Dr. Sriram Seshadri

Assistant Professor
Nirma University, India

Highest Degree
Ph.D. in Science from University of Rajasthan, Jaipur, India

My URL
https://livedna.org/91.7966

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Biography

Dr. Sriram Seshadri is currently working as Assistant Professor and Academic Coordinator at Nirma University, India. He obtained his Ph.D. in Science from University of Rajasthan, Jaipur, India. His main area of interest related to Pharmacology and Toxicology, Animal and Veterinary Sciences, Biomedical Sciences, and Molecular Sciences. His area of expertise includes Gut Microbiota, Pattern Recognition Receptors, Type II Diabetes, Inflammation, Male Reproductive Physiology, Insulin Resistance, Mucoal Immunology, and Hepatic Cancer. He has published 42 research articles in journals as well as 3 books contributed as author/co-author.

Area of Interest:

Animal and Veterinary Sciences
Biochemistry
Protein Chemistry
Molecular Biology
Animal and Veterinary Sciences

Selected Publications

  1. Patel, S., D. Mandaliya and S. Seshadri, 2022. Colonic microflora protagonist of liver metabolism and gut permeability: Study on mice model. Indian J. Microbiol., 62: 540-549.
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  2. Mandaliya, D.K., S. Patel and S. Seshadri, 2021. The combinatorial effect of acetate and propionate on high-fat diet induced diabetic inflammation or metaflammation and t cell polarization. Inflammation, 44: 68-79.
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  3. Bai, L., S. Kumar, S. Verma and S. Seshadri, 2020. Bacteriocin PJ4 from probiotic lactobacillus reduced adipokine and inflammasome in high fat diet induced obesity. 3 Biotech, Vol. 10. 10.1007/s13205-020-02317-y.
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  4. Pasupureddy, R., S. Verma, A. Pant, R. Sharma and S. Seshadri et al., 2019. Crucial residues in falcipains that mediate hemoglobin hydrolysis. Exp. Parasitol., 197: 43-50.
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  5. Mandaliya, D.K. and S. Seshadri, 2019. Short chain fatty acids, pancreatic dysfunction and type 2 diabetes. Pancreatology, 19: 280-284.
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  6. Das, M., A. Solanki, A. Joshi, R. Devkar, S. Seshadri and S. Thakore, 2019. β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery. Carbohydr. Polym., 206: 694-705.
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  7. Prajapati, B., P.K. Jena, S. Patel and S. Seshadri, 2018. Divergent outcomes of gut microbiota alteration upon use of spectrum antibiotics in high sugar diet-induced diabetes in rats. RSC Adv., 8: 26201-26211.
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  8. Bung, N., S. Surepalli, S. Seshadri, S. Patel and S. Peddasomayajula et al., 2018. 2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK. Sci. Rep., Vol. 8. 10.1038/s41598-018-27974-1.
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  9. Bhargava, A., N. Pathak, S. Seshadri, N. Bunkar, D.K. Mishra, N.K. Lohiya and P.K. Mishra, 2018. Pre-clinical validation of mito-targeted nano-engineered flavonoids isolated from Selaginella bryopteris (Sanjeevani) as a novel cancer prevention strategy. Anti-Cancer Agents Med. Chem., 18: 1860-1874.
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  10. Behera, S., B. Kapadia, V. Kain, N.P. Alamuru-Yellapragada and V. Murunikkara et al., 2018. ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis., 1864: 1702-1716.
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  11. Seshadri, S., K. Purandhar and N. Pareek, 2016. Age-dependent expression of catspers in human and mice sperm. Andrology, Vol. 5. .
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  12. Purandhar, K., N. Pareek, D. Patel, B. Patel and S. Seshadri, 2016. Study of the histoarchitectural and biochemical changes with progression of age in male mice. Zool. Poloniae, 59: 53-78.

  13. Prajapati, B., P.K. Jena, T. Mehta and S. Seshadri, 2016. Preparation and optimization of moxifloxacin microspheres for colon targeted delivery using quality by design approach: In vitro and In vivo study. Curr. Drug Delivery, 13: 1021-1033.
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  14. Prajapati, B., P. Rajput, P.K. Jena and S. Seshadri, 2016. Investigation of chitosan for prevention of diabetic progression through gut microbiota alteration in sugar rich diet induced diabetic rats. Curr. Pharm. Biotechnol., 17: 173-184.
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  15. Khambhala, P., S. Verma, S. Joshi, S. Seshadri and V. Kothari, 2016. Inhibition of bacterial quorum-sensing by Ferula asafoetida Essential Oil. Adv. Genet. Eng., Vol. 5. 10.4172/2169-0111.1000i10.
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  16. Jena, P.K., B. Prajapati, P.K. Mishra and S. Seshadri, 2016. Influence of gut microbiota on inflammation and pathogenesis of sugar rich diet induced diabetes. Immunome Res., 12: 1-10.
    PubMed  |  

  17. Talari, M., B. Kapadia, V. Kain, S. Seshadri and B. Prajapati et al., 2015. MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts. Biochimie, 119: 16-26.
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  18. Seshadri, S., 2015. Exploiting the Vaginal Microbiota for Therapeutic Interventions. In: Perspectives of Reproductive Health Research on a Post-2015 Development Framework, Mishra, P.K. and R.S. Sharma (Eds.). Pointer Publishers, India, pp: 81-83.

  19. Sahoo, T.K., P.K. Jena, N. Nagar, A.K. Patel and S. Seshadri, 2015. In vitro evaluation of probiotic properties of lactic acid bacteria from the gut of Labeo rohita and Catla catla. Probiotics Antimicrobial Proteins, 7: 126-136.
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  20. Sahoo, T.K., P.K. Jena, A.K. Patel and S. Seshadri, 2015. Purification and molecular characterization of the novel highly potent bacteriocin TSU4 produced by Lactobacillus animalis TSU4. Applied Biochem. Biotechnol., 177: 90-104.
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  21. Kain, V., B. Kapadia, N. Viswakarma, S. Seshadri and B. Prajapati et al., 2015. Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Sci. Rep., Vol. 5. 10.1038/srep15197.
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  22. Trivedi, D., P.K. Jena and S. Seshadri, 2014. Colicin E2 expression in Lactobacillus brevis DT24, a vaginal probiotic isolate, against uropathogenic Escherichia coli. ISRN Urol., Vol. 2014. 10.1155/2014/869610.
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  23. Seshadri, S., P. Nair, K. Purandhar, B. Prajapati, P. Rajput and P.K. Jena, 2014. Determining the reversible potentials of hydro alcoholic extracts of Eclipta alba in boric acid induced male accessory reproductive organ toxicity. J. Toxicol. Health, 104: 381-394.

  24. Sahoo, T.K., P.K. Jena, A.K. Patel and S. Seshadri, 2014. Bacteriocins and their applications for the treatment of bacterial diseases in aquaculture: A review. Aquaculture Res., 45: 1737-1746.
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  25. Purandhar, K., P.K. Jena, B. Prajapati, P. Rajput and S. Seshadri, 2014. Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis. World J. Men's Health, 32: 123-132.

  26. Prajapati, B., P.K. Jena, P. Rajput, K. Purandhar and S. Seshadri, 2014. Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes. Curr. Diabetes Rev., 10: 190-200.

  27. Jena, P.K., S. Singh, B. Prajapati, G. Nareshkumar, T. Mehta and S. Seshadri, 2014. Impact of targeted specific antibiotic delivery for gut microbiota modulation on High-fructose-fed rats. Applied Biochem. Biotechnol., 172: 3810-3826.
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  28. Jena, P.K., S. Singh and S. Seshadri, 2014. Sugar Rich Diet Induced Insulin Resistance and Alteration in Gut Microbiota: Diabetes and Human Health Care, a Holistic Approach to Diagnosis and Treatment. In: Advances in Diabetes Care, Anna, G. (Ed.). Apple Academic Press, New Jersey, USA., pp: 393-429.

  29. Chaudhary, H., P.K. Jena and S. Seshadri, 2014. In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent. Nutr. Cancer, 66: 904-913.
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  30. Chaudhary, H., P.K. Jena and S. Seshadri, 2014. In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent. Nutr. Cancer, 66: 904-913.
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  31. Bhumika, P., P.K. Jena, P. Rajput and S. Seshadri, 2014. Role of pattern recognition receptors and inflammatory mediators following gut microbiota alteration in high sugar diet mediated type 2 diabetes. J. Obesity Weight Loss Therapeut., 4: S1-014.

  32. Trivedi, D., P.K. Jena, J.K. Patel and S. Seshadri, 2013. Partial purification and characterization of a bacteriocin DT24 produced by probiotic vaginal Lactobacillus brevis DT24 and determination of its anti-uropathogenic Escherichia coli potential. Probiotics Antimicrob. Proteins, 5: 142 -151.
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  33. Purandhar, K. and S. Seshadri, 2013. Age associated variations in human neutrophil and sperm functioning. Asian Pacific J. Reprod., 2: 201-208.
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  34. Jena, P.K., D. Trivedi, K. Thakore, H. Chaudhary, S.S. Giri and S. Seshadri, 2013. Isolation and characterization of probiotic properties of Lactobacilli isolated from rat fecal microbiota. Microbiol. Immunol., 57: 407-416.
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  35. Jena, P.K., D. Trivedi, H. Chaudhary, T.K. Sahoo and S. Seshadri, 2013. Bacteriocin PJ4 active against enteric pathogen produced by Lactobacillus helveticus PJ4 isolated from gut microflora of wistar rat (Rattus norvegicus): Partial purification and characterization of bacteriocin. Applied Biochem. Biotechnol., 169: 2088-2100.
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  36. Chaudhary, H., P.K. Jena and S. Seshadri, 2013. Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: An in vitro study. Nutr. Cancer, 65: 775-780.
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  37. Seshadri, S., 2012. Plant Extracts Against Pseudomonas Aeroginosa-in Vitro and in Vovo Studies. GRIN Verlag, San Francisco, USA., ISBN: 9783656123804, Pages: 95.

  38. Purandhar, K., N. Vora, P. Nair and S. Seshadri, 2012. The ART Industry-the Legal, Ethical and Health Issues in Surrogacy and ART. In: Law, Science and Society: Dynamics, Dilemmas, Disparities, Prasad, A.B. and M. Rao (Eds.). Institute of Law, Nirma University, Ahmedabad, pp: 25-34.

  39. Nair, P., N. Vora, K. Purandhar, V. Kamle and S. Seshadri, 2012. Hydroalcoholic extracts of eclipta alba as a reversal agent in boric acid induced male reproductive toxicity. Zool. Poloniae, 57: 21-46.
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  40. Nair, P., N. Vora, K. Purandhar, V. Kamle and S. Seshadri, 2012. Evaluating the reversal potentials of hydroalcoholic extracts of Eclipta alba in boric acid induced male reproductive toxicity. Central Eur. J. Exp. Biol., 1: 77-93.

  41. Chaudhary, H., R. Arora, A. Vora, P.K. Jena and S. Seshadri, 2012. Evaluating the anti-cancer potential of hydro-alcoholic extract of Allium sativum L.-An in vitro and in vivo study. J. Ethnobiol. Trad. Med., 117: 189-198.

  42. Chaudhary, H., P.K. Jena, D. Trivedi, K. Purandhar and N. Vora et al., 2012. Cathepsin D: A novel target for apoptotic induction, as a future Anti-cancer therapy. J. Physiol. Pharmacol. Adv., 2: 87-96.

  43. Seshadri, S., A.K. Jain and B. Kapadia, 2011. Preliminary investigation for a potential ameliorative role of methanolic extract of leaves of Polyalthia longifolia and Trigonella foenum and seeds of Murraya koenigii on lindane treated male rats. Inventi Impact Ethnopharmacol., 2: 59-65.

  44. Kothari, V., S. Seshadri and P. Mehta, 2011. Fractionation of antibacterial extracts of Syzygium cumini (Myrtaceae) seeds. Res. Biotechnol., 2: 53-63.
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  45. Jena, P.K., D. Trivedi, K. Purandhar, H. Chaudhary and S. Seshadri, 2011. Antimicrobial peptides and its role in Gastro-intestinal diseases: A review. J. Anim. Sci. Adv., 1: 1-11.

  46. Chaudhary, H., V. Dhuna, J. Singh, S.S. Kamboj and S. Seshadri, 2011. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study. J. Ethnopharmacol., 136: 363-367.
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  47. Chaudhari, K., V. Bhatt, A. Bhargava and S. Seshadri, 2011. Combinational system for the treatment of textile waste water: A future perspective. Asian J. Water Environ. Pollut., 8: 127-136.
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  48. Seshadri, S., 2010. Reversal of Pseudomonas Infections by Plant Extracts. LAP Lambert Academic Publishing, Germany, ISBN-13: 978-3-8433-5404-2, Pages: 104.

  49. Seshadri, S., 2010. Evaluation of the effect of combination of extracts of Acorus calamus and Semecarpus anacardium in chronic Pseudomonas aeruginosa lung infection in rats. Inventi Impact Mol. Pharmacol., 1: 13-16.

  50. Kothari, V., S. Pathan and S. Seshadri, 2010. Antioxidant activity, free radical scavenging activity, phenol and flavonoid contents of Manilkara zapota and Citrus limon seeds. J. Nat. Remedies, 10: 175-180.

  51. Kothari, V. and S. Sriram, 2010. In vitro antibacterial activity in extracts of seeds of Manilkara zapota, Anona squamosa and Tamarindus indica. Biol. Res., 43: 165-168.
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  52. Kothari, V. and S. Seshadri, 2010. In vitro antibacterial activity in seed extracts of Manilkara zapota, Anona squamosa and Tamarindus indica. Biol. Res., 43: 165-168.
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  53. Kothari, V. and S. Seshadri, 2010. Antioxidant activity of seed extracts of Annona squamosa and Carica papaya. Nutr. Food Sci., 40: 403-408.
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  54. Seshadri, S. and C. Chhatbar, 2009. Multidrug resistance in Pseudomonas aeruginosa: New insight into the molecular mechanisms. Afr. J. Microbiol. Res. (South Africa), 3: 195-199.

  55. Chhatbar, C., P. Salma and S. Seshadri, 2009. Intrinsically unstructured proteins: Potential targets for drug discovery. Am. J. Infect. Dis., 1: 133-141.
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  56. Surana, B., J. Mehta and S. Seshadri, 2008. Toxicological effects of quinalphos and its subsequent reversal by using root extract of Withania somnifera and leaf pulp of Aloe barbadensis. J. Indian Soc. Toxicol., 4: 2-5.
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  57. Seshadri, S., 2008. Pathogenic Plant Toxins as an Agent for Bioterrorism. In: Bioterrorism and Biological Warfare, Bhatia, A.L. and S.K. Kulshrestha (Eds.). Pointer Publishers, Jaipur, pp: 308-320.

  58. Borad, V. and S. Sriram, 2008. Pathogenesis-related proteins for the plant protection. Asian J. Exp. Sci., 22: 189-196.
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  59. Manivannan, B., S.S. Bhande, S. Panneerdoss, S. Sriram and N.K. Lohiya, 2005. Safety evaluation of long-term vas occlusion with styrene maleic anhydride and its non-invasive reversal on accessory reproductive organs in langurs. Asian J. Androl., 7: 195-204.
    PubMed  |  

  60. Lohiya, N.K., P.K. Mishra, N. Pathak, B. Manivannan, S.S. Bhande, S. Panneerdoss and S. Sriram, 2005. Efficacy trial on the purified compounds of the seeds of Carica papaya for male contraception in albino rat. Reprod. Toxicol., 20: 135-148.
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  61. Lohiya, N.K., B. Manivannan, P.K. Mishra, S. Sriram, S.S. Bhande and S. Panneerdoss, 2005. Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys. Contraception, 71: 214-226.
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  62. Manivannan, B., P.K. Mishra, N. Pathak, S. Sriram, S.S. Bhande, S. Panneerdoss and N.K. Lohiya, 2004. Ultrastructural changes in the testis and epididymis of rats following treatment with the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya. Phytother. Res., 18: 285-289.
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  63. Mishra, P.K., B. Manivannan, N. Pathak, S. Sriram, S.S. Bhande, S. Panneerdoss and N.K. Lohiya, 2003. Status of spermatogenesis and sperm parameters in langur monkeys following Long-term vas occlusion with styrene maleic anhydride. J. Androl., 24: 501-509.
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  64. Manivannan, P.K. Mishra, N. Pathak, S. Sriram, S.S. Bhande, S. Panneerdoss and N.K. Lohiya, 2002. Current Advances in Male Contraception. In: Reproductive Biology and Comparative Endocrinology, Akbarsha, M.A. (Ed.). SRBCE, Chennai and BU, Tiruchirappali, India, pp: 23-24.

  65. Lohiya, N.K., B. Manivannam, P.K. Mishra, N. Pathak, S. Sririam, S.S. Bhande and S. Panneerdoss, 2002. Chloroform extract of Carica papaya seeds induces long-term reversible azoospermia in Langur monkey. Asian J. Androl., 41: 17-26.
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