Dr. Balasubramanian Narasimhan

Lecturer
Maharshi Dayanand University, India

Highest Degree
Ph.D. in Pharmaceutical Chemistry from Maharshi Dayanand University, India

My URL
https://livedna.org/91.5198

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Area of Interest:

Chemistry
Pharmaceutical Chemistry
Computer-Aided Drug Design
Synthesis
Anticancer Drugs

Selected Publications

  1. Narang, R., B. Narasimhan, S. Sharma, E.D. Clercq and C. Pannecouque et al., 2013. Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis. Med. Chem., 9: 249-274.
    CrossRef  |  PubMed  |  

  2. Malhotra, M., R. Dhingra, T. Sharma, A. Deep and B. Narasimhan et al., 2013. Cabazitaxel: a novel drug for hormone-refractory prostate cancer. Mini Rev. Med. Chem., 13: 915-920.
    CrossRef  |  PubMed  |  

  3. Kumar, S., P. Kumar, R.K. Marwaha and B. Narasimhan, 2013. Synthesis, antimicrobial evaluation and QSAR studies of propionic acid derivatives. Arab. J. Chem., 10.1016/j.arabjc.2012.12.024.
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  4. Kumar, P., B. Narasimhan, D. Sharma, V. Judge and R. Narang, 2013. Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of cefadroxil. Ukrainica Bioorg. Acta, .

  5. Kumar, P. and B. Narasimhan, 2013. Hydrazides/hydrazones as antimicrobial and anticancer agents in the new millennium. Mini Rev. Med. Chem., 13: 971-987.
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  6. Kumar, M., K. Ramasamy, V. Mani, R.K. Mishra, A.B.A. Majeed, E.D. Clercq and B. Narasimhan, 2013. Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides. Arab. J. Chem., 10.1016/j.arabjc.2012.12.005.
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  7. Kumar, H., P. Kumar, B. Narasimhan, K. Ramasamy, V. Mani, R.K. Mishra and A.B. Abdul Majeed, 2013. Synthesis, in vitro antimicrobial, antiproliferative and QSAR studies of N-(substituted phenyl)-2/4-(1H-indol-3-ylazo)-benzamides. Med. Chem. Res., 22: 1957-1971.
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  8. Judge, V., B. Narasimhan, M. Ahuja, D. Sriram and P. Yogeeswari et al., 2013. Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N2-acyl isonicotinic acid hydrazide derivatives. Med. Chem., 9: 53-76.
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  9. Gupta, R., P. Kumar and B. Narasimhan, 2013. Synthesis, antimicrobial evaluation and QSAR studies of monochloroacetic acid derivatives. Arab. J. Chem., 10.1016/j.arabjc.2012.12.027.
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  10. Verma, V., K. Singh, D. Kumar, T.M. Klapotke and J. Stierstorfor et al., 2012. Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines. Eur. J. Med. Chem., 56: 195-202.
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  11. Thangadurai, A., M. Minu, S. Wakode, S. Agrawal and B. Narasimhan, 2012. Indazole: A medicinally important heterocyclic moiety. Med. Chem. Res., 21: 1509-1523.
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  12. Singh, M., S. Kumar, A. Kumar, P. Kumar and B. Narasimhan, 2012. Synthesis, Antimicrobial Evaluation and QSAR Analysis of 2-isopropyl-5-methylcyclohexanol derivatives. Med. Chem. Res., 21: 511-522.
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  13. Sigroha, S., B. Narasimhan, P. Kumar, A. Khatkar and K. Ramasamy et al., 2012. Design, synthesis, antimicrobial, anticancer evaluation and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones. Med. Chem. Res., 21: 3863-3875.
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  14. Sharma, S.K., P. Kumar, B. Narasimhan, K. Ramasamy, V. Mani, R.K. Mishra and A.B.A. Majeed, 2012. Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. Eur. J. Med. Chem., 48: 16-25.
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  15. Sapra, A., A. Kakkar and B. Narasimhan, 2012. Sources of impurities: A review. Int. Res. J. Pharm., 3: 57-59.
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  16. Narasimhan, B., D. Sharma and P. Kumar, 2012. Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir. Med. Chem. Res., 20: 796-803.

  17. Narasimhan, B., D. Sharma and P. Kumar, 2012. Benzimidazole: A medicinally important heterocyclic moiety. Med. Chem. Res., 21: 269-283.
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  18. Narang, R., S. Sharma and B. Narasimhan, 2012. Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives. Hygeia: J. D. Med., 4: 15-20.
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  19. Narang, R., B. Narasimhan, S. Sharma, D. Sriram and P. Yogeeswari et al., 2012. Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives. Med. Chem. Res., 21: 1557-1576.
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  20. Narang, R., B. Narasimhan and S. Sharma, 2012. A review on biological activities and chemical synthesis of hydrazide derivatives. Curr. Med. Chem., 19: 569-612.
    CrossRef  |  PubMed  |  

  21. Narang, R., B. Narasimhan and S. Sharma, 2012. (Naphthalen-1-yloxy)-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazide derivatives: Synthesis, antimicrobial evaluation, and QSAR studies. Med. Chem. Res., 21: 2526-2547.
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  22. Mor, S., P. Pahal and B. Narasimhan, 2012. Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents. Eur. J. Med. Chem., 57: 196-210.
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  23. Mor, S., P. Pahal and B. Narasimhan, 2012. Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. Eur. J. Med. Chem., 53: 176-189.
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  24. Malhotra, M., P. Ghai, B. Narasimhan and A. Deep, 2012. Dalfampridine: Review on its recent development for symptomatic improvement in patients with multiple Sclerosis. Arab. J. Chem., 10.1016/j.arabjc.2012.03.017.
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  25. Mahiwal, K., P. Kumar and B. Narasimhan, 2012. Synthesis, antimicrobial evaluation, ot-QSAR and mt-QSAR studies of 2-amino benzoic acid derivatives. Med. Chem. Res., 21: 293-307.
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  26. Kumar, R., P. Kumar, M. Kumar and B. Narasimhan, 2012. Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives. Med. Chem. Res., 21: 4301-4310.
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  27. Kumar, D., A. Narang, V. Judge, D. Kumar and B. Narasimhan, 2012. Antimicrobial evaluation of 4-methylsulfanyl benzylidene/3-hydroxy benzylidene hydrazides and QSAR studies. Med. Chem. Res., 21: 382-394.
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  28. Judge, V., B. Narasimhan, M. Ahuja, D. Sriram and P. Yogeeswari et al., 2012. Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies. Med. Chem. Res., 21: 1451-1470.
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  29. Judge, V., B. Narasimhan, M. Ahuja, D. Sriram and P. Yogeeswari et al., 2012. Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of Isonicotinic acid-1-(substituted phenyl)-ethylidene/ cycloheptylidene hydrazides. Med. Chem. Res., 21: 1935-1952.
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  30. Judge, V., B. Narasimhan and M. Ahuja, 2012. Topological models for the prediction of antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines. Med. Chem. Res., 21: 1363-1375.
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  31. Judge, V., B. Narasimhan and M. Ahuja, 2012. Isoniazid: The magic molecule. Med. Chem. Res., 21: 3940-3957.
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  32. Judge, V., B. Narasimhan and M. Ahuja, 2012. A review of Biological potential of Pyrazinamide derivatives. Hygeia: J. D. Med., 4: 1-6.
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  33. Dhiman, A., A. Nanda, S. Ahmad and B. Narasimhan, 2012. In vitro antimicrobial status of methanolic extract of Citrus sinensis Linn. Fruit peel. Chronicles Young Sci., 3: 204-208.
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  34. Anand, R.V., B. Narasimhan, R.V.P. Chandran and K.N. Jayaveera, 2012. 7-chloro-3-(substituted benzylidene/phenyl ethylidene amino)-2-phenylquinazolin-4(3H)-ones: synthesis, antimicrobial and antitubercular evaluation. Med. Chem. Res., 21: 2831-2836.
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  35. Thangadurai, A., M. Minu, S. Wakode, S. Agrawal, U. kulandaivelu and B. Narasimhan, 2011. Biological value of the Heterocyclic compound quinazoline. Acta Pharm. Sci., 53: 347-361.

  36. Sarova, D., A. Kapoor, R. Narang, V. Judge and B. Narasimhan, 2011. Dodecanoic acid derivatives: Synthesis, antimicrobial evaluation and development of one-target and multi-target QSAR models. Med. Chem. Res., 20: 769-781.
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  37. Narasimhan, B., R. Saharan and P. Kumar, 2011. Hansch analysis of anti-inflammatory and analgesic activities of substituted 1-alkyl/aryl-3-ethoxy carbonyl-5-hydroxy-2-methyl indoles. Acta Pharm. Sci., 53: 117-126.

  38. Narasimhan, B., D. Sharma, P. Kumar, P. Yogeswari and D. Sriram, 2011. Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones. J. Enzyme Inhib. Med. Chem., 26: 720-727.
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  39. Narasimhan, B., D. Sharma and P. Kumar, 2011. Biological importance of imidazole nucleus in the new millennium. Med. Chem. Res., 20: 1119-1140.
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  40. Narang, R., B. Narasimhan, S. Sharma, D. Sriram and P. Yogeeswari et al., 2011. Nicotinic acid benzylidene/phenyl-ethylidene hydrazides: Synthesis, antimicrobial evaluation and QSAR studies. Lett. D. Des. Dis., 8: 733-749.
    CrossRef  |  

  41. Kumar, D., A. Kapoor, A. Thangadurai, P. Kumar and B. Narasimhan, 2011. Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides. Chin. Chem. Lett., 22: 1293-1296.
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  42. Judge, V., R. Narang, D. Sharma, B. Narasimhan and P. Kumar, 2011. Hansch analysis for the prediction of antimycobacterial activity of ofloxacin derivatives. Med. Chem. Res., 20: 826-837.
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  43. Judge, V., B. Narasimhan, M. Ahuja, D. Sriram and P. Yogeeswari, 2011. Isonicotinic acid hydrazide derivatives: Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies. Lett. D. Des. Dis., 8: 792-810.
    CrossRef  |  

  44. Dhiman, A., A. Nanda, S. Ahmad and B. Narasimhan, 2011. In vitro antimicrobial activity of methanolic leaf extract of Psidium guajava L. J. Pharm. BioAllied Sci., 3: 226-229.
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  45. Yadav, S., P. Kumar, E.D. Clercq, J. Balzarini, C. Pannecouque, S.K. Dewan and B. Narasimhan, 2010. 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation. Eur. J. Med. Chem., 45: 5985-5997.
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  46. Narasimhan, B., P. Kumar and D. Sharma, 2010. Biological activities of hydrazide derivatives in the new millennium. Acta Pharm. Sci., 52: 169-180.

  47. Kumar, P., B. Narasimhan, P. Yogeswari and D. Sriram, 2010. Synthesis and antitubercular activities of substituted benzoic acid N'-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides. Eur. J. Med. Chem., 45: 6085-6089.
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  48. Kumar, D., V. Judge, R. Narang, S. Sangwan, E.D. Cercq, J. Balzarini and B. Narasimhan, 2010. Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation. Eur. J. Med. Chem., 45: 2806-2816.
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  49. Sharma, D., B. Narasimhan, P. Kumar, V. Judge, R. Narang, E.D. Clercq and J. Balzarini, 2009. Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. Eur. J. Med. Chem., 44: 2347-2353.
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  50. Sharma, D., B. Narasimhan, P. Kumar, R. Narang, V. Judge, E.D. Clerq and J. Balzarini, 2009. Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles. J. Enzyme Inhib. Med. Chem., 24: 1161-1168.
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  51. Sharma, D., B. Narasimhan, P. Kumar and A. Jalbout, 2009. Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. Eur. J. Med. Chem., 44: 1119-1127.
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  52. Narasimhan, B., S. Ohlan, R. Ohlan, V. Judge and R. Narang, 2009. Hansch analysis of veratric acid derivatives as antimicrobial agents. Eur. J. Med. Chem., 44: 689-700.
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  53. Narang, R., B. Narasimhan, V. Judge, O. Sucheta and O. Ruchita, 2009. Evaluation of preservative effectiveness in an official antacid preparation. Acta Pharm. Sci., 51: 225-229.

  54. Minu, M., A. Thangadurai, S.R. Wakode, S.S. Agrawal and B. Narasimhan, 2009. Synthesis, Antimicrobial activity and QSAR studies of new 2,3-Disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazoles. Bioorg. Med. Chem. Lett., 19: 2960-2964.
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  55. Kumar, P., B. Narasimhan, D. Sharma, V. Judge and R. Narang, 2009. Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. Eur. J. Med. Chem., 44: 1853-1863.
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  56. Sucheta, O., O. Ruchita, B. Narasimhan, V. Judge and R. Narang, 2008. Evaluation of Veratric acid derivatives as preservative in aluminium Hydroxide gel. Acta Pharm. Sci., 50: 241-245.

  57. Ohlan, R., B. Narasimhan, S. Ohlan, R. Narang and V. Judge, 2008. Synthesis and antimicrobial evaluation of urea inclusion complexes. Org. Commun., 1: 24-32.
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  58. Narasimhan, B., N. Singh, A. Panghal and A.S. Dhake, 2008. Efficiency Of anacardic acid as preservative in tomato products. J. Food Process. Preservat., 32: 600-609.
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  59. Narasimhan, B., K. Abida and K. Srinivas, 2008. Stability indicating RP-HPLC method development and validation for oseltamivir API. Chem. Pharm. Bull., 56: 413-417.
    PubMed  |  Direct Link  |  

  60. Minu, M., A. Thangadurai, S.R. Wakode, S.S. Agrawal and B. Narasimhan, 2008. 3,4-Disubstituted-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones: Synthesis, antimicrobial evaluation and QSAR investigations using Hansch analysis. Arch. Pharm., 341: 231-239.
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  61. Kumar, P., B. Narasimhan and D. Sharma, 2008. Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis. ARKIVOC, 13: 159-178.
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  62. Judge, V., B. Narasimhan, R. Narang, R. Ohlan and S. Ohlan, 2008. Preservative evaluation of novel 2,4-hexadienoic acid derivatives in aluminium Hydroxide gel-USP. Sci. Pharm., 76: 269-277.
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  63. Datusalia, A.K., P. Kalra, B. Narasimhan, S. Sharma and R.K. Goyal, 2008. Anxiolytic and antiseizure effects of Sida tiagii Bhandri. J. Health Sci., 54: 544-550.
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  64. Chaudhary, J., A.K. Rajpal, V. Judge, R. Narang and B. Narasimhan, 2008. Preservative evaluation of caprylic acid derivatives in aluminium Hydroxide gel-USP. Sci. Pharm., 76: 533-539.
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  65. Ohlan, R., S. Ohlan, V. Judge, R. Narang, M. Ahuja and B. Narasimhan, 2007. 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol Derivatives: Synthesis, Antifungal evaluation and QSAR studies by Hansch analysis. ARKIVOC, 14: 172-184.
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  66. Narasimhan. B., V.K. Mourya and A.S. Dhake, 2007. QSAR studies of antibacterial ricinoleic acid derivatives. Pharm. Chem. J., 41: 133-139.
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  67. Narasimhan, B., V. Judge, R. Narang, R. Ohlan and S. Ohlan, 2007. Quantitative structure activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-Hexadienoic acid derivatives. Bioorg. Med. Chem. Lett., 21: 5836-5845.
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  68. Narasimhan, B., R. Narang, V. Judge, R. Ohlan and S. Ohlan, 2007. Synthesis, antimicrobial and QSAR studies of substituted anilides. ARKIVOC, 15: 112-126.
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  69. Narasimhan, B., A.S. Dhake and V.K. Mourya, 2007. QSAR studies of 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines as potent angiotensin II receptor antagonists by MLR and NLR analysis. ARKIVOC, 1: 189-204.
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  70. Kumar, A., B. Narasimhan and D. Kumar, 2007. Synthesis, antimicrobial, and QSAR studies of substituted benzamides. Bioorg. Med. Chem., 15: 4113-4124.
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  71. Narasimhan, B., V. Mourya and A. Dhake, 2006. Design, synthesis, antibacterial and QSAR studies of myristic acid derivatives. Bioorg. Med. Chem. Lett., 16: 3023-3029.
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  72. Narasimhan, B., M. Kumari, N. Jain, A. Dhake, C. Sundaravelan, 2006. Correlation Of antibacterial activity of some N-[5-(2-furanyl)-2-methyl-4-Oxo-4H-thieno[2,3-D]pyrimidin-3-Yl]-carboxamide And 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-D]pyrimidin4-ones with topological indices using hansch analysis. Bioorg. Med. Chem. Lett., 16: 4951-4958.
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  73. Narasimhan, B., M. Kumari, A. Dhake and C. Sundaravelan, 2006. QSAR studies on structurally similar 2-Arylidene-4-(4-phenoxy -phenyl) but-3-en-4-olides as anti-inflammatory agents. ARKIVOC, 13: 73-82.

  74. Narasimhan, B., A.M. Ansari, N. Singh, V. Mourya and A.S. Dhakee, 2006. A QSAR approach for the prediction of stability of enzoglycolamide ester prodrugs. Chem. Pharm. Bull., 54: 1067-1071.
    PubMed  |  

  75. Narasimhan, B. and A.S. Dhake, 2006. Biological value of active principles of Myristica fragrans. Curr. Pharm. Res. J., 1: 15-20.

  76. Narasimhan, B. and A.S. Dhake, 2006. Antibacterial principles from Myristica fragrans seeds. J. Med. Food, 9: 395-399.
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  77. Narasimhan B., A.S. Dhake, 2006. Antibacterial constituents from nut shell of Anacardium occidentale. Planta Indica, 2: 4-7.

  78. Balasubramanian, N., B. Deepak, P. Devayani, M. Vishnukant and D. Avinash, 2004. Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations. Eur. J. Med. Chem., 39: 827-834.
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  79. Narasimhan B., U.R. Kothawade, D.S. Pharande, V.K. Mourya and A.S. Dhake, 2003. Syntheses and QSAR studies of sorbic, cinnamic and ricinoleic acid derivatives as potential antibacterial agents. Indian J. Chem., 42: 2828-2834.
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  80. Gangwal, N.A., B. Narasimhan, V.K. Mourya and A.S. Dhake, 2003. Synthesis and QSAR studies of substituted - 4 (1H) - quinazolinones. Indian J. Heterocycl. Chem., 12: 201-204.
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