Dr. Pradeepkiran Jangampalli Adi

Research Assistant Professor
Texas Tech University Health Sciences Center (TTUHSC), Lubbock, USA

Highest Degree
Ph.D. in Zoology from Sri Venkateswara University, India

My URL
https://livedna.org/91.38820

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Biography

I obtained my Ph.D. from Sri Venkateswara University, Tirupati, India. My research experience in drug discovery, and small molecule design/validation through computational/bimolecular studies. I have strong interest and passion to work in the field of small molecule research and the identification of small molecules/drugs for neurodegenerative diseases, such as Alzheimer’s, Huntington’s.

Area of Interest:

Biomedical Sciences
Neurobiology Aging
Computational Chemistry
Genomics
Molecular Modeling

Selected Publications

  1. Prathima, P., K. Venkaiah, R. Pavani, K.V.L.S. Rao and P.G. Krishnaet al., 2023. Transcriptomic profiling identified altered expression of genes associated with testicular functions in adult F1 rats exposed to carbimazole during fetal period. J. Proteomics. Vol. 274. 10.1016/j.jprot.2022.104811.
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  2. Pradeepkiran, J.A., J. Baig, A. Selman and P.H. Reddy, 2023. Mitochondria in Aging and Alzheimer’s Disease: Focus on Mitophagy. Neuroscientist, 10.1177/10738584221139761.
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  3. Manna, P.R., S. Ramachandran, J.A. Pradeepkiran, D. Molehin and I. Castro-Piedraset al., 2023. Expression and function of star in cancerous and non-cancerous human and mouse breast tissues: new insights into diagnosis and treatment of hormone-sensitive breast cancer. Int. J. Mol. Sci. Vol. 24. 10.3390/ijms24010758.
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  4. Vijayan, M., R.V. Alvir, L.E. Bunquin, J.A. Pradeepkiran and P.H. Reddy, 2022. A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model. Aging Cell, Vol. 21. 10.1111/acel.13663.
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  5. Sowjanya, M., B.V. Sandeep, K. Venkaiah, V.R. Dirisala, M.H. Reddy, J.A. Pradeepkiran and S.B. Sainath, 2022. Purification, structural elucidation, and anticancerous properties of a novel flavonoid from flowers of Leucas indica. Processes, Vol. 10. 10.3390/pr10112341.
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  6. S. Mahesh, B.P. Narasaiah, B. Himabindu, G.L. Balaji, J.A. Pradeepkiran and H. Padhy, 2022. Sunflower-assisted bio-derived zno-nps as an efficient nanocatalyst for the synthesis of novel quinazolines with highly antioxidant activities. Antioxidants, Vol. 11. 10.3390/antiox11040688.
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  7. Pradeepkiran, J.A., M. Munikumar, A.P. Reddy and P.H. Reddy, 2022. Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease. Hum. Mol. Genet., 31: 244-261.
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  8. Pradeepkiran, J.A., A. Hindle, S. Kshirsagar and P.H. Reddy, 2022. Are mitophagy enhancers therapeutic targets for Alzheimer’s disease? Biomed. Pharmacother., Vol. 149. 10.1016/j.biopha.2022.112918.
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  9. Manna, P.R., A.P. Reddy, J.A Pradeepkiran, S. Kshirsagar and P.H. Reddy, 2022. Regulation of retinoid mediated StAR transcription and steroidogenesis in hippocampal neuronal cells: Implications for StAR in protecting Alzheimer's disease. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis. (In Press), 10.1016/j.bbadis.2022.166596.
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  10. Kshirsagar, S., R.V. Alvir, A. Hindle, S. Kumar and M. Vijayan et al., 2022. Early cellular, molecular, morphological and behavioral changes in the humanized amyloid-beta-knock-in mouse model of late-onset Alzheimer’s Disease. Cells, Vol. 11. 10.3390/cells11040733.
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  11. Kandimalla, R., M. Manczak, J.A. Pradeepkiran, H. Morton and P.H. Reddy, 2022. A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease. Hum. Mol. Genet., 31: 1788-1805.
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  12. K. Venkaiah, T. Daveedu, P. Prathima, R. Pavani and S. Sukeerthi et al., 2022. Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats. Toxicol. Res., 11: 426-436.
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  13. Hindle, A., S.P. Singh, J.A. Pradeepkiran, C. Bose and M. Vijayan et al., 2022. Rlip76: An unexplored player in neurodegeneration and Alzheimer’s Disease? Int. J. Mol. Sci., Vol. 23. 10.3390/ijms23116098.
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  14. Venkataramaiah, C., S. Payani, B.L. Priya and J.A. Pradeepkiran, 2021. Therapeutic potentiality of a new flavonoid against ketamine induced glutamatergic dysregulation in schizophrenia: In vivo and in silico approach. Biomed. Pharmacother., 10.1016/j.biopha.2021.111453.
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  15. Venkataramaiah, C., B.L. Priya, S. Payani and J.A. Pradeepkiran, 2021. Pharmacological potentiality of bioactive flavonoid against ketamine induced cell Death of PC 12 cell lines: An in vitro study. Antioxidants, 10.3390/antiox10060934.
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  16. Suvarnamma, A. and J.A. Pradeepkiran, 2021. SmartBin system with waste tracking and sorting mechanism using IoT. Cleaner Eng. Technol., 10.1016/j.clet.2021.100348.
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  17. Pradeepkiran, J.A., S.B. Sainath, P.K. Balne and M. Bhaskar, 2021. Computational Modeling and Evaluation of Best Potential Drug Targets Through Comparative Modeling. In: Brucella Melitensis, Pradeepkiran, J.A. and S.B. Sainath, (Eds.), Academic Press, pp: 39-78.
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  18. Pradeepkiran, J.A., S.B. Sainath, M. Munikumar and K. Hema, 2021. Identification and Characterization of Vaccine Targets for Brucella melitensis Through In Silico Approaches. In: Brucella Melitensis, Pradeepkiran, J.A. and S.B. Sainath, (Eds.), Academic Press, pp: 25-38.
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  19. Pradeepkiran, J.A., S.B. Sainath and K.V.L. Shrikanya, 2021. In Silico Validation and ADMET Analysis for the Best Lead Molecules. In: Brucella Melitensis Pradeepkiran, J.A. and S.B. Sainath, (Eds.), Academic Press, pp: 133-176.
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  20. Pradeepkiran, J.A., M. Munikumar, K. Hema, P. Natarajan and S.B. Sainath, 2021. Molecular Docking and Dynamics Simulations of Novel Drug Targets. In: Brucella Melitensis, Pradeepkiran, J.A. and S.B. Sainath, (Eds.), Academic Press, pp: 79-131.
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  21. Pradeepkiran, J.A., M. Bhaskar, K.V.L. Shrikanya, P.G. Krishna, M.H. Reddy, Ch. Venkatrayulu and S.B. Sainath, 2021. Introduction to Brucellosis. In: Brucella Melitensis, Pradeepkiran, J.A. and S.B. Sainath, (Eds.), Academic Press, pp:1-23.
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  22. Pradeepkiran, J.A. and P.H. Reddy, 2021. Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis., Vol. 1867. 10.1016/j.bbadis.2021.166162.
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  23. Morton, H., S. Kshirsagar, E. Orlov, L.E. Bunquin and N. Sawant et al., 2021. Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse. Free Radical Biol. Med., 172: 652-667.
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  24. Kumar, S., H. Morton, N. Sawant, E. Orlov and L.E. Bunquin et al., 2021. MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease. Redox Biol., Vol. 48. 10.1016/j.redox.2021.102182.
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  25. Bhatti, J.S., K. Tamarai, R. Kandimalla, M. Manczak and X. Yin, et al., 2021. Mitochondrial dysfunctioning induced by hyperglycemia in the liver tissues of diabetic mice, TALLYHO/JngJ strain and ameliorative action of a small peptide, SS31. Metabolism, 10.1016/j.metabol.2020.154608.
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  26. Bhatti, J.S., K. Tamarai, R. Kandimalla, M. Manczak and X. Yin et al., 2021. Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice. Mitochondrion, 58: 49-58.
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  27. Sholapuri, P., V. Chintha, B. Matcha and J.A. Pradeepkiran, 2020. Beneficial effects of polyherbal formulation (Bronco-T) on formaldehyde-induced lung toxicity in male Wistar rats. Toxicol. Res., 9: 798-807.
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  28. Ranjani, T.S., G.K. Pitchika, K. Yedukondalu, Y. Gunavathi, T. Daveedu, S.B. Sainath, G.H. Philip and J.A. Pradeepkiran, 2020. Phenotypic and transcriptomic changes in zebrafish (Danio rerio) embryos/larvae following cypermethrin exposure. Chemosphere, 10.1016/j.chemosphere.2020.126148.
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  29. Pradeepkiran, J.A., V.S. Nandyala and M. Bhaskar, 2020. Trigonella foenum-graecum seeds extract plays a beneficial role on brain antioxidant and oxidative status in alloxan-induced Wistar rats. Food Qual. Saf., 4: 83-89.
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  30. Pradeepkiran, J.A., A.P. Reddy, X. Yin, M. Manczak, P.H. Reddy, 2020. Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease. Hum. Mol. Genet., 29: 49-69.
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  31. Pradeepkiran, J.A. and P.H. Reddy, 2020. Defective mitophagy in Alzheimer’s disease. Ageing Res. Rev., 10.1016/j.arr.2020.101191.
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  32. Veeraragavulu, P.C., N.K. Yellapu, S. Yerrathota, P.J. Adi and B. Matcha, 2019. Three novel mutations I65S, R66S, and G86R divulge significant conformational variations in the PTB domain of the IRS1 gene. ACS Omega, 4: 2217-2224.
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  33. Sudhana, S.M. and P.J. Adi, 2019. Synthesis, biological evaluation and molecular docking studies of novel di-hydropyridine analogs as potent antioxidants. Curr. Top. Med. Chem., 19: 2676-2686.
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  34. Rekha, S.S., J.A. Pradeepkiran and M. Bhaskar, 2019. Bioflavonoid hesperidin possesses the anti-hyperglycemic and hypolipidemic property in STZ induced diabetic myocardial infarction (DMI) in male Wister rats. J. Nutr. Intermediary Metab., 15: 58-64.
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  35. Reddy, P.H., R.H. Swerdlow, J. Culberson, D. Kang and T.L. Mitchell, et al., 2019. Current status of healthy aging and dementia research: A symposium summary. J. Alzheimers Dis., 72: S11-S35.
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  36. Pradeepkiran, J.A., A.P. Reddy and P.H. Reddy, 2019. Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease. Drug Discovery Today, 24: 616-623.
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  37. Pradeepkiran, J.A., 2019. Insights of rheumatoid arthritis risk factors and associations. J. Transl. Autoimmunity, 10.1016/j.jtauto.2019.100012.
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  38. Pradeepkiran, J.A., 2019. Aquaculture role in global food security with nutritional value: A review. Transl. Anim. Sci., 3: 903-910.
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  39. Pradeepkiran, J.A. and P. Reddy, 2019. Structure based design and molecular docking studies for phosphorylated tau inhibitors in Alzheimer’s disease. Cells, 10.3390/cells8030260.
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  40. Yellapu, N.K., K. Kandlapalli, R. Kandimalla and P.J. Adi, 2018. Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4. FEBS Open Bio, 8: 1202-1208.
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  41. Saddala, M.S. and P.J. Adi, 2018. Discovery of small molecules through pharmacophore modeling, docking and molecular dynamics simulation against Plasmodium vivax Vivapain-3 (VP-3). Heliyon, 10.1016/j.heliyon.2018.e00612.
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  42. Reddy, P.H., X. Yin, M. Manczak, S. Kumar, J.A. Pradeepkiran, M. Vijayan and A.P. Reddy, 2018. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease. Hum. Mol. Genet., 27: 2502-2516.
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  43. Reddy, P.H., M. Manczak, X. Yin, M.C. Grady and A. Mitchell, et al., 2018. Protective effects of Indian spice curcumin against amyloid-β in alzheimer’s disease. J. Alzheimers Dis., 61: 843-866.
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  44. Adi, P.J. and B. Matcha, 2018. Analysis of aflatoxin B1 in contaminated feed, media, and serum samples of Cyprinus carpio L. by high-performance liquid chromatography. Food Qual. Saf., 2: 99-204.
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  45. Saddala, M.S., R. Kandimalla, P.J. Adi, S.S. Bhashyam and U.R. Asupatri, 2017. Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity. Sci. Rep., 10.1038/srep45211.
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  46. Adi, P.J., J.R. Naidu and B. Matcha, 2017. Multiplex quantification of Escherichia coli, Salmonella typhi and Vibrio cholera with three DNA targets in single reaction assay. Microb. Pathogen., 110: 50-55.
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  47. Saddala, M.S., P.K.J. Adi and A.U. Rani, 2016. In silico drug design and molecular docking studies of potent inhibitors against Cathepsin-L (Ctsl) for sars disease. J. Res. Dev., 10.4172/2311-3278.1000145.
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  48. Saddala, M.S. and P.K.J. Adi, 2016. Selenoergothionein as a potential inhibitor against amyloid β-protein (Aβ): Docking and molecular dynamics studies. Int. J. Biomed. Data Min., 10.4172/2090-4924.1000120.
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  49. Adi, P.J., S.P. Burra, A.R. Vataparti and B. Matcha, 2016. Calcium, zinc and vitamin E ameliorate cadmium-induced renal oxidative damage in albino Wistar rats. Toxicol. Rep., 3: 591-597.
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  50. Adi, P.J., N.K. Yellapu and B. Matcha, 2016. Modeling, molecular docking, probing catalytic binding mode of acetyl-CoA malate synthase G in Brucella melitensis 16M. Biochem. Biophys. Rep., 8: 192-199.
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  51. Pradeepkiran, J.A., S.B. Sainath, K.K. Kumar, L. Balasubramanyam, K.V. Prabhakar and M. Bhaskar, 2015. CGMD: An integrated database of cancer genes and markers. Sci. Rep., 10.1038/srep12035.
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  52. Pradeepkiran, J.A., K. Konidala, N. Yellapu and M. Bhaskar, 2015. Modeling, molecular dynamics, and docking assessment of transcription factor rho: A potential drug target in Brucella melitensis 16M. Drug Des., Dev. Ther., 9: 1897-1912.
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  53. Pradeepkiran, J.A., D.B. Sainath, K.K. Kumar and M. Bhaskar, 2015. Complete genome-wide screening and subtractive genomic approach revealed new virulence factors, potential drug targets against bio-war pathogen Brucella melitensis 16M. Drug Des., Dev. Ther., 9: 1691-1706.
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  54. Adi, P.J., R.B. Pappithi, P.C. Veeraraghavulu and B. Matcha, 2015. Multiplex PCR assay for the simultaneous detection of C. perfringens, P. aeruginosa and K. pneumoniae. Pathogenesis, 2: 21-26.
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