Dr. Mohammed Ibrahim El Said Ali El-Gamal

Dr. Mohammed Ibrahim El Said Ali El-Gamal

Lecturer
University of Sharjah, UAE


Highest Degree
Ph.D. in Medicinal Chemistry from Korea Institute of Science and Technology, Korea

Share this Profile

Biography

Dr. Mohammed Ibrahim El Said Ali El-Gamal is currently working as Assistant Professor of Medicinal Chemistry at College of Pharmacy, University of Sharjah, Sharjah, UAE. He has completed his PhD degree in Medicinal Chemistry from Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea, and University of Science and Technology (UST). Previously he was appointed as Assistant lecturer and Assistant Professor at University of Mansoura-Egypt, Star Postdoctoral Fellow of Medicinal Chemistry at Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea, Visiting Assistant Professor at College of Pharmacy, University of Sharjah, Sharjah, UAE. He has published 25 research articles in journals, 2 patents and 43 presentations contributed as author/co-author. He also reviewed number of articles in journals. He is also serving as member of editorial board for 13 journals. He has completed 3 research grants. Dr. Ibrahim received honors includes Egyptian Pharmacists Syndicate award for excellence for outstanding M.Sc. holders, College excellence award that is gifted to outstanding students during all the five undergraduate years, International R&D Academy (IRDA) Excellence Award, Academic Excellence Award, and Excellence Award for research achievements.

Area of Interest:

Chemistry
100%
Medicinal Chemistry
62%
Pharmacokinetics
90%
Organic Synthesis
75%
Drug Design
55%

Selected Publications

  1. Semreen, M.H., M.I. El-Gamal, S. Abdin, H. Alkhazraji and L. Kamal et al., 2018. Recent updates of marine antimicrobial peptides. Saudi Pharmaceut. J., 26: 396-409.
    CrossRef  |  Direct Link  |  
  2. Iqbal, J., M.I. El-Gamal, S.A. Ejaz, J. Lecka, J. Sevigny and C.H. Oh, 2018. Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: In vitro and docking studies. J. Enzyme Inhibit. Med. Chem., 33: 479-484.
    CrossRef  |  Direct Link  |  
  3. El-Gamal, M.I., S.K. Al-Ameen, D.M. Al-Koumi, M.G. Hamad, N.A. Jalal and C.H. Oh, 2018. Recent advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) kinase and its inhibitors. J. Med. Chem., (In Press). 10.1021/acs.jmedchem.7b00873.
    CrossRef  |  Direct Link  |  
  4. Park, B.J., M.I. El-Gamal, W.S. Lee, J.S. Shin, K.H. Yoo, K.T. Lee and C.H. Oh, 2017. Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages. Med. Chem. Res., 26: 2161-2171.
    CrossRef  |  Direct Link  |  
  5. Khan, M.A., M.I. El-Gamal and C.H. Oh, 2017. A progressive review of V600E-B-RAF-dependent melanoma and drugs inhibiting it. Mini-Rev. Med. Chem., 17: 351-365.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. El-Gamal, M.I., M.S. Abdel-Maksoud, M.M. Gamal El-Din, J.S. Shin, K.T. Lee, K.H. Yoo and C.H. Oh, 2017. Synthesis, in vitro antiproliferative and antiinflammatory activities and kinase inhibitory effects of new 1,3,4-triarylpyrazole derivatives. Anti-Cancer Agents Med. Chem., 17: 75-84.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. El-Gamal, M.I., M.A. Khan, H. Tarazi, M.S. Abdel-Maksoud, M.M.G. El-Din, K.H. Yoo and C.H. Oh, 2017. Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives. Eur. J. Med. Chem., 127: 413-423.
    CrossRef  |  Direct Link  |  
  8. El-Gamal, M.I., I. Brahim, N. Hisham, R. Aladdin, H. Mohammed and A. Bahaaeldin, 2017. Recent updates of carbapenem antibiotics. Eur. J. Med. Chem., 131: 185-195.
    CrossRef  |  Direct Link  |  
  9. El-Gamal, M.I. and H.S. Anbar, 2017. Recent advances of pyrrolopyridines derivatives: A patent and literature review. Expert Opin. Therapeut. Patents, 27: 591-606.
    CrossRef  |  Direct Link  |  
  10. El-Gamal, M.I. and H.S. Anbar, 2017. Recent advances of pyrrolopyridines derivatives: A patent and literature review. Expert Opin. Therapeut. Patents, (In Press). 10.1080/13543776.2017.1280465.
    CrossRef  |  Direct Link  |  
  11. Khan, M.A., M.I. El-Gamal, H. Tarazi, H.S. Choi and C.H. Oh, 2016. Design and synthesis of a new series of highly potent RAF kinase-inhibiting triarylpyrazole derivatives possessing antiproliferative activity against melanoma cells. Future Med. Chem., 8: 2197-2211.
    CrossRef  |  Direct Link  |  
  12. Gamal El-Din, M.M., M.I. El-Gamal, M.S. Abdel-Maksoud, K.H. Yoo and D. Baek et al., 2016. Design, synthesis and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents. J. Enzyme Inhibit. Med. Chem., 31: 111-122.
    CrossRef  |  Direct Link  |  
  13. El-Gamal, M.I., W.S. Lee, J.S. Shin, C.H. Oh and K.T. Lee et al., 2016. Synthesis of new tricyclic and tetracyclic fused coumarin sulfonate derivatives and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages: Part 2. Archiv Pharmazie, 349: 853-863.
    CrossRef  |  Direct Link  |  
  14. El-Gamal, M.I., M.H. Semreen, P.A. Foster and B.V. Potter, 2016. Design, synthesis and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors. Bioorg. Med. Chem., 24: 2762-2767.
    CrossRef  |  Direct Link  |  
  15. El-Gamal, M.I., D. Baek and C.H. Oh, 2016. A new series of cycloalkane-fused coumarin sulfonates: Synthesis and In Vitro antiproliferative screening. Bull. Korean Chem. Soc., 37: 184-191.
    CrossRef  |  Direct Link  |  
  16. El-Din, M.M.G., M.I. El-Gamal, M.S. Abdel-Maksoud, K.H. Yoo and C.H. Oh, 2016. Design, synthesis, broad-spectrum antiproliferative activity and kinase inhibitory effect of triarylpyrazole derivatives possessing arylamides or arylureas moieties. Eur. J. Med. Chem., 119: 122-131.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Abdel-Maksoud, M.S., M.I. El-Gamal, M.M.G. El-Din, S.S. Kwak, H.I. Kim and C.H. Oh, 2016. Broad-spectrum antiproliferative activity of a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo [2, 1-b] thiazole derivatives. Med. Chem. Res., 25: 824-833.
    CrossRef  |  Direct Link  |  
  18. El-Din, M.M.G., M.I. El-Gamal, M.S. Abdel-Maksoud, K.H. Yoo and C.H. Oh, 2015. Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1, 3, 4-oxadiazole derivatives. Bioorg. Med. Chem. Lett., 25: 1692-1699.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. El-Din, M.M.G., M.I. El-Gamal, M.S. Abdel-Maksoud, K.H. Yoo and C.H. Oh, 2015. Synthesis and in vitro antiproliferative activity of new 1, 3, 4-oxadiazole derivatives possessing sulfonamide moiety. Eur. J. Med. Chem., 90: 45-52.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Abdel-Maksoud, M.S., M.R. Kim, M.I. El-Gamal, M.M.G. El-Din and J. Tae et al., 2015. Design, synthesis, in vitro antiproliferative evaluation and kinase inhibitory effects of a new series of imidazo [2, 1-b] thiazole derivatives. Eur. J. Med. Chem., 95: 453-463.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Khan, M.A., M.I. El-Gamal, M.S. Abdel-Maksoud, M.M.G. El-Din, K.H. Yoo and C.H. Oh, 2014. Broad-spectrum antiproliferative activity of diarylureas and diarylamides possessing pyrrolo [3, 2-c] pyridine scaffold. J. Pharm. Pharmacol., 2: 157-169.
    Direct Link  |  
  22. Jang, H.L., M.I. El-Gamal, H.E. Choi, H.Y. Choi, K.T. Lee and C.H. Oh, 2014. Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE 2 productions in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett., 24: 571-575.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Hassan, A.A., T.M. Bebair and M.I. El-Gamal, 2014. Synthesis of pyrazolylthiazole and pyrazolyl-1, 2, 4-triazepine derivatives. J. Chem. Res., 38: 27-31.
    CrossRef  |  Direct Link  |  
  24. El-Gamal, M.I., M.S. Abdel-Maksoud, M.M.G. El-Din, K.H. Yoo, D. Baek and C.H. Oh, 2014. Cell-based biological evaluation of a new bisamide FMS kinase inhibitor possessing pyrrolo [3, 2-c] pyridine scaffold. Arch. Pharm., 347: 635-641.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. El-Gamal, M.I., M.A. Khan, M.S. Abdel-Maksoud, M.M.G. El-Din and C.H. Oh, 2014. A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities and kinase inhibitory effect. Eur. J. Med. Chem., 87: 484-492.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. El-Gamal, M.I. and C.H. Oh, 2014. Synthesis, in vitro antiproliferative activity and in silico studies of fused tricyclic coumarin sulfonate derivatives. Eur. J. Med. Chem., 84: 68-76.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. El-Gamal, M.I. and C.H. Oh, 2014. Diarylureas and diarylamides with pyrrolo [2, 3-d] pyrimidine scaffold as broad-spectrum anticancer agents. Chem. Pharm. Bull., 62: 25-34.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Koh, E.J., M.I. El-Gamal, C.H. Oh, S.H. Lee and T. Sim et al., 2013. New diarylamides and diarylureas possessing 8-amino (acetamido) quinoline scaffold: Synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition and in silico studies. Eur. J. Med. Chem., 70: 10-21.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Kim, H.J., M.I. El-Gamal, Y.S. Lee and C.H. Oh, 2013. Synthesis and preliminary cytotoxicity evaluation of new diarylamides and diarylureas possessing 2,3-dihydropyrrolo[3,2-b]quinoline scaffold. Bull. Korean Chem. Soc., 34: 2480-2486.
  30. Khan, M.A., M.I. El-Gamal and C.H. Oh, 2013. Optimization of the reaction conditions for synthesis of 3-(Aryloxy)quinoline derivatives via Friedlander's Cyclization Reaction. Bull. Korean Chem. Soc., 34: 1848-1852.
  31. El-Gamal, M.I., Y.S. Park, D.Y. Chi, K.H. Yoo and C.H. Oh, 2013. New triarylpyrazoles as broad-spectrum anticancer agents: Design, synthesis and biological evaluation. Eur. J. Med. Chem., 65: 315-322.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. El-Gamal, M.I., M.S. Abdel-Maksoud and C.H. Oh, 2013. Recent advances in the research and development of marine antimicrobial peptides. Curr. Top. Med. Chem., 13: 2026-2033.
    PubMed  |  
  33. El-Gamal, M.I., H.S. Choi, K.H. Yoo, D. Baek and C.H. Oh, 2013. Antiproliferative diarylpyrazole derivatives as dual inhibitors of the ERK pathway and COX-2. Chem. Biol. Drug Des., 82: 336-347.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. El-Gamal, M.I., H.S. Anbar, K.H. Yoo and C.H. Oh, 2013. FMS Kinase Inhibitors: Current status and future prospects. Med. Res. Rev., 33: 599-636.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. El-Gamal, M.I., H.S. Anbar, H.J. Chung, H.I. Kim and Y.J. Cho et al., 2013. Discovery of olmesartan hexetil: A new potential prodrug of olmesartan. Bioorg. Med. Chem., Lett., 23: 1347-1350.
    CrossRef  |  
  36. Cho, H.J., M.I. El-Gamal, C.H. Oh, S.H. Lee and T. Sim et al., 2013. Novel quinolinylaminoisoquinoline bioisosteres of sorafenib as selective RAF1 kinase inhibitors: Design, synthesis and antiproliferative activity against melanoma cell line. Chem. Pharm. Bull., 61: 747-756.
    PubMed  |  
  37. Kim, S.K., W.S. Lee, S.J. Han, E.J. Kim and M.I. El-Gamal et al., 2012. Radiosynthesis and biodistribution of an 125I-labeled resveratrol derivative. Bull. Korean Chem. Soc., 33: 489-491.
  38. Kim, H.J., H.J. Cho, H. Kim, M.I. El-Gamal and C.H. Oh et al., 2012. New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis and antiproliferative activity against melanoma cell line. Bioorg. Med. Chem. Lett., 22: 3269-3273.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Jung, M.H., M.I. El-Gamal, M.S. Abdel-Maksoud, T. Sim, K.H. Yoo and C.H. Oh, 2012. Design, synthesis and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2. Bioorg. Med. Chem. Lett., 22: 4362-4367.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. El-Gamal, M.I. and C.H. Oh, 2012. Design and synthesis of an anticancer diarylurea derivative with multiple-kinase inhibitory effect. Bull. Korean Chem. Soc., 33: 1571-1576.
  41. Choi, W.K., M.I. El-Gamal, H.S. Choi, J.H. Hong, D. Baek, K. Choi and C.H. Oh, 2012. Design, synthesis and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold. Bull. Korean Chem. Soc., 33: 2991-2998.
  42. Cho, H.J., M.I. El-Gamal, C.H. Oh, S.H. Lee and G. Kim et al., 2012. Synthesis and antiproliferative activity of new aminoisoquinolinylurea derivatives against melanoma cell line. Bull. Korean Chem. Soc., 33: 3635-3639.
  43. Park, J.H., M.I. El-Gamal, Y.S. Lee and C.H. Oh, 2011. New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation and in silico studies. Eur. J. Med. Chem., 46: 5769-5777.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Jo, N.H., J.Y. Kim, M.I. El-Gamal, W.K. Choi and J.H. Park et al., 2011. ''Radiosynthesis and in vitro evaluation of 1-(tetrahydro-5-hydroxy-6-(hydroxymethyl)-2H-pyran-3-yl)-5-[125I]iodouracil: A new potential agent for HSV1-tk reporter gene monitoring. J. Labelled Compd. Rad., 54: 93-97.
    in vitro evaluation of 1-(tetrahydro-5-hydroxy-6-(hydroxymethyl)-2H-pyran-3-yl)-5-[125I]iodouracil: A new potential agent for HSV1-tk reporter gene monitoring.' target='_blank'>CrossRef  |  in vitro evaluation of 1-(tetrahydro-5-hydroxy-6-(hydroxymethyl)-2H-pyran-3-yl)-5-[125I]iodouracil: A new potential agent for HSV1-tk reporter gene monitoring.' target='_blank'>Direct Link  |  
  45. El-Gamal, M.I., T.B. Sim, J.H. Hong, J.H. Cho, K.H. Yoo and C.H. Oh, 2011. Synthesis of 1H-pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line. Arch. Pharm. Chem. Life Sci., 344: 197-204.
    CrossRef  |  Direct Link  |  
  46. El-Gamal, M.I., S.J. Kim and C.H. Oh, 2011. Synthesis and in vitro antibacterial activity of new meropenem analogs. J. Antibiot., 64: 687-688.
    CrossRef  |  PubMed  |  
  47. El-Gamal, M.I., M.H. Jung, W.S. Lee, T. Sim, K.H. Yoo and C.H. Oh, 2011. Design, synthesis and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Eur. J. Med. Chem., 46: 3218-3226.
    CrossRef  |  Direct Link  |  
  48. El-Gamal, M.I., H.S. Choi, H.G. Cho, J.H. Hong, K.H. Yoo and C.H. Oh, 2011. Design, synthesis and antiproliferative activity of 3,4-diarylpyrazole-1-carboxamide derivatives against melanoma cell line. Arch. Pharm. Chem. Life Sci., 344: 745-754.
    CrossRef  |  PubMed  |  
  49. El-Gamal, M.I. and C.H. Oh, 2011. Design and synthesis of 3-(3-chloro-4-substituted phenyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line. Bull. Korean Chem. Soc., 32: 821-828.
  50. Choi, W.K., M.I. El-Gamal, H.S. Choi, D. Baek and C.H. Oh, 2011. New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition and molecular docking studies. Eur. J. Med. Chem., 46: 5754-5762.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Chang, J.S., M.I. El-Gamal, W.S. Lee, H.S. Anbar and H.J. Chung et al., 2011. Design, synthesis, bioconversion and pharmacokinetics evaluation of new ester prodrugs of olmesartan. Eur. J. Med. Chem., 46: 3564-3569.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Park, J.H., J.S. Chang, M.I. El-Gamal, W.K. Choi and W.S. Leeet al., 2010. Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion and pharmacokinetic evaluation. Bioorg. Med. Chem. Lett., 20: 5895-5899.
    CrossRef  |  
  53. Moon, B.S., N. H. Jo, K.C. Lee, M.I. El-Gamal and G. An et al., 2010. Comparison of D-[18F]FMAU and L-[18F]FMAU as pet imaging agents for HSV1-TK gene expression. Bull. Korean Chem. Soc., 31: 3309-3312.
  54. Kim, H.J., M.H. Jung, H. Kim, M.I. El-Gamal and T.B. Sim et al., 2010. Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma. Bioorg. Med. Chem. Lett., 20: 413-417.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Kim, E.J., S.H. Hong, T.H. Choi, E.A. Lee and K.M. Kim et al., 2010. Effects of structural differences between radioiodine-labeled 1-(2'fluoro-2'deoxy-d-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'fluoro-2'deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging. Applied Radiat. Isotopes, 68: 971-978.
    CrossRef  |  
  56. El-Gamal, M.I., S.M. Bayomi, S.M. El-Ashry, S.A. Said, A.A.-M. Abdel-Aziz and N.I. Abdel-Aziz, 2010. Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: Molecular modeling study. Eur. J. Med. Chem., 45: 1403-1414.
    CrossRef  |  PubMed  |  Direct Link  |  
  57. El-Gamal, M.I., M.H. Jung and C.H. Oh, 2010. Discovery of a new potent bisamide FMS kinase inhibitor. Bioorg. Med. Chem. Lett., 20: 3216-3218.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. El-Gamal, M.I. and C.H. Oh, 2010. Current status of carbapenem antibiotics. Curr. Top. Med. Chem., 10: 1882-1897.
    CrossRef  |  PubMed  |  
  59. Jung, M.H., H. Kim, W.K. Choi, M.I. El-Gamal and J.H. Park et al., 2009. Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line. Bioorg. Med. Chem. Lett., 19: 6538-6543.
    CrossRef  |  PubMed  |  Direct Link  |