Dr. Juan Jose Sastre Belloch
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Dr. Juan Jose Sastre Belloch

Professor
University of Valencia, Spain

Highest Degree
Ph.D. in Pharmacy from University of Valencia, Spain

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacology
62%
Hepatology
90%
Free Redicals
75%
Gastrointestinal Pharmacology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tormos, A.M., R. Talens-Visconti, A.R. Nebreda and J. Sastre, 2013. p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species. Free Radic. Res., 47: 905-916.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Tormos, A.M., A. Arduini, R. Talens-Visconti, I. del Barco Barrantes and A.R. Nebreda et al., 2013. Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice. Hepatology, 57: 1950-1961.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Sastre, J., 2013. Special issue on Oxidative stress and redox signaling in the gastrointestinal tract and related organs. Free Radic. Res., 47: 851-853.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Pascual, I., L. Sabater, R. Anon, J. Calvete and G. Pacheco et al., 2013. Surgical versus nonsurgical treatment of infected pancreatic necrosis: More arguments to change the paradigm. J. Gastrointest Surg., 17: 1627-1633.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Escobar, J., K. Teramo, V. Stefanovic, S. Andersson and M.A. Asensi et al., 2013. Amniotic fluid oxidative and nitrosative stress biomarkers correlate with fetal chronic hypoxia in diabetic pregnancies. Neonatology, 103: 193-198.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Escobar, J., E. Cubells, M. Enomoto, G. Quintas and J. Kuligowski et al., 2013. Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups. Redox Biol., 1: 297-303.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Escobar, J., J. Pereda, G. Lopez-Rodas and J. Sastre, 2012. Redox signaling and histone acetylation in acute pancreatitis. Free Rad. Biol. Med., 52: 819-837.
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  8. Escobar, J., J. Pereda, A. Arduini, J. Sandoval and M.L. Moreno et al., 2012. Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol. Biochem. Pharmacol., 83: 122-130.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Arduini, A., G. Serviddio, A.M. Tormos, M. Monsalve and J. Sastre, 2012. Mitochondrial dysfunction in cholestatic liver diseases. Front Biosci., 4: 2233-2252.
    PubMed  |  Direct Link  |  
  10. Arduini, A., G. Serviddio, J. Escobar, A.M. Tormos and F. Bellanti et al., 2011. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Am. J. Physiol. Gastrointest. Liver Physiol., 301: G119-G127.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Serviddio, G., F. Bellanti, J. Sastre, G. Vendemiale and E. Altomare, 2010. Targeting mitochondria: A new promising approach for the treatment of liver diseases. Curr. Med. Chem., 17: 2325-2337.
    CrossRef  |  PubMed  |  
  12. Serviddio, G. and J. Sastre, 2010. Measurement of mitochondrial membrane potential and proton leak. Meth. Mol. Biol., 594: 107-121.
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  13. Sandoval, J., J. Pereda, J.L. Rodriguez, J. Escobar and J. Hidalgo et al., 2010. Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis. Cell Mol. Life Sci., 67: 1687-1697.
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  14. Romagnoli, M., M.C. Gomez-Cabrera, M.G. Perrelli, F. Biasi and F.V. Pallardo et al., 2010. Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats. Free Rad. Biol. Med., 49: 171-177.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Escobar, J., J. Pereda, A. Arduini, J. Sandoval and L. Sabater et al., 2010. Role of redox signaling, protein phosphatases and histone acetylation in the inflammatory cascade in acute pancreatitis: Therapeutic implications. Inflammat. Allergy-Drug Targets, 9: 97-108.
    CrossRef  |  PubMed  |  
  16. Escobar, J., J. Pereda, A. Arduini, J. Sandoval and L. Sabater et al., 2010. Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis. World J. Gastrointest. Pharmacol. Ther., 1: 75-80.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Caro, P., J. Gomez, A. Arduini, M. Gonzalez-Sanchez and M. Gonzalez-Garcia et al., 2010. Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age. Mitochondrion, 10: 479-486.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Vento, M., M. Moro, R. Escrig, L. Arruza and G. Villar et al., 2009. Preterm resuscitation with low oxygen causes less oxidative stress, inflammation and chronic lung disease. Pediatrics, 124: e439-e449.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Vento, M., M. Aguar, J. Escobar, A. Arduini and R. Escrig et al., 2009. Antenatal steroids and antioxidant enzyme activity in preterm infants: Influence of gender and timing. Antioxid. Redox Signal, 11: 2945-2955.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Sandoval, J., J. Escobar, J. Pereda, N. Sacilotto and J.L. Rodriguez et al., 2009. Pentoxifylline prevents loss of PP2A phosphatase activity and recruitment of histone acetyltransferases to proinflammatory genes in acute pancreatitis. J. Pharmacol. Exp. Ther., 331: 609-617.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Ledo, A., A. Arduini, M.A. Asensi, J. Sastre and R. Escrig et al., 2009. Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants. Am. J. Clin. Nutr., 89: 210-215.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Escobar, J., J. Pereda, J. Sandoval, L. Sabater, L. Aparisi, G. Lopez-Rodas and J. Sastre, 2009. Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: A key role for protein phosphatases. Curr. Pharm. Des., 15: 3027-3042.
    CrossRef  |  PubMed  |  
  23. Vina, J., J. Sastre, F.V. Pallardo, J. Gambini and C. Borras, 2008. Modulation of longevity-associated genes by estrogens or phytoestrogens. Biol. Chem., 389: 273-277.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Valles, S.L., C. Borras, J. Gambini, J. Furriol and A. Ortega et al., 2008. Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell, 7: 112-118.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Serviddio, G., J. Sastre, F. Bellanti, J. Vina, G. Vendemiale and E. Altomare, 2008. Mitochondrial involvement in non-alcoholic steatohepatitis. Mol. Aspects Med., 29: 22-35.
    CrossRef  |  Direct Link  |  
  26. Serviddio, G., F. Bellanti, R. Tamborra, T. Rollo and N. Capitanio et al., 2008. Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut, 57: 957-965.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Pereda, J., J. Escobar, J. Sandoval, J.L. Rodriguez and L. Sabater et al., 2008. Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis. Free Radic. Biol. Med., 44: 1599-1609.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Lopez-Gines, C., R. Gil-Benso, R. Benito, M. Mata and J. Pereda et al., 2008. The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFRamplification. Neuropathology, 28: 507-515.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Gomez-Cabrera, M.C., E. Domenech, M. Romagnoli, A. Arduini and C. Borras et al., 2008. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am. J. Clin. Nutr., 87: 142-149.
    PubMed  |  Direct Link  |  
  30. Aparisi, L., L. Sabater, J. Del-Olmo, J. Sastre and M.A. Serra et al., 2008. Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects? World J. Gastroenterol., 14: 6171-6179.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Vina, J., A. Lloret, S.L. Valles, C. Borras and M.C. Badia et al., 2007. Mitochondrial oxidant signalling in Alzheimer's disease. J. Alzheimers Dis., 11: 175-181.
    PubMed  |  Direct Link  |  
  32. Vina, J., A. Lloret, S.L. Valles, C. Borras and M.C. Badia et al., 2007. Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide. Antioxid. Redox Signal, 9: 1677-1690.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Sastre, J., G. Serviddio, J. Pereda, J.B. Minana and A. Arduini et al., 2007. Mitochondria in chronic liver disease. Front Biosci., 12: 1200-1209.
    CrossRef  |  PubMed  |  
  34. Rodriguez, J.L., A. Boukaba, J. Sandoval, E.I. Georgieva and M.U. Latasa et al., 2007. Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. Int. J. Biochem. Cell Biol., 39: 842-850.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Markovic, J., C. Borras, A. Ortega, J. Sastre, J. Vina and F.V. Pallardo, 2007. Glutathione is recruited into the nucleus in early phases of cell proliferation. J. Biol. Chem., 282: 20416-20424.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Lloret, A., J. Buj, M.C. Badia, J. Sastre, J. Morera and J. Vina, 2007. Obstructive sleep apnea: arterial oxygen desaturation coincides with increases in systemic oxidative stress markers measured with continuous monitoring. Free Radic. Biol. Med., 42: 893-894.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Garcia-de-la-Asuncion, J., L.G. Gomez-Cambronero, M.L. Del Olmo, F.V. Pallardo, J. Sastre and J. Vina, 2007. Vitamins C and E prevent AZT-induced leukopenia and loss of cellularity in bone marrow. Studies in mice. Free Radic Res., 41: 330-334.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Garcia de la Asuncion, J., F.J. Belda, R. Greif, G. Barber, J. Vina and J. Sastre, 2007. Inspired supplemental oxygen reduces markers of oxidative stress during elective colon surgery. Br. J. Surg., 94: 475-477.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Casado, D., L. Sabater, J. Calvete, E. Mayordomo, L. Aparisi, J. Sastre and S. Lledo, 2007. Multiple intrahepatic pseudocysts in acute pancreatitis. World J. Gastroenterol., 13: 4655-4657.
    PubMed  |  Direct Link  |  
  40. Aranda, R., E. Domenech, A.D. Rus, J.T. Real, J. Sastre, J. Vina and F.V. Pallardo, 2007. Age-related increase in xanthine oxidase activity in human plasma and rat tissues. Free Radic. Res., 41: 1195-1200.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Vina, J., J. Sastre, F.V. Pallardo, J. Gambini and C. Borras, 2006. Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens. Free Radic Res., 40: 1359-1365.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Vento, M., R. Escrig, P. Saenz, I. Izquierdo, J. Sastre and J. Vina, 2006. Does oxygen concentration used for resuscitation influence outcome of asphyxiated newly born infants treated with hypothermia? Pediatrics, 117: 2326-2328.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Rodriguez, J.L., J. Sandoval, G. Serviddio, J. Sastre and M. Morante et al., 2006. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Biochem. J., 398: 431-437.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Pereda, J., L. Sabater, L. Aparisi, J. Escobar and J. Sandoval et al., 2006. Interaction between cytokines and oxidative stress in acute pancreatitis. Curr. Med. Chem., 13: 2775-2787.
    CrossRef  |  PubMed  |  
  45. Pereda, J., L. Gomez-Cambronero, A. Alberola, G. Fabregat and M. Cerda et al., 2006. Co-administration of pentoxifylline and thiopental causes death by acute pulmonary oedema in rats. Br. J. Pharmacol., 149: 450-455.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Gomez-Cabrera, M.C., A. Martinez, G. Santangelo, F.V. Pallardo, J. Sastre and J. Vina, 2006. Oxidative stress in marathon runners: Interest of antioxidant supplementation. Br. J. Nutr., 1: 31-33.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Borras, C., J. Gambini, M.C. Gomez-Cabrera, J. Sastre, F.V. Pallardo, G.E. Mann and J. Vina, 2006. Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFκB. FASEB J., 20: 2136-2138.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Vina, J., C. Borras, J. Gambini, J. Sastre and F.V. Pallardo, 2005. Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. FEBS Lett., 579: 2541-2545.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Vento, M., J. Sastre, M.A. Asensi and J. Vina, 2005. Room-air resuscitation causes less damage to heart and kidney than 100% oxygen. Am. J. Respir. Crit. Care. Med., 172: 1393-1398.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Gomez-Cabrera, M.C., C. Borras, F.V. Pallardo, J. Sastre, L.L. Ji and J. Vina, 2005. Decreasing xanthine Oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J. Physiol., 567: 113-120.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Borras, C., J. Gambini, M.C. Gomez-Cabrera, J. Sastre, F.V. Pallardo, G.E. Mann and J. Vina, 2005. 17β-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFκB cascade. Aging Cell, 4: 113-118.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Aparisi, L., A. Farre, L. Gomez-Cambronero, J. Martinez and G. De Las Heras et al., 2005. Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis. Relevance for diagnosis of autoimmune pancreatitis. Gut, 54: 703-709.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Serviddio, G., J. Pereda, F.V. Pallardo, J. Carretero and C. Borras et al., 2004. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology, 39: 711-720.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. De la Asuncion, J.G., M.L. Del Olmo, L.G. Gomez-Cambronero, J. Sastre, F.V. Pallardo and J. Vina, 2004. AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E. Life Sci., 76: 47-56.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Borras, C., J.M. Esteve, J.R. Vina, J. Sastre, J. Vina and F.V. Pallardo, 2004. Glutathione regulates telomerase activity in 3T3 fibroblasts. J. Biol. Chem., 279: 34332-34335.
    CrossRef  |  PubMed  |  
  56. Vina, J., J. Sastre, F. Pallardo and C. Borras, 2003. Mitochondrial theory of aging: Importance to explain why females live longer than males. Antioxidants Redox Signaling, 5: 549-556.
    CrossRef  |  PubMed  |  Direct Link  |  
  57. Vento, M., M. Asensi, J. Sastre, A. Lloret, F. Garcia-Sala and J. Vina, 2003. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J. Pediatrics, 142: 240-246.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Sastre, J., F.V. Pallardo and J. Vina, 2003. The role of mitochondrial oxidative stress in aging. Free Rad. Biol. Med., 35: 1-8.
    CrossRef  |  PubMed  |  Direct Link  |  
  59. Sabater, L., E. Pareja, L. Aparisi, J. Calvete and B. Camps et al., 2003. Pancreatic function after severe acute biliary pancreatitis: The role of necrosectomy. Pancreas, 28: 65-68.
    PubMed  |  Direct Link  |  
  60. Gomez-Cabrera, M.C., F.V. Pallardo, J. Sastre, J. Vina and L. Garcia del Moral, 2003. Allopurinol and markers of muscle damage among participants in the Tour de france. JAMA, 289: 2503-2504.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Borras, C., J. Sastre, D. Garcia-Sala, A. Lloret, F.V. Pallardo and J. Vina, 2003. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Rad. Biol. Med., 34: 546-552.
    CrossRef  |  PubMed  |  Direct Link  |  
  62. Vento, M., M. Asenis, J. Sastre, A. Lloret, F. Garcia-Sala, J.B. Minana and J. Vina, 2002. Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly born infants. Semin. Perinatol., 26: 406-410.
    CrossRef  |  PubMed  |  Direct Link  |  
  63. Vento, M., J. Sastre, J.A. Martin, A. Lloret, J.B. Minana and J. Vina, 2002. Cysteine may be an essential amino acid in the premature infant from a functional point of view. Ital. J. Pediatr., 28: 352-358.
  64. Sastre, J., C. Borras, D. Garcia-Sala, A. Lloret, F.V. Pallardo and J. Vina, 2002. Mitochondrial damage in aging and apoptosis. Ann. N.Y. Acad. Sci., 959: 448-451.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Sastre, J., A. Lloret, C. Borras, J. Pereda and D. Garcia-Sala et al., 2002. Ginkgo biloba extract EGB 761 protects against mitochondrial aging in the brain and in the liver. Cell. Mol. Biol., 48: 685-692.
    PubMed  |  Direct Link  |  
  66. Minana, J.B., L.G. Gomez-Cambronero, A. Lloret, F.V. Pallardo and J. del Olmo et al., 2002. Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology, 35: 1205-1214.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Gomez-Cambronero, L.G., L. Sabater, J. Pereda, N. Cassinello, B. Camps, J. Vina and J. Sastre, 2002. Role of cytokines and oxidative stress in the pathophysiology of - 5 -acute pancreatitis: Therapeutical implications. Curr. Drug Targets Inflammat. Allergy, 1: 393-403.
    CrossRef  |  PubMed  |  
  68. Asensi, M., M.C. Desco, R. Marquez, J. Martinez-Valls and M. Vento et al., 2002. Xanthine oxidase is involved in free radical production in type 1 diabetes. Protection by allopurinol. Diabetes, 51: 1118-1124.
    CrossRef  |  PubMed  |  Direct Link  |  
  69. Vento, M., M. Asensi, J. Sastre, F. Garcia-Sala, F.V. Pallardo and J. Vina, 2001. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics, 107: 642-647.
    PubMed  |  Direct Link  |  
  70. Vento, M., M. Asensi, J. Sastre, F. Garcia-Sala and J. Vina, 2001. Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants. Biol. Neonate, 79: 261-267.
    CrossRef  |  PubMed  |  Direct Link  |  
  71. Martin, J.A., J. Sastre, J. Garcia de la Asuncion, F.V. Pallardo and J. Vina, 2001. Hepatic γ-cystathionase deficiency in patients with AIDS. JAMA, 285: 1444-1445.
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  72. Marquez, R., G. Santangelo, J. Sastre, P. Goldschmidt, J. Luyckx, F.V. Pallardo and J. Vina, 2001. Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress. Pharmacol. Toxicol., 89: 255-258.
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  73. Vina, J., M.C. Gomez-Cabrera, A. Lloret, R. Marquez, J.B. Minana, F.V. Pallardo and J. Sastre, 2000. Free radicals in exhaustive physical exercise: Mechanism of production, and protection by antioxidants. IUBMB Life, 50: 271-277.
    CrossRef  |  PubMed  |  Direct Link  |  
  74. Vina, J., A. Gimeno, J. Sastre, C. Desco and M. Asensi et al., 2000. Mechanism of free radical production in exhaustive exercise in humans and rats; Role of xanthine oxidase and protection by allopurinol. IUBMB Life, 49: 539-544.
    CrossRef  |  PubMed  |  Direct Link  |  
  75. Sastre, J., F.V. Pallardo, J.G. de la Asuncion and J. Vina, 2000. Mitochondria, oxidative stress and aging. Free Radic. Res., 32: 189-198.
    PubMed  |  Direct Link  |  
  76. Sastre, J., F.V. Pallardo and J. Vina, 2000. Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life, 49: 427-435.
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  77. Gomez-Cambronero, L., B. Camps, J. Garcia de la Asuncion, M. Cerda and A. Pellin et al., 2000. Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: Role of glutathione and nitric oxide. J. Pharmacol. Exp. Ther., 293: 670-676.
    PubMed  |  Direct Link  |