Dr. Panagiotis  Zoumpoulakis

Dr. Panagiotis Zoumpoulakis

Research Scientist
National Hellenic Research Foundation, Greece


Highest Degree
Ph.D. in Chemistry from University of Patras, Greece

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Area of Interest:

Chemistry
100%
Bioorganic Chemistry
62%
Medicinal Chemistry
90%
Chemical Compound
75%
Food Chemistry
55%

Selected Publications

  1. Tsatsaroni, A., G. Zoidis, P. Zoumpoulakis, A. Tsotinis, M.C. Taylor, J.M. Kelly and G. Fytas, 2013. An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. Tetrahedron Lett., 54: 3238-3240.
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  2. Sinanoglou, V.J., I.F. Strati, S.M. Bratakos, C. Proestos, P. Zoumpoulakis and S. Miniadis-Meimaroglou, 2013. On the combined application of iatroscan TLC-FID and GC-FID to identify total, neutral and polar lipids and their fatty acids extracted from foods. ISRN Chromatogr., Vol. 2013 10.1155/2013/859024.
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  3. Proestos, C., P. Zoumpoulakis and V.J. Sinanoglou, 2013. Determination of plant bioactive compounds. Antioxidant capacity and antimicrobial screening. Focusing Modern Food Ind., 2: 26-35.
  4. Proestos, C., K. Lytoudi, O.K. Mavromelanidou, P. Zoumpoulakis and V.J. Sinanoglou, 2013. Antioxidant capacity of selected plant extracts and their essential oils. Antioxidants, 2: 11-22.
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  5. Matsoukas, M.T., C. Potamitis, P. Plotas, M.E. Androutsou, G. Agelis, J. Matsoukas and P. Zoumpoulakis, 2013. Insights into AT1 receptor activation through angii binding studies. J. Chem. Inform. Modeling, 53: 2798-2811.
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  6. Kritsi, E., C. Potamitis, S. Durdagi, P. Zoumpoulakis, S.G. Grdadolnik and T. Mavromoustakos, 2013. Molecular insights into the AT1 antagonism based on biophysical and in silico studies of telmisartan. Med. Chem. Res., 22: 4842-4857.
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  7. Fotakis, C., K. Kokkotou, P. Zoumpoulakis and M. Zervou, 2013. NMR metabolite fingerprinting in grape derived products: An overview. Food Res. Int., 54: 1184-1194.
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  8. Fotakis, C., D. Christodouleas, K. Kokkotou, M. Zervou and P. Zoumpoulakis et al., 2013. NMR metabolite profiling of Greek grape marc spirits. Food Chem., 138: 1837-1846.
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  9. Zoumpoulakis, P., V.J. Sinanoglou, A. Batrinou, I.F. Strati, S. Miniadis-Meimaroglou and K. Sflomos, 2012. A combined methodology to detect γ-irradiated white sesame seeds and evaluate the effects on fat content, physicochemical properties and protein allergenicity. Food Chem., 131: 713-721.
  10. Zoumpoulakis, P., C. Camoutsis, G. Pairas, M. Sokovic, J. Glamoclija, C. Potamitis and A. Pitsas, 2012. Synthesis of novel sulfonamide-1, 2, 4-triazoles, 1, 3, 4-thiadiazoles and 1, 3, 4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies. Bioorg. Med. Chem., 20: 1569-1583.
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  11. Parmenopoulou, V., D.S. Chatzileontiadou, S. Manta, S. Bougiatioti and P. Maragozidis et al., 2012. Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical and structural evaluation. Bioorg. Med. Chem., 20: 7184-7193.
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  12. Manta, S., A. Xipnitou, C. Kiritsis, A.L. Kantsadi and J.M. Hayes et al., 2012. 3‐Axial CH2OH substitution on glucopyranose does not increase glycogen phosphorylase inhibitory potency. QM/MM‐PBSA calculations suggest why. Chem. Biol. Drug Design, 79: 663-673.
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  13. Kantsadi, A.L., S. Manta, A.M. Psarra, A. Dimopoulou and C. Kiritsis et al., 2012. The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment. Eur. J. Med. Chem., 54: 740-749.
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  14. Kantsadi, A.L., J.M. Hayes, S. Manta, V.T. Skamnaki and C. Kiritsis et al., 2012. The σ‐Hole phenomenon of halogen atoms forms the structural basis of the strong inhibitory potency of C5 halogen substituted glucopyranosyl nucleosides towards glycogen phosphorylase b. ChemMedChem, 7: 722-732.
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  15. Hodzic, A., P. Zoumpoulakis, G. Pabst, T. Mavromoustakos and M. Rappolt, 2012. Losartan's affinity to fluid bilayers modulates lipid-cholesterol interactions. Phys. Chem. Chem. Phys., 14: 4780-4788.
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  16. Fotakis, C., G. Megariotis, D. Christodouleas, E. Kritsi and P. Zoumpoulakis et al., 2012. Comparative study of the AT1 receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers. Biochim. Biophys. Acta, 1818: 3107-3120.
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  17. Feuillastre, S., A.S. Chajistamatiou, C. Potamitis, M. Zervou and P. Zoumpoulakis et al., 2012. C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors. Bioorg. Med. Chem., 20: 5592-5599.
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  18. Skendi, A., C.G. Biliaderis, M.S. Izydorczyk, M. Zervou and P. Zoumpoulakis, 2011. Structural variation and rheological properties of water-extractable arabinoxylans from six Greek wheat cultivars. Food Chem., 126: 526-536.
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  19. Moutevelis-Minakakis, P., E. Papavassilopoulou, G. Michas, K. Georgikopoulou and M.E. Ragoussi et al., 2011. Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity. Bioorg. Med. Chem., 19: 2888-2902.
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  20. Matsoukas, M.T., P. Zoumpoulakis and T. Tselios, 2011. Conformational analysis of aliskiren, a potent renin inhibitor, using high-resolution nuclear magnetic resonance and molecular dynamics simulations. J. Chem. Inform. Modeling, 51: 2386-2397.
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  21. Fotakis, C., D. Christodouleas, P. Zoumpoulakis, E. Kritsi and N.P. Benetis et al., 2011. Comparative biophysical studies of sartan class drug molecules losartan and candesartan (CV-11974) with membrane bilayers. J. Phys. Chem. B, 115: 6180-6192.
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  22. Zervou, M., C. Koukoulitsa and P. Zoumpoulakis, 2010. Screening for Bioactive Compounds of Plant Origin using NMR-Based and in silico Approaches. In: Plants in Traditional and Modern Medicine: Chemistry and Activity, Kokalou E. (Ed.). Research Signpost, Kerala, India, pp: 235-266.
  23. Politi, A.P., M.V. Zervou, H. Triantafyllidi, P.G. Zoumpoulakis and T.M. Mavromoustakos et al., 2010. Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening. J. Renin-Angiotensin-Aldosterone Syst., 11: 103-110.
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  24. Omar, K., A. Geronikaki, P. Zoumpoulakis, C. Camoutsis, M. Sokovic, A. Ciric and J. Glamoclija, 2010. Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. Bioorg. Med. Chem., 18: 426-432.
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  25. Durdagi, S., M.G. Papadopoulos, P.G. Zoumpoulakis, C. Koukoulitsa and T. Mavromoustakos, 2010. A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: Homology modeling, docking, de novo drug design and molecular dynamics analysis. Mol. Diversity, 14: 257-276.
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  26. Camoutsis, C., A. Geronikaki, A. Ciric, M. Sokovic, P. Zoumpoulakis and M. Zervou, 2010. Sulfonamide-1, 2, 4-thiadiazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity and conformational studies. Chem. Pharm. Bull., 58: 160-167.
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  27. Potamitis, C., M. Zervou, V. Katsiaras, P. Zoumpoulakis and S. Durdagi et al., 2009. Antihypertensive drug valsartan in solution and at the AT1 receptor: Conformational analysis, dynamic NMR spectroscopy, in silico docking and molecular dynamics simulations. J. Chem. Inform. Modeling, 49: 726-739.
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  28. Gabriel, C., M. Menelaou, M. Daskalakis, A. Lakatos and T. Kiss et al., 2008. Synthetic, structural, spectroscopic and solution speciation studies of the binary Al (III)-quinic acid system. Relevance of soluble Al (III)-hydroxycarboxylate species to molecular toxicity. Polyhedron, 27: 2911-2920.
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  29. Ezabadi, I.R., C. Camoutsis, P. Zoumpoulakis, A. Geronikaki, M. Sokovic, J. Glamocilija and A. Ciric, 2008. Sulfonamide-1, 2, 4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity and conformational studies. Bioorg. Med. Chem., 16: 1150-1161.
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  30. Zoumpoulakis, P., A. Politi, S.G. Grdadolnik, J. Matsoukas and T. Mavromoustakos, 2006. Structure elucidation and conformational study of V8: A novel synthetic non peptide AT1 antagonist. J. Pharm. Biomed. Anal., 40: 1097-1104.
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  31. Mavromoustakos, T., P. Moutevelis-Minakakis, C.G. Kokotos, P. Kontogianni and A. Politi et al., 2006. Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues. Bioorg. Med. Chem., 14: 4353-4360.
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  32. Mavromoustako, T.M., M.V. Zervou and P.G. Zoumpoulakis, 2006. Design and discovery of novel antihypertensive drugs through conformation and bioactivity studies. Front. Med. Chem., 3: 87-111.
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  33. Zoumpoulakis, P. and T. Mavromoustakos, 2005. Seeking the active site of the AT1 receptor for computational docking studies. Drug Des. Rev. Online, 2: 537-545.
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  34. Kapou, A., M.A. Fousteris, S.S. Nikolaropoulos, M. Zervou and S.G. Grdadolnik et al., 2005. 2D NMR and conformational analysis of a prototype anti-tumour steroidal ester. J. Pharm. Biomed. Anal., 38: 428-434.
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  35. Mavromoustakos, T., P. Zoumpoulakis, I. Kyrikou, A. Zoga and E. Siapi et al., 2004. Efforts to understand the molecular basis of hypertension through drug: Membrane interactions. Curr. Topics Med. Chem., 4: 445-459.
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  36. Mavromoustakos, T., M. Zervou, P. Zoumpoulakis, I. Kyrikou and N.P. Benetis et al., 2004. Conformation and bioactivity. Design and discovery of novel antihypertensive drugs. Curr. Topics Med. Chem., 4: 385-401.
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  37. Zoumpoulakis, P., I. Daliani, M. Zervou, I. Kyrikou and E. Siapi et al., 2003. Losartan's molecular basis of interaction with membranes and AT1 receptor. Chem. Phys. Lipids, 125: 13-25.
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  38. Zoumpoulakis, P., A. Zoga, P. Roumelioti, N. Giatas and S.G. Grdadolnik et al., 2003. Conformational and biological studies for a pair of novel synthetic AT1 antagonists: Sstereoelectronic requirements for antihypertensive efficacy. J. Pharm. Biomed. Anal., 31: 833-844.
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  39. Moutevelis-Minakakis, P., M. Gianni, H. Stougiannou, P. Zoumpoulakis and A. Zoga et al., 2003. Design and synthesis of novel antihypertensive drugs. Bioorg. Med. Chem. Lett., 13: 1737-1740.
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  40. Zoumpoulakis, P., S.G. Grdadolnik, J. Matsoukas and T. Mavromoustakos, 2002. Structure elucidation and conformational properties of eprosartan a non peptide Angiotensin II AT1 antagonist. J. Pharm. Biomed. Anal., 28: 125-135.
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  41. Zervou, M., S.G. Grdadolnik, T. Mavromoustakos and P. Zoumpoulakis, 2002. Structure Elucidation and Conformational Properties of Irbesartan. In: Drug Discovery and Design: Medical Aspects, Matsoukas, J. and T. Mavromoustakos (Eds.). IOS Press, Washington, DC., USA., pp: 174-179.
  42. Roumelioti, P., L. Polevaya, P. Zoumpoulakis, N. Giatas and I. Mutule et al., 2002. Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3, 5 side-chain bridges: Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists. Bioorg. Med. Chem. Lett., 12: 2627-2633.
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  43. Polevaya, L., P. Roumelioti, T. Mavromoustakos, P. Zoumpoulakis and N. Giatas et al., 2002. Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity. In: Drug Discovery and Design: Medical Aspects, Matsoukas, J. and T. Mavromoustakos (Eds.). IOS Press, Washington, DC., USA., pp: 3-12.
  44. Deraos, S., T. Tselios, I. Daliani, P. Zoumpoulakis and L. Probert et al., 2002. Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP1-11. In: Drug Discovery and Design: Medical Aspects, Matsoukas, J. and T. Mavromoustakos (Eds.). IOS Press, Washington, DC., USA., pp: 116-121.
  45. Polevaya, L., T. Mavromoustakos, P. Zoumboulakis, S.G. Grdadolnik and P. Roumelioti et al., 2001. Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*-π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists. Bioorg. Med. Chem., 9: 1639-1647.
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