Dr. Ezenyi Ifeoma  Chinwude Obidike

Dr. Ezenyi Ifeoma Chinwude Obidike

Senior Research Fellow
National Institute for Pharmaceutical Research and Development, Nigeria


Highest Degree
Ph.D. in Pharmacology and Toxicology from University of Nigeria, Nsukka, Nigeria

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Area of Interest:

Pharmacology and Toxicology
100%
Molecular Modeling
62%
Antidiabetic Activity
90%
Drug Discovery
75%
Malaria
55%

Selected Publications

  1. Okpoko, C., I. Ezenyi, B. Adzu, O. Salawu, 2020. Evaluation of two medicinal plants used for arthritis in northern Nigeria with focus on Terminalia avicennioides Guill. & Perr. and its mechanism of action. Sci. Afr., 10.1016/j.sciaf.2020.e00357.
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  2. Ezenyi, I.C., V. Verma, S. Singh, S.E. Okhale and B. Adzu, 2020. Ethnopharmacology-aided antiplasmodial evaluation of six selected plants used for malaria treatment in Nigeria. J. Ethnopharmacol., 10.1016/j.jep.2020.112694.
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  3. Ezenyi, I.C., R.C. Okechukwu, G.A. Alle, S.A. Fidelis and O.A. Salawu, 2019. Enhanced gastric mucus production by syzygium guineense leaf extract mediates is antiulcer properties. Asian J. Biol. Sci., 12: 765-771.
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  4. Ezenyi, I.C., G. Onavbavba, B. Adzu, S.E. Okhale and O.A. Salawu, 2018. Sesamum indicum leaf extract therapy for symptoms of acute malaria: Evaluation of anti-inflammatory, antipyretic and analgelsic effects. J. Phytomed. Ther., 17: 167-179.
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  5. Ezenyi, I.C. and J.O. Igoli, 2018. Antidiarrhoeal properties of Syzygium guineense leaf extract and identification of chemical constituents in its active column fractions. J. Complementary Integ. Med., 10.1515/jcim-2016-0074.
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  6. Nwafuru, S.K., T.C. Akunne, I.C. Ezenyi and C.O. Okoli, 2017. Anti-inflammatory activity of leaf extract and fractions of Tapinanthus bangwensis (Engl. & K.Krause) Danser parasitic on Citrus angustifolia. Eur. J. Med. Plants, 21: 1-10.
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  7. Nwaeze, A.C., O.I. Ajayi, I.C. Ezenyi, A.Y. Tijani and O.A. Salawu, 2017. Evaluation of ethanol extract of Artemisia maciverae aerial part for antiplasmodial activity in mice. J. Phytomed. Ther., 16: 77-85.
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  8. Ezeani, C., I. Ezenyi, T. Okoye and C. Okoli, 2017. Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes. J. Intercult. Ethnopharmacol., 6: 22-28.
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  9. Chinelo, E., E. Ifeoma, O. Theophine and O. Charles, 2017. Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes. J. Intercult. Ethnopharmacol., 6: 22-28.
  10. Muoghalu, G.U., P.A. Akah, T.C. Okoye, I.C. Ezenyi, S. Ibeneme and C.O. Okoli, 2016. Anti-inflammatory activity of fatty extract of Vitalleria paradoxa Kernel (Shea butter) and pattern of its clinical use in arthritis in Enugu, South East Nigeria. Int. J. Basic Clin. Pharmacol., 5: 2345-2351.
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  11. Ezenyi, I.C., P.A. Akah and C.O. Okoli, 2016. Stachytarpheta cayennensis methanol leaf extract and solvent fractions display antiplasmodial activity against Plasmodium berghei berghei in vivo. Int. J. Phytopharmacol., 7: 1-9.
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  12. Ezenyi, I.C., O.N. Mbamalu, L. Balogun, L. Omorogbe, F.S. Ameh and O.A. Salawu, 2016. Antidiabetic potentials of Syzygium guineense methanol leaf extract. J. Phytopharmacol., 5: 150-156.
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  13. Ezenyi, I.C. and O.A. Salawu, 2016. Approaches, Challenges and Prospects of Antimalarial Drug Discovery from Plant Sources. In: Current Topics in Malaria, Rodriguez-Morales, A.J. (Ed.). InTech Inc., Rijeka, ISBN: 978-953-51-2789-5, pp: 187-204.
  14. Chinwude, E.I., A.P. Achunike and O.C. Ogbonnaya, 2016. Antiplasmodial activity and some active compounds from Stachytarpheta cayennensis Vahl.(Verbenaceae) leaf fractions. Anti-Infect. Agents, 14: 132-138.
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  15. Obidike, I.C., B. Amodu and M.O. Emeje, 2015. Antimalarial properties of SAABMAL®: An ethnomedicinal polyherbal formulation for the treatment of uncomplicated malaria infection in the tropics. Indian J. Med. Res., 141: 221-227.
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  16. Idakwoji, P.A., O.A. Salawu, B.B. Maiha, I. Obidike and A.Y. Tijani, 2015. Co-administeration of ethanolic leaf extract of Moringa oleifera and metformin improves glucose, lipid and protein profiles of diabetic wistar rats. Biokemistri, 27: 129-138.
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  17. Emeje, O.M., B.I. Ifiora, C.I. Ezenyi and S.I. Ofoefule, 2015. Assessment of bread safety in Nigeria: One decade after the ban on the use of potassium bromate. J. Food Process Technol., Vol. 6. 10.4172/2157-7110.1000409.
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  18. Adejoh, I.P., O.A. Salawu, B.B. Maiha, O. Ifeoma and A.Y. Tijani, 2015. Assessment of biochemical and histopathological changes in diabetic wistar rats co-administered ethanolic leaf extract of Moringa oleifera and metformin. Int. J. Biol. Pharm. Res., 6: 1008-1019.
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  19. Ezenyi, I.C., O.A. Salawu, R. Kulkarni and M. Emeje, 2014. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitol. Res., 113: 4415-4422.
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  20. Ezenyi, I.C., L. Ranarivelo, S.A. Oluwakanyinsola and M. Emeje, 2014. Analgesic, anti-inflammatory and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum. J. Basic Clin. Physiol. Pharmacol., 25: 217-223.
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  21. Chinwude, E.I., K.Roshan, J. Swati, S.O. Adeola and E. Martins, 2014. Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pac. J. Trop. Biomed., 4: 707-713.
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  22. Ifeoma, O., O. Samuel, A.M. Itohan and S.O. Adeola, 2013. Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pac. J. Trop. Med., 6: 169-175.
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  23. Emeje, M.O., I.C. Obidike, E.I. Akpabio and S.I. Ofoefule, 2012. Nanotechnology in Drug Delivery. In: Recent Advances in Novel Drug Carrier Systems, Sezer, A.D. (Ed.). Chapter 4, InTech Publisher, Rijeka, ISBN: 978 953-51-0810-8, pp: 69-106.
  24. Okoli, C.O., I.C. Obidike, A.C. Ezike, P.A. Akah and O.A. Salawu, 2011. Studies on the mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri L. Pharma. Biol., 49: 248-255.
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  25. Obidike, I.C., M. Idris-Usman, L.B. John-Africa and O.A. Salawu, 2011. An evaluation of acute and sub chronic toxicological effects of Hymenocardia acida leaf extract in adult wistar rats. J. Pharm. Toxicol., 6: 400-408.
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  26. Obidike, I.C. and M.O. Emeje, 2011. Microencapsulation enhances the antiulcerogenic properties of Entada africana leaf extract. J. Ethnopharmacol., 137: 553-561.
    PubMed  |  
  27. Isimi, C., I. Obidike, M. Aboh and M. Emeje, 2011. Anti-plasmodial activity of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana and in vitro evaluation of its tablet dosage form. J. Herbs Spices Med. Plants, 17: 419-435.
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  28. Emeje, M., S. Boyi, I. Obidike, C. Isimi, O. Kunle and S. Ofoefule, 2011. Natural antidiabetic compound for the therapeutic management of diabetes mellitus and its drug delivery system. J. Dietary Suppl., 8: 266-279.
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  29. Obidike, I.C., O.A. Salawu, M. Ndukuba, C.O. Okoli and U.A. Osunkwo, 2010. The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system. J. Dietary Suppl., 7: 341-350.
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  30. Salawu, O.A., B.A. Chindo, A.Y. Tijani, I.C. Obidike, T.A. Salawu and A.J. Akingbasote, 2009. Acute and sub-acute toxicological evaluation of the methanolic stem bark extract of Crossopteryx febrifuga in rats. Afr. J. Pharm. Pharmacol., 3: 621-626.
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  31. Salawu, O.A., A.Y. Tijani, I.C. Obidike, S.Z. Tags and S. Dzarma et al., 2009. Safety evaluation of NIPRD AD-1, an antidiabetic phytomedicine, in rabbits. J. Phytomed. Ther., 13: 34-46.
  32. Salawu, O.A., A.Y. Tijani, I.C. Obidike, H.A. Rafindadi and M. Emeje, 2009. Anti-ulcerogenic properties of methanolic root extract of Piliostigma reticulatum (DC) hoechst (Syn. Bauhinia reticulate DC)-leguminosae in rats. Afr. J. Pharm. Pharmacol., 3: 252-258.
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  33. Builders, F.P., C. Chukwu, I. Obidike, M.I. Builders, A.A. Attama and M.U. Adikwu, 2009. A novel xyloglucan gum from seeds of Afzelia africana Se. Pers.: Some functional and physicochemical properties. Int. J. Green Pharm., 3: 112-118.
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  34. Obidike, I.C., O.A. Salawu, Y.A. Tijani and A.T. Salawu, 2008. Antiplasmodial activities of singly administered three Nigerian medicinal plants and their co-administration. Nig. J. Pharm. Res., 7: 83-88.
  35. Salawu, O.A., A.Y. Tijani, I.C. Obidike and B.A. Chindo, 2007. Evaluation of antidiarrhoeal properties of methanolic root extract of Piliostigma reticulatum in rats. J. Phytomed. Ther., 12: 44-50.
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