Dr. Praveen Thaggikuppe Krishnamurthy

Professor
Department of Pharmacology, JSS College of Pharmacy, Ooty, India

Highest Degree
Ph.D. in Pharmaceutical Sciences from Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India

My URL
https://livedna.org/91.39433

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Area of Interest:

Biomedical Sciences
Antioxidant Activity
Pharmaceutical Sciences
Phytochemicals
Herbal Medicine

Selected Publications

  1. Sola, P., P.T. Krishnamurthy, M. Kumari, G. Byran, H.V. Gangadharappa and K.K. Garikapati, 2022. Neuroprotective approaches to halt Parkinson's disease progression. Neurochem. Int., Vol. 158. 10.1016/j.neuint.2022.105380.
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  2. Praveen, T.K., H.V. Gangadharappa, A.S.A. Lila, A. Moin and K. Mehmood et al., 2022. Inflammation targeted nanomedicines: Patents and applications in cancer therapy. Semin. Cancer Biol., 86: 645-663.
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  3. Mayuri, M., P.T. Krishnamurthy and T.M. Vijayakumar, 2022. NK1 receptor antagonistic effect of 17-trifluoromethyl phenyl trinor prostaglandin F2α on the growth of human breast cancer cell line. Exp. Mol. Pathol., Vol. 127. 10.1016/j.yexmp.2022.104817.
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  4. Manandhar, S., K.S.R. Pai, P.T. Krishnamurthy, A.V.V.V.R. Kiran and G.K. Kumari, 2022. Identification, virtual screening and molecular dynamic analysis of novel TMPRSS2 inhibitors from natural compound database as potential entry-blocking agents in SARS-CoV-2 therapy. Struct. Chem., 33: 1609-1617.
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  5. Li, Y., K.S. Nagashree, G. Byran and P.T. Krishnamurthy, 2022. Identification of selective PPAR-γ modulators by combining pharmacophore modeling, molecular docking, and adipogenesis assay. Appl. Biochem. Biotechnol., 10.1007/s12010-022-04190-2.
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  6. Kiran, A.V.V.V.R., G.K. Kumari and P.T. Krishnamurthy, 2022. Preliminary evaluation of anticancer efficacy of pioglitazone combined with celecoxib for the treatment of non-small cell lung cancer. Invest. New Drugs, 40: 1-9.
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  7. Khaydarov, R., O. Gapurova, M. Abdukhakimov, I. Sadikov and I. Garipov et al., 2022. Antimicrobial properties of nanofiltration membranes modified with silver nanoparticles. Emergent Mater., 5: 1477-1483.
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  8. Khaydarov, R., M. Abdukhakimov, I. Garipov, I. Sadikov, P.T. Krishnamurthy and S. Evgrafova, 2022. Silver-containing cation exchange resin: Synthesis and application. Mater. Sci., 28: 89-92.
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  9. Jayaram, S., P.T. Krishnamurthy, M. Joshi and V. Kumar, 2022. Nrf2 as a Potential Therapeutic Target for Treatment of Huntington’s Disease. In: From Pathophysiology to Treatment of Huntington's Disease, Szejko, N. (Ed.), IntechOpen, London, UK, ISBN: 978-1-80355-426-6, .
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  10. Garikapati, K.K., V.V.V.R.K. Ammu, P.T. Krishnamurthy, S.T. Narenderan, B. Babu and K. Nagappan, 2022. Quantification of rosiglitazone in rat plasma and tissues via LC–MS/MS: Method development, validation, and application in pharmacokinetic and tissue distribution studies. Biomed. Chromatogr., Vol. 36. 10.1002/bmc.5326.
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  11. Esakkimuthukumar, M., A.K. Swaroop, S.K. Patnaik, R.R. Kumar, T.K. Praveen, M.R. Naik and S. Jubie, 2022. A novel family of small molecule HIF-1 alpha stabilizers for the treatment of diabetic wounds; an integrated in silico, in vitro, and in vivo strategy. RSC Adv., 12: 31293-31302.
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  12. Daniels, J.A., 2022. Advances in Environmental Research. Nova Science Publishers, Hauppauge, New York, ISBN: 979-8-88697-362-4 Pages: 208.
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  13. Sulaiman, C.T., M. Deepak, T.K. Praveen, K.R. Lijini, E.M. Anandan, M. Salman and I. Balachandran, 2021. Purification of bhallathaka (Semecarpus anacardium L.f.) enhanced anti-cancer activity. Regul. Toxicol. Pharmacol., Vol. 122. 10.1016/j.yrtph.2021.104898.
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  14. Sanapalli, B.K.R., V. Yele, M.K. Singh, P.T. Krishnamurthy and V.V.S.R. Karri, 2021. Preclinical models of diabetic wound healing: A critical review. Biomed. Pharmacother., Vol. 142. 10.1016/j.biopha.2021.111946.
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  15. Sanapalli, B.K.R., K.C. Gounder, N.S. Ambhore, G. Kuppuswamy, P.T. Krishnamurthy and V.V.S.R. Karri, 2021. Doxycycline loaded collagen-chitosan composite scaffold for the accelerated healing of diabetic wounds. JoVE J., Vol. 174. 10.3791/62184.
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  16. Sajini, D.V., P.T. Krishnamurthy and A.C. Kandiyil, 2021. Neuroprotective activities of orientin: A Review. Curr. Traditional Med., Vol. 8. 10.2174/2215083807666210913104505.
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  17. Magham, S.V., P.T. krishnamurthy, N. Shaji, L. Mani and S. Balasubramanian, 2021. Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials. J. Neurosci. Res., 99: 2888-2905.
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  18. Lakshmanan, K., T. K. Praveen, S.R.K. Pai, K. Rajagopal and G. Byran, 2021. Discovery of potential inhibitors for stat3: ligand based 3D pharmacophore, virtual screening, molecular docking, dynamic studies and in vitro evaluation J. Biomol. Struct. Dyn., 10.1080/07391102.2021.1957717.
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  19. Kumari, M., P.T. Krishnamurthy, S.k.S.S. Pinduprolu and P. Sola, 2021. DR-5 and DLL-4 mAb functionalized SLNs of gamma-secretase inhibitors- An approach for TNBC treatment. Adv. Pharm. Bull., 11: 618-623.
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  20. Kumari, G.K., A.V.V.V.R. Kiran and P.T. Krishnamurthy, 2021. Preliminary evaluation on the beneficial effects of pioglitazone in the treatment of endometrial cancer. Med. Oncol., Vol. 38. 10.1007/s12032-021-01521-x.
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  21. Kumari G.K., P.T. Krishnamurthy, R.K.V.V.V. Ammu, K. Vishwanath, S.T. Narenderan, B. Babu and N. Krishnaveni, 2021. Development and validation of a sensitive LC-MS/MS method for pioglitazone: Application towards pharmacokinetic and tissue distribution study in rats. RSC Adv., 11: 11437-11443.
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  22. Kiran, A.V.V.V.R., G.K. Kumari, P.T. Krishnamurthy, P.K. Chintamaneni and S.K.S.S. Pindiprolu, 2021. Carbon Nanotubes in Cancer Therapy. In: Handbook of Carbon Nanotubes, Abraham, J., S. Thomas and N. Kalarikkal (Eds.), Springer International Publishing, Cham, Switzerland, ISBN: 978-3-319-70614-6, pp: 1-33.
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  23. Kiran, A.V.V.V.R., G.K. Kumari, P.T. Krishnamurthy and R.R. Khaydarov, 2021. Tumor microenvironment and nanotherapeutics: Intruding the tumor fort. Biomater. Sci., 9: 7667-7704.
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  24. Kaviarasan, L., E. Eldhose, P.T. Krishnamurthy, K. Rajagopal, M. Mohammed, P. Prudviraj and G. Byran, 2021. 1,3,4-thiadiazolo (3,2-Α) pyrimidine-6-carbonitrile scaffold as PARP1 inhibitors. Anti-Cancer Agents Med. Chem., 21: 2050-2065.
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  25. Kakhramonovich, A.M., G.I. Tagirovich, K. Ra, K.R. Rashidovich and G.O. Urumbaevna, 2021. Novel ion exchange fibers for wastewater treatment from heavy metal ions. Manage. Technosphere, 4: 88-97.
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  26. Jayaram, S., P.T. Krishnamurthy, 2021. Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson's disease: The therapeutic role of Nrf2 activators. Neurochem. Int., Vol. 145. 10.1016/j.neuint.2021.105014.
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  27. Chintamaneni, P.K., P.T. Krishnamurthy and S.K.S.S. Pindiprolu, 2021. Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease. RSC Adv., 11: 5325-5334.
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  28. Baboota S. and J. Ali, 2021. Nanocarriers for the Delivery of Combination Drugs. Elsevier, Amsterdam, Netherlands, ISBN: 978-0-12-820779-6 Pages: 508.
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  29. Sravanthi, B., L. Kaviarasan, T.K. Praveen, P.S.S.S. Kiran, C. Pavankumar and B. Gowramma, 2020. Synthesis and pharmacological evaluation of 1,3,4-thiadiazole bearing pyrimidine derivatives as STAT3 inhibitor for treatment of breast cancer. J. Iran. Chem. Soc., 17: 2359-2370.
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  30. Pindiprolu, S.K.S.S., P.T. Krishnamurthy, C. Dev and P.K. Chintamaneni, 2020. DR5 antibody conjugated lipid-based nanocarriers of gamma-secretase inhibitor for the treatment of triple negative breast cancer. Chem. Phys. Lipids, Vol. 235. 10.1016/j.chemphyslip.2020.105033.
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  31. Kumari, M., P.T. Krishnamurthy and P. Sola, 2020. Targeted drug therapy to overcome chemoresistance in triple-negative breast cancer. Curr. Cancer Drug Targets, 20: 559-572.
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  32. Krishnamurthy, P.T., 2020. Coronavirus disease 2019: Virology and drug targets. Infect. Disord. Drug Targets, 10.2174/1871526520666201209145302.
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  33. Krishna, S., B. Gowramma, M. Mohammed, R. Kalirajan, L. Kaviarasan and T.K. Praveen, 2020. Synthesis, in silico and in vivo evaluation of novel 1, 3, 4-thiadiazole analogues as novel anticancer agents. Lett. Drug Des. Discovery, 17: 434-444.
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  34. Kiran, A.V.V.V.R., G.K. Kumari and P.T. Krishnamurthy, 2020. Carbon nanotubes in drug delivery: Focus on anticancer therapies. J. Drug Delivery Sci. Technol., Vol. 59. 10.1016/j.jddst.2020.101892.
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  35. Anisetty, V., A. Wadhwani, D. Mani, T.K. Praveen and V. Patel et al., 2020. In vitro efficacy of anti-HSV drugs on breast cancer cells MCF-7 & MDA-MB-231-A drug repurposing approach. Int. J. Pharm. Res., 12: 514-523.
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  36. Reddy, P.R.K., J. Saravanan and T.K. Praveen, 2019. Evaluation of neuroprotective activity of Melissa officinalis in MPTP model of Parkinson's disease in mice. Res. J. Pharm. Technol., 12: 2103-2108.
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  37. Pindiprolu, S.K.S.S., P.K. Chintamaneni, P.T. Krishnamurthy and K.R.S. Ganapathineedi, 2019. Formulation-optimization of solid lipid nanocarrier system of STAT3 inhibitor to improve its activity in triple negative breast cancer cells. Drug Dev. Ind. Pharm., 45: 304-313.
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  38. Nagashree, K.S. and P.T. Krishnamurthy, 2019. Comparative analysis of ligand binding modes of ppar-γ full and partial agonists. Int. Res. J. Pharm., 10: 85-93.
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  39. Lakkappa, N., P.T. Krishnamurthy, M.D. Pandareesh, B.D. Hammock and S.H. Hwang, 2019. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson’s disease. NeuroToxicology, 70: 135-145.
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  40. Janani, K.A., T.K. Praveen and A. Wadhwani, 2019. Experimental models to study tumour angiogenesis-in-vitro, ex-vivo and in-vivo approach. Int. J. Pharm. Sci. Res., 10: 3648-3659.
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  41. Jana, B.A., P.K. Chintamaneni, P.T. Krishnamurthy, A. Wadhwani and S.K. Mohankumar, 2019. Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: A molecular insight. Mol. Biol. Rep., 46: 957-963.
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  42. Ghanta, V.R., N. Madala, A. Pasula, S.K.S.S. Pindiprolu, K.S. Battula, P.T. Krishnamurthy and B. Raman, 2019. Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity. RSC Adv., 9: 18670-18677.
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  43. Garikapati, K.K., V.V.V.R.K. Ammu, P.T. Krishnamurthy, P.K. Chintamaneni and S.K.S.S. Pindiprolu, 2019. Type-II endometrial cancer: Role of adipokines. Arch. Gynecology Obstetrics, 300: 239-249.
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  44. Garikapati, K.K., V.V.V.R.K. Ammu, P.T. Krishnamurthy, P.K. Chintamaneni and S.K.S.S. Pindiprolu, 2019. Possible role of thiazolidinedione in the management of type-II endometrial cancer. Med. Hypotheses, 126: 78-81.
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  45. Chinnappan, S.M., A. George, P. Thaggikuppe, Y.K. Choudhary, V.K. Choudhary, Y. Ramani and R. Dewangan, 2019. Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats. Evidence-Based Complementary Altern. Med., Vol. 2019. 10.1155/2019/4916519.
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  46. Ammu, V.V.V.R.K., K.K. Garikapati, P.T. Krishnamurthy, P.K. Chintamaneni and S.K.S.S. Pindiprolu, 2019. Possible role of PPAR-γ and COX-2 receptor modulators in the treatment of non-Small Cell lung carcinoma. Med. Hypotheses, 124: 98-100.
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  47. Thondawada, M., A.D. Wadhwani, D.S. Palanisamy, H.S. Rathore and R.C. Gupta et al., 2018. An effective treatment approach of DPP-IV inhibitor encapsulated polymeric nanoparticles conjugated with anti-CD-4 mAb for type 1 diabetes. Drug Dev. Ind. Pharm., 44: 1120-1129.
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  48. Rao, P.V., P.T. Krishnamurthy, S.P. Dahapal and P.K. Chinthamaneni, 2018. An updated review on “Miracle tree”: Moringa oleifera. Res. J. Pharmacogn. Phytochem., 10: 101-108.
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  49. Pindiprolu, S.S.S.K., P.T. Krishnamurthy and P.K. Chintamaneni, 2018. Lipid bioconjugated nanocarriers for potentiating chemotherapeutic efficacy and preventing metastasis in triple negative breast cancer. Eur. J. Cancer, Vol. 92. 10.1016/S0959-8049(18)30592-6.
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  50. Pindiprolu, S.K.S.S., P.T. Krishnamurthy, P.K. Chintamaneni and V.V.S.R. Karri, 2018. Nanocarrier based approaches for targeting breast cancer stem cells. Artif. Cells Nanomed. Biotechnol., 46: 885-898.
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  51. Pindiprolu, S.K.S.S., P.T. Krishnamurthy and P.K. Chintamaneni, 2018. Pharmacological targets of breast cancer stem cells: A review. Naunyn-Schmiedeberg's Arch. Pharmacol., 391: 463-479.
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  52. Lakkappa, N., P.T. Krishnamurthy, K. Yamjala, S.H. Hwang, B.D. Hammock and B. Babu, 2018. Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC–MS/MS method development. J. Pharm. Biomed. Anal., 149: 457-464.
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  53. Gowramma, B., T.K. Praveen, S. Gomathy, R. Kalirajan, B. Babu and N. Krishnavenic, 2018. Synthesis of 2-(Bis (2-chloroethyl)amino)-N-(5-substitutedphenyl)- 1,3,4- thiadiazol-2-Yl)acetohydrazide and evaluation of anticancer activity. Curr. Bioact. Compd., 14: 309-316.
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  54. Chintamaneni, P.K., P.T. Krishnamurthy, P.V. Rao and S.S.S. Pindiprolu, 2017. Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer’s disease. Med. Hypotheses, 101: 17-22.
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  55. Chalichem, N.S.S., C. Gonugunta, P.T. Krishnamurthy and B. Duraiswamy, 2017. DPP4 inhibitors can be a drug of choice for type 3 diabetes: A mini review. Am. J. Alzheimers Dis. Other Dementias, 32: 444-451.
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  56. Bando, Y. and S. Yoshida, 2017. Poster sessions WTH Wednesday/Thursday. J. Neurochem., 142: 165-259.
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  57. Tummala, S., K. Gowthamarajan, M.N.S. Kumar, T.K. Praveen, K. Yamjala, N.S. Tripuraneni and A. Prakash, 2016. Formulation and optimization of oxaliplatin immuno-nanoparticles using box-Behnken design and cytotoxicity assessment for synergistic and receptor-mediated targeting in the treatment of colorectal cancer. Artif. Cells Nanomed. Biotechnol., 44: 1835-1850.
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  58. Tummala, S., G. Kuppusamy, M.N.S. Kumar, T.K. Praveen and A. Wadhwani, 2016. 5-Fluorouracil enteric-coated nanoparticles for improved apoptotic activity and therapeutic index in treating colorectal cancer. Drug Delivery, 23: 2902-2910.
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  59. Lakkappa, N., P.T. Krishnamurthy, B.D. Hammock, D. Velmurugan and M.M.S. Bharath, 2016. Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Med. Hypotheses, 93: 161-165.
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  60. Basavan, D., N.S. Chalichem, P. Krishnamurthy, P. Chintamaneni and B. Vanitha, 2016. Possible targets of herbals for type 3 diabetes: A review. Curr. Trad. Med., 2: 148-185.
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  61. Shrestha, A., P.T. Krishnamurthy, P. Thomas, B.D. Hammock and S.H. Hwang, 2014. Soluble epoxide hydrolase inhibitor,t-TUCB, protects against myocardial ischaemic injury in rats. J. Pharm. Pharmacol., 66: 1251-1258.
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  62. Praveen, T., M. Chandrasekar and M. Nanjan, 2013. Novel glitazones with diverse peroxisome proliferator activated receptor modulatory potential. Curr. Bioact. Compd., 9: 221-234.
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  63. Krishnamurthy, P.T., M.J.N. Chandrasekar and M.J. Nanjan, 2013. Newer approaches to the discovery of glitazones. Mini-Rev. Org. Chem., 10: 66-72.
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  64. Krishnamurthy, P. and A. Wadhwani, 2012. Antioxidant Enzymes and Human Health. In: Antioxidant Enzyme, El-Missiry, M.A. (Ed.), IntechOpen, London, UK, ISBN: 978-953-51-0789-7.
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  65. El-Missiry, M.A., 2012. Antioxidant Enzyme. IntechOpen, London, UK, ISBN: 978-953-51-0789-7, Pages: 412.
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  66. Muruganantham, N., K.H. Basavaraj, S.P. Dhanabal, T.K. Praveen, N.M. Shamasundar and K.S. Rao, 2011. Screening of Caesalpinia bonduc leaves for antipsoriatic activity. J. Ethnopharmacol., 133: 897-901.
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  67. Praveen, T K., S. Dharmaraj, J. Bajaj, S.P. Dhanabal, S. Manimaran, M.J. Nanjan and R. Razdan, 2009. Hepatoprotective activity of petroleum ether, diethyl ether and methanol extract of Scoparia dulcis L. against CCl4-induced acute liver injury in mice. Indian J. Pharmacol., 41: 110-114.
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  68. Nanjan, M.J., T.K. Praveen, B. Suresh, J. Vergheese, B.J. Desai and B.R.P. Kumar, 2008. CoMFA study on thiazolidine-2,4-diones for their antihyperglycemic activity. Lett. Drug Des. Discovery, 5: 79-87.
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  69. Kumar, B.R.P., T.K. Praveen, M.J. Nanjan, M.D. Karvekar and B. Suresh, 2007. Serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance. Indian J. Pharmacol., 39: 299-302.
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