Dr. Pierri Ciro Leonardo

Dr. Pierri Ciro Leonardo

Assistant Professor
University of Bari, Italy


Highest Degree
Ph.D. in Pharmaceutical Sciences from University of Basilicata, Potenza, Italy

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Area of Interest:

Molecular Sciences
100%
Protein
62%
Protein Chemistry
90%
Molecular Microbiology
75%
Biochemistry
55%

Selected Publications

  1. Vozza, A., F. De Leonardis, E. Paradies, A. De Grassi and C.L. Pierri et al., 2016. Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim. Biophys. Acta Bioenerg., 1858: 137-146.
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  2. Todisco, S., M.A. Di Noia, A. Onofrio, G. Parisi and G. Punzi et al., 2016. Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays. Biochem. Pharmacol., 100: 112-132.
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  3. Pietropaolo, A., C.L. Pierri, F. Palmieri and M. Klingenberg, 2016. The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes. Biochim. Biophys. Acta Bioenerg., 1857: 772-781.
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  4. Pietropaolo, A., C.L. Pierri, F. Palmieri and M. Klingenberg, 2016. Dataset of the AAC2 conformations in the c-, intermediate- and m-states obtained from free-energy simulations. Data Brief, 7: 1355-1357.
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  5. Pierri, C.L., F. Bossis, G. Punzi, A. De Grassi, M. Cetrone, G. Parisi and D. Tricarico, 2016. Molecular modeling of antibodies for the treatment of TNFα-related immunological diseases. Pharmacol. Res. Perspect., Vol. 4. 10.1002/prp2.197.
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  6. Curcio, R., L. Muto, C.L. Pierri, A. Montalto and G. Lauria et al., 2016. New insights about the structural rearrangements required for substrate translocation in the bovine mitochondrial oxoglutarate carrier. Biochim. Biophys. Acta Proteins Proteomics, 1864: 1473-1480.
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  7. Cigliola, V., C. Populaire, C.L. Pierri, S. Deutsch and J.A. Haefliger et al., 2016. A variant of GJD2, encoding for connexin 36, alters the function of insulin producing β-cells. Plos One, Vol. 11. 10.1371/journal.pone.0150880.
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  8. Amoedo, N.D., G. Punzi, E. Obre, D. Lacombe, A. De Grassi, C.L. Pierri and R. Rossignol, 2016. AGC1/2, the mitochondrial aspartate-glutamate carriers. Biochim. Biophys. Acta Mol. Cell. Res., 1863: 2394-2412.
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  9. Shteyer, E., S. Edvardson, S.L. Wynia-Smith, C.L. Pierri and T. Zangen et al., 2015. Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. Gastroenterology, 148: 533-536.
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  10. Palmieri, E.M., I. Spera, A. Menga, V. Infantino and V. Porcelli et al., 2015. Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation. Biochim. Biophys. Acta Bioenerg., 1847: 729-738.
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  11. Marobbio, C.M., G. Punzi, C.L. Pierri, L. Palmieri, R. Calvello, M.A. Panaro and F. Palmieri, 2015. Pathogenic potential of SLC25A15 mutations assessed by transport assays and complementation of Saccharomyces cerevisiae ORT1 null mutant. Mol. Genet. Metab., 115: 27-32.
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  12. Pierri, C.L., F. Palmieri and A. De Grassi, 2014. Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers. Cell. Mol. Life Sci., 71: 349-364.
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  13. Onofrio, A., G. Parisi, G. Punzi, S. Todisco and M.A. Di Noia et al., 2014. Distance-dependent hydrophobic-hydrophobic contacts in protein folding simulations. Phys. Chem. Chem. Phys., 16: 18907-18917.
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  14. Gibellini, L., M. Pinti, F. Beretti, C.L. Pierri and A. Onofrio et al., 2014. Sirtuin 3 interacts with Lon protease and regulates its acetylation status. Mitochondrion, 18: 76-81.
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  15. Chaouch, A., V. Porcelli, D. Cox, S. Edvardson and P. Scarcia et al., 2014. Mutations in the mitochondrial citrate carrier SLC25A1 are associated with impaired neuromuscular transmission. J. Neuromuscular Dis., 1: 75-90.
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  16. Carrozzo, R., A. Torraco, G. Fiermonte, D. Martinelli and M. Di Nottia et al., 2014. Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2. Mitochondrion, 18: 49-57.
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  17. Bossis, F., A. De Grassi, L.L. Palese and C.L. Pierri, 2014. Prediction of high-and low-affinity quinol-analogue-binding sites in the aa3 and bo3 terminal oxidases from Bacillus subtilis and Escherichia coli. Biochem. J., 461: 305-314.
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  18. Ta-Shma, A., C.L. Pierri, P. Stepensky, A. Shaag, S. Zenvirt, O. Elpeleg and A.J. Rein, 2013. Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene. Am. J. Med. Genet. Part A, 161: 3115-3120.
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  19. Regalado, A., C.L. Pierri, M. Bitetto, V.L. Laera and C. Pimentel et al., 2013. Characterization of mitochondrial dicarboxylate/tricarboxylate transporters from grape berries. Planta, 237: 693-703.
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  20. Lunetti, P., A.R. Cappello, R.M. Marsano, C.L. Pierri and C. Carrisi et al., 2013. Mitochondrial glutamate carriers from Drosophila melanogaster: Biochemical, evolutionary and modeling studies. Biochim. Biophys. Acta Bioenerg., 1827: 1245-1255.
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  21. Edvardson, S., V. Porcelli, C. Jalas, D. Soiferman and Y. Kellner et al., 2013. Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter. J. Med. Genet., 50: 240-245.
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  22. De Paola, D., E. Blanco, C.L. Pierri and G. Sonnante, 2012. Isolation and characterization of novel variants of BBI coding genes from the legume Lathyrus sativus. Plant Physiol. Biochem., 57: 45-53.
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  23. Agrimi, G., A. Russo, C.L. Pierri and F. Palmieri, 2012. The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives. J. Bioenergy Biomembr., 44: 333-340.
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  24. Palmieri, F., C.L. Pierri, A. De Grassi, A. Nunes-Nesi and A.R. Fernie, 2011. Evolution, structure and function of mitochondrial carriers: A review with new insights. Plant J., 66: 161-181.
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  25. Fiermonte, G., G. Parisi, D. Martinelli, F. De Leonardis and G. Torre et al., 2011. A new Caucasian case of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): A clinical, molecular and functional study. Mol. Genet. Metab., 104: 501-506.
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  26. Sonnante, G., R. D'Amore, E. Blanco, C.L. Pierri and M. De Palma et al., 2010. Novel hydroxycinnamoyl-coenzyme A quinate transferase genes from artichoke are involved in the synthesis of chlorogenic acid. Plant Physiol., 153: 1224-1238.
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  27. Pierri, C.L., G. Parisi and V. Porcelli, 2010. Computational approaches for protein function prediction: A combined strategy from multiple sequence alignment to molecular docking-based virtual screening. Biochim. Biophys. Acta Proteins Proteomics, 1804: 1695-1712.
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  28. Palmieri, F. and C.L. Pierri, 2010. Structure and function of mitochondrial carriers: Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett., 584: 1931-1939.
    PubMed  |  
  29. Palmieri, F. and C.L. Pierri, 2010. Mitochondrial metabolite transport. Essays Biochem., 47: 37-52.
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  30. Wibom, R., F.M. Lasorsa, V. Tohonen, M. Barbaro and F.H. Sterky et al., 2009. AGC1 deficiency associated with global cerebral hypomyelination. N. Engl. J. Med., 361: 489-495.
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  31. Tessa, A., G. Fiermonte, C. Dionisi-Vici, E. Paradies and M.R. Baumgartner et al., 2009. Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: A clinical, molecular and functional study. Hum. Mutat., 30: 741-748.
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  32. Pierri, C.L., A. De Grassi and A. Turi, 2008. Lattices for ab initio protein structure prediction. Proteins Struct. Funct. Bioinf., 73: 351-361.
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  33. Marobbio, C.M., G. Giannuzzi, E. Paradies, C.L. Pierri and F. Palmieri, 2008. α-isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. J. Biol. Chem., 283: 28445-28453.
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  34. Lauria, G., G. Lauria, P. Sanchez, B.M.D. Rocca and C.L. Pierri et al., 2008. Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling. Mol. Membr. Biol., 25: 236-244.
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