Dr. Ilona Petrikovics
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Dr. Ilona Petrikovics

Associate Professor
Sam Houston State University, USA

Highest Degree
Ph.D. in Medicinal Biology from University Medical School, Hungary

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Area of Interest:

Biomedical Sciences
100%
Enzyme Mechanism
62%
Drug Antagonism
90%
Drug Formulation
75%
Medical Education
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wijesooriya, C., M. Budai, L. Budai, M.E. Szilasi and I. Petrikovics, 2013. Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation. J. Basic Clin. Pharm., 4: 73-75.
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  2. Marziaz, M.L., K. Frazier, P.B. Guidry, R.A. Ruiz, I. Petrikovics and D.C. Haines, 2013. Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD50 yields insight into the efficacy of prophylactics. J. Applied Toxicol., 33: 50-55.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Kovacs, K., M. Ancha, M. Jane, S. Lee and S. Angalakurthi et al., 2013. Identification, Solubility enhancement and in vivo testing of a cyanide antidote candidate. Eur. J. Pharm. Sci., 49: 352-358.
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  4. Budai, L., N. Kaszas, P. Grof, K. Lenti and K. Maghami et al., 2013. Liposomes for topical use: A physico-chemical comparison of vesicles prepared from egg or soy lecithin. Sci. Pharm. (In Press). 10.3797/scipharm.1305-11.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Yu, J.C.C., S. Martin, J. Nasr, K. Stafford, D.E. Thompson and I. Petrikovics, 2012. LC-MS/MS analysis of 2-aminothiazoline-4-carboxylic acid as a forensic biomarker for cyanide poisoning. J. World Methodol., 2: 33-41.
    Direct Link  |  
  6. Szilasi, M., M. Budai, L. Budai and I. Petrikovics, 2012. Nanoencapsulated and microencapsulated enzymes in drug antidotal therapy. Toxicol. Ind. Health, 28: 522-531.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Petrikovics, I., M. Wales, M. Budai, J.C.C. Jorn and M. Szilasi, 2012. Nano-intercalated organophosphorus-hydrolyzing enzymes in organophosphorus antagonism. AAPS PharmSciTech., 13: 112-117.
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  8. Petrikovics, I., J.C.C. Yu, D.E. Thompson, P. Jayanna and B.A. Logue et al., 2012. Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem spectrometry. J. Chromatography B, 891-892: 81-84.
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  9. Manage, B.W.M. and I. Petrikovics, 2012. Confidence limit calculation for antidotal potency ratio derived from lethal dose 50. J. World Methodol., 3: 7-10.
    Direct Link  |  
  10. Bhandari, R.K., R.P. Oda, S.I. Youso, I. Petrikovics, V.S. Bebarta, G.A. Rockwoodand B.A. Logue, 2012. Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS). Analyt. Bioanalytical Chem., 404: 2287-2294.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Petrikovics, I., P. Jayanna, J. Childress, M. Budai, S. Martin, G. Kuzmitcheva and G.A. Rockwood, 2011. Optimization of liposomal lipid composition for a new, reactive sulfur donor, and in vivo efficacy studies on mice to antagonize cyanide intoxication. J. Drug Delivery, (In Press). 10.1155/2011/928626.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Petrikovics, I., D.E. Thompson, G.A. Rockwood and B.A. Logue et al., 2011. Organ-Distribution of the metabolite 2-aminothiazoline-4-carboxylic acid in a rat model following cyanide exposure. Biomarkers, 16: 686-690.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Petrikovics, I., S.I. Baskin, K.M. Beigel, B.J. Schapiro and G.A. Rockwood et al., 2010. Nano-intercalated rhodanese in cyanide antagonism. Nanotoxicology, 4: 247-254.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Jackson, R., I. Petrikovics, E.P. Lai and J.C.C., Yu, 2010. Molecularly imprinted polymer stir bar sorption extraction and electrospray ionization tandem mass spectrometry for determination of 2-aminothiazoline-4-carboxylic acid as a marker for cyanide exposure in forensic urine analysis. Analyt. Methods, 2: 552-557.
    CrossRef  |  Direct Link  |  
  15. Petrikovics, I., M. Budai, S.I. Baskin, G.A. Rockwood and J. Childress et al., 2009. Characterization of liposomal vesicles encapsulating rhodanese for cyanide antagonism. Drug Delivery, 16: 312-319.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Budai, M., P. Chapela, L. Budai, M.E. Wales and I. Petrikovics et al., 2009. Liposomal oxytetracycline and doxycycline: studies on enhancement of encapsulation efficiency. Drug Discov. Ther., 3: 13-17.
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  17. Budai, M. P. Chapela, P. Grof, I. Klebovich and A. Zimmer et al., 2009. Physicochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme. J. Liposome Res., 2: 163-168.
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  18. Petrikovics, I., M.E. Wales, J.C. Jaszberenyi, M. Budai and S.I. Baskin et al., 2007. Enzyme-based intravascular defense against organophosphorus neurotoxins: Synergism of dendritic-enzyme complexes with 2-PAM and atropine. Nanotoxicology, 1: 85-92.
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  19. Baskin, S.I., I. Petrikovics, G.E. Platoff, G.A. Rockwood and B.A. Logue, 2006. Spectrophotometric analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid (ATCA). Toxicol. Methods Mechanism, 16: 339-345.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Logue, B.A., N.P. Kirschten, I. Petrikovics, M.A. Moser, G.A. Rockwood and S.I. Baskin, 2005. Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry. J. Chromatography, 819: 237-244.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Arsenault, W.G., D.M. Boothe, S.G. Gordon, M.W. Miller, J.R. Chalkley and I. Petrikovics, 2005. Pharmacokinetics of carvedilol after intravenous and oral administration in conscious healthy dogs. Am. J. Vet. Res., 66: 2172-2176.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Petrikovics, I., D. Papahadjapoulos, K. Hong, T.C. Cheng and S.I. Baskin et al., 2004. Comparing therapeutic and prophylactic protection against the lethal effects of paraoxon. Toxicol. Sci., 77: 258-262.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Cheng, T.C., S.P. Harvey, J.J. De Frank, I. Petrikovics and V.P. Rastogi, 2004. Bacterial Ezymes- Potential Applications for Personnel/Casualty Decontamination Against G,V and H,D Chemical Agents. In: Pharmacological Perspectives of Toxic Chemicals and Their Antidotes, Flora, S.J.S., J.A. Romano S.I. Baskin and K. Sekhar (Eds.). Narosa Publishing House, New Delhi, India, pp: 87-95.
  24. Baskin, S.I., I. Petrikovics, J.S. Kurche, J.D. Nicholson, B.A. Logue, B.I. Maliner and G.A. Rockwood, 2004. Insights on Cyanide Toxicity and Methods of Treatment. In: Pharmacological Perspectives of Toxic Chemicals and their Antidotes, Flora, S.J.S., J.A. Romano, S.I. Baskin and K. Sekhar (Eds.). Narosa Publishing House, New Delhi, India, pp: 105-146.
  25. Petrikovics, I., T.C. Cheng, D. Papahadjapoulos, K. Hong and R. Yin et al., 2000. Long Circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism. Toxicol. Sci., 57: 16-21.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Petrikovics, I., K. Hong, D. Papahadjapoulos, P. Yuzapavik and et al., 2000. In vitro studies on sterically stabilized liposomes (sl) as enzyme carriers in organophosphorus (OP) antagonism. Drug Delivery, 7: 83-89.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Petrikovics, I., K. Hong, G. Omburo, Q. Hu and L. Pei et al., 1999. Antagonism of paraoxon intoxication by recombinant phosphotriesterase encapsulated within sterically stabilized liposomes. Toxicol. Applied Pharmacol., 156: 56-63.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Way, J.L., L. Pei, I. Petrikovics, D.W. McGuinn and C. Tamulinas et al., 1996. Organophosphorus Antagonism by Resealed Erythrocytes Containing Recombinant Paraoxonase. In: Erythrocytes as Drug Carriers in Medicine, Sprandel, U. and J.L. Way (Eds.). Plenum Press, New York, pp: 89-92.
    CrossRef  |  Direct Link  |  
  29. Petrikovics, I., E.P. Cannon, W.D. McGuinn, L. Pei and J.L. Way, 1995. Cyanide antagonism with organic thiosulfonates and carrier red blood cells containing rhodanese. Fundamental Applied Toxicol., 24: 1-8.
  30. Pei, L., I. Petrikovics and J.L. Way, 1995. Antagonism of the lethal effect of paraoxon by carrier erythrocytes containing organophosphorous acid anhydrase. Fundamental Applied Toxicol., 28: 209-214.
  31. Petrikovics, I., W.D. McGuinn, E.P. Cannon, L. Pei and J.L. Way, 1994. Encapsulation of rhodanese and organic thiosulfonates by mouse erythrocytes. Fundamental Applied Toxicol., 23: 70-75.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. Pei, L., W.D. McGuinn, G. Omburo, A.H. Zitzer, I. Petrikovics and J.L. Way, 1994. Spectrophotometric determination of paraoxonase within mouse carrier red blood cells. Biochem. Applied Biotechnol., 23: 35-41.
    PubMed  |  
  33. Pei, L., G. Omburo, W.D. McGuinn, I. Petrikovics and K. Dave et al., 1994. Encapsulation of phosphotriesterase within murine erythrocytes. Toxicol. Applied Pharmacol., 124: 296-301.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. McGuinn, W.D., L. Baxter, L. Pei, I. Petrikovics, E.P. Cannon and J.L. Way, 1994. Antagonism of the lethal effects of cyanide by a synthetic water-soluble cobalt(III) porphyrin compound. Fundamental Applied Toxicol., 23: 76-80.
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  35. Cannon, E.P., P. Leung, A.H. Zitzer, I. Petrikovics, J. Deloach and J.L. Way, 1994. Antagonism of cyanide intoxication with murine carrier erythrocytes containing bovine rhodanese and sodium thiosulfate. J. Toxicol. Environ. Health, 41: 267-274.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Petrikovics, I., W.D. McGuinn, E.P. Cannon, L. Pei, L. Pu, A. Chen and J.L. Way, 1993. Carrier Red Blood Cells in Cyanide Antagonism. In: Resealed Carrier Red Blood Cells as Bioreactors, DeLoach, J.R. and J.L. Way (Eds.). Vol. 92, Pergamon Press, Oxford, UK., pp: 125-129.
  37. Pei, L., W.D. McGuinn, I. Petrikovics, L. Pu and J.L. Way, 1993. Hydrolysis of Paraoxon by Paraoxonase Encapsulated within Carrier Murine Erythrocytes. In: Resealed Carrier Red Blood Cells as Bioreactors, DeLoach, J.R. and J.L. Way (Eds.). Vol. 92, Pergamon Press, Oxford, UK., pp: 131-135.
  38. Pei, L., W.D. McGuinn, I. Petrikovics, E.P. Cannon and J.L. Way, 1993. Determination of organophorous acid anhydrase in blood. Toxicol. Methods, 3: 261-267.
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  39. McGuinn, W.D., E.P. Cannon, C.K. Chui, L. Pei, I. Petrikovics and J.L. Way, 1993. The encapsulation of squid diisopropylphosphorofluoridate-hydrolyzing enzyme within mouse erythrocytes. Fundam. Applied Toxicol., 21: 38-43.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. Way, J.L., L. Baxter, W.D. McGuinn, H.A. Zitzer and I. Petrikovics, 1992. Occupational Hazards and Ocular Toxicity. In: Ophthalmic Toxicology, Chiou, G.C.Y. (Ed.). Raven Press Ltd., New York, pp: 291-305.
  41. Way, J.L., E.P. Cannon, P. Leung, H.A. Zitzer, L. Pei and I. Petrikovics, 1992. Antagonism of the Lethal Effects of Cyanide with Resealed Erythrocytes Containing Rhodanese and Thiosulfate. In: The Use of Resealed Erythrocytes as Carriers and Bioreactors, Magnani, M. and J.R. Deloach (Eds.). Plenum Press, New York, pp: 159-163.
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  42. Cannon, E.P., A.H. Zitzer, D.W. McGuinn, I. Petrikovics, P. Leung and J.L. Way, 1992. Antagonism of the lethal effects of cyanide with rhodanese containing murine carrier erythrocytes. Proc. West. Pharmacol. Soc., 35: 187-190.
    PubMed  |  
  43. Petrikovics, I., J.C. Jaszberenyi, F. Hernadi, F. Sztaricskai, R. Bognar, G. Batta and L. Benesch, 1991. Synthesis and bioactivity of β-lactamase inhibitory iodopenicillanic acid derivatives. Acta Chim. Acad. Sci. Hung., 128: 41-52.
  44. Leung, P., E.P. Cannon, I. Petrikovics and J.L. Way, 1991. In vivo studies on rhodanese encapsulation in mouse carrier erythrocytes. Toxicol. Applied Pharmacol., 110: 268-274.
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  45. Jaszberenyi, J.C., J. Pitlik, K. Kollar, I. Petrikovics, K. Erdodine-Kover and G. Batta, 1989. Synthesis and 1,3-dipolar cycloadditions of 2-methylenecephalosporins. Acta Chim. Acad. Sci. Hung., 126: 81-97.
  46. Hernadi, F., I. Petrikovics, J.C. Jaszberenyi and M. Frommer-Filep, 1989. Inhibition of β-lactamases by halopenicillanic acid derivatives. Int. J. Exp. Clin. Chemotheraphy, 2: 209-214.
  47. Hernadi, F., J.C. Jaszberenyi and I. Petrikovics, 1986. Complex analysis methods for study of β-lactamase inhibitors. Am. Clin. Prod. Rev., 5: 18-27.
  48. Kiss, L., Z. Gal, B.L. Tothmartinez and I. Petrikovics, 1983. Use of chromatofocusing for separation of β-lactamases: II. β-Lactamase of a characterized Pseudomonas aeruginosa strain. J. Chromatography A, 262: 379-384.
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  49. Jaszberenyi, J.C., I. Petrikovics, E.T. Gunda and S. Hosztafi, 1982. On the mannich-reaction of cephalosporin sulphoxides and sulphones. Acta Chim. Acad. Sci. Hung., 110: 81-84.
  50. Jaszberenyi, J.C., Z. Dinya, M. Punyiczki, E.K. Kover, J. Schag and I. Petrikovics, 1981. Synthesis and β-lactamase inhibitory properties of derivatives of β-lactam antibiotics. Biol. Nat. Prod., 3: 78-81.