Dr. Ezenyi Ifeoma Chinwude Obidike
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Dr. Ezenyi Ifeoma Chinwude Obidike

Senior Research Fellow
National Institute for Pharmaceutical Research and Development, Nigeria

Highest Degree
Ph.D. in Pharmacology and Toxicology from University of Nigeria, Nsukka, Nigeria

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Area of Interest:

Pharmacology and Toxicology
100%
Molecular Modeling
62%
Antidiabetic Activity
90%
Drug Discovery
75%
Malaria
55%

Research Publications in Numbers

Books
0
Chapters
2
Articles
33
Abstracts
0

Selected Publications

  1. Okpoko, C., I. Ezenyi, B. Adzu, O. Salawu, 2020. Evaluation of two medicinal plants used for arthritis in northern Nigeria with focus on Terminalia avicennioides Guill. & Perr. and its mechanism of action. Sci. Afr., 10.1016/j.sciaf.2020.e00357.
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  2. Ezenyi, I.C., V. Verma, S. Singh, S.E. Okhale and B. Adzu, 2020. Ethnopharmacology-aided antiplasmodial evaluation of six selected plants used for malaria treatment in Nigeria. J. Ethnopharmacol., 10.1016/j.jep.2020.112694.
    CrossRef  |  Direct Link  |  
  3. Ezenyi, I.C., R.C. Okechukwu, G.A. Alle, S.A. Fidelis and O.A. Salawu, 2019. Enhanced gastric mucus production by syzygium guineense leaf extract mediates is antiulcer properties. Asian J. Biol. Sci., 12: 765-771.
    CrossRef  |  Direct Link  |  
  4. Ezenyi, I.C., G. Onavbavba, B. Adzu, S.E. Okhale and O.A. Salawu, 2018. Sesamum indicum leaf extract therapy for symptoms of acute malaria: Evaluation of anti-inflammatory, antipyretic and analgelsic effects. J. Phytomed. Ther., 17: 167-179.
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  5. Ezenyi, I.C. and J.O. Igoli, 2018. Antidiarrhoeal properties of Syzygium guineense leaf extract and identification of chemical constituents in its active column fractions. J. Complementary Integ. Med., 10.1515/jcim-2016-0074.
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  6. Nwafuru, S.K., T.C. Akunne, I.C. Ezenyi and C.O. Okoli, 2017. Anti-inflammatory activity of leaf extract and fractions of Tapinanthus bangwensis (Engl. & K.Krause) Danser parasitic on Citrus angustifolia. Eur. J. Med. Plants, 21: 1-10.
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  7. Nwaeze, A.C., O.I. Ajayi, I.C. Ezenyi, A.Y. Tijani and O.A. Salawu, 2017. Evaluation of ethanol extract of Artemisia maciverae aerial part for antiplasmodial activity in mice. J. Phytomed. Ther., 16: 77-85.
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  8. Ezeani, C., I. Ezenyi, T. Okoye and C. Okoli, 2017. Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes. J. Intercult. Ethnopharmacol., 6: 22-28.
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  9. Muoghalu, G.U., P.A. Akah, T.C. Okoye, I.C. Ezenyi, S. Ibeneme and C.O. Okoli, 2016. Anti-inflammatory activity of fatty extract of Vitalleria paradoxa Kernel (Shea butter) and pattern of its clinical use in arthritis in Enugu, South East Nigeria. Int. J. Basic Clin. Pharmacol., 5: 2345-2351.
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  10. Ezenyi, I.C., P.A. Akah and C.O. Okoli, 2016. Stachytarpheta cayennensis methanol leaf extract and solvent fractions display antiplasmodial activity against Plasmodium berghei berghei in vivo. Int. J. Phytopharmacol., 7: 1-9.
  11. Ezenyi, I.C., O.N. Mbamalu, L. Balogun, L. Omorogbe, F.S. Ameh and O.A. Salawu, 2016. Antidiabetic potentials of Syzygium guineense methanol leaf extract. J. Phytopharmacol., 5: 150-156.
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  12. Ezenyi, I.C. and O.A. Salawu, 2016. Approaches, Challenges and Prospects of Antimalarial Drug Discovery from Plant Sources. In: Current Topics in Malaria, Rodriguez-Morales, A.J. (Ed.). InTech Inc., Rijeka, ISBN: 978-953-51-2789-5, pp: 187-204.
  13. Chinwude, E.I., A.P. Achunike and O.C. Ogbonnaya, 2016. Antiplasmodial activity and some active compounds from Stachytarpheta cayennensis Vahl.(Verbenaceae) leaf fractions. Anti-Infect. Agents, 14: 132-138.
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  14. Obidike, I.C., B. Amodu and M.O. Emeje, 2015. Antimalarial properties of SAABMAL®: An ethnomedicinal polyherbal formulation for the treatment of uncomplicated malaria infection in the tropics. Indian J. Med. Res., 141: 221-227.
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  15. Idakwoji, P.A., O.A. Salawu, B.B. Maiha, I. Obidike and A.Y. Tijani, 2015. Co-administeration of ethanolic leaf extract of Moringa oleifera and metformin improves glucose, lipid and protein profiles of diabetic wistar rats. Biokemistri, 27: 129-138.
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  16. Emeje, O.M., B.I. Ifiora, C.I. Ezenyi and S.I. Ofoefule, 2015. Assessment of bread safety in Nigeria: One decade after the ban on the use of potassium bromate. J. Food Process Technol., Vol. 6. 10.4172/2157-7110.1000409.
    CrossRef  |  
  17. Adejoh, I.P., O.A. Salawu, B.B. Maiha, O. Ifeoma and A.Y. Tijani, 2015. Assessment of biochemical and histopathological changes in diabetic wistar rats co-administered ethanolic leaf extract of Moringa oleifera and metformin. Int. J. Biol. Pharm. Res., 6: 1008-1019.
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  18. Ezenyi, I.C., O.A. Salawu, R. Kulkarni and M. Emeje, 2014. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitol. Res., 113: 4415-4422.
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  19. Ezenyi, I.C., L. Ranarivelo, S.A. Oluwakanyinsola and M. Emeje, 2014. Analgesic, anti-inflammatory and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum. J. Basic Clin. Physiol. Pharmacol., 25: 217-223.
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  20. Chinwude, E.I., K.Roshan, J. Swati, S.O. Adeola and E. Martins, 2014. Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pac. J. Trop. Biomed., 4: 707-713.
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  21. Ifeoma, O., O. Samuel, A.M. Itohan and S.O. Adeola, 2013. Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pac. J. Trop. Med., 6: 169-175.
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  22. Emeje, M.O., I.C. Obidike, E.I. Akpabio and S.I. Ofoefule, 2012. Nanotechnology in Drug Delivery. In: Recent Advances in Novel Drug Carrier Systems, Sezer, A.D. (Ed.). Chapter 4, InTech Publisher, Rijeka, ISBN: 978 953-51-0810-8, pp: 69-106.
  23. Okoli, C.O., I.C. Obidike, A.C. Ezike, P.A. Akah and O.A. Salawu, 2011. Studies on the mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri L. Pharma. Biol., 49: 248-255.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Obidike, I.C., M. Idris-Usman, L.B. John-Africa and O.A. Salawu, 2011. An evaluation of acute and sub chronic toxicological effects of Hymenocardia acida leaf extract in adult wistar rats. J. Pharm. Toxicol., 6: 400-408.
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  25. Obidike, I.C. and M.O. Emeje, 2011. Microencapsulation enhances the antiulcerogenic properties of Entada africana leaf extract. J. Ethnopharmacol., 137: 553-561.
    PubMed  |  
  26. Isimi, C., I. Obidike, M. Aboh and M. Emeje, 2011. Anti-plasmodial activity of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana and in vitro evaluation of its tablet dosage form. J. Herbs Spices Med. Plants, 17: 419-435.
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  27. Emeje, M., S. Boyi, I. Obidike, C. Isimi, O. Kunle and S. Ofoefule, 2011. Natural antidiabetic compound for the therapeutic management of diabetes mellitus and its drug delivery system. J. Dietary Suppl., 8: 266-279.
    CrossRef  |  Direct Link  |  
  28. Obidike, I.C., O.A. Salawu, M. Ndukuba, C.O. Okoli and U.A. Osunkwo, 2010. The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system. J. Dietary Suppl., 7: 341-350.
    CrossRef  |  
  29. Salawu, O.A., B.A. Chindo, A.Y. Tijani, I.C. Obidike, T.A. Salawu and A.J. Akingbasote, 2009. Acute and sub-acute toxicological evaluation of the methanolic stem bark extract of Crossopteryx febrifuga in rats. Afr. J. Pharm. Pharmacol., 3: 621-626.
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  30. Salawu, O.A., A.Y. Tijani, I.C. Obidike, S.Z. Tags and S. Dzarma et al., 2009. Safety evaluation of NIPRD AD-1, an antidiabetic phytomedicine, in rabbits. J. Phytomed. Ther., 13: 34-46.
  31. Salawu, O.A., A.Y. Tijani, I.C. Obidike, H.A. Rafindadi and M. Emeje, 2009. Anti-ulcerogenic properties of methanolic root extract of Piliostigma reticulatum (DC) hoechst (Syn. Bauhinia reticulate DC)-leguminosae in rats. Afr. J. Pharm. Pharmacol., 3: 252-258.
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  32. Builders, F.P., C. Chukwu, I. Obidike, M.I. Builders, A.A. Attama and M.U. Adikwu, 2009. A novel xyloglucan gum from seeds of Afzelia africana Se. Pers.: Some functional and physicochemical properties. Int. J. Green Pharm., 3: 112-118.
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  33. Obidike, I.C., O.A. Salawu, Y.A. Tijani and A.T. Salawu, 2008. Antiplasmodial activities of singly administered three Nigerian medicinal plants and their co-administration. Nig. J. Pharm. Res., 7: 83-88.
  34. Salawu, O.A., A.Y. Tijani, I.C. Obidike and B.A. Chindo, 2007. Evaluation of antidiarrhoeal properties of methanolic root extract of Piliostigma reticulatum in rats. J. Phytomed. Ther., 12: 44-50.
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