Dr. Howard Grant Shertzer
My Social Links

Dr. Howard Grant Shertzer

Professor
University of Cincinnati Medical Center, USA

Highest Degree
Ph.D. in Cell Biology from University of California, USA

Share this Profile

Area of Interest:

Molecular Sciences
100%
Oxidative Stress
62%
Inflammation
90%
Obesity
75%
Fatty Liver Disease
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tobia, C.M., H.G. Shertzer and K.J. Pearson, 2013. Dietary whey protein protects mice from high fat diet-induced liver damage. Lipids Health Dis. .
  2. Shertzer, H.G., M. Krishan and M.B. Genter, 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci. Lett., 548: 159-164.
    CrossRef  |  PubMed  |  
  3. Krishan, M., H.G. Shertzer and M.B. Genter, 2013. Enhanced delivery of intranasally administered gemcitabine to the central nervous system. Fund. Clin. Pharmacol. .
  4. Dong, H., H.G. Shertzer, M.B. Genter, F.J. Gonzalez and V. Vasiliou et al., 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem. Biophys. Res. Commun., 435: 727-732.
    CrossRef  |  PubMed  |  
  5. Chen, Y., H. Dong, D.C. Thompson, H.G. Shertzer, D.W. Nebert and V. Vasiliou, 2013. Glutathione defense mechanism in liver injury: Insights from animal models. Food Chem. Toxicol., 60: 38-44.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Woods, S.E., M.B. Genter and H.G. Shertzer, 2012. A comparison of the effectiveness of metformin and acetaminophen in preventing olanzapine toxicity in mice. Pharmacologia, 3: 233-238.
    Direct Link  |  
  7. Thompson, C.M., D.M. Proctor, M. Suh, L.C. Haws and C.D. Hebert et al., 2012. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Toxicol. Sci., 125: 79-90.
    CrossRef  |  PubMed  |  
  8. Genter, M.B., N.C. Newman, H.G. Shertzer, B. Bolon and S.F. Ali, 2012. Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice. Toxicol. Pathol., 40: 1004-1013.
    PubMed  |  
  9. Chen, Y., M. Krishan, D.W. Nebert, H.G. Shertzer, 2012. Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. Chem. Res. Toxicol., 25: 94-100.
    CrossRef  |  PubMed  |  
  10. Thompson, C.M., D.M. Proctor, L.C. Haws, C. Hebert and S. Grimes et al., 2011. The oral toxicity of hexavalent chromium in B6C3F1 mice: A potential role of oxidative stress in intestinal cytotoxicity. Toxicol. Sci. .
  11. Shertzer, H.G., S.E. Woods, M. Krishan, M.B. Genter and K.J. Pearson, 2011. Dietary whey protein prevents high fat diet-induced changes in energy balance in mice. J. Nutr., 141: 1-6.
  12. Kendig, E.L., Y. Chen, M. Krishan, E. Johansson and S.N. Schneider et al., 2011. Lipid metabolism and body composition in Gclm(-/-) mice. Toxicol. Applied Pharmacol., 257: 338-348.
    CrossRef  |  PubMed  |  
  13. Shertzer, H.G., E.L. Kendig, H.A. Nasrallah, E. Johansson and M.B. Genter, 2010. Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole. Int. J. Obesity, 34: 970-979.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Shertzer, H.G., 2010. Protective effects of the antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole against TCDD toxicity in C57BL/6J mice. Int. J. Toxicol., 29: 40-48.
    CrossRef  |  PubMed  |  
  15. Peng, Z., E. Geh, L. Chen, Q. Meng and Y. Fan et al., 2010. IkB kinase β regulates redox homeostasis by controlling the constitutive levels of glutathione. Mol. Pharmacol., 77: 784-792.
  16. Johansson, E., S.C. Wesselkamper, H.G. Shertzer, G.D. Leikauf, D.W. Nebert, T.P. Dalton and Y. Chen, 2010. Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury. Biochem. Biophys. Res. Commun., 396: 407-412.
    CrossRef  |  PubMed  |  
  17. Chen, Y., Y. Yang, M.L. Miller, D.X. Shen and E. Johansson et al., 2010. N-Acetylcysteine-treated hepatocyte-specific Gclc knockout mice: Progression from steatosis to hepatic cirrhosis. J. Hepatol. .
  18. Shertzer, H.G., S.N. Schneider, E.L. Kendig, D.J. Clegg, D.A. D'Alessio, E. Johansson and M.B. Genter, 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chem. Biol. Interact., 177: 71-80.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Eismann, T., N. Huber, T. Shin, S. Kuboki and E. Galloway et al., 2009. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 296: G266-G274.
    PubMed  |  
  20. Dong, H., T.P. Dalton, M.L. Miller, Y. Chen and S. Bansal et al., 2009. Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: Differing responses to dietary benzo[a]pyrene as proof of principle. Mol. Pharm., 75: 555-567.
    CrossRef  |  PubMed  |  
  21. Chen, Y., E. Johansson, Y. Fan, H.G. Shertzer, V. Vasiliou, D.W. Nebert and T.P. Dalton, 2009. Early onset senescence occurs when fibroblasts lack glutamate cysteine ligase modifier subunit. Free Radic. Biol. Med., 47: 410-418.
    CrossRef  |  PubMed  |  
  22. Shertzer, H.G., S.N. Schneider, E.L. Kendig, D.J. Clegg, D.A. D'Alessio and M.B. Genter, 2008. Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. Biochem. Pharmacol., 75: 1402-1410.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Kendig, E.L., S.N. Schneider, D.J. Clegg, M.B. Genter and H.G. Shertzer, 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochem. Pharmacol., 76: 216-224.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Yang, Y., Y. Chen, E. Johansson, S.N. Schneider, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2007. Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. Biochem. Pharmacol., 74: 372-381.
    PubMed  |  
  25. Shertzer, H.G., M.B. Genter, G. Talaska, C.P. Curran, D.W. Nebert and T.P. Dalton, 2007. 7H-Dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28: 1371-1378.
    PubMed  |  
  26. Peng, Z., L. Peng, Y. Fan, E. Zandi, H.G. Shertzer and Y. Xia, 2007. A critical role for IκKβ in metallothionein-1 expression and protection against arsenic toxicity. J. Biol. Chem., 282: 21487-21496.
  27. Chen, Y., Y. Yang, M.L. Miller, D.X. Shen and H.G. Shertzer et al., 2007. Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology, 45: 1118-1128.
    CrossRef  |  PubMed  |  
  28. Uno, S., T.P. Dalton, N. Dragin, C.P. Curran and S. Derkenne et al., 2006. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol. Pharmacol., 69: 1103-1114.
    PubMed  |  
  29. Shertzer, H.G., M.B. Genter, D.X. Shen, D.W. Nebert, Y. Chen and T.P. Dalton, 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F0F1-ATP synthase and ubiquinone. Toxicol. Appllied Pharmacol., 217: 363-374.
  30. Genter, M.B., C.D. Clay, T.P. Dalton, H.B. Dong, D.W. Nebert and H.G. Shertzer, 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochem. Biophys. Res. Commun., 342: 1375-1381.
    PubMed  |  
  31. Dragin, N., T.P. Dalton, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2006. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J. Biol. Chem., 281: 18591-18600.
    PubMed  |  
  32. Curran, C.P., K.A. Miller, T.P. Dalton, C.V. Vorhees, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol. Sci., 89: 454-464.
    PubMed  |  
  33. Shen, D.X., T.P. Dalton, D.W. Nebert and H.G. Shertzer, 2005. Glutathione redox state regulates mitochondrial reactive oxygen production. J. Biol. Chem., 280: 25305-25312.
    PubMed  |  
  34. Reichard, J.F., T.P. Dalton, H.G. Shertzer and A. Puga, 2005. Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-Response, 3: 306-331.
    CrossRef  |  PubMed  |  
  35. Kann, S., C. Estes, J.F. Reichard, M.Y. Huang and M.A. Sartor et al., 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol. Sci., 87: 365-384.
    PubMed  |  
  36. Kadekaro, A.L., H. Kanto, R. Kavanagh, S. Schwemberger and J. Cornelius et al., 2005. α-Melanocortin and endothelin-1 promote the survival of human melanocytes by activating anti-apoptotic pathways and enhancing the repair of DNA photoproducts. Cancer Res., 65: 4292-4299.
    CrossRef  |  Direct Link  |  
  37. Jiang, Z., T.P. Dalton, L. Jin, B. Wang and Y. Tsuneoka et al., 2005. Toward the evaluation of function in genetic variability: Characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum. Mutat., 25: 196-206.
    PubMed  |  
  38. Deshmukh, H.S., L.M. Case, S.C. Wesselkamper, M.T. Borchers and L.D. Martin et al., 2005. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am. J. Respir. Crit. Care Med., 171: 305-314.
    CrossRef  |  Direct Link  |  
  39. Chen, Y., H.G. Shertzer, S.N. Schneider, D.W. Nebert and T.P. Dalton, 2005. Glutamate cysteine ligase catalysis: Dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J. Biol. Chem., 280: 33766-33774.
    PubMed  |  
  40. Uno, S., T.P. Dalton, S. Derkenne, C.P. Curran, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2004. Oral exposure to benzo[a]pyrene in the mouse: Detoxication by inducible cytochrome P450 is more important than metabolic activation. Mol. Pharmacol., 65: 1225-1237.
    PubMed  |  
  41. Uno, S., T.P. Dalton, P. Sinclair, N. Gorman and B. Wang et al., 2004. Cyp1a1(-/-) male mice: Protection against high-dose TCDD-induced lethality and wasting syndrome and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol. Applied Pharmacol., 196: 410-421.
    PubMed  |  
  42. Uno, S., B. Wang, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2004. Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. Biochem. Biophys. Res. Commun., 312: 494-499.
    PubMed  |  
  43. Shertzer, H.G., C.D. Clay, M.B. Genter, S.N. Schneider, D.W. Nebert and T.P. Dalton, 2004. CYP1A2 protects against reactive oxygen production in mouse liver microsomes. Free Radic. Biol. Med., 36: 605-617.
    PubMed  |  
  44. Shertzer, H.G., C.D. Clay, M.B. Genter, M.C. Chames and S.N. Schneider et al., 2004. Uncoupling-Mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free Radic. Biol. Med., 36: 618-631.
    PubMed  |  
  45. Derkenne, S., C.P. Curran, T.P. Dalton, H.G. Shertzer and D.W. Nebert, 2004. Theophylline pharmacokinetics: Comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene and Cyp1 (+/+) wild-type mice. Pharmacogenet. Genomics, 15: 503-511.
    PubMed  |  
  46. Dalton, T.P., Y. Chen, S.N. Schneider, D.W. Nebert and H.G. Shertzer, 2004. Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radical Biol. Med., 37: 1511-1526.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Yang, Y., M.Z. Dieter, Y. Chen, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2003. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J. Biol. Chem., 277: 49446-49452.
    PubMed  |  
  48. Tsuneoka, Y., T.P. Dalton, M.L. Miller, C.D. Clay, H.G. Shertzer, G. Talaska and D.W. Nebert, 2003. 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. J. Natl. Cancer Inst., 95: 1227-1237.
    PubMed  |  
  49. Shertzer, H.G. and D.W. Nebert, 2003. A Toxicological Perspective on Catastrophic Injury: Environmental Arsenic. In: The Catastrophic Injury Handbook, Anchor, K.N., J.E. Shmerling and J.M. Anchor (Eds.). Chapter 23, Kendall/Hunt Publishers, Dubuque, IA., USA., pp: 280-288.
  50. Roberts, R.A., J.I. Goodman, H.G. Shertzer, T.P. Dalton and W.H. Farland, 2003. Rodent toxicity and nongenotoxic carcinogenesis: Knowledge-based human risk assessment based on molecular mechanisms. Toxicol. Mech. Methods, 13: 21-29.
    CrossRef  |  PubMed  |  
  51. Dieter, M.Z., S.L. Freshwater, H.G. Shertzer, M. Miller, T.P. Dalton and D.W. Nebert, 2003. Pharmacological rescue of the 14CoS/14CoS mouse: Hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radic. Biol. Med., 35: 351-367.
    PubMed  |  
  52. Dalton, T.P., L. He, H.G. Shertzer and A. Puga, 2003. Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase-1. In: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, Torres, M., J. Fukuto and H.J. Forman (Eds.). Chapter 18, Kluwer Press, Amsterdam, Netherlands, pp: 333-364.
  53. D'Souza, V.M., H.G. Shertzer, D.J. Buckley, S.P. Yadav, A.R. Buckley and G.M. Pauletti, 2003. Glucose-mediated regulation of intestinal PepT-1 in the Caco-2 cell culture model. AAPS Pharm. Sci., 5: 247-255.
  54. Burman, D.M., H.G. Shertzer, A.P. Senft, T.P. Dalton and M.B. Genter, 2003. Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats. Biochem. Pharmacol., 66: 1707-1715.
    PubMed  |  
  55. Solis, W.A., T.P. Dalton, M.Z. Dieter, S. Freshwater and J.M. Harrer et al., 2002. Glutamate-cysteine ligase modifier subunit: Mouse Gclm gene structure and regulation by agents that cause oxidative stress. Biochem. Pharmacol., 63: 1739-1754.
    PubMed  |  
  56. Shertzer, H.G., T.P. Dalton, G. Talaska and D.W. Nebert, 2002. 4-Aminobiphenyl-induced methemoglobinemia: Protection by cytochrome P450 1A2 (CYP1A2). Toxicol. Appl. Pharmacol., 181: 32-37.
  57. Senft, A.P., T.P. Dalton, D.W. Nebert, M.B. Genter, R.J. Hutchinson and H.G. Shertzer, 2002. Dioxin increases reactive oxygen production in mouse liver mitochondria. Toxicol. Appl. Pharmacol., 178: 15-21.
    PubMed  |  
  58. Senft, A.P., T.P. Dalton, D.W. Nebert, M.B. Genter and A. Puga et al., 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radic. Biol. Med., 33: 1268-1278.
    PubMed  |  
  59. Dalton, T.P., A. Puga and H.G. Shertzer, 2002. Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chem. Biol. Interact., 141: 77-95.
    CrossRef  |  PubMed  |  Direct Link  |  
  60. Uno, S., T.P. Dalton, H.G. Shertzer, M.B. Genter, D. Warshawski, G. Talaska and D.W. Nebert, 2001. Benzo[a]pyrene-induced toxicity: Paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochem. Biophys. Res. Commun., 289: 1049-1056.
    PubMed  |  
  61. Shertzer, H.G., D.W. Nebert, A.P. Senft, M. Dingeldein, M.B. Genter and T.P. Dalton, 2001. A spectrophotometric assay for acetanilide 4-hydroxylase, an estimate for CYP1A2 enzyme activity. Toxicol. Methods, 11: 81-88.
  62. Shertzer, H.G., 2001. Organic Sulfur Compounds. In: Patty's Toxicology, Bingham, E., B. Cohrssen and C.H. Powell (Eds.). 5th Edn., Vol. 7, Chapter 94, John Wiley and Sons, Inc., New York, USA., pp: 681-765.
  63. Dumaswala, U.J., L. Zhuo, S. Mahajan, P.N.M. Nair, H.G. Shertzer, P. Dibello and D.W. Jacobsen, 2001. Glutathione protects chemokine scavenging and antioxidative defense functions in human red blood cells. Am. J. Physiol. Cell Physiol., 280: C867-C873.
    PubMed  |  
  64. Dalton, T.P., J.K. Kerzee, B. Wang, M. Miller and M.Z. Dieter et al., 2001. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovasc. Toxicol., 1: 285-298.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Shertzer, H.G. and A.P. Senft, 2000. The micronutrient indole-3-carbinol: Implications for disease and chemoprevention. Drug Metabol. Drug Interact., 17: 159-188.
    PubMed  |