Dr. Ahmed Mohammed Mahmoud Al-Abd
My Social Links

Dr. Ahmed Mohammed Mahmoud Al-Abd

Associate Professor
Gulf Medical University, United Arab Emirates


Highest Degree
Ph.D. in Biomedical Sciences from The Catholic University of Korea, Korea

Share this Profile

Biography

Dr. Ahmed Mohammed Mahmoud Al-Abd obtained his Ph.D. in Pharmacology and Toxicology from Supreme Council of University, Egypt. Since then he has working in the fields of Research/Academia holding the following titles; QC-Specialist, Research Assistant, BAV/BEQ-Specialist, Assistant Researcher, Teaching Assistant, Research Fellow, Pharmacology Screening Unit Board Member, and Researcher. Currently he is working as Assistant Professor King Abdulaziz University KAU, Jeddah, Saudi Arabia. He also received 8 national and international awards. He is co-inventor in 2 patents. He is co-author in more than 30 publications published in peer-reviewed medical journals. He is also co-supervising more than 10 graduate students in pursuing their M.Sc. /Ph.D. degrees. He is editor board member in 7 journals. His area of research interest focused on Onco-pharmacology, In-Vitro Cancer Modeling and Simulating in-Vivo Solid Tumor Microenvironment, siRNA, Aptamers and Non-Conventional Drug Discovery: special focus on Solid Tumors, Pharmacodynamic-Pharmacokinetic interaction in Solid Tumors Microenvironment, Drug Delivery Systems for Solid Tumor, Optimization and Spatial PK-PD Interaction, Natural Products and their role as Chemomodulors and Enhancers for Conventional Anti Cancer Agent, Special focus on Solid Tumors and MDR Variants. He is also working on 4 research projects as co-investigator. He is member of following scientific societies, American Association of Cancer Research, European Association of Cancer Research, Saudi Pharmaceutical Society, Korean Society of Applied Pharmacology, Korean Society of Pharmaceutical Sciences and Technology, Korean Pharmaceutical Society, Diseases of the Prostate Gland Research Group, Medicinal Plant Research Group, and Translational Medical Research Group. He also gives presentations in more than 30 international conferences.

Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Analysis
62%
Pharmacognosy
90%
Drug Delivery
75%
Pharmacy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
57
Abstracts
0

Selected Publications

  1. Henidi, H.A., A.M. Al-Abd, F.A. Al-Abbasi, H.A. BinMahfouz and I.M. El-Deeb, 2019. Design and synthesis of novel phenylaminopyrimidines with antiproliferative activity against colorectal cancer. RSC Adv., 9: 21578-21586.
    CrossRef  |  Direct Link  |  
  2. Fekry, M.I., S.M. Ezzat, M.M. Salama, O.Y. Alshehri and A.M. Al-Abd, 2019. Bioactive glycoalkaloides isolated from Solanum melongena fruit peels with potential anticancer properties against hepatocellular carcinoma cells. Scient. Rep., Vol. 9. 10.1038/s41598-018-36089-6.
    CrossRef  |  Direct Link  |  
  3. El-Shitany, N.A.E.A., A.T. Abbas, S.S. Ali, B. Eid and S. Harakeh et al., 2019. Nanoparticles ellagic acid protects against cisplatin-induced hepatotoxicity in rats without inhibiting its cytotoxic activity. Int. J. Pharmacol., 15: 465-477.
    CrossRef  |  Direct Link  |  
  4. Kassem, M.A., M.A. Megahed, S.K. Abu Elyazid, F.I. Abd-Allah, T.M. Abdelghany, A.M. Al-Abd and M. Khalid, 2018. Enhancing the therapeutic efficacy of tamoxifen citrate loaded span-based nano-vesicles on human breast adenocarcinoma cells. AAPS PharmSciTech, 19: 1529-1543.
    CrossRef  |  Direct Link  |  
  5. El-Sawy, H.S., A.M. Al-Abd, T.A. Ahmed, K.M. El-Say and V.P. Torchilin, 2018. Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: Past, present and future perspectives. ACS Nano, 12: 10636-10664.
    CrossRef  |  Direct Link  |  
  6. Bashmail, H.A., A.A. Alamoudi, A. Noorwali, G.A. Hegazy, G. AJabnoor, H. Choudhry and A.M. Al-Abd, 2018. Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities. Scient. Rep., Vol. 8. 10.1038/s41598-018-30046-z.
    CrossRef  |  Direct Link  |  
  7. Baghdadi, M., F. Al-Abbasi, A. El-Halawany, A. Aseeri and A. Al-Abd, 2018. Anticancer profiling for coumarins and related O-naphthoquinones from Mansonia gagei against solid tumor cells in vitro. Molecules, Vol. 23, No. 5. 10.3390/molecules23051020.
    CrossRef  |  Direct Link  |  
  8. Allam, R.M., A.M. Al-Abd, A. Khedr, O.A. Sharaf and S.M. Nofal et al., 2018. Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicol. Lett., 291: 77-85.
    CrossRef  |  Direct Link  |  
  9. Alahdal, A.M., H.Z. Asfour, S.A. Ahmed, A.O. Noor, A.M. Al-Abd, M.A. Elfaky and S.S. Elhady, 2018. Anti-Helicobacter, antitubercular and cytotoxic activities of scalaranes from the red sea sponge Hyrtios erectus. Molecules, Vol. 23, No. 4. 10.3390/molecules23040978.
    CrossRef  |  Direct Link  |  
  10. Ahmed, T.A. and A.M. Al-Abd, 2018. Effect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation. Drug Deliv., 25: 555-563.
    CrossRef  |  Direct Link  |  
  11. Abdel-Naim, A.B., A.A. Alghamdi, M.M. Algandaby, F.A. Al-Abbasi and A.M. Al-Abd et al., 2018. Rutin isolated from Chrozophora tinctoria enhances bone cell proliferation and ossification markers. Oxid. Med. Cell. Longevity, Vol. 2018. 10.1155/2018/5106469.
    CrossRef  |  Direct Link  |  
  12. Mohamed, G.A., A.M. Al-Abd, A.M. El-Halawany, H.M. Abdalla and S.R.M. Ibrahim, 2017. New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast and colorectal cancer cell lines. J. Ethnopharmacol., 198: 302-312.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. El-Araby ME, A.M. Omar, M.T. Khayat, H.A. Assiri and A.M. Al-Abd. 2017. Molecular mimics of classic P-glycoprotein inhibitors as multidrug resistance suppressors and their synergistic effect on paclitaxel. PLoS One. 12: 1-19.
    Direct Link  |  
  14. Alaufi, O.M., A. Noorwali, F. Zahran, A.M. Al-Abd and S. Al-Attas, 2017. Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro. Scient. Rep., Vol. 7. 10.1038/s41598-017-13357-5.
    CrossRef  |  Direct Link  |  
  15. Al-Abd, A.M., A.J. Alamoudi, A.B. Abdel-Naim, T.A. Neamatallah and O.M. Ashour, 2017. Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies-A review. J. Adv. Res., 8: 591-605.
    CrossRef  |  Direct Link  |  
  16. Abdel-Naim, A.B., A.A. Alghamdi, M.M. Algandaby, F.A. Al-Abbasi and A.M. Al-Abd et al., 2017. Phenolics isolated from Aframomum meleguta enhance proliferation and ossification markers in bone cells. Molecules, Vol. 22. 10.3390/molecules22091467.
    CrossRef  |  Direct Link  |  
  17. Mahmoud A.M., M.A. Aboul-Soud ,J. Han ,Y.A. Al-Sheikh, A.M. Al-Abd , H.A. El-Shemy, et al., 2016. Transcriptional profiling of breast cancer cells in response to mevinolin: Evidence of cell cycle arrest, DNA degradation and apoptosis. Int. J. Oncol., 10.3892/ijo.2016.3418.
    CrossRef  |  Direct Link  |  
  18. Khaleel S.A., A.M. Al-Abd , A.A. Ali and A.B. Abdel-Naim 2016. Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P- glycoprotein activity. Sci. Rep., .
    Direct Link  |  
  19. ElHady S.S., A.M. Al-Abd , A.M. El-Halawany , A.M. Alahdal , H.A. Hassanean, et al., 2016. Antiproliferative scalarane-based metabolites from the red sea sponge hyrtios erectus. Mar. Drugs, .
    Direct Link  |  
  20. Al-Abbasi F.A., E.A. Alghamdi , M.A. Baghdadi , A.J. Alamoudi and A.M. El-Halawany, et al., 2016. Gingerol Synergizes the Cytotoxic Effects of doxorubicin against liver cancer cells and protects from its vascular toxicity. Mol., 10.3390/molecules21070886.
    CrossRef  |  Direct Link  |  
  21. Aboul-Soud M.A.M., H.A. El-Shemy, K.M. Aboul-Enein, A.M. Mahmoud, A.M. Al-Abd et al., 2016. Effects of plant-derived anti-leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncol. Lett., 11: 642-648.
    Direct Link  |  
  22. Abdel-Lateff, A., A.M. Al-Abd, A.M. Alahdal, W.M. Alarif , S.E. Ayyad et al ., 2016. Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells Z. Naturforsch. C., 71: 29-35.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. ,
  24. Abdel-Latif G.A., A.M. Al-Abd, M.G. Tadros, F.A. Al-Abbasi, A.E. Khalifa, et al ., 2015,. The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci. Rep., 10.1038/srep12054.
    CrossRef  |  
  25. Habib, C.N., A.M. Al-Abd, M.F. Tolba, A.E. Khalifa, A. Khedr, H.A. Mosli and A.B. Abdel-Naim, 2015. Leptin influences estrogen metabolism and accelerates prostate cell proliferation. Life Sci., 121: 10-15.
    CrossRef  |  Direct Link  |  
  26. Al-Abd, A.M., F.A. Al-Abbasi and V.P. Torchilin, 2015. Intratumoral pharmacokinetics: challenges to nanobiomaterials. Curr. Pharm. Des. 21: 3208-3214.
    Direct Link  |  
  27. Al-Abd A.M., Z.K. Aljehani, R.W. Gazzaz, S.H. Fakhri, A.H. Jabbad et al ., 2015. Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors. J. Control Release, 10: 269-277.
    CrossRef  |  Direct Link  |  
  28. Abdallah, H.M., A.M. Al-Abd, R.S. El-Dine and A.M. El-Halawany, 2015. P-glycoprotein inhibitors of natural origin as potential tumor Chemo-sensitizers: A review. J. Adv. Res., 6: 45-62.
    CrossRef  |  Direct Link  |  
  29. Soliman, F.M., M.M. Fathy, M.M. Salama, A.M. Al-Abd, F.R. Saber and A.M. El-Halawany, 2014. Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt. Scient. Rep., Vol. 4. 10.1038/srep05410.
    CrossRef  |  Direct Link  |  
  30. Bakr, R.O., R.K. Arafa, A.M. Al-Abd and H.M. Elshishtawy, 2014. Phenolics of Achillea fragrantissima growing in Egypt and its cytotoxic activity. J. Med. Plants Res., 8: 763-771.
    Direct Link  |  
  31. Al-Abd, A.M., F.A. Al-Abbasi, S.M. Nofal, A.E. Khalifa and R.O. Williams et al., 2014. Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111843.
    CrossRef  |  Direct Link  |  
  32. Al-Abd, A.M. and F.A. Al-Abbasi, 2014. Technical aspects of 3-dimentional culture of mammalian cells. Biochem. Pharmacol., Vol. 3. 10.4172/2167-0501.1000134.
    CrossRef  |  Direct Link  |  
  33. Abou El-Ella, D.A., M.M. Hussein, R.A.T. Serya, R.M. Abdel Naby and A.M. Al-Abd et al., 2014. Molecular design and synthesis of 1,4-disubstituted piperazines as α1-adrenergic receptor blockers. Bioorgan. Chem., 54C: 21-30.
    CrossRef  |  Direct Link  |  
  34. Abdallah, H.M., A.M. Al-Abd, G.F. Asaad, A.B. Abdel-Naim and A.M. El-Halawany, 2014. Isolation of antiosteoporotic compounds from seeds of Sophora japonica. PLoS ONE, Vol. 9. 10.1371/journal.pone.0098559.
    CrossRef  |  Direct Link  |  
  35. Tolba, M.F., A.E. Amer, A.M. Al-Abd, S.S. Azab, A.E. Khalifa, H.A. Mosli and A.B. Abdel-Naim, 2013. Caffeic ocid phenethyl ester augments docetaxel- cytotoxicity in PC-3 cells by inducing dpoptosis through modulation of estrogen receptors. IUBMB Life, 65: 716-729.
  36. Nawwar, M., N. Swilam, A. Hashim, A. Al-Abd, A. Abdel-Naim and U. Lindequist, 2013. Cytotoxic isoferulic acidamide from Myricaria germanica (Tamaricaceae). Plant Signal. Behav., Vol. 8. 10.4161/psb.22642.
    CrossRef  |  
  37. Mosli, H.A., M.F. Tolba, A.M. Al-Abd and A.B. Abdel-Naim, 2013. Catechol estrogens induce proliferation and malignant transformation in prostate epithelial cells. Toxicol. Lett., 220: 247-258.
    CrossRef  |  Direct Link  |  
  38. El-Sayed, M.A., A.A. Shabaka, O.A. El-Shabrawy, N.A. Yassin and S.S. Mahmoud et al., 2013. Tissue distribution and efficacy of systemically administered gold nanorods coupled with laser-induced photo-plasmonic therapy in Ehrlich carcinoma solid tumor model. PLoS ONE, Vol. 8. 10.1371/journal.pone.0076207.
    CrossRef  |  Direct Link  |  
  39. Alarif, W.M., A. Abdel-Lateff, A.M. Al-Abd, S.A. Basaif, F.A. Badria, M. Shams and S.E.N. Ayyad, 2013. Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia. Eur. J. Med. Chem., 66: 204-210.
    CrossRef  |  Direct Link  |  
  40. Al-Abd, A.M., F.A. Al-Abbasi, G.F. Asaad and A.B. Abdel-Naim, 2013. Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity. Eur. J. Pharmacol., 718: 361-369.
    CrossRef  |  Direct Link  |  
  41. Abdel-Rahman, M.A. and A.M. Al-Abd, 2013. Thermoresponsive dendrimers based on oligoethylene glycols: Design, synthesis and cytotoxic activity against MCF-7 breast cancer cells. Eur. J. Med. Chem., 69: 848-854.
    CrossRef  |  Direct Link  |  
  42. Nawwar, M.A., N.A. Ayoub, M.A. El-Rai, F. Bassyouny and E.S. Mostafa, 2012. Cytotoxic ellagitannins from Reaumuria vermiculata. Fitoterapia, 83: 1256-1266.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Mosli, H.A., A.M. Al-Abd, M.A. El-Shaer, A. Khedr, F.S. Gazzaz and A.B. Abdel-Naim, 2012. Local inflammation influences oestrogen metabolism in prostatic tissue. BJU Int., 110: 274-282.
    CrossRef  |  Direct Link  |  
  44. Mahmoud, A.M., A.M. Al-Abd, D.A. Lightfoot and H.A. El-Shemy, 2012. Anti-cancer characteristics of mevinolin against three different solid tumor cell lines was not solely p53-dependent. J. Enzyme Inhib. Med. Chem., 27: 673-679.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Khalil, N.A., E.M. Ahmed, H.B. El-Nassan, O.K. Ahmed and A.M. Al-Abd, 2012. Synthesis and biological evaluation of novel pyrazoline derivatives as anti-inflammatory and antioxidant agents. Arch. Pharm. Res., 35: 995-1002.
    CrossRef  |  
  46. Abouzid, K.A.M., N.A. Khalil, E.M. Ahmed, A. Esmat and A.M. Al-Abd, 2012. Design, synthesis and evaluation of anti-inflammatory and ulcerogenicity of novel pyridazinone derivatives. Med. Chem. Res., 21: 3581-3590.
    CrossRef  |  Direct Link  |  
  47. Al-Abd, A.M., A.M. Mahmoud, G.A. El-Sherbiny, M.A. El-Moselhy and S.M. Nofal et al., 2011. Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro. Cell Proliferation, 44: 591-601.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Aboul-Enein, A.M., A.M. Al-Abd, E. Shalaby, F. Abul-Ela, A.A. Nasr-Allah, A.M. Mahmoud and H.A. El-Shemy, 2011. Eichhornia crassipes (Mart) solms: From water parasite to potential medicinal remedy. Plant Signaling Behav., 6: 834-836.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Aboul-Enein A.M., E. Shalaby, F. Abul-Ela, A.A. Nasr-Allah, A.M. Mahmoud, et al ., 2011. Back to Nature Spotlight on Cancer Therapeutics Drug Discovery Dev. .
    Direct Link  |  
  50. Al-Abd, A.M., K.Y. Hong, S.C. Song and H.J. Kuh, 2010. Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice. J. Controlled Release, 142: 101-107.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Al-Abd, A.M., J.J. Inglis, S.M. Nofal, A.E. Khalifa, R.O. Williams, W.I. El-Eraky and A.B. Abdel-Naim, 2010. Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis. Eur. J. Pharmacol., 644: 245-250.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Al-Abd, A.M., S.H. Lee, S.H. Kim, J.H. Cha, T.G. Park, S.J. Lee and H.J. Kuh, 2009. Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro. J. Controlled Release, 137: 130-135.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Al-Abd, A.M., N.H. Kim, S.C. Song, S.J. Lee and H.J. Kuh, 2009. A simple HPLC method for doxorubicin in plasma and tissues of nude mice. Achieve Pharma. Res., 32: 605-611.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Al-Abd, A.M., J.H. Lee, S.Y. Kim, N. Kun and H.J. Kuh, 2008. Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel. Cancer Sci., 99: 423-431.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Trung, T.Q., P.H. Long, A.M. Al-Abd, H.J. Kuh, H.Y. Lee, S.J. Hwang and K.H. Kim, 2007. Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique. Arch. Pharma. Res., 30: 890-897.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Lee, S.H., A.M. Al-Abd, J.K. Park, J.H. Cha, S.K. Ahn, J.K. Kim and H.J. Kuh, 2006. Pharmacodynamics of CKD-602 (Belotecan) in 3D cultures of human colorectal carcinoma cells. J. Applied Pharmacol., 14: 119-124.
  57. Choi, M.S., J.K. Park, A.M. Al-Abd and H.J. Kuh, 2006. Penetration of paclitaxel in multicellular layers of human colorectal cancer cells. J. Korean Pharma. Sci., 36: 385-392.
  58. Al-Abd, A.M., J.H. Lee and H.J. Kuh, 2006. Simultaneous evaluation of cellular vitality and drug penetration in multicellular layers of human cancer cells. J. Korean Pharma. Sci., 36: 293-298.