Prof. Olorunfemi Abraham Eseyin

Prof. Olorunfemi Abraham Eseyin

Professor
University of Uyo, Nigeria


Highest Degree
PostDoc Fellow in Natural Products from Universiti Sains Malaysia, Malaysia

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Biography

Professor of Pharmaceutical and Medicinal Chemistry with research interests in the following areas: bioprospecting for novel anti-diabetic and anti-malaria drugs; food-drug interactions and natural products. Grantee of IFS individual research grant and also collaborative research grant. USM-TWAS postdoctoral fellow and head of Drug Discovery and Research Group. Author of over 70 scientific publications in peer reviewed journals and member of some international learned societies. Immediate past Head of the department of Pharmacognosy and Natural Medicine; and former acting Head of the department of Pharmaceutical and Medicinal Chemistry, both in the University of Uyo, Nigeria. Pioneer Editor in Chief of Nigerian Journal of pharmaceutical and Applied Science Research and Regional Editor of International Journal of Pharmacology, American Journal of Biochemistry and molecular Biology, Asian Journal of Biochemistry, Research Journal of Medicinal Plants etc.

Area of Interest:

Biomedical Sciences
100%
Natural Products
62%
Medicinal Plants
90%
Pharmacokinetics
75%
Pharmacy
55%

Selected Publications

  1. Ebong, A.S., O.A. Eseyin, E.E. Iweh, J.E. Okokon, V.U. Anah, E.E. Attih and G.E. Charles, 2020. Telfairia occidentalis potentiates the antiplasmodial activity of artemisinins and amodiaquine combination therapy. Anti-Infective Agents Med. Chem., 10.2174/2211352517666190206160812.
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  2. Eseyin, O.A., U. Benedict, P.S. Thomas, I. Etim and E. Essien et al., 2019. Isolation and characterization of antioxidant constituents of the fruit of Telfairia occidentalis Hook F (Cucurbitaceae). Trop. J. Pharm. Res., 10.4314/tjpr.v17i10.9.
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  3. Ebong, A.S., O.A. Eseyin, E.I. Etim, V.U. Anah, A.S. Udobre, E.C. Johnson and G.E. Charles, 2019. Effect of Telfairia occidentalis on the Pharmacokinetic parameters and efficacy of Dihydroartemisinin and amodiaquine combination therapy. World J. Pharm. Pharm. Sci., 10.20959/wjpps201911-14899.
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  4. Eseyin, O.A., M.A. Sattar, H.A. Rathore, F. Aigbe, S. Afzal, A. Ahmad, M. Lazhari and S. Akthar, 2018. HPLC and GC-MS analyses of Phenolics in the leaf of Telfairia occidentalis. Pak. J. Pharm. Sci., 31: 45-50.
  5. 1. Eseyin, O.A., E. Edem, E. Johnson, S. Afzal and A. Ahmad, 2018. Synthesis and in vitro antidiabetic activity of some alkyl carbazole compounds. Trop. J. Pharm. Res., 17: 537-541.
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  6. Eseyin, A., D. Akaninyene, S.P. Thomas, E. Attih and E. Essien et al., 2017. Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae). Nat. Prod. Res., 32: 444-447.
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  7. Edet, AE., E. Olorunfemi, E. Patrick, I. Godwin, T.P. Sunday and E. Aniekan, 2017. Antiplasmodial activity of ethanol extract and fractions of Nauclea latifolia smith (rubiacea) roots. World J. Pharm. Sci., 5: 106-118.
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  8. Asangha, E.E., G.O. Igile, I.A. Iwara, P.E. Ebong and O.A. Eseyin, 2017. Hematological Indices of Plasmodium berghei infected mice treated with ethanol extract and fractions of Nauclea latifolia roots. Int. J. Curr. Microbiol. Applied. Sci, 6: 2546-2556.
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  9. Aigbe, F.R., A.S.Z. Munavvar, H. Rathore, O. Eseyin and Y.P. Pei et al., 2017. Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens vahl. (aristolochiaceae). J. Trad. Complementary Med., 8: 72-80.
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  10. Umoh, I.J., O.A. Eseyin and A.A. Ahmadu, 2016. Phytosterol from the leaves of vernonia conferta benth (asteraceae). Nigerian J. Pharm. Applied Sci. Res., 5: 16-17.
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  11. Johnson, E.C., M. Ilyas, M.I. Sule, O.A. Eseyin and H.O. Oladimeji, 2016. Antimicrobial activity of compounds isolated from the leaves of Aspilia africana (Pers.) C. D. Adams (Asteraceae). Afr. J. Pharmacol. Ther., 5: 149-154.
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  12. Johnson, E., M. Ilyas, O. Eseyin, E. Etim and E. Edem, 2016. Isolation, Characterization and anti-diabetic potential of oleanolic acid from leaf of Aspilia Africana (pers) C.D adams (asteraceae). J. Pharm. Med. Res., 2: 62-65.
  13. Edet, E.A., A.E. Olorunfemi, N.E. Aniebiet and A. Dennis, 2016. Changes in serum zinc, magnesium and copper in sickle cell patients: A case study in Jos, Nigeria. World J. Pharm. Sci., 4: 195-199.
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  14. Eseyin, O.A., G.C. Etiemmana, M. Enobong, A. Ebong and E. Iweh et al., 2015. Evaluation of the antioxidant properties of some commonly eaten vegetables in Akwa Ibom State of Nigeria. Annu. Res. Rev. Biol., 5: 165-173.
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  15. Attih, E., C. Usifoh, D.A. Ambe and O.A. Eseyin, 2015. Quantitative Titrimetric and Spectrophotometric determination of Dihydroartemisinin based on the redox reaction with cerium ammonium sulphate. J. Chem. Pharma. Res., 7: 732-738.
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  16. Eseyin, O.A., M.A. Sattar, H.A. Rathore, A. Ahmad and S. Afzal et al., 2014. Hypoglycemic potential of polysaccharides of the leaf extract of Telfairia occidentalis. Annu. Res. Rev. Biol., 4: 1813-1826.
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  17. Eseyin, O.A., M.A. Sattar and H.A. Rathore, 2014. A review of the pharmacological and biological activities of the aerial parts of Telfairia occidentalis Hook.f. (Cucurbitaceae). Trop. J. Pharmaceut. Res., 13: 1761-1769.
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  18. Ekpo, A.J., E.O. Jimmy and O.A. Eseyin, 2014. Glycemic response of premature varieties of plantain meals. Int. J. Innov. Med. Health Sci., 3: 1-8.
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  19. Etim, E.I., E.E. Essien, O.A. Eseyin and I.E. Udoh, 2013. Effect of some artemisinin and combination therapy regimens with and without concomitant administration of phospholipids on the levels of plasma aminotransferases and bilirubin in Nigerian male subjects. Afr. J. Pharmacol. Therapeut., 2: 17-25.
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  20. Eseyin, O.A., A. Ebong, M. Akpanabiatu and U. Ufot, 2013. Evaluation of the effect of some common Nigerian vegetables on the pharmacokinetics of chloroquine and dihydroartemisinin in rat. Indo Am. J. Pharm. Res., 3: 1695-1710.
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  21. Effiong, A.E., P. Ebong and O.A. Eseyin, 2013. Hypoglycemic effect of ethanol extract and fractions of Nauclea latifolium leaf on normal and alloxan-induced diabetic rats. Int. J. Biochem. Biotechnol., 2: 457-460.
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  22. Edet, A.E., E.E. Patrick and A.O. Eseyin, 2013. Hematological parameters of alloxan-induced diabetic rats treated with ethanol extracts and fractions of Nauclea lafiloia leaf. Eur. Scient. J., 9: 203-210.
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  23. Edet, A., P. Ebong, O. Eseyin, I. Udoh, R. Eyo and G. Effiong, 2013. Lipid profile of alloxan-induced diabetic Albino Wistar rats treated with ethanol whole extract and fractions of Nauclea latifolia leaves. ARPN J. Sci. Technol., 3: 1009-1013.
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  24. Edet, A., P. Ebong, O. Eseyin, I. Udoh and R. Eyo, 2013. Anti-diabetic effect and RNA content of the pancreas of Albino Wistar rats treated with aqueous extract of Vernonia amygdalina roots. Int. J. Pharma Sci., 3: 391-393.
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  25. Asanga, E.E., E.P. Ebong, A.O. Eseyin, E.I. Udoh and A.R. Eyo, 2013. Effect of ethanol extract and fractions of Nauclea latifolia leaves on some biochemical parameters of alloxan-induced diabetic rats. Int. J. Res. Rev. Pharm. Applied Sci., 3: 147-154.
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  26. Ahmad, A., M.Z.A. Sattar, H.A. Rathore, T. Fatima and S.A. Khan et al., 2013. Pharmacological importance of Nardostachys jatamansi DC: A potential therapeutic agent in different pathological ailments. J. Chem. Pharmaceut. Res., 5: 431-438.
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  27. Udobre, A.S., C.O. Usifoh, O.A. Eseyin, A.E. Udoh and O.A. Awofisayo et al., 2012. The wound healing activity of methanol extract of the stem bark of Nauclea latifolia. Int. J. Pharm. Biomed. Sci., 3: 136-139.
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  28. Olorunfemi, E.A., I.C. Arnold, I. Chinenye, I. Adaora, E. Johnson and D. Barido, 2012. Effects of the leaf extract of vernonia amygdalina on the pharmacokinetics of dihydroartemisinin in rat. Pharmacologia, 3: 713-718.
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  29. Johnson, E., M. Chuodhury, E.O. Abraham and U.A. Sunday, 2012. Pharmacological studies of the bark of Commiphora africana (Burseraceae). J. Pharmacol. Toxicol., 7: 52-57.
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  30. Igboasoiyi, A.C., O.A. Eseyin, H.O. Oladimeji and R.J. Akpan, 2012. Quality assessment of some brands of piroxicam capsules. Nig. J. Pharm. Applied Sci. Res., 1: 91-97.
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  31. Eseyin, O.A., A. Ebong, A. Udobre, J. Ekarika and I. Udoh, 2012. Changes in some pharmacokinetics parameters of Chloroquine by Gnetum Africana. Macedonian J. Med. Sci., 5: 275-279.
  32. Attih, E.E., E.E. Essien, O.A. Eseyin, H.O. Oladimeji and A.C. Igboasoiyi, 2012. Assay of dihydroartemisinin by iodometric titration. Nig. J. Pharm. Applied Sci. Res., 1: 74-82.
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  33. Udobre, A.S., O.A. Eseyin, U.E. Osonwa, A.E. Udoh and E.C. Johnson, 2011. Effects of artesunate alone and in combination with folic acid on the liver and serum iron level of male wistar rats. Nig. J. Pharm. Applied. Sci. Res., 1: 59-65.
  34. Olorunfemi, E., E. Aniekan, A. Udobre and I. Udoh, 2011. Effects of the leaf of Lasianthera africana on the pharmacokinetics of chloroquine in rats. J. Med. Plants Res., 5: 2665-2669.
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  35. Nkereuwem, A.O., O.A. Eseyin, S.A. Udobre and A. Ebong, 2011. Evaluation of antioxidant activity and chemical analysis of the leaf of Telfairia occidentalis. Niger. J. Pharmaceut. Applied Sci. Res., 1: 21-28.
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  36. Johnson, E.C., O.A. Eseyin, A.S. Udobre and P. Ike, 2011. Evaluation of chemical constituents and anti-microbial effect of methanolic extract of the root of Aspilia Africana. Nigerian J. Pharm. Applied Sci. Res., 1: 44-50..
  37. Ekpo, B., K. Ajibesin, O.A. Eseyin and D. Bala, 2011. Evaluation of hypoglycaemic activity of Musa paradisiacal (Musaceae) in rat. Int. J. Res. Ayurveda. Pharm., 2: 498-501.
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  38. Udobre, A., O.A. Eseyin, E. Iweh and U. Umoh, 2010. Effect of artemisinin alone and artemisinin with folic acid on the lipid profile of male wistar rats. Int. J. Biol. Chem. Sci., 4: 2421-2426.
  39. Eseyin, O.A., P. Ebong, E.U. Eyong, E. Umoh and H. Agboke, 2010. Hypoglycaemic activity of ethyl acetate fraction of the leaf extract of Telfairia Occidentalis. Pak. J. Pharm. Sci., 23: 341-343.
    PubMed  |  
  40. Eseyin, O.A., P. Ebong, E. Eyong, O. Awofisayo and A. Agboke, 2010. Effect of Telfairia occidentalis on oral glucose tolerance in rats. Afr. J. Pharm. Pharmacol., 4: 368-372.
  41. Eseyin, O., O.S. Jackson, A. Udobre, A. Agboke and O. Awofisayo, 2010. Comparative study of the effects of aqueous and ethanolic leaf extracts of Musa paradisiaca L. (Musaceae) on some biochemical parameters in rat. Int. J. Phytopharm. Res., 1: 21-24.
  42. Eseyin, O., A. Ebong, E. Attih and U. Imo, 2010. Effects of the leaf of Heinsia crinata on the pharmacokinetics of chloroquine in rats. Int. J. Biol. Pharm. Sci., 1: 88-93.
  43. Eseyin, A.O., O. Awofisayo, E. Iweh and J.S. Obot, 2010. Hematological effect of the aqueous and ethanolic leaf extracts of Musa paradisiaca L. (Musaceae) in rat. Afr. J. Anim. Biomed. Sci., 5: 115-117.
  44. Olorunfemi, A., P.E. Eseyin, E.U. Eyong, E. Umoh and E. Attih, 2010. Comparative hypoglycaemic effects of ethanolic and aqueous extracts of the leaf and seed of Telfairia occidentalis. Turk. J. Pharm. Sci., 7: 29-34.
  45. Udobre, A., E.J. Edoho, O. Eseyin and E.I. Etim, 2009. Effect of Artemisin with folic acid on the activities of aspartate amino transferase, alanine amino transferase and alkaline phosphatase in rat. Asian J. Biochem., 4: 55-59.
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  46. Okokon, J.E., A. Ekpo and O.A. Eseyin, 2009. Antiplasmodial activity of ethanolic leaf and seed extracts of Telfairia occidentalis. J. Med. Food, 12: 1-5.
  47. Igboasoiyi, A.C., O.A, Eseyin and N.F. Udoma, 2008. The effect of ethanolic extract of Vernonia amygdalina leaves on some pharmacokinetic parameters of chloroquine in rats. Res. J. Pharmacol., 2: 24-27.
  48. Okokon, J.E., A.J. Ekpo and O.A. Eseyin, 2007. Antiplasmodial activity of ethanolic root extract of Telfairia occidentalis. Res. J. Parasitol., 2: 94-98.
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  49. Igboasoiyi, A.C., O.A. Eseyin, N.K. Ezenwa and H.O. Oladimeji, 2007. Studies on the toxicity of Ageratum conizoides. J. Pharmacol. Toxicol., 2: 743-747.
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  50. Igboasoiyi, A.C., E.E. Essien, O.A. Eseyin and G. Ubam, 2007. Screening of the seed of Picralima nitida for hypoglycaemic activity. Pak. J. Biol. Sci., 10: 828-830.
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  51. Eseyin, O.A., P. Ebong, A. Ekpo, A. Igboasoiyi and E. Oforah, 2007. Hypoglycemic effect of the seed extract of Telfairia occidentalis in rat. Pak. J. Biol. Sci., 10: 498-501.
    CrossRef  |  Direct Link  |  
  52. Eseyin, O.A., I. Udoh, A. Ekpo, E.J. Edoho and A.C. Igboasoiyi, 2007. Biochemical effects of the seed extract of Telfairia occidentalis in rats. Int. J. Pharmacol., 3: 198-200.
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  53. Eseyin, O.A., E.J. Edoho, N.E. Godwin, A.C. Igboasoiyi and A. Ekpo, 2007. Effects of the leaf extract of Telfairia occidentalis on the pharmacokinetics of chloroquine in rats. Int. J. Biol. Sci., 1: 256-260.
    CrossRef  |  
  54. Eseyin, O.A., A. Ekpo, I. Idem, A.C. Igboasoiyi and E.J. Edoho, 2007. Effects of the fruit of Telfairia occidentalis on some biomolecules in rat. Pak. J. Biol. Sci., 10: 3240-3242.
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  55. Ekpo, A., O.A. Eseyin, A.O. Ikpeme and J.E. Edoho, 2007. Studies on some biochemical effects of Vernonia amygdalina in rats. Asian J. Biochem., 2: 193-197.
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  56. Ekpo, A., O. Eseyin, N. Kalu, O. Jackson and E.J. Edoho, 2007. Studies on the biochemical effects of Talinum triangulare in rat. J. Pharmacol. Toxicol., 2: 300-303.
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  57. Igboasoiyi, A.C., O.E.Okoye and O.A. Eseyin, 2006. Analysis of some chloroquine preparations in the Nigerian Market. J. Applied Sci., 9: 6439-6445.
    CrossRef  |  
  58. Eseyin, O.A., P. Ebong, A. Ekpo, A. Igboasoiyi and F. Ekpo, 2006. Effect of the root extract of Telfairia occidentalis on some biochemical parameters in rat. J. Pharm. Bioresour., 3: 1-4.
  59. Eseyin, O.A., A.C. Igboasoiyi, E. Oforah, N. Nkop and A. Agboke, 2005. Hypoglycaemic activity of Telfairia occidentalis in rats. J. Pharmacol. Bioresour., 2: 36-42.
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  60. Eseyin, O.A., A.C. Igboasoiyi, E. Oforah, C. Poh and C. Okoli, 2005. Effects of leaf extract of Telfairia occidentalis on some biochemical parameters in rat. Global J. Pure Applied Sci., 11: 85-87.
  61. Eseyin, O., A.C. Igboasoiyi, E. Oforah, N. Nkop and A. Agboke, 2005. Hypoglycaemic activity of Telfairia occidentalis in rats. J. Pharmacy Bioresources, 2: 36-42.
  62. Eseyin, A.O., A.C. Igboasoiyi, H. Mbagwu, E. Umoh and F.J. Ekpe, 2005. Studies of the effects of an alcohol extract of the leaves of Telfairia occidentalis on alloxan induced diabetic rats. Global J. Pure Applied Sci., 11: 77-79.
  63. Eseyin, O.A. and E. Oforah, 2002. Interaction among the components of guanidine nucleotide proteins: A review. J. Applied Sci., 2: 2786-2804.
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  64. Eseyin, A.O., E. Oforah and S. Awofisayo, 2002. Chart condensed cross talk among G protein mediated signal processes. A review. J. Sci. Eng. Technol., 9: 4016-4023.
  65. Eseyin, A.O. and E. Oforah, 2002. Activity of G proteins receptor kinases in G protein signaling process: A review. J. Sci. Eng. Technol., 9: 4106-4112.
  66. Oforah, E. and A. Eseyin, 2000. Serum Cathepsin activity as a probe of cardiac necrotic foci during long-term Chlorpromazine administration in rat. Nig. Med. J., 38: 46-49.
  67. Eseyin, O., E. Oforah and B.D. Dooka, 2000. Preliminary study of the hypoglycemic action of the extract of leaf of Telfairia occidentalis in Normoglycemic guinea pigs. Global J. Pure Appl. Sci., 6: 639-641.
  68. Eseyin, A.O., A. Kaoje and E. Oforah, 2000. Kinetics of commercial invertase. J. Sci. Eng. Technol., 7: 2739-2747.
  69. Oforah, E. and A. Eseyin, 1999. Chirality in drug molecules. Brief perspective in principles and biological activities. J. Sci. Eng. Technol., 6: 1486-1491.