Dr. Azhar Rasul

Assistant Professor
Government College University, Faisalabad, Pakistan

Highest Degree
Ph.D. in Cell Biology from Northeast Normal University, China

My URL
https://livedna.org/92.4855

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Biography

Dr. Azhar Rasul is an Assistant Professor at Faculty of Life Sciences, Government College University Faisalabad. He received MSc and M. Phil degree in Biology from Bahauddin Zakariya University, Multan, Pakistan. He obtained PhD fellowship jointly awarded by Ministry of Education (MOE), Pakistan and China Scholarship Council (CSC), China and completed his Ph.D. in Cell Biology (Chemical Cancer Biology) from Northeast Normal University, China. He later received China postdoctoral fellowship in 2012, Japanese Society for Promotion of Science (JSPS) Postdoctoral fellowship in 2013, and subsequently Tokyo Biochemical Research Foundation (TBRF) fellowship in 2015. He has published over 82 peer-reviewed articles with cumulative impact factor over 166 and with over 1472 citations. He also has published four book chapters. He has presented several invited talks at National and International level. He has attended more than 20 International conferences in Japan, China, South Korea, Dubai, Sri Lanka, Qatar, Turkey, Thailand, Malaysia and France. Under his supervision, thirteen MPhil students completed their research work. Three PhD and four MPhil students are currently working under his supervision. He has obtained several national and international research grants (HEC-Pak Turk Mobility Grant, ISSESCO RG, HEC-NRPU RG(s), The Nagai Foundation Tokyo RG(s) and COMSTECH-TWAS RG). His lab is actively engaged in interdisciplinary research on novel tumor biomarkers, cancer-related health disparities, and identification of non-toxic anti-cancer compounds for various hallmarks of cancer (cancer stem cells, cancer cell metabolism, and tumor hypoxia) from natural sources. He is reviewer and editorial board member of several well-reputed journals.

Area of Interest:

Molecular Sciences
Cell Biology
Anti-Cancer Drug Discovery
Nanomaterials
Biological Control

Selected Publications

  1. Nageen, B., I. Sarfraz, A. Rasul, G. Hussain and F. Rukhsar et al., 2020. Eupatilin: a natural pharmacologically active flavone compound with its wide range applications. J. Asian Nat. Prod. Res., 22: 1-16.
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  2. Hussain, G., J. Wang, A. Rasul, H. Anwar and M. Qasim et al., 2020. Current status of therapeutic approaches against peripheral nerve injuries: A detailed story from injury to recovery. Int. J. Biol. Sci., 16: 116-134.
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  3. Wei, W., A.A.S. Rasul, I. Sarfraz, G. Hussain, B. Nageen, X. Liu and J. Li, 2019. Curcumol: From plant roots to cancer roots. Int. J. Biol. Sci., 15: 1600-1609.
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  4. Sharif, F., A. Rasul, A. Ashraf, G. Hussain and T. Younis et al., 2019. Phosphoglycerate mutase 1 in cancer: A promising target for diagnosis and therapy. IUBMB Life, 71: 1418-1427.
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  5. Shah, S., A. Rasul, A. Rasul, M. Saadullah and M.A. Abrar et al., 2019. Sensitive and Inexpensive HPLC method for combined monitoring of metformin and sitagliptin in plasma. Latin Am. J. Pharm., 38: 1874-1878.
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  6. Riaz, A., B. Saleem, G. Hussain, I. Sarfraz, B. Nageen, R. Zara, M. Manzoor and A. Rasul, 2019. Eriocalyxin B biological activity: A review on its mechanism of action. Nat. Prod. Commun., 10.1177/1934578X19868598.
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  7. Rasul, A., A.A. Al-Shawi, S.A. Malik, H. Anwar, B. Rasool, 2019. Neurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury. Pak. J. Pharm. Sci., 32: 1761-1766.

  8. Mukhtar, I., H. Anwar, G. Hussain, A. Rasul and S.A.R. Naqvi et al., 2019. Detection of paracetamol as substrate of the gut microbiome. Pak. J. Pharm. Sci., 32: 751-757.

  9. Manzoor, M., Q.U.A. Ahmad, A. Aslam, F. Jabeen, A. Rasul, P.M. Schenk and J.I. Qazi, 2019. Mixotrophic cultivation of Scenedesmus dimorphus in sugarcane bagasse hydrolysate. Environ. Progr. Sustainable Energy, 10.1002/ep.13334.
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  10. Latif, M.A., F. Jabeen, M. Ali, A. Rasul, S. Naz and M. Akram, 2019. Neurotoxic effects of titanium dioxide nanoparticles on the brain of male sprague dawley rats. Pak. J. Pharm. Sci., 32: 2311-2316.

  11. Kua, V.M.D., A. Rasul, S. Sasidharan, B. Rasool, T. Younis and N.S. Lai, 2019. Hydrochloride and leukemia cells: effects on cell viability, DNA fragmentation, and apoptotic proteins expression level. Pak. J. Pharm. Sci., 32: 1797-1803.

  12. Jiang, D., A. Rasul, R. Batool, I. Sarfraz, G. Hussain, 2019. Potential anticancer properties and mechanisms of action of formononetin. BioMed. Res. Int., 10.1155/2019/5854315.
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  13. Imran, A., L. Xiao, W. Ahmad, H. Anwar and A. Rasul et al., 2019. Foeniculum vulgare (Fennel) promotes functional recovery and ameliorates oxidative stress following a lesion to the sciatic nerve in mouse model. J. Food Biochem., Vol. 43. 10.1111/jfbc.12983.
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  14. Hussain, S.M., A. Khalid, M.M. Shahzad, A. Rasul, A.M. Akram, N. Ahmad and F. Khalid, 2019. Effect of dietary supplementation of selenium nanoparticles on growth performance and nutrient digestibility of common carp (Cyprinus carpio Linnaeus, 1758) fingerlings fed sunflower meal based diet. Indian J. Fisher., 66: 55-61.

  15. Hussain, G., J. Wang, A. Rasul, H. Anwar and A. Imran et al., 2019. Role of cholesterol and sphingolipids in brain development and neurological diseases. Lipids Health Dis., Vol. 18, No. 1. 10.1186/s12944-019-0965-z.
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  16. Hussain, G., J. Huang, A. Rasul, H. Anwar and A. Imran et al., 2019. Putative roles of plant-derived tannins in neurodegenerative and neuropsychiatry disorders: An updated review. Molecules, Vol. 24. 10.3390/molecules24122213.
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  17. Aslam, S., F. Wang, M. Ahmad, A.F. Zahoor, A. Mansha, A. Rasul and L. Fu, 2019. Benzothiazine based acetohydrazides and acetamides as anticancer agents. Pak. J. Pharm. Sci., 32: 2795-2800.

  18. Akhtar, R., A.F. Zahoor, A. Rasul, M. Ahmad, M.N. Anjum, M. Ajmal and Z. Raza, 2019. Design, synthesis, in-silico study and anticancer potential of novel n-4-piperazinyl-ciprofloxacin-aniline hybrids. Pak. J. Pharm. Sci., 32: 2215-2222.

  19. Akhtar, N., U. Hussain, M. Zulhussnain, M.A. Zahoor and A. Rasul et al., 2019. Insecticidal and genotoxic activities of some indigenous weed plant extracts in fruit fly, Drosophila melanogaster. Zeitschrift Fur Arznei- Gewurzpflanzen, 24: 10-16.

  20. Ahmad, S., S. Jalil, S. Zaib, S. Aslam and M. Ahmad et al., 2019. Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4, 6-dihydrobenzo [c] pyrano [2, 3-e][1, 2] thiazine 5, 5-dioxides: In vitro studies and docking analysis. Eur. J. Pharm. Sci., 131: 9-22.
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  21. Zafar, M., I. Sarfraz, A. Rasul, F. Jabeen and K. Samiullah et al., 2018. Tubeimoside-1, triterpenoid saponin, as a potential natural cancer killer. Nat. Prod. Commun., 13: 643-650.

  22. Younis, T., M.I. Khan, M.R. Khan, A. Rasul, M. Majid, V.M. Adhami and H. Mukhtar, 2018. Nummularic acid, a triterpenoid, from the medicinal plant Fraxinus xanthoxyloides, induces energy crisis to suppress growth of prostate cancer cells. Mol. Carcinog., 57: 1267-1277.
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  23. Younis, T., A. Rasul, F. Jabeen, G. Hussain, J. Altaf, I. Sarfraz and M. Ali et al., 2018. Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl4-challanged nephrotoxicity in rats. Pak. J. Pharm. Sci., 31: 1475-1484.

  24. Yar, A.M., G. Zaman, A. Hussain, Y. Changhui and A. Rasul et al., 2018. Comparative genome analysis of 2 Mycobacterium tuberculosis strains from Pakistan: Insights globally into drug resistance, virulence and niche adaptation. Evolut. Bioinform., Vol. 14. 10.1177/1176934318790252.
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  25. Sevindik, M., A. Rasul, G. Hussain, H. Anwar, M.K. Zahoor, 2018. Determination of anti-oxidative, anti-microbial activity and heavy metal contents of Leucoagaricus leucothites. Pak. J. Pharm. Sci., 31: 2163-2168.

  26. Javeed, M., A. Rasul, G. Hussain, F. Jabeen and B. Rasool et al., 2018. Harmine and its derivatives: Biological activities and therapeutic potential in human diseases. Bangladesh J. Pharmacol., 13: 203-213.
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  27. Jabeen, F., A. Hussain, M. Manzoor, T. Younis, A. Rasul and J.I. Qazi, 2018. Potential of bacterial chitinolytic, Stenotrophomonas maltophilia, in biological control of termites. Egypt. J. Biol. Pest Control, Vol. 28, No. 1. 10.1186/s41938-018-0092-6.
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  28. Hussain, G., A. Rasul, H. Anwar, N. Aziz and A. Razzaq et al., 2018. Role of plant derived alkaloids and their mechanism in neurodegenerative disorders. Int. J. Biol. Sci., 14: 341-357.
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  29. Riaz, A., A. Rasul, G. Hussain, M.K. Zahoor and F. Jabeen et al., 2018. Astragalin: A bioactive phytochemical with potential therapeutic activities. Adv. Pharmacol. Sci., Vol. 2018. 10.1155/2018/9794625.
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  30. Sarfraz, I., A. Rasul, F. Jabeen, T. Younis, M.K. Zahoor, M. Arshad and M. Ali, 2017. Fraxinus: A plant with versatile pharmacological and biological activities. Evidence-Based Complement. Altern. Med., Vol. 2017. 10.1155/2017/4269868.
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  31. Qin, H., A. Rasul, X. Li, M. Masood and G. Yang et al., 2017. CD147-induced cell proliferation is associated with Smad4 signal inhibition. Exp. Cell Res., 358: 279-289.
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  32. Jiang, C., M. Masood, A. Rasul, W. Wei and Y. Wang et al., 2017. Altholactone inhibits NF-κB and STAT3 activation and induces reactive oxygen species-mediated apoptosis in prostate cancer DU145 cells. Molecules, Vol. 22, No. 2. 10.3390/molecules22020240.
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  33. Rasul, A., X. Shen, B. Wang, B. Liu, X. Li and J. Tang, 2014. Tubeimoside-1 upregulates p21 expression and induces apoptosis and G2/M phase cell cycle arrest in human bladder cancer T24 cells. Bangladesh J. Pharmacol., 9: 595-603.
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  34. Rasul, A., B.J. Zhao, J. Liu, B. Liu, J.X. Sun, J. Li and X.M. Li, 2014. Molecular mechanisms of casticin action: An update on its antitumor functions. Asian Pac. J. Cancer Prev., 15: 9049-9058.
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  35. Di, W., M. Khan, A. Rasul, M. Sun and Y. Sui et al., 2014. Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction. Oncol. Rep., 32: 1585-1593.
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  36. Zhang, Y., A. Rasul, X. Li, M. Malhi, X. Fang, L. Wang and Y. Wang, 2013. Lentivirus-mediated shRNA targeting decoy receptor 3 (DcR3) inhibits proliferation and augments apoptosis in pancreatic cancer Capan-1 cells. Afr. J. Pharm. Pharmacol., 7: 203-210.
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  37. Yang, N., B. Zhao, A. Rasul, H. Qin, J. Li and X. Li, 2013. PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis. Cell Death Dis., Vol. 4. 10.1038/cddis.2013.333.
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  38. Wei, W., J. Di, A. Rasul, C. Zhao and F.M. Millimouno et al., 2013. Dracorhodin perchlorate induces apoptosis in bladder cancer cells through Bcl-2, Bcl-XL, survivin down-regulation and caspase-3 activation. Bangladesh J. Pharmacol., 8: 276-282.
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  39. Shen, J., X. Ma, F. Yi, A. Rasul, M. Cui and T. Ma, 2013. Increased expression levels of vitronectin in the maternal-fetal interface of placenta in early-onset severe preeclampsia. Mol. Med. Rep., 7: 53-58.
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  40. Rasul, A., R. Bao, M. Malhi, B. Zhao, I. Tsuji, J. Li and X. Li, 2013. Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules, 18: 1418-1433.
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  41. Rasul, A., M. Khan, M. Ali, J. Li and X. Li, 2013. Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. Scient. World J., Vol. 2013. 10.1155/2013/248532.
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  42. Rasul, A., J. Liu, Y. Liu, F.M. Millimouno and X. Wang et al., 2013. Eriocalyxin B inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells. Bangladesh J. Pharmacol., 8: 116-123.
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  43. Rasul, A., J. Di, F.M. Millimouno, M. Malhi and I. Tsuji et al., 2013. Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules, 18: 9382-9396.
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  44. Rasul, A., F.M. Millimouno, W.A. Eltayb, M. Ali, J. Li and X. Li, 2013. Pinocembrin: A novel natural compound with versatile pharmacological and biological activities. BioMed Res. Int. 10.1155/2013/379850.
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  45. Kong, M., L. Liu, F. Yi, M. Khan and A. Rasul et al., 2013. Prevalence of infarct and villous clumps, and the expression of α-smooth muscle actin in the placental basal plate in severe preeclampsia. Mol. Med. Rep., 8: 1067-1073.
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  46. Khan, M., T. Li, A. Khan, M. Khalil and A. Rasul et al., 2013. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation and mitochondrial dysfunction. BioMed Res. Int., Vol. 2013. 10.1155/2013/719858.
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  47. Khan, M., J.I. Qazi, A. Rasul, Y. Zheng and T. Ma, 2013. Evodiamine induces apoptosis in pancreatic carcinoma PANC-1 cells via NF κB inhibition. Bangladesh J. Pharmacol., 8: 8-14.
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  48. Iqbal, F., R.M. Khattak, S. Ozubek, M.N.K. Khattak, A. Rasul and M. Aktas, 2013. Application of the reverse line blot assay for the molecular detection of Theileria and Babesia sp. in sheep and goat blood samples from Pakistan. Iran. J. Parasitol., 8: 289-295.
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  49. Chen, Z., A. Rasul, C. Zhao, F.M. Millimouno and I. Tsuji et al., 2013. Antiproliferative and apoptotic effects of pinocembrin in human prostate cancer cells. Bangladesh J. Pharmacol., 8: 255-262.
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  50. Rasul, A., S. Parveen and T. Ma, 2012. Costunolide: A novel anti-cancer sesquiterpene lactone. Bangladesh J. Pharmacol., 7: 6-13.
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  51. Rasul, A., R. Song, W. Wei, Y. Nishino, I. Tsuji, X. Li and J. Li, 2012. Tubeimoside-1 inhibits growth via the induction of cell cycle arrest and apoptosis in human melanoma A375 cells. Bangladesh J. Pharmacol., 7: 150-156.
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  52. Rasul, A., C. Ding, X. Li, M. Khan, F. Yi, M. Ali and T. Ma, 2012. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53 and enhances apoptosis. Apoptosis, 17: 1104-1119.
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  53. Rasul, A., B. Yu, Z. Kun, M. Khan, H. Yang and T. Ma, 2012. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep., 27: 1481-1487.
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  54. Rasul, A., B. Yu, Z. Kun, M. Khan, F. Iqbal, T. Ma and H. Yang, 2012. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int. J. Oncol., 40: 1153-1161.
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  55. Khattak, R.M., A. Sharafat, M. Jahangir, M.N. Khan, A. Rasul and F. Iqbal, 2012. Prevalence of ectoparasites in wild and domesticated grey (Francolinus pondicerianus) and black partridges (Francolinus francolinus) from Khyber Pakhtoonkhwa province of Pakistan. Pak. J. Zool., 44: 1239-1244.
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  56. Khan, M., Y. Xiao, B. Yu, N. Wang and A. Rasul et al., 2012. Artabotryside A, a constituent from Descurainia sophia (L.) induces cell death in U87 glioma cells through apoptosis and cell cycle arrest at G2/M phase. J. Med. Plants Res., 6: 3754-3765.
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  57. Khan, M., C. Ding, A. Rasul, F. Yi and T. Li et al., 2012. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. Int. J. Biol. Sci., 8: 533-547.
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  58. Khan, M., B. Zheng, F. Yi, A. Rasul and Z. Gu et al., 2012. Pseudolaric acid B induces caspase-dependent and caspase-independent apoptosis in U87 glioblastoma cells. Evidence-Based Complement. Altern. Med., Vol. 2012. 10.1155/2012/957568.
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  59. Shawi, A.A., A. Rasul, M. Khan, F. Iqbal and M. Tonghui, 2011. Eupatilin, A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells. Afr. j. Pharm. Pharmacol., 5: 582-587.
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  60. Rasul, A., M. Khan, B. Yu, T. Ma and H. Yang, 2011. Xanthoxyletin, a coumarin induces s phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells. Asian Pac. J. Cancer Prev., 12: 1219-1223.
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  61. Naeem, M., A. Rasul, A. Salam, S. Iqbal, A. Ishtiaq, M. Khalid and M. Athar, 2011. Proximate analysis of female population of wild feather back fish (Notopterus notopterus) in relation to body size and condition factor. Afri. J. Biotech., 10: 3867-3871.
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  62. Khan, M., A. Rasul, F. Yi, L. Zhong and T. Ma, 2011. Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells. Asian Pac. J. Cancer Prev., 12: 3235-3238.
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