Dr. Rafat Ali Siddiqui

Dr. Rafat Ali Siddiqui

Professor
Indiana University Health, USA


Highest Degree
Ph.D. in Biochemistry from Australian National University, Australia

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Area of Interest:

Molecular Sciences
100%
Cell Biology
62%
Biochemistry
90%
Cancer
75%
Lipids
55%

Education

1988

Ph.D.

Australian National University, Australia

Biochemistry

Selected Publications

  1. Xu, X., K.A. Harvey, T. Pavlina, G. Dutot and M. Hise et al., 2012. Steroidal compounds in commercial parenteral lipid emulsions. Nutrients, 4: 904-921.
    CrossRef  |  

  2. VanHorn, F., J.D. Altenburg, K.A. Harvey, Z. Xu, R.J. Kovacs and R.A. Siddiqui, 2012. Attenuation of niacin-induced prostaglandin D2 generation by omega-3 fatty acids in THP-1 macrophages and Langerhans dendritic cells. J. Inflammat. Res., 5: 37-50.
    CrossRef  |  

  3. Siddiqui, R.A., K.A. Harvey, C. Walker and Z. Xu, 2012. Synergistic effects of Docosahexaenoic acid and curcumin in Breast Cancer. Proceedings of the 2012-Hobart Symposium, October 6-7, 2012, Tasmania, Australia, -.

  4. Harvey, K.A., C.L. Walker, Z. Xu, P.Whitley and R.A. Siddiqui, 2012. Trans fatty acids: Induction of a pro-inflammatory phenotype in endothelial cells. Lipids, 47: 647-657.
    PubMed  |  

  5. Siddiqui, RA., K.A. Harvey, Z. Xu, E.M. Bammerlin, C. Walker and J.D. Altenburg, 2011. Docosahexaenoic acid: A natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. BioFactors, 37: 399-412.
    CrossRef  |  

  6. Antalis, C.J., A. Uchida, K.K. Buhman and R.A. Siddiqui, 2011. Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification. Clin. Exp. Metastasis, 28: 733-741.
    PubMed  |  

  7. Altenburg, J.D., K.A. Harvey, S. McCray, Z. Xu and R.A. Siddiqui, 2011. A novel 2,6-diisopropylphenyl Docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines. Biochem. Biophys Res. Communi., 411: 427-432.
    PubMed  |  

  8. Altenburg, J.D., A.A. Bieberich, C. Terry, K.A. Harvey and J.F. Vanhorn et al., 2011. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: Unique signaling not explained by the effects of either compound alone. BMC-Cancer, 11: 149-149.
    PubMed  |  

  9. Altenburg, J.D. and R.A. Siddiqui, 2011. The Beneficial Effects of Nutritional Compounds on Breast Cancer Metastasis. In: Breast Cancer: Current and Alternative Therapeutics Modalities, Gunduz, E. (Eds.). InTech Open Access Publisher, Rijeka Croatia, pp: 295.

  10. Xu, Z., K. Harvey, T. Pavlina, G. Dutot, G. Zaloga and R. Siddiqui, 2010. An improved method for determining medium-and long-chain FAMEs using gas chromatography. Lipids, 45: 199-208.
    CrossRef  |  PubMed  |  

  11. Harvey, K.A., Z. Xu, P. Whitley, V.J. Davisson and R.A. Siddiqui, 2010. Characterization of anticancer properties of 2,6-diisopropylphenol-docosahexaenoate and analogues in breast cancer cells. Bioorganic Med. Chem., 18: 1866-1874.
    CrossRef  |  

  12. Harvey, K.A., Z. Welch, D. Sliva and R.A. Siddiqui, 2010. Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. Mol. Cell Biochem., 342: 7-19.
    PubMed  |  

  13. Harvey, K.A., C.L. Walker, Z. Xu, P. Whitley and T.M. Pavlina et al., 2010. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. J. Lipid Res., 51: 3470-3480.

  14. Harvey, K.A., C.L. Walker, T.M. Pavlina, Z. Xu, G.P. Zaloga and R.A. Siddiqui, 2010. Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. Clin. Nutr., 29: 492-500.
    CrossRef  |  

  15. Antalis, C.J., T. Arnold, T. Rasool, B. Lee, K.K. Buhman and R.A. Siddiqui, 2010. High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation. Breast Cancer Res. Treat., 122: 661-670.
    PubMed  |  

  16. Altenburg, J.D. and R.A. Siddiqui, 2010. Docosahexaenoic acid downregulates interferon gamma-induced expression of CXCL16 in human aortic smooth muscle cells. Biochem. Biophys. Res. Commun., 391: 609-614.
    PubMed  |  

  17. Siddiqui, R.A., S. Hassan, K. Harvey, T. Das, P. Mukerji and S. DeMichele, 2009. Attenuation of cancer cachexia by curcumin C3 complex in MAC-16 tumor-bearing mice. Br. J. Nutr., 102: 967-975.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Siddiqui, R.A., K.A. Harvey, N. Ruzmetov, S.J. Miller and G.P. Zaloga, 2009. Omega-3 fatty acids prevent whereas Trans fatty acids induce vascular inflammation and sudden cardiac death. Br. J. Nutr., 102: 1811-1819.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Minner, D.E., P. Rauch, A.P. Siegel, J. Stelzer and J. Kas et al., 2009. Tuning cellular mechano-response using biomembrane-mimicking substrates of adjustable fluidity. Biophys. J., 96: 521a-521a.
    CrossRef  |  

  20. Antalis, C.J., T. Arnold, B. Lee, K.K. Buhman and R.A. Siddiqui, 2009. Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells. Prostaglandins Leukotrienes Essential Fatty Acids, 80: 165-171.
    PubMed  |  

  21. Altenburg, J.D. and R.A. Siddiqui, 2009. Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. Mol. Cancer Res., 7: 1013-1020.
    PubMed  |  

  22. Siddiqui, R.A., K.A. Harvey, S.J. Miller and G.P. Zaloga, 2008. Impact of omega-3 and trans fatty acids on vascular remodeling: Opposing roles in cardiovascular health. Curr. Enzyme Inhib., 4: 60-72.
    CrossRef  |  

  23. Siddiqui, R.A., K.A. Harvey and G.P. Zaloga, 2008. Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health. J. Nutr. Biochem., 19: 417-437.
    Direct Link  |  

  24. Siddiqui, R.A., K. Harvey and W. Stillwell, 2008. Anticancer properties of oxidation products of docosahexaenoic acid. Chem. Phys. Lipids, 153: 47-56.
    PubMed  |  

  25. Harvey, K.A., T. Arnold, T. Rasool, C. Antalis, S.J. Miller and R.A. Siddiqui, 2008. Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. Br. J. Nutr., 99: 723-731.
    PubMed  |  

  26. Friedman, A.N., R. Siddiqui and B.A. Watkins, 2008. Acute rise of omega-3 polyunsaturated fatty acids during hemodialysis treatment. J. Renal Nutr., 18: 301-303.
    PubMed  |  

  27. Siddiqui, R.A., S. Hassan, K. Harvey, T. Das, P. Mukerji and S. DeMichele, 2007. Attenuation of muscle loss and proteolysis by curcumin C3 complex in MAC-16 tumor-bearing mice. Proceedings of the 4th Cachexia Conference, December 5-9, 2007, Tampa, FL., USA -.

  28. Siddiqui, R.A., N. Ruzmetov, K. Harvey, T. Arnold, S. Hassan, T. Rasool and C. Antalis, 2007. Trans fatty acids promote Atherosclerotic lesions and induce sudden Cardiac death. Proceedings of the 47th Annual Conference on cardiovascular diseases, February 28-March 3,2007, American heart Association, Orlando, Florida. -.

  29. Siddiqui, R.A., K.A. Harvey, G.P. Zaloga and W. Stillwell, 2007. Modulation of lipid rafts by Ω-3 fatty acids in inflammation and cancer: Implications for use of lipids during nutrition support. Nutr. Clin. Pract., 22: 74-88.
    CrossRef  |  PubMed  |  

  30. Siddiqui, R., N. Ruzmetov, K. Harvey, T. Arnold, C. Antalis and G. Zaloga, 2007. Trans fatty acids promote Atherosclerosis and sudden Cardiac death in experimental models. Proceedings of the 5th EuroFed Lipid Congress, September 16-19, 2007, Gothenburg, Sweden, USA. -.

  31. Harvey, K.A., C.N. Paranavitana, G.P. Zaloga and R.A. Siddiqui, 2007. Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. J. Cell Physiol., 211: 353-363.
    CrossRef  |  PubMed  |  

  32. Antalis, C., K.K. Buhman and R.A. Siddiqui, 2007. Differential expression of ACAT-1 and ACAT-2 in mammary epithelial cells at various stages of transformation. Proceedings of the 2nd Annual Symposium on The Role of Dietary Fatty Acids in the Prevention and treatment of Disease, October 24-26, 2007, Winston-Salem, NC., USA -.

  33. Amtul, Z., C. Follmer, S. Mahboob, Atta-Ur-Rahman and M. Mazhar et al., 2007. Germa-gamma-lactones as novel inhibitors of bacterial urease activity. Biochem. Biophys. Res. Commun., 35: 457-463.
    CrossRef  |  PubMed  |  

  34. Zieger, M.A.J., M. Gupta and R.A. Siddiqui, 2006. Endothelial cell fatty acid unsaturation mediates cold-induced oxidative stress. J. Cell Biochem., 99: 784-796.
    PubMed  |  Direct Link  |  

  35. Zhang, Y., R.A. Siddiqui, G.P. Zaloga, D.A. Ingram and J. Rehman, 2006. Modulation of endothelial progenitor cells by polyunsaturated omega-3 fatty acids. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  36. Zaloga, G.P., N. Ruzmetov, K.A. Harvey, C. Terry, N. Patel, W Stillwell and R. Siddiqui, 2006. (N-3) long-chain polyunsaturated fatty acids prolong survival following myocardial infarction in rats. J. Nutr., 136: 1874-1878.
    PubMed  |  

  37. Zaloga, G.P., K.A. Harvey, W. Stillwell and R. Siddiqui, 2006. Trans fatty acids and coronary heart disease. Nutr. Clin. Pract., 21: 505-512.
    Direct Link  |  

  38. Zaloga, G.P. and R.A. Siddiqui, 2006. A soluble ATP-dependent proteolytic system is responsible for protein degradation. Nutr. Clin. Prac., 21: 88-91.
    CrossRef  |  

  39. Zaloga, G., K. Harvey, W. Stillwell and R. Siddiqui, 2006. Trans fatty acids and coronary heart disease. Nutr. Clin. Pract., 21: 505-512.
    CrossRef  |  

  40. Stillwell, W., S.R. Shaikh, D. Lo Cascio, R.A. Siddiqui, J. Seo, R.S. Chapkin and S.R. Wassall, 2006. Docosahexaenoic Acid: An Important Membrane-Altering Omega-3 Fatty Acid. In: Frontiers in Nutrition Research, Huamg, J.D. (Ed.). Chapter 8. NOVA Science Publishers, New York, USA., pp: 249-271.

  41. Siddiqui, RA., N. Ruzmetov, K. Harvey, W. Stillwell and G. Zaloga, 2006. Omega-3 polyunsaturated fatty acids inprove survival following myocardial infarction and inhibit phenylephrine-induced hypertrophy by regulating protein kinase activities. Proceedings of the 10th International Symposium on Natural Product Chemistry, January 6-9, 2006, Karachi, Pakistan -.

  42. Siddiqui, R.A., N. Ruzmetov, K.A. Harvey, W. Stillwell and G. Zaloga, 2006. Omega-3 polyunsaturated fatty acids improve survival following myocardial infarction and inhibit phenylephrine-induced hypertrophy by regulating protein kinase activities. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  43. Siddiqui, R.A., K.A. Harvey, D. Herera, N. Patel, C. Paranavitana, W. Stillwell and G. Zaloga, 2006. Docosahexaenoic acid and polyphenols synergistically induce apoptosis in breast cancer cells by activating protein phosphatses. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  44. Siddiqui, R.A., K. Harvey, T. Arnold, T. Rasool and C. Antalis, 2006. Trans fatty acids induce Pro-inflammatory responses and Endothelial dysfunction. Proceedings of the 46th Annual Meeting of the American Society of Cell Biology, December 9-13, 2006, San Diego, USA. -.

  45. Siddiqui, R., D. Pandya, K. Harvey and G.P. Zaloga, 2006. Nutrition modulation of cachexia/proteolysis. Nutr. Clin. Pract., 21: 155-167.
    PubMed  |  

  46. Ruzmetov, N., M. Sosa, N. Courtney and R. Siddiqui, 2006. Anesthesia, mechanical ventilation and related complications in rodents. Adequacy of Anesthesia and Modern Technologies in Intensive Therapy, September 7-9, 2006, Samarkand, Uzbekistan. -.

  47. Paranavitana, C., K. Harvey and R.A. Siddiqui, 2006. Omega-3 polyunsatureated fatty acids induce apoptosis in breast cancer cells through activation and translocation of neutral sphingomyelinase-2. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  48. Mesaik, M.A., Zaheer-ul-Haq, S. Murad, Z. Ismail and N.R. Abdullah et al., 2006. Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor. Mol. Immunol., 43: 1855-1863.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Mesaik, M.A., Z.U. Haq, A.R. Rahman, M. Yousaf, R.A. Siddiqui, A. Ahmad and M.I. Choudhary, 2006. Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor. Proceedings of the 10th International Symposium on Natural Product Chemistry, January 6-9, 2006, Karachi, Pakistan -.

  50. Harvey, K.A., C. Paranavitana, G. Zaloga and R.A. Siddiqui, 2006. Rho Kinase activation through diverse receptor-mediated pathways regulates fibroblast differentiation and transformation. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  51. Bush-O'Donnell, J., R.A. Siddiqui and W. Stillwell, 2006. Trans-fats increase proliferation and membrane complexity in A549 human lung carcinoma cells. Proceedings of the Experimental Biology Meeting, April 1-6, 2006, San Francisco, USA -.

  52. Wu, M., K.A. Harvey, N. Ruzmetov, Z. Welch and L. Sech et al., 2005. Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of aneutral sphingomyelinase-mediated pathway. Int. J. Cancer, 117: 340-348.
    PubMed  |  

  53. Wassall, S.R., S.R. Shaikh, M.R. Brzustowicz, V. Cherezov, R.A. Siddiqui, M. Caffrey and W. Stillwell, 2005. Interaction of polyunsaturated fatty acids with cholesterol: A role in lipid raft phase separation. Macromol. Symp., 219: 73-84.
    CrossRef  |  

  54. Stillwell, W., S.R. Shaikh, M. Zerouga, R.A. Siddiqui and S.R. Wassall, 2005. Docosahexaenoic acid affects cell signaling by altering lipid rafts. Rep. Nutr. Dev., 45: 559-579.
    CrossRef  |  

  55. Slivova, V., G. Zaloga, S.J. DeMichele, P. Mukerji and Y.S. Huang et al., 2005. Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells. Nutr. Cancer, 51: 66-73.
    PubMed  |  

  56. Siddiqui, R.A., N. Ruzmetov, K.A. Harvey, M. Zerouga and C. Terry et al., 2005. Omega-3 fatty acids inhibit PKA and CaMKII activities and improve survival following myocardial infarction. Proceedings of the 2nd Annual Symposium of America Heart association-Targeting Heart Failure: New Science, New Tools, New Strategies, July 24-27, 2005, Keystone, Colorado -.

  57. Siddiqui, R.A., M. Zerouga, M. Wu, A. Castillo, K. Harvey, G.P. Zaloga and W. Stillwell, 2005. Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells. Breast Cancer Res., 7: R645-R645.
    CrossRef  |  

  58. Mesaik, M.A., K.M. Khan, Z. Ullah, S. Rahat and M.I. Choudhary et al., 2005. Immunomodulatory properties of synthetic imidazolone derivatives. Lett. Drug Design Discovery, 2: 490-496.
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  59. Castillo, A., N. Ruzmetov, K. Harvey, W. Stillwell, G. Zaloga and R. Siddiqui, 2005. Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes. J. Mol. Gene. Med., 1: 18-25.
    Direct Link  |  

  60. Zaloga, G.P., R. Siddiqui, C. Terry and P.E. Marik, 2004. Arginine: Mediator or modulator of sepsis? Nutr. Clin. Pract., 19: 201-215.
    CrossRef  |  PubMed  |  

  61. Zaloga, G.P. and R.A. Siddiqui, 2004. Biologically active detary peptides. Mini-Rev. Med. Chem., 4: 815-821.
    PubMed  |  

  62. Siddiqui, R.A., S.R. Shaikh, W. Stillwell and G.P. Zaloga, 2004. Inhibition of phenylephrin-induced cardiac hypertrophy by docosahexaenoic acid. J. Cell. Biochem., 92: 1141-1159.
    CrossRef  |  

  63. Siddiqui, R.A., S.R. Shaikh, R. Kovacs, W. Stillwell and G. Zaloga, 2004. Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid. Proceedings of the 6th Congress of the International Society for the Study of Fatty Acids and Lipids, June 27-July 1, 2004, Brighton, UK -.

  64. Siddiqui, R.A., S.R. Shaikh, L.A. Sech, H.R. Yount, W. Stillwell and G.P. Zaloga, 2004. Omega 3- fatty acids: Health benefits and cellular mechanism of action. Mini-Rev. Med. Chem., 4: 859-871.
    PubMed  |  

  65. Siddiqui, R.A., M. Zerouga, M. Wu, A. Castillo, G.P. Zaloga and W. Stillwell, 2004. Novel conjugates, docosahexaenoyl-Propofol and eicosapentaenoyl (EPA)-Propofol, inhibit metastasis and induce apoptosis in breast cancer cells. Proceedings of the Annual Meeting of the 95th American Association for Cancer Research, March 27-31, 2004, Orlando, Florida, pp: 884-884.

  66. Shaikh, S.R., R.A. Siddiqui, D. LoCascio, W. Stillwell and S.R. Wassall, 2004. A role for docosahexaenoic acid-containing phosphatidylethanolamine in lipid raft phase separations. Biophys. J., 87: 1752-1766.
    CrossRef  |  Direct Link  |  

  67. Shaikh, S.R., R. Siddiqui, V. Cherezov, M. Caffrey, D. LoCascio, S.R. Wassall and W. Stillwell, 2004. Polyunsaturation and lipid rafts: Implications for cellular signaling. Proceedings of the Keystone Symposium on Molecular Cell Biology of Lipid Domains, March 26-31, 2004, Vancouver, Canada -.

  68. Shaikh, S.R., A. Dumaual, S.R. Wassall, V. Cherezov, M. Caffrey, R. Siddiqui and W. Stillwell, 2004. Docosahexaenoic and oleic acid differentially phase separate from lipid rafts in model membranes and cells. Proceedings of the 36th Central Regional Meeting of the American Chemical Society, June 2-4, 2004, Indianapolis, IN., USA -.

  69. Jackson, K.R., R. Siddiqui, S.R. Shaikh and W. Stillwell, 2004. Synthesis and characterization of novel fatty acid conjugated anti-cancer agents. Proceedings of the 36th Central Regional Meeting of the American Chemical Society, June 2-4, 2004, Indianapolis, IN., USA -.

  70. Jackson, K., R.A. Siddiqui and W. Stillwell, 2004. Development and characterization of a novel anticancer agent using a polyunsaturated fatty acid conjugated to a commonly utilized anesthetic. Proceedings of the 39th Annual Southeastern Regional Lipid Conference, November 6-8, 2004, Cashiers, NC., USA -.

  71. Dumaual, A., R. Siddiqui and W. Stillwell, 2004. Docosahexaenoic Acid (DHA)-induced lateral phase separation in sphingomyelin-rich, cholesterol-rich planar lipid bilayers as visualized by Atomic Force Microscopy (AFM). Proceedings of the 36th Central Regional Meeting of the American Chemical Society, June 2-4, 2004, Indianapolis, IN., USA -.

  72. Bush, J., K. Hypes, L. Jenski, R.A. Siddiqui and W. Stillwell, 2004. DHA inhibits TRAIL-mediated apoptosis in H460 human lung cancer cells. Proceedings of the 39th Annual Southeastern Regional Lipid Conference, November 6-8, 2004, Cashiers, NC., USA -.

  73. Siddiqui, R.A., L.J. Jenski, K. Harvey, J. Wiesehan, W. Stillwell and G. Zaloga, 2003. Cell cycle arrest in Jurkat leukemic cells: A possible role for dososahexaenoic acid. Biochem. J., 371: 621-629.
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  74. Shaikh, S.R., R.A. Siddiqui, M. Wu, A. Castillo, S.R. Wassall, A. Dumaual and W. Stillwell, 2003. A role of docosahexaenoic acid in phase separation from lipid rafts: Implications for cellular signaling. Proceedings of the 38th Annual Southeastern Regional Lipid Conference, November 12-14, 2003, Cashiers, North Carolina -.

  75. Shaikh, S.R., A.C. Dumaual, D. LoCascio, R.A. Siddiqui and W. Stillwell, 2003. Acylchain unsaturation in PEs modulates phase separation in from lipid raft molecules. Biochim. Biophys. Res. Comm., 311: 793-796.
    CrossRef  |  PubMed  |  

  76. Jackson, K., R.A. Siddiqui, S.R. Shaikh, A. Castillo, M. Zeruga and W. Stillwell, 2003. The Mediterranean Diet: A molecular study. Proceedings of the 38th Annual Southeastern Regional Lipid Conference, November 12-14, 2003, Cashiers, North Carolina -.

  77. Vasquez, C., R.A. Siddiqui, A.P. Moreno and E.J. Berbari, 2002. A fibroblast-myocyte odel which accounts for slow conductance and fractionated electrogram in Infarct border zones. Comput. Cardiol., 29: 245-248.
    Direct Link  |  

  78. Siddiqui, R.A., M. Hunter, G. Zaloga and W. Stillwell, 2002. Docosahexaenoic acid prevents phenylephrine-induced cardiac hypertrophy through Ras-Raf-MAP kinase pathway. Proceedings of the 5th Congress of the International Society for the Study of Fatty Acids and Lipids, May 7-11, 2002, Montreal, Canada -.

  79. Siddiqui, R.A., L.J. Jenski, K.A. Harvey, J.D. Weisehan, W. Stillwell and G.P. Zaloga, 2002. Docosahexaenoic acid induces cell cycle arrest by inhibiting phosphorylation of retinoblastoma protein in Jurkat leukemic cells. Proceedings of the 37th Annual Southeastern Regional Lipid Conference, November 6-8, 2002, Cashiers, North Carolina -.

  80. Siddiqui, R.A., J.D. Wiesehan, H. Hunter, K. Harvey, G. Zaloga and W. Stillwell, 2002. Docosahexaenoic acid induces cell cycle arrest via hypophosphorylation of human retinoblastoma protein in Jurkat leukemic cells. Proceedings of the 5th Congress of the International Society for the Study of Fatty Acids and Lipids, May 7-11, 2002, Montreal, Canada -.

  81. Shaikh, S.R., R.A. Siddiqui, S. Wassall and W. Stillwell, 2002. Fish oils, membranes and eternal life. Proceedings of the 37th Annual Southeastern Regional Lipid Conference, November 6-8, 2002, Cashiers, North Carolina -.

  82. Harvey, K., R.A. Siddiqui, D. Sliva, J.G.N. Garcia and D. English, 2002. Serum factors involved in human microvascular endothelial cell morphogenesis. J. Lab. Clin. Med., 140: 188-198.
    CrossRef  |  PubMed  |  

  83. Amtul, Z., A.U. Rahman, R.A. Siddiqui and M.I. Choudhary, 2002. Chemistry and mechanism of urease inhibition. Curr. Med. Chem., 9: 1323-1348.
    CrossRef  |  PubMed  |  Direct Link  |  

  84. Xio, H., R.A. Siddiqui, M.A. Al-Hassani, D. Sliva and R.J. Kovacs, 2001. Phospholipids released from activated platelets improve platelet aggregation and endothelial cell migration. Platelets, 12: 163-170.
    PubMed  |  

  85. Siddiqui, R.A., L.J. Jenski, J.D. Wiesehan, M.V. Hunter, R.J. Kovacs and W. Stillwell, 2001. Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. Biochem. Biophys. Acta., 1541: 188-200.
    PubMed  |  

  86. Siddiqui, R.A., L. Jenski, K. Neff., K. Harvey, R.J. Kovacs and W. Stillwell, 2001. Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process. Biochem Biophys Acta, 1499: 265-275.
    CrossRef  |  

  87. Siddiqui, R.A., J.D. Wiesehan, M. Slimko, W. Stillwell, L.J. Jenski and R.J. Kovacs, 2001. Phosphatidic acid prevents the cytotoxic effects of docosahexaenoic acid in Jurkat leukemic cells. Proceedings of the 34th International Congress of Physiological Sciences, August 26-31, 2001, Christchurch, New Zealand -.

  88. Siddiqui, R.A., J. Weisehan, L. Jenski, W. Stillwell and R. Kovacs, 2001. Induction of cell cycle arrest and apoptosis by docosahexaenoic acid in serum in Jurkat cells. Proceedings of the 34th International Congress of Physiological Sciences, August 26-31, 2001, Christchurch, New Zealand -.

  89. Siddiqui, R.A., D. Burtschi and R. Kovacs, 2000. Phosphatidic acid induces calcium influx in neutrophils via verapamil-sensitive calcium channels. J. Cellular Biochem., 78: 297-304.
    PubMed  |  

  90. Siddiqui, R.A., C.A. Labarrere and R.J. Kovacs, 2000. Prevention of cardiac hypertrophy with omega 3-fatty acids: Potential cell signaling targets. Curr Org. Chem., 4: 1145-1156.
    CrossRef  |  

  91. Siddiqui, R.A. and D. English, 2000. Phosphatidylinosityol 3-kinase is involved in phosphatidic acid-induced neutrophil chemotaxis. Biochem. Biophys. Acta, 1483: 161-173.

  92. Siddiqui, R.A., L.P. Akard, J.G.N. Garcia, Y. Cui and D. English, 1999. Chemotactic migration triggers interleukin-8 generation in neutrophilic leukocytes. J. Immunol., 162: 1077-1083.

  93. Harvey, K.A., R.A. Siddiqui, M. Reeves, T. Kovala, M. Dugan, P. Akard and D. English, 1999. Characterization and partial purification of CD34+ progenitor cell ecto-phosphatidic acid phosphohydrolase. Biochem. Mol. Biol. Int., 47: 9-23.
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  94. Garcia, J.G.N., A. Verin, K. Schaphosrt, R.A. Siddiqui, C.E. Patterson, C. Csortos and V. Natarajan, 1999. Regulation of endothelial cell myosin light chain kinase by Rho, cortactin and p60src. Am. J. Physiol., 276: L989-L998.

  95. English, D., T. Kovala, Z. Welch, K. Harvey, R.A. Siddiqui, D.N. Brindley and J.G.N. Garcia, 1999. Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. J. Hematothr. Stem cell Res., 8: 627-634.
    PubMed  |  Direct Link  |  

  96. English, D., C. Yi, R.A. Siddiqui, C. Patterson, V. Natarajan, D. Brindley and J.G.N. Garcia, 1999. Induction of endothelial monolayer permeability by phosphatidate. J. Cell. Biochem., 75: 105-117.
    PubMed  |  Direct Link  |  

  97. Bentz, M., K. Harvey, D. Butrschi, D. English and R.A. Siddiqui, 1999. Induction of neutrophil calcium mobilization by phospjatidic acid-enriched plasma membranes. IUBMB-Life, 48: 1-7.

  98. Song, A., X.L. Xia, R.A. Siddiqui and M.A. Harrington, 1998. PLA2-independent induction of CSF-1 gene expression in growth-arrested fibroblasts. Int. J. Hematol., 67: 249-256.
    PubMed  |  Direct Link  |  

  99. Siddiqui, R.A. and D. English, 1997. Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: A mechanism for induction of chemotaxis. Biochem. Biophys. Acta (BBA)-Lipids Lipid Metab., 1349: 82-95.
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  100. Reeves, M.I., R.A. Siddiqui and D. English, 1997. Role of phosphatidic acid in neutrophil cellular signalling. ISBBP Symp. Biochem. Biophys., 2: 147-156.

  101. Harvey, K., R.A. Siddiqui and D. English, 1997. Up regulation of CD11b adhesion molecules to neutrophil plasma membranes by phosphatidic acid. ISBBP Symp. Biochem. Biophys., 2: 205-209.

  102. English, D., M. Martin, K. Harvey, L.P. Akard and R. Allen et al., 1997. Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase. Biochem. J., 324: 941-950.
    Direct Link  |  

  103. Cui, Y., D.K. English, R.A. Siddiqui, M. Herenyiova and G.N. Garcia, 1997. Activation of endothelial cell phospholipase D by migrating neutrophils. J. Invest. Med., 45: 388-393.
    PubMed  |  

  104. Siddiqui, R.A. and D. English, 1996. Phosphatidic acid binding to human neutrophils: Effects on tyrosine kinase-regulated intracellular Ca2+ mobilization. Cell. Signalling, 8: 349-354.
    CrossRef  |  

  105. Jin, N., R.A. Siddiqui, D. English and R.A. Rhoads, 1996. Communication between tyrosine kinase pathway and myosin light chain kinase pathway in smooth muscle. Am. J. Physiol., 271: H1348-H1355.
    Direct Link  |  

  106. Harvey, K.A., R.A. Siddiqui, J. Jansen, L.P. Akard and J.M. Thompson et al., 1996. Growth factor induction of cytosolic protein tyrosine kinase activity in human haemopoietic progenitor cells isolated by flow cytometry. Br. J. Haemotol., 93: 515-521.
    PubMed  |  

  107. English, D., Y. Cui and R.A. Siddiqui, 1996. Messenger functions of phosphatidic acid. Chem. Phy. Lipids, 80: 117-132.
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  108. Cui, Y., K. Harvey, R.A. Siddiqui, J. Jansen and L. Akard et al., 1996. Cytosolic inactivation of translocated neutrophil plasma membrane protein tyrosine phosphatase. Blood, 87: 341-349.
    Direct Link  |  

  109. Siddiqui, R.A., D. English, Y. Cui, M. Martin and J. Wentland et al., 1995. Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts. J. Leukocyte Biol., 257: 187-194.
    PubMed  |  

  110. Siddiqui, R.A., D. English and J.G.N. Garcia, 1995. Rationale for juxtacrine regulation of neutrophil interactions with the stimulated endothelium. J. Lab. Clin. Med., 125: 18-25.
    PubMed  |  Direct Link  |  

  111. Siddiqui, R.A. and Y.C. Yang, 1995. Interleukin-11 induces phosphatidic Acid formation and activates MAP kinase in mouse 3T3-L1 cells. Cell. Signalling, 7: 247-259.
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  112. Siddiqui, R. and D. English, 1995. Neutrophil calcium mobilization is stimulated by phosphatidic acid: A receptor driven process. Proceedings of the 9th International Conference on Second Messengers and Phosphopoteins, October 27-November 1, 1995, Nashville, TN -.

  113. Rizzo, M.T., S.H. Boswell, R. Siddiqui, C. Carlo-Stella and V. Rizzoli, 1995. Transcriptional activation of c-jun by arachidonic acid is mediated by a protein tyrosine kinase cascade involving activation of c-jun kinase. Proceedings of the 9th International Conference on Second Messengers and Phosphoproteins, October 27-November 1, 1995, Nashville, TN -.

  114. Siddiqui, R.A., J.G.N. Garcia, M. Martin, J. Wentland, L. Akard, J. Thompson and D. English, 1994. Role of diacylglycerol and phosphatidic acid in superoxide release and protein tyrosine phosphorylation in neutrophils. Proceedings of the 30th National Meeting, Society of Leukocyte Biology, September 21-24, 1994, Tucson, Arizona -.

  115. Harvey, K., Y. Cui, L. Akard, J. Jansen, R. Ash, R.A. Siddiqui and D. English, 1994. Cytokine-Stimulated Up-Regulation of Protein Tyrosine Phosphatase in Neutrophils. In: Progress in Clinical and Biological Research, Worthington-Shite, D., A. Gee and S. Gross (Eds.). Wiley-Liss and Co., New York, USA., pp: 257-260.

  116. Cui, Y., K. Harvey, L. Akard, J. Jansen, C. Hughes, R.A. Siddiqui and D. English, 1994. Regulation of neutrophil responses by phosphotyrosine phosphatase. J. Immunol., 152: 5420-5428.
    Direct Link  |  

  117. Cui, Y., D. English, S. Neel, K. Harvey and R. Siddiqui et al., 1994. Parallel up-regulation of CD11B and CD45 on neutrophilic leukocytes exposed to soluble factors of oral pathogens. Biochem. Mol. Biol. Int., 33: 45-54.
    PubMed  |  Direct Link  |  

  118. Siddiqui, R.A., S.N. McCutcheon, H.T. Blair, D.D. Mackenzie, P.C. Morel, B.H. Breier and P.D. Gluckman, 1992. Growth allometry of organs, muscles and bones in mice from lines divergently selected on the basis of plasma insulin-like growth factor-I. Growth Dev. Aging., 56: 53-60.
    PubMed  |  Direct Link  |  

  119. Siddiqui, R.A. and J.H. Exton, 1992. Phospholipid base exchange activity in rat liver plasma membranes. Evidence for regulation by G-protein and P2y-purinergic receptor. J. Biol. Chem., 267: 5755-5761.
    Direct Link  |  

  120. Siddiqui, R.A. and J.H. Exton, 1992. Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase. Eur. J. Biochem., 210: 601-607.
    CrossRef  |  

  121. Williams, J.F. and R.A. Siddiqui, 1990. Biochemistry of cancer cachexia: Review of results, a new hypothesis and a proposal for treatment. Med. Sci. Res., 18: 3-10.

  122. Siddiqui, R.A., H.T. Blair, S.N. McCutcheon, D.D.S. Mackenzie, P.D. Gluckman and B.H. Breier, 1990. Developmental patterns of plasma insulin-like growth factor-I (IGF-I) and body growth in mice from lines divergently selected on the basis of plasma IGF-I. J. Endocrinol., 124: 151-158.
    CrossRef  |  PubMed  |  

  123. Siddiqui, R.A. and J.F. Williams, 1990. Tentative identification of the toxohormones of cancer cachexia: Roles of vasopressin, prostaglandin E2 and cachectin-TNF. Biochem. Int., 20: 787-797.
    PubMed  |  

  124. Williams, J.F. and R.A. Siddiqui, 1989. Cancer cachexia: A hypothesis revisited and a proposal for treatment. Cancer Forum, 13: 87-97.

  125. Siddiqui, R.A., S.N. McCutcheon, D.D.S. Mackenzie, H.T. Blair, J.E. Ormsby, P.D. Gluckman and B.H. Breier, 1989. Role of testosterone in regulating the growth of mice from lines selected for low vs high plasma insulin-like growth factor-I concentrations. Acta Endocrinol., 121: 686-690.
    CrossRef  |  

  126. Siddiqui, R.A. and J.F. Williams, 1989. The regulation of fatty acid and branched-chain amino acid oxidation in cancer cachectic rats: A proposed role for a cytokine, eicosanoid and hormone trilogy. Biochem. Med. Metab. Biol., 42: 71-86.
    CrossRef  |  

  127. O'Sullivan, U., P.D. Gluckman, B.H. Breier, S. Woodall, R.A. Siddiqui and S.N. McCutcheon, 1989. Insulin-like Growth Factor-1 (IGF-1) in mice reduces weight loss during starvation. Endocrinology, 125: 2793-2794.
    CrossRef  |  

  128. McCutcheon, S.N., H.T. Blair, R.A. Siddiqui, D.D.S. Mackenzie, B.H. Breier and P.D. Gluckman, 1989. Prediction of genetic merit for productivity based on metabolic characteristics during the growth period. Proceedings of the 7th International Conference on Production Disease in Farm Animals, July 25-27, 1989, Cornell University, New York, pp: 38-40.

  129. Kroonsberg, C., S.N. McCutcheon, R.A. Siddiqui, D.D.S. Mackenzie and H.T. Blair et al., 1989. Reproductive performance and fetal growth in female mice from lines divergently selected on the basis of plasma IGF-1 concentrations. J. Reprod. Fertil., 87: 349-353.
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  130. Siddiqui, R.A., 1988. An enquiry into the metabolic basis of cancer cachexia using Walker 256 carcinosarcoma. Ph.D. Thesis, Australian National University, Canberra, Australia..

  131. Blair, H.T., S.N. McCutcheon, D.D.S. Mackenzie, J.E. Ormsby, R.A. Siddiqui, P.D. Gluckman and B.H. Breier, 1988. Genetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth. Endocrinology, 123: 1690-1692.
    CrossRef  |  

  132. Siddiqui, R.A. and J.F. Williams, 1987. Interaction of vasopressin and prostaglandin E2 in the development of cancer cachexia. Med. Sci. Res., 15: 45-46.

  133. Siddiqui, R.A., J.H. Darakshan and H.A. Haleem, 1983. Effect of drugs on the distribution of tryptophan in plasma, liver and brain in a desert lizard. Pak. J. Biochem., 16: 1-5.

  134. Siddiqui, R.A., 1980. Effects of drugs on tryptophan-protein binding. M.Sc. Thesis, University of Karachi, Karachi, Pakistan..