Dr. Mohammad Reza Shakibaie

Professor
Department of Medical Microbiology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman Iran

Highest Degree
PostDoc. in Medical Microbiology from Mysore University, India

My URL
https://livedna.org/98.4102

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Biography

Dr. Mohammad Reza Shakibaie earned his Ph.D. from the University of Pune India from 1992 to 1997. He completed one year of postdoctoral research training at Aquatic Microbial Lab in Mysore, India in 2006. Dr. Shakibaie Joined the Department of Microbiology as Assistant Professor at Kerman University of Medical Sciences in 1998. He guided more than 15 M.Sc. theses and 18 projected. His main area of interest related to Biomedical Sciences, Molecular Sciences, and Environmental Sciences. His area of expertise includes Molecular Biology, Bacteriology, Microbiology, Antibiotic Resistance, Gene Transfer in Environment, Bioremediation, Cloning, Sequencing, Real-Time PCR, Gene Mapping, Identification by PCR, Biofilm, Genes, Plasmids, Conjugation, Waste Water Effluents, Prokaryotes, Unicellular Eukaryotes, Uncultivated Bacteria, Quorum Sensing, Hospital Isolates, Transformation, Metals Resistance, Gene Expression, Molecular Quorum Sensing, Biofilm, Pathogenic Organisms, Pathogens, and Biosorption. He has published 28 research articles in journals, 8 abstracts in seminars, and 3 books contributed as author/co-author. He is a member of the following scientific societies such as New York Academy of Science, Science Advisory Board (USA), Asian Pacific Research Foundation for Infectious Diseases (ARFFID), affiliated member of European Society for Microbiologists (FEMS), and member of Iranian Society of Microbiology, and Iranian Biotechnology Society. He is also serving as a member of the editorial board in journals such as the World Academy of Sciences (Waset), the International Journal of Biological and Life Sciences, Journal of Biotechnology and Molecular Biology Review, Current Research Journal of Biological Sciences, and Journal of Bacteriology Research.

Area of Interest:

Biomedical Sciences
Molecular Biology
Genetic
Bacteriology
Microbiology

Selected Publications

  1. Shakibaie, M.R., F. Modaresi, O. Azizi, O. Tadjrobehkar and M.M. Ghaemi, 2023. Conformational changes in the AdeB transmembrane efflux pump by amphiphilic peptide Mastoparan-B, down-regulates expression of theadeB Gene and restores antibiotics susceptibility. bioRxiv 2023.01.03.522678; https://doi.org/10.1101/2023.01.03.522678.

  2. Ganeshan, S., 2022. Insights from the molecular docking analysis of colistin with the PmrA protein model from Acinetobacter baumannii. Bioinformation, 18: 41-49.
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  3. Dorri, K., F. Modaresi, M.R. Shakibaie and E. Moazamian, 2022. Effect of gold nanoparticles on the expression of efflux pump mexA and mexB genes of Pseudomonas aeruginosa strains by Quantitative real-time PCR. Pharmacia, 69: 125-133.
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  4. R.A. Mahmoudian, M.L. Gharaie, R. Abbaszadegan, M.M. Forghanifard and M.R. Abbaszadegan, 2021. Interaction between linc-ror and stemness state in gastric cancer cells with Helicobacter pylori infection. Iran Biomed. J., 25: 157-168.
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  5. Kandehkar-Ghahraman, M.R., H. Hosseini-Nave, O. Azizi, M.R. Shakibaie, H. Mollaie and S. Shakibaie, 2021. Stereochemical trajectories of a two-component regulatory system PmrA/B in a colistin-resistant Acinetobacter baumannii clinical isolate. Iran. Biomed. J., 25: 193-201.
    CrossRef  |  Direct Link  |  

  6. Ghahraman, M.R.K., H. Hosseini-Nave, O. Azizi, M.R. Shakibaie, H.R. Mollaie and S. Shakibaie, 2020. Molecular characterization of lpxacd and pmra/b two-component regulatory system in the colistin resistance Acinetobacter baumannii clinical isolates. Gene Rep., 10.1016/j.genrep.2020.100952.
    CrossRef  |  Direct Link  |  

  7. Ziasistani, M., M.R. Shakibaie and D. Kalantar-Neyestanaki, 2019. Genetic characterization of two vancomycin-resistant Staphylococcus aureus isolates in kerman, Iran. Infec. Drug Resist., 12: 1869-1875.
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  8. Taghadosi, R., M.R. Shakibaie and H.H. -Nave, 2019. Antibiotic resistance, esbl genes, integrons, phylogenetic groups and mlva profiles of Escherichia coli pathotypes isolated from patients with diarrhea and farm animals in south-east of Iran. Comparative Immunol., Microbiol. Infect. Dis., 63: 117-126.
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  9. Sharifi, H., G. Pouladfar, M.R. Shakibaie, B. Pourabbas, J. Mardaneh and S. Mansouri, 2019. Prevalence of β-lactamase genes, class 1 integrons, major virulence factors and clonal relationships of multidrug-resistant Pseudomonas aeruginosa isolated from hospitalized patients in southeast of Iran. Iran. J. Basic Med. Sci., 22: 806-812.
    CrossRef  |  Direct Link  |  

  10. Masoumi, S., M.R. Shakibaie, M. Gholamrezazadeh and F. Monirzadeh, 2018. Evaluation synergistic effect of Tio2, zno nanoparticles and amphiphilic peptides (mastoparan-b, indolicidin) against drug-resistant Pseudomonas aeruginosa, klebsiella pneumoniae and Acinetobacter baumannii. Arch. Pediatr. Infect. Dis., DOI:10.5812/pedinfect.57920.
    CrossRef  |  Direct Link  |  

  11. Gholamrezazadeh, M., M.R. Shakibaie, F. Monirzadeh, S. Masoumi and Z. Hashemizadeh, 2018. Effect of nano-silver, nano-copper, deconex and benzalkonium chloride on biofilm formation and expression of transcription regulatory quorum sensing gene (rh1 R) in drug-resistance Pseudomonas aeruginosa burn isolates. Burns, 44: 700-708.
    CrossRef  |  Direct Link  |  

  12. Shakibaie, M.R., O. Azizi and F. Shahcheraghi, 2017. Insight into stereochemistry of a new IMP allelic variant (IMP-55) metallo-β-lactamase identified in a clinical strain of Acinetobacter baumannii. Infect. Genet. Evol., 51: 118-126.
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  13. Azizi, O., M.R. Shakibaie, F. Badmasti, F. Modarresi, R. Ramazanzadeh, S. Mansouri and F. Shahcheraghi, 2016. Class 1 integrons in non-clonal multidrug-resistant Acinetobacter baumannii from Iran, description of the new blaIMP-55 allele in In1243. J. Med. Microbiol., 65: 928-936.
    CrossRef  |  Direct Link  |  

  14. Ahmadrajabi, R., M.R. Shakibaie, Z. Iranmanesh, H.R. Mollaei and M.H. Sobhanipoor, 2016. Prevalence of mip virulence gene and PCR-base sequence typing of Legionella pneumophila from cooling water systems of two cities in Iran. Virulence, 7: 602-609.
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  15. Taghadosi, R., M.R. Shakibaie and S. Masoumi, 2015. Biochemical detection of N-Acyl homoserine lactone from biofilm-forming uropathogenic Escherichia coli isolated from urinary tract infection samples. Rep. Biochem. Mol. Biol., 3: 1-6.
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  16. Shakibaie, M., H. Forootanfar, Y. Golkari, T. Mohammadi-Khorsand and M.R. Shakibaie, 2015. Anti-biofilm activity of biogenic selenium nanoparticles and selenium dioxide against clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa and Proteus mirabilis. J. Trace Elem. Med. Biol., 29: 235-241.
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  17. Nezarieh, R., M.R. Shakibaie, H.H. Nave, A. Norouzi, G. Salajegheh and M. Hayatbakhsh, 2015. Distribution of virulence genes, enterotoxin and biofilm formation among enteroaggregative Escherichia coli (EAEC) strains isolated from stools of children with diarrhea in south east Iran. Arch. Pediatr. Infect. Dis., 10.5812/pedinfect.29745v2.
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  18. Modarresi, F., O. Azizi, M.R. Shakibaie, M. Motamedifar, E. Mosadegh and S. Mansouri, 2015. Iron limitation enhances acyl homoserine lactone (AHL) production and biofilm formation in clinical isolates of Acinetobacter baumannii. Virulence, 6: 152-161.
    CrossRef  |  Direct Link  |  

  19. Modarresi, F., O. Azizi, M.R. Shakibaie, M. Motamedifar, B. Valibeigi and S. Mansouri, 2015. Effect of iron on expression of efflux pump (adeABC) and quorum sensing (luxI,luxR) genes in clinical isolates of Acinetobacter baumannii. J. Pathol. Microbiol. Immunol., 123: 959-968.
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  20. Azizi, O., M.R. Shakibaie, F. Modarresi and F. Shahcheraghi, 2015. Molecular detection of class-D OXA carbapenemase genes in biofilm and non-biofilm forming clinical isolates of Acinetobacter baumannii. Jundishapur J. Microbiol., Vol. 8, No. 1. 10.5812/jjm.21042.
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  21. Shakibaie, M.R., Y. Golkari and G. Salajegheh, 2014. Evaluation of the antimicrobial susceptibility, virulence factors and biofilm formation among Staphylococcus aureus hospital infections in Kerman, Iran. J. Microbiol. Infect. Dis., 4: 87-90.

  22. Shakibaie, M.R., S. Adeli and M.H. Salehi, 2014. Antimicrobial susceptibility pattern and ESBL production among uropathogenic Escherichia coli isolated from UTI children in pediatric unit of a hospital in Kerman, Iran. Br. Microbiol. Res. J., 4: 262-271.
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  23. Shikh-Bardsiri, H. and M.R. Shakibaie, 2013. Antibiotic resistance pattern among biofilm producing and non producing Proteus strains isolated from hospitalized patients; matter of hospital hygiene and antimicrobial stewardship. Pak. J. Biol. Sci., 16: 1496-1502.
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  24. Sheykh-Bardsiri H., M.R. Shakibaie and S.A. Kafiabad, 2013. Plasmid pattern of biofilm producing proteus mirabilis and proteus vulgaris among clinical isolates in Kerman University Hospitals during 2011-2012. J. kerman Univ. Med. Sci., Vol. 20, .
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  25. Arabzadeh, A.M., M. Ansari-Dogaheh, F. Sharififar, M. Shakibaie and M. Heidarbeigi, 2013. Anti Herpes simplex-1 activity of A standard extract of Zataria multiflora boiss. Pak. J. Biol. Sci., 16: 180-184.
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  26. Shakibaie, M.R., S. Adeli and M.H. Salehi, 2012. Antibiotic resistance patterns and extended-spectrum β-lactamase production among Acinetobacter spp. isolated from an intensive care Unit of a hospital in Kerman, Iran. Antimicrob Resistance infection control., Vol. 1, 10.1186/2047-2994-1-1.
    CrossRef  |  Direct Link  |  

  27. Shakibaie, M.R., 2012. Antibiotic resistant pattern and ESBL production among Acinetobacter spp. isolated from ICU of a hospital in Kerman, Iran. Antibiotic Resist. Infect. Control, 1: 1-8.

  28. Mirkamandar, E., M.R. Shakibaie, S. Adeli, M. Mehrabani and M.M. Hayatbakhsh, 2012. In vitro antimicrobial activity of Salvadora persica extract on Helicobacter pylori strains isolated from duodenal ulcer biopsies. Microbiol. Res., 3: 38-41.
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  29. Dokhani, A., M.R. Shakibaie, A. Khosravan, Z. Asgarani and M. Moghbeli, 2012. Molecular genetic identification and metal biosorption by a Geobacillus genospecies IRKM1 isolated from Deeymand hot spring, Kerman, Iran. Int. J. Env. Health Eng., 1: 36-41.
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  30. Shakibaie, M.R., K. Shams and M. Khalili, 2011. Detection of Legionella pneumophila in cooling water systems of hospitals and nursing homes of Kerman city, Iran by Semi-nested PCR. World Acad. Sci. Eng. Technol., 52: 20-23.

  31. Shakibaie, M.R. and M. Moradie, 2011. Detection of Carbenicillin hydrolyzing (CARB) type of ESBL in hospital isolates of Acinetobacter baumannii. Int. J. Biol. Biomed. Sci., 1: 1-6.
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  32. Nia, K.M., G. Sepehri, H. Khatmi and M.R. Shakibaie, 2011. Isolation and antimicrobial susceptibility of bacteria from chronic supportive otitismedia patients in Kerman, Iran. Iran. Red. Crescent Med. J., 13: 891-894.
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  33. Shakibaie, M.R., 2010. Plasmid-encoded resistance to penicillin's in Acinetobacter baumannii BL54 mediated by carbenicillin‐hydrolysing (carb) type of β‐lactamase. Proceedings of the 8th International Symposium on the Biology of Acinetobacter, September 1-3, 2010, Rome, Italy -.

  34. Shacheraghi, F., M.R. Shakibaie and H. Noveiri, 2010. Molecular identification of ESBL genes blaGES-1, blaVEB-1, blaCTX-M blaOXA-1, blaOXA-4, blaOXA-10 and blaPER-1 in Pseudomonas aeruginosa isolated from burn patients by PCR-RFLP and sequencing techniques. Int. J. Biol. Life Sci., 6: 138-142.
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  35. Kermani, A.J.N., M.F. Ghasemi, A. Khosravan, A. Farahmand and M.R. Shakibaie, 2010. Bioremediation of cadmium (Cd) using Cd resistant bacteria isolated from activate sludge industrial waste effluent in batch bed reactor, Iran. J. Environ. Health. Sci. Eng., 7: 279-286.

  36. Shakibaie, M.R., P. Dhakephalker, B.P. Kapadnis and B.A. Chopade, 2009. Conjugational transfer and survival of plasmid encoding silver and antibiotic resistance genes of Acinetobacter baumannii BL54, E.coli K12 J53.2 transconjugants and pseudomonas transformants in different soil microcosms. J. Bacteriol. Res., 1: 79-84.
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  37. Shakibaie, M.R., K.A. Jalilzadeh and S.M. Yamakanamardi, 2009. Horizontal transfer of antibiotic resistance genes among gram negative bacteria in sewage and lake water and influence of some physico-chemical parameters of water on conjugation process. J. Environ. Biol., 30: 45-49.
    PubMed  |  

  38. Shakibaie, M.R., 2009. Horizontal transfer of antibiotic resistance genes among gram negative bacteria in sewage and lake water and effect of some physicochemical of water in conjugation. Proceedings of the 3rd Conference of European Microbiologist, July 2, 2009, Gothenburg, Sweden -.

  39. Shakibaie, M.R., 2009. Detection of ESBL genes and their heterogeneity in Pesudomonas aeruginosa isolates. Proceeidngs of the 3rd Conference of European Microbiologist, July 2, 2009, Gothenburg, Sweden -.

  40. Shakibaie, M.R., K. Shams and M. Khalili, 2008. 16SRDNA PCR amplification and semi‐nested PCR for detection of Legionella pneumophila in cooling water systems of different hospitals and nursing homes of Kerman, Iran. Proceedings of the 10th Iranian Genetics Congress, May 21‐23, 2008, Tehran, Iran -.

  41. Shakibaie, M.R., F. Shahcheraghi, A. Hashemi and N.S. Adeli, 2008. Detection of SHV, PER and TEM type of ESBL genes among Pseudomonas aeruginosa isolated from burn patients in Shafa-hospital Kerman, Iran. IJBMS, 11: 104-111.

  42. Shakibaie, M.R., A. Khosravan, A. Frahmand and S. Zare, 2008. Application of metal resistant bacteria by mutational enhancement technique for bioremediation of copper and zinc from industrial wastes. Iran. J. Environ. Health. Sci. Eng., 5: 251-256.
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  43. Shakibaie, M.R., A. Ardebili, S.H. Alii, A.A. Ketabchi and N. Shahabinejad, 2008. Antibiotic resistance, β‐lactamase production and plasmid profile of Neisseria gonorrhoeae strains isolated from urethritis and cervicitis patients in kerman, Iran. Med. J. Tabriz Univer. Med. Sci., Vol. 30., .
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  44. Shakibaie, M.R., 2008. Gene therapy of monogenic diseases, new approach to genetics. Proceedings of the 10th Iranian Genetics Congress, May 21‐23, 2008, Tehran, Iran -.

  45. Shakibaei M.R., S.C. Fereshteh, H. Ali and N.A. Saeid Adeli, 2008. Detection of TEM, SHV AND PER type extended-spectrum 8-lactamase genes among clinical strains of pseudomonas aeruginosa isolated from burnt patients at sbafa-hospital, KERMAN, IRAN. Iranian J. Basic Med. Sci., 11: 104-111.

  46. Mohammadi, A., A. Vaziri Gohar and M.R. Shakibaie, 2008. Mutations in tumor suppressor TP53 gene in formalin- fixed, paraffin embedded tissues of Squamous Cell Carcinoma (SCC) of lung cancer. Am. J. Biochem. Biotehcnol., 4: 1-6.
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  47. Mansouri, S., M.R. Shakibaie and S. Mahbob, 2005. Isolation species distribution, antibacterial resistance pattern and β-lactamase production of enterococci isolated from Human samples in southeast of Iran. Iranian J. Med. Sci., 30: 68-72.

  48. Gholamhoseinian, A., M.R. Shakibaie and Z. Jamali, 2005. The mechanism of antibacterial effects of methanolic extract of green Myrtus communis on E.coli K12 HB101. J Rafsanjan Univ. Med. Sci. Health Serv., 4: 220-227.

  49. Shakibaie, M.R. and A. Harati, 2004. Metal accumulation in Pseudomonas aeruginosa occur in the form of nanoparticles on the cell surface. Iran. J. Biotechnol., 2: 55-60.
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  50. Shakibaie, M.R., B.A. Dhakephalker, B.P. Kapadnis and B.A. Chopade, 2003. Silver resistance in Acinetobacter baumannii BL54 occurs through binding to a Ag-binding protein. Iran. J. Biotechnol., 1: 41-46.
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  51. Shakibaie, M.R. and Z.H. Ehsan, 2003. Conjugative plasmids among antibiotic resistance Escherichia coli isolates from hospitals in Kerman, Iran. Modarres J. Med. Sci., 6: 75-83.

  52. Shakibaie, M.R., 2002. Plasmid mediated metal and antibiotic resistance in Pseudomonas aeruginosa strains isolated from burn patients. Med. J. Islamic Republic Iran, 16: 159-163.
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  53. Shakibaie, M.R., S. Adeli and Y. Nikian, 2001. Emergence of Ciprofloxacin resistance among Pseudomonas aeruginosa isolated from burn patients. Iran. J. Med. Sci., 26: 155-159.

  54. Shakibaie, M.R., 2001. Antibiotic resistance among Pseudomonas aeruginosa exhibit different RFLP with regards to gyrA gene. Proceedings of the 2nd National Biotechnology Congress, Islamic Republic of Iran, October 9‐11, 2001, Agricultural Biotechnology Research Institute of Iran -.

  55. Kiani, M.A., M.R. Shakibaie and M.H. Kariminejad, 2000. A 22;22 Robertsonian translocation in patient with repeated abortions. Arch Irn. Med., 3: 151-153.

  56. Shakibaie, M.R., S. Mansouri and S. Hakak, 1999. Plasmid pattern of antibiotic resistance in β-lactamase producing Staphylococcus aureus isolated from hospitals in Kerman, Iran. Arch Irn. Med., 2: 93-97.

  57. Shakibaie, M.R., P.A. Dhakephalker, B.P. Kapadnis and B.A. Chopade, 1999. Removal of silver from waste water effluents using Acenitobacter baumannii BL54. Can. J. Microbiol., 45: 995-1000.
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  58. Shakibaie, M.R., P. Dhakephalker, G.A. Salajaghe and B.A. Chopade, 1998. Plasmid mediated silver and antibiotic resistance in Acinetobacter baumannii BL54. Iran. J. Med. Sci., 23: 30-36.
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