sajad, M.M. Ansari and U. Hussain et al., 2012. Anti-inflammatory and antioxidant activity of Trachyspermum ammi seeds in collagen induced arthritis in rats. Int. J. Drug Dev. Res., 4: 210-219.
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  24. Umar, S., J. Zargan, K. Umar, S. Ahmad, C.K. Katiyar and H.A. Khan, 2012. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chemico-Biol. Interact., 197: 40-46.
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  25. Bhat, J.U., N. Qudsia, A. Asia, A.P. Shabir and S.T. Ahmad et al., 2012. Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice. EXCLI J., 11: 1-6.
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  26. Aslam, M., S.T. Ahmad, R. Dayal, K. Javid and S. Umar et al., 2012. Nephroprotective action of Peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats. EXCLI J., 11: 444-452.
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  27. Asif, M., S. Umar and H.A. Khan, 2012. Trigonella foenum graecum mitigates proteases and restores antioxidant balance in collagen induced arthritis in rats. Int. J. Pharmaceut. Res., 4: 104-109.
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  28. Zargan, J., S. Umar, M. Sajad, M. Naime, S. Ali and H.A. Khan, 2011. Scorpion venom (Odontobuthus doriae) induces apoptosis by depolarization of mitochondria and reduces S-phase population in human breast cancer cells (MCF-7). Toxicol. In vitro, 25 : 1748-1756.
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  29. Zargan, J., M. Sajad, S. Umar, M. Naime, S. Ali and H.A. Khan, 2011. Scorpion (Odontobuthus doriae) venom induces apoptosis and inhibits DNA synthesis in human neuroblastoma cells. Mol. Cell Biochem., 348: 173-181.
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  30. Zargan, J., M. Sajad, S. Umar, M. Naime, S. Ali and H.A. Khan, 2011. Scorpion (Androctonus crassicauda) venom limits growth of transformed cells (SH-SY5Y and MCF-7) by cytotoxicity and cell cycle arrest. Exp. Mol. Pathol., 91: 447-454.
    PubMed  |  

  31. Sajad, M., J. Zargan, R. Chawla, S. Umar and H.A. Khan, 2011. Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE. J. Mol. Neurosci., 43: 531-540.
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  32. Sajad, M., J. Zargan, J. Sharma, R. Chawla, R. Arora, S. Umar and H.A. Khan, 2011. Increased spontaneous apoptosis of rat primary neurospheres in vitro after experimental autoimmune encephalomyelitis. Neurochem. Res., 36: 1017-1026.
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  33. Sajad, M., R. Chawla, J. Zargan, S. Umar, M. Sadaqat and H.A. Khan, 2010. Cytokinetics of adult rat SVZ after EAE. Brain Res., 31: 140-149.
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  34. Sajad, M., M. Asif, S. Umar, J. Zargan and M. Rizwan et al., 2010. Amelioration of inflammation induced oxidative stress and tissue damage by aqueous methanolic extract of Nigella sativa Linn. in arthritic rats. J. Complement. Integr. Med., Vol. 7, No. 1. 10.2202/1553-3840.1454.
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  35. Hayat, F., A. Salahuddin, S. Umar and A. Azam, 2010. Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail. Eur. J. Med. Chem., 45: 4669-4675.
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  36. Sajad, M., J. Zargan, R. Chawla, S. Umar, M. Sadaqat and H.A. Khan, 2009. Hippocampal neurodegeneration in Experimental Autoimmune Encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase. Mol. Cell. Biochem., 328: 183-188.
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Member since June, 2010