Dr. Thoraya Abd El Reheem Farghaly
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Dr. Thoraya Abd El Reheem Farghaly

Assistant Professor
Cairo University, Egypt


Highest Degree
Ph.D. in Organic Chemistry from Cairo University, Egypt

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Biography

Dr. Thoraya abd El Reheem Farghaly is currently working as Assistant Professor of Organic Chemistry at Faculty of Science, Cairo University, Egypt. She obtained her PhD in Organic Chemistry from same university in 2005. She is also giving her services as reviewer in several journals such as European Journal of Medicinal Chemistry, Journal Heterocyclic Chemistry, Arabian Journal of Chemistry, Research on Chemical Intermediates and Molecules. She is also working as supervisor of 8 MSc and 2 PhD students. She has published 66 articles in journals contributed as writer/co-writer. She also attended international conferences.

Area of Interest:

Chemistry
100%
Chemical Engineering
62%
Life Sciences
90%
Organic Chemistry
75%
Medicinal Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
60
Abstracts
0

Selected Publications

  1. Thoraya A.F., M.E.H. Huwaida and S.A.E. Heba, 2015. Eco-friendly synthesis and 2d-qsar study of novel pyrazolines as potential anticolon cancer agents. Med. Chem. Res., 24: 652-668.
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  2. Shawali, A.S., T.A. Farghaly, M.R. Shehata and S.M. Hussein, 2015. Synthesis and tautomeric structure of tris (arylazo) derivatives of novel 1h-bis-imidazo [1, 2-b: 2′, 1′-e] pyrazole ring system. J. Heterocycl. Chem., 52: 545-550.
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  3. Mahran, A.M., T.A. Farghaly and A.A. Nada, 2015. Hydrazonoyl halides in heterocycles: synthesis and anti-microbial activity of new 1, 2, 4-benzotriazine and bis-1, 2, 4-benzotriazine derivatives. Res. Chem. Intermed., 41: 2961-2969.
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  4. Farghaly, T.A., M.K. Dawood and R.M. Shaaban, 2015. Chemistry and biological activity of pyridotriazolopyrimidines. Curr. Org. Synth., 12: 230-260.
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  5. Farghaly, T.A., M.A. Abdallah and Z.A. Muhammad, 2015. New 2-heterocyclic perimidines: synthesis and antimicrobial activity Res. Chem. Intermed., 41: 3937-3947.
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  6. Farghaly, A.T., A.S. Shawali, , E.M.H. Abbas and A. N. Abdel-hafez, 2015. A facile synthesis of new polyazaheterocycles via one-pot three-components condensation reaction and study of their reactions with nitrilimines. Curr. Org. Synth., 12: 95-101.
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  7. Thoraya, A.F., A.A. Magda and R.A.A. Mohamed, 2014. Exocyclic enaminones as building blocks for synthesis of bioactive polyheterocyclic compounds. J. Adv. Chem., 10: 2753-2765.
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  8. Thoraya, A.F., A.A. Magda and R.A.A. Mohamed, 2014. Azo-hydrazone tautomerism and antimicrobial activity of new substituted imidazolines and perimidines. J. Adv. Chem., 10: 2694-2704.
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  9. Hassaneen, H.M.E and T.A. Farghaly, 2014. A simple, convenient, one-pot synthesis of dihydro-azolopyrimidines, dft calculation, and nmr determination by using h-ferrierite zeolite as catalyst. J. Heterocycl. Chem., 10.1002/jhet.2152.
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  10. Farghaly, T.A.E.R., I.M. Abbas, W.M.I. Hassan and M.S. Lotfy, 2014. Study on regioselective synthesis of bioactive bis-spiropyrazolines using molecular orbital calculations. Eur. J. Chem., 5: 577-583.
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  11. Farghaly, T.A., S.M. Gomha and M.M. Abdalla, 2014. Synthesis of a new series of angiotensin II receptor antagonists and antibacterial agents. Arch. Pharmacal Res., 37: 306-314.
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  12. Farghaly, T.A., E.M. Abbas, K.M. Dawood and T. El-Naggar, 2014. Synthesis of 2-phenylazonaphtho [1, 8-ef][1, 4] diazepines and 9-(3-arylhydrazono) pyrrolo [1, 2-a] perimidines as antitumor agents. Mol., 19: 740-755.
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  13. Farghaly, T.A and H.M. Hassaneen, 2014. H-ferrierite zeolite: as an effective and reusable heterogeneous catalyst for synthesis of 1, 5-benzothiazepine under solvent free condition and 1, 3-dipolar cycloaddition in water. Arabian J. Chem., 10.1016/j.arabjc.2013.12.024.
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  14. Farghaly, T.A and H.K. Mahmoud, 2014. 86 Site-and regioselectivity of the reaction of hydrazonoyl chlorides with perimidine ketene aminal. Antimicrobial Evaluation of the Products. J. Heterocycl. Chem., 52: 86-91.
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  15. Abbas, E.M.H., S.M. Gomha and T.A. Farghaly, 2014. Multicomponent reactions for synthesis of bioactive polyheterocyclic ring systems under controlled microwave irradiation. Arabian J. Chem., 7: 623-629.
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  16. Shawali, A.S., T.A. Farghaly, S.M. Hussein and M.M. Abdalla, 2013. Site-selective reactions of hydrazonoyl chlorides with cyanoacetic hydrazide and its N-arylidene derivatives and anti-aggressive activity of prepared products. Arch. Pharmacal Res., 36: 694-701.
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  17. Kheder, N.A and T.A.R. Farghaly, 2013. Bis-hydrazonoyl chloride as precursors for synthesis of novel polysubstituted bis-azoles. Arabian J. Chem., 10.1016/j.arabjc.2013.11.040.
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  18. Farghaly, T.A. and H.M. E. Hassaneen, 2013. Synthesis of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones 3 as potential antimicrobial agents. Arch. Pharm. Res., 36: 564-572.
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  19. Farghaly, T.A. and H.K. Mahmoud, 2013. Synthesis, tautomeric structures and antitumor activity of new perimidines. Arch. Pharm. Chem. Life Sci., 346: 392-402.
    PubMed  |  
  20. El-Gamel, N.E.A. and T.A. Farghaly, 2013. Design and synthesis of novel complexes containing N-phenyl-1H-pyrazole moiety: Ni complex as potential antifungal and antiproliferative compound. Spectrochim Acta A Mol. Biomol. Spectrosc., 115: 469-475.
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  21. Edrees, M.M and T.A. Farghaly, 2013. Synthesis and antitumor activity of benzo [6 ″, 7 ″] cyclohepta [1 ″, 2 ″: 4′, 5′] pyrido [2′, 3′-d][1, 2, 4] triazolo [4, 3-a] pyrimidin-5-ones. Arabian J. Chem., 10.1016/j.arabjc.2013.06.002.
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  22. Shawali, A.S., T.A. Farghaly and T.M.S. Nawar, 2012. Solvent and substituent effects on the electronic spectra of 3-arylazo-imidazo[1,2-b]pyrazolo[4,3-d]-pyridazines. J. Chem. Res., 36: 615-618.
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  23. Riyadh, S.M. and T.A. Farghaly, 2012. Effect of solvent on the regioselective synthesis of spiropyrazoles. Tetrahedron, 68: 9056-9060.
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  24. Farghaly, T.A., S.M. Gomha, E.M.H. Abbas and M.M. Abdalla, 2012. Hydrazonoyl halides as precursors for new fused heterocycles of 5α-reductase inhibitors. Arch. Pharm. Chem. Life Sci., 2012: 117-122.
    PubMed  |  
  25. Farghaly, T.A., M.M. Edrees and M.A.N. Mosselhi, 2012. Synthesis, tautomeric structure and antimicrobial activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-dione. Molecules, 17: 8483-8493.
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  26. Farghaly, T.A., M.A. Abdallah and M.R. Abdel Aziz, 2012. Synthesis and antimicrobial activity of some new 1,3,4-Thiadiazole derivatives. Molecules, 17: 14625-14636.
    PubMed  |  
  27. Farghaly, T.A., I.M. Abbas, M.M. Abdalla and R.O.A. Mahgoub, 2012. Synthesis of new pentaheterocyclic ring systems as anti-androgene, anti-HCV and anti-H1N1 agents. ARKIVOC, 2012: 57-70.
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  28. Farghaly, T.A. and E.M.H. Abbas, 2012. Hydrazonoyl halides as precursors for synthesis of novel bioactive thiazole and formazan derivatives. J. Chem. Res., 36: 660-664.
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  29. Farghaly, T.A. and A.S. Shawali, 2012. Synthesis and tautomeric structure of novel 3-arylazoimidazo[1,2-b]pyrazolo[4,3-d]pyridazines. J. Chem. Res., 36: 296-299.
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  30. Farghaly, T.A., S.M. Riyadh, M.A. Abdallah and M.A. Ramadan, 2011. A facile one-pot synthesis and antimicrobial activity of pyrido [2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones. Acta Chim. Slov., 58: 87-94.
    PubMed  |  
  31. Farghaly, T.A., M.A. Abdallah and Z.A. Muhammad, 2011. Synthesis and evaluation of the anti-microbial activity of new heterocycles containing the 1,3,4-Thiadiazole Moiety. Molecules, 16: 10420-10432.
    PubMed  |  
  32. Farghaly, T.A., I.M. Abass, M.M. Abdalla and R.O.A. Mahgoub, 2011. Synthesis and pharmacological activities of fused pyrimidinones. World J. Chem., 2011: 8-18.
  33. Ali, K.A., E.A. Ragab, T.A. Farghaly and M.M. Abdalla, 2011. Synthesis of new functionalized 3-Subsitituted[1,2,4]triazolo[4,3-a] pyrimidine dreivatives: Potential antihypertensive agents. Acta Poloniae Pharmaceutica Drug Research, 68: 237-247.
  34. Abdallah, M.A., T.A. Farghaly, M.M. Abdalla and Z.A. Muhammad, 2011. Anti-Alzheimer Activity of Novel 1,3,4-Thiadiazole Derivatives. World J. Chem., 2011: 96-106.
  35. Shawali, A.S., T.A. Farghaly and A.R. Al-Dahshoury, 2010. An efficient synthesis of functionalized 3-(hetaryl)pyrazoles. Arkivoc, 2010: 19-30.
  36. Riyadh, S.M., T.A. Farghaly, M.A. Abdallah, M.M. Abdalla and M.R.A. El-Aziz, 2010. New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity. Eur. J. Med. Chem., 45: 1042-1050.
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  37. Riyadh, S.M., T.A. Farghaly and S.M. Gomha, 2010. Novel polyazaheterocyclic systems: Synthesis, antitumor and antimicrobial activities. Arch. Pharm. Res., 33: 1721-1728.
    CrossRef  |  PubMed  |  
  38. Hafez, N.A.A., T.A. Farghaly, M.A. Al-Omar and M.M. Abdalla, 2010. Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors. Eur. J. Med. Chem., 45: 4838-4844.
  39. Farghaly, T.A., N.A.A. Hafez, E.A. Ragab, H.M. Awad and M.M. Abdalla, 2010. Synthesis, anti-HCV, antioxidant and peroxynitrite inhibitory activity of fused benzosuberone derivatives. Eur. J. Med. Chem., 45: 492-500.
    PubMed  |  
  40. Farghaly, T.A. and A.S. Shawali, 2010. Synthesis and single-crystal X-ray diffraction analysis of new heterocyclic coloured materials. 3-Arylazo-8H-imidazo[1,2-b] pyrazolo[4,3-d]pyridazines. Tetrahedron, 66: 2700-2704.
    CrossRef  |  
  41. Edrees, M.M., T.A. Farghaly, F.A.A. El-Hag and M.M. Abdalla, 2010. Antimicrobial, Antitumor and 5α-reductase inhibitor activities of some hydrazonoyl substituted pyrimidinones. Eur. J. Med. Chem., 45: 5702-5707.
  42. Abbas, E.M.H. and T.A. Farghaly, 2010. Synthesis, reactions and biological activity of 1,4-benzothiazine derivatives. Monatsh. Chem., 141: 661-667.
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  43. Shawali, A.S. and T.A. Farghaly, 2009. Synthesis and tautomeric structure of 6-arylhydrazono 1H-pyrazolo [3',4':4,5]pyrimido[1,6-b][1,2,4]triazepines. Tetrahedron, 65: 644-647.
  44. Farghaly, T.A. and M.M. Abdalla, 2009. Synthesis, tautomerism, antimicrobial, anti-HCV, anti-SSPE, antioxidant and antitumor activities of arylazobenzosuberones. Bioorg. Med. Chem., 17: 8012-8019.
    PubMed  |  
  45. El Reheem Farghaly, T.A. and S.M. Riyadh, 2009. Microwave assisted synthesis of annelated benzosuberone as new penta-heterocyclic ring system. Arkivok, 2009: 64-64.
  46. Ahmed, M.S.M. and T.A. Farghaly, 2009. Synthesis and reactions of 3-hydrazino-2,7,8,9-tetrahydro-1H-benzo[6',7'] cyclohepta[1',2':4,5]pyrido[2,3-d]pyrimidin-1-one. Arkivok , 2009: 31-41.
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  47. Shawali, A.S., S.M. Sherif, T.A. Farghaly and M.A.A. Darwish, 2008. Site-selective synthesis and tautomerism of arylazo derivatives of pyrazolo[3,4-d]pyrimido-[1,6-b][1,2,4]triazine. Afinidad, 536: 314-318.
  48. Shawali, A.S., M.A.N. Mosselhi, T.A. Farghaly, M.R. Shehata and N.M. Tawfik, 2008. Synthesis and tautomeric structure of 3,6-bis(arylazo)pyrazolo[1,5-a] pyrimidine-5,7(4H,6H)-diones. J. Chem. Res., 2008: 452-456.
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  49. Shawali, A.S., M.A. Mosselhi, F.M.A. Altablawy, T.A. Farghaly and N.M. Tawfik, 2008. Synthesis and tautomeric structure of 3,7-bis(arylazo)-6-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazoles in ground and excited states. Tetrahedron, 64: 5524-5530.
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  50. Shawali, A.S. and T.A. Farghaly, 2008. Site selectivity in reaction of hydrazonoyl halides with 2-(aroylmethyl)-6-methylpyrimidin-4(3H)-ones. J. Chem. Res., 2008: 688-692.
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  51. Farghaly, T.A., 2008. Synthesis and reactions of 3-[3-(dimethylamino)propenoyl]-1,7-diphenyl [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one. J. Chem. Res., 2008: 152-156.
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  52. Farghaly, T.A. and Z.A. Abdallah, 2008. Synthesis, azo-hydrazone tautomerism and antitumor screening of N-(3-ethoxycarbonyl-4,5,6,7-tetrahydro-benzo[b]thien-2-yl)-2-arylhydrazono-3-oxobutanamide derivatives. Arkivok, 2008: 295-305.
  53. Shawali, A.S., S.M. Sherif, T.A. Farghaly, M.R. Shehata and M.A.A. Darwish, 2007. Synthesis and tautomeric structure of the azo-coupling products of 2-methyl-7-phenylpyrimido[1,2-b][1,2,4]triazepine-4,9(3H,5H)-dione. J. Chem. Res., 2007: 44-47.
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  54. Shawali, A.S., M.A.N. Mosselhi and T.A. Farghaly, 2007. Synthesis and tautomeric structure of 2-arylazo-4H-imidazo[2,1-b] [1,3,4]thiadiazines. J. Chem. Res., 2007: 479-483.
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  55. Shawali, A.S., T.A. Farghaly and M.M. Edrees, 2006. Synthesis, tautomeric structure and cyclization of diazonium coupling products of 3-(aroylmethyl)-8-phenylpyrimido[1,2-b][1,2,4]triazine-2,6(1H)-dione. Int. J. Pure App. Chem., 1: 531-537.
  56. Shawali, A.S., M.M. Zayed and T.A. Farghaly, 2005. Synthesis and biological activity of new 1H-pyrazolo[3,4-b]quinoxalines (Flavazoles). J. Heterocycli. Chem., 42: 185-189.
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  57. Shawali, A.S., M.A.N. Mosselhi and T.A. Farghaly, 2005. Site selectivity in reactions of hydrazonoyl halides with 2-amino-3-quinoxalinethiol: A new general access to functionalized 4H-1,3,4-thiadiazino-[5,6-b]quinoxalines. Phosphorus, Sulfur Silicon, 180: 2391-2402.
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  58. Shawali, A.S. and T.A. Farghaly, 2004. Synthesis and tautomeric structure of 2-[N-aryl-2-oxo-2-arylethane hydrazonoyl]-6-methyl-4(3H)-pyrmidinones. Tetrahedron, 60: 3051-3057.
  59. Mosselhi, M.A.N., M.A. Abdalla, T.A. Farghaly and A.S. Shawali, 2004. Novel pentaheterocycles. First general synthesis entry to functionalized derivatives of pyrido[2,3-f:6,5-f']di-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-diones Monatsch. Chem., 135: 211-222.
  60. Shawali, A.S., M.A. Abdalla, M.A.N. Mosselhi and T.A. Farghaly, 2002. A facile one-pot regioselective synthesis of [1,2,4]triazolo[4,3-a]-5(1H)-pyrimidinones via tandem Japp-Klingemann, Smiles rearrangement and cyclization reactions. Heteroatom Chem., 13: 136-140.
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