Dr. Adriana  Georgescu
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Dr. Adriana Georgescu

Head of Department
Institute of Cellular Biology and Pathology Nicolae Simionescu, Romania


Highest Degree
PostDoc. in Biomaterials Science from Institute of Cellular Biology and Pathology Nicolae Simionescu, Romaia

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Biography

Dr. Adriana Georgescu is currently working as Group leader, Principal Investigator I, and PhD supervisor in Department Pathophysiology and Pharmacology. She has completed her Ph.D. in Natural Sciences (Summa Cum Laude), from Institute of Cellular Biology and Pathology Nicolae Simionescu, Romaia. She also served as Project manager for 14 national projects and 2 international grants, Mentor for 2 Postdoctoral research projects, collaborator at 22 national projects and 4 international grants. She is also serving as reviewer for many international journals. She is member of many scientific societies such as The Romanian Society for Cell Biology, Romanian Society for Developmental Biology, The Healthy Nutrition Foundation, The National Society for Regenerative Medicine and Surgery, Romanian Society of Hypertension, European Atherosclerosis Society, The Diabetes and Cardiovascular Disease EASD Study Group (D&CVD), European Vascular Biology Organization (EVBO), European Society of Cardiology (ESC), and working Group on Atherosclerosis and Vascular Biology. She has laureate of 30 Romanian and 7 International Awards. She also participated at 8 International Courses. She is author and co-author of 68 original papers in peered-reviewed journals, 34 abstracts in peered-reviewed journals, 5 book chapters, and 3 books. She also presented 4 invited talks at prestigious Universities (Institutes), 20 invited talks at prestigious international conferences, 21 invited talks at prestigious national conferences, and 18 national and 115 international poster communications.

Area of Interest:

Biomedical Sciences
100%
Macromolecules
62%
Biomedicine
90%
Biomarkers
75%
Regenerative Medicine
55%

Research Publications in Numbers

Books
3
Chapters
5
Articles
71
Abstracts
34

Selected Publications

  1. Filippi, A., A. Constantin, N. Alexandru, G. Voicu and C.A. Constantinescu et al., 2020. Integrins u03b14u03b21 and u03b1vu03b23 are reduced in endothelial progenitor cells from diabetic dyslipidemic mice and may represent new targets for therapy in aortic valve disease. Cell Transplant., 10.1177/0963689720946277.
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  2. Constantin, A., A. Filippi, N. Alexandru, M. Nemecz and A. Georgescu, 2020. Extracellular vesicles from adipose tissue stem cells in diabetes and associated cardiovascular disease; pathobiological impact and therapeutic potential. Int. J. Mol. Sci., 10.3390/ijms21249598.
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  3. Alexandru, N., E. Andrei, F. Safciuc, E. Dragan, A.M. Balahura, E. Badila and A. Georgescu, 2020. Intravenous administration of allogenic cell-derived microvesicles of healthy origins defends against atherosclerotic cardiovascular disease development by a direct action on endothelial progenitor cells. Cells, 10.3390/cells9020423.
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  4. Tucureanu, M.M., A. Filippi, N. Alexandru, C.A. Constantinescu and L. Ciortan et al., 2019. Diabetes-induced early molecular and functional changes in aortic heart valves in a murine model of atherosclerosis. Diabetes Vasc. Dis. Res., 10.1177/1479164119874469.
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  5. Gherghiceanu, M., N. Alexandru, S.L. Magda, A. Constantin and M. Nemeczet al., 2019. Extracellular Vesicles As Valuable Players In Diabetic Cardiovascular Diseases. In: Extracellular Vesicles, De Bona, A.G. (Ed.)., IntechOpen Rijeka, Croatia, ISBN: 978-1-78923-944-7, pp: 1-25.
  6. Constantin, A., M. Dumitrescu, M. Nemecz, A. Picu and B. Smeu et al., 2019. Sera of obese type 2 diabetic patients undergoing metabolic surgery instead of conventional treatment exert beneficial effects on beta cell survival and function: Results of a randomized clinical study. Obesity Surg., 29: 1485-1497.
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  7. Ceafalan, L.C., O.C. Ioghen, D.S. Marta, A. Constantin and N. Alexandru et al., 2019. Extracellular Vesicles as Risk Factor in Neurodegenerative Diseases. In: Extracellular Vesicles, De Bona, A.G. (Ed.)., InTechOpen, Rijeka, Croatia, ISBN: 978-1-78923-944-7, pp: 1-21.
  8. Alexandru, N., F. Safciuc, A. Constantin, M. Nemecz and G. Tanko et al., 2019. Platelets of healthy origins promote functional improvement of atherosclerotic endothelial progenitor cells. Front. Pharmacol., Vol. 10. 10.3389/fphar.2019.00424.
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  9. Alexandru, N., A. Constantin, M. Nemecz, I.K. Comariu0163a and A. Vu00eelcu et al., 2019. Hypertension associated with hyperlipidemia induced different microrna expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of endothelial progenitor cell therapy. Front. Med., 10.3389/fmed.2019.00280.
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  10. Alexandru, N., A. Constantin, M. Nemecz, I.K. Comariu0163a and A. Vu00eelcu et al., 2019. Hypertension associated with hyperlipidemia induced different MicroRNA expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of endothelial progenitor cell therapy. Front. Med., 10.3389/fmed.2019.00280.
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  11. Stępien, E.L., M. Durak-Kozica, A. Kaminska, M. Targosz-Korecka and M. Libera et al., 2018. Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes. Theranostics, 8: 3874-3890.
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  12. Nemecz, M., A. Constantin, M. Dumitrescu, N. Alexandru, A. Filippi, G. Tanko and A. Georgescu, 2018. The distinct effects of palmitic and oleic acid on pancreatic beta cell function: The elucidation of associated mechanisms and effector molecules. Front. Pharmacol., Vol. 9. 10.3389/fphar.2018.01554.
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  13. Georgescu, A., 2018. Understanding the functional role of micro RNA‐214‐3p in atherosclerosis for the identification of novel targeted therapies to prevent or reverse endothelial cell dysfunction and stimulate autophagy. ACTA Physiol., Vol. 222. 10.1111/apha.12997.
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  14. Costa, A., N. Alexandru, F. Silva, A. Magalhães, S. Dias and A. Georgescu, 2018. Extracellular vesicles by in situ hybridization using formalin-frozen paraffin embedded sections. Ann. Romanian Soci. Biol., 21: 29-35.
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  15. Alexandru, N., E. Andrei, L. Niculescu, E. Dragan, V. Ristoiu and A. Georgescu, 2017. Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model. Acta Physiol. 10.1111/apha.12896.
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  16. Alexandru, N., A. Costa, A. Constantin, D. Cochior and A. Georgescu, 2017. Microparticles: From biogenesis to biomarkers and diagnostic tools in cardiovascular disease. Curr. Stem Cell Res. Therapy, 12: 89-102.
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  17. Nemecz, M., N. Alexandru, G. Tanko and A. Georgescu, 2016. Role of microRNA in endothelial dysfunction and hypertension. Curr. Hypertens. Rep., 18: 1-21.
  18. Georgescu, A., N. Alexandru, E. Andrei, E. Dragan, D. Cochior and S. Dias, 2016. Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development. Biol. Cell, 108: 219-243.
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  19. Alexandru, N., E. Badila, E. Weiss, D. Cochior, E. Stępień and A. Georgescu, 2016. Vascular complications in diabetes: Microparticles and microparticle associated MicroRNAs as active players. Biochem. Biophys. Res. Commun., 472: 1-10.
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  20. Georgescu, A., 2014. Cardiovascular Dysfunction: New Biomarkers and Therapies. Scholars' Press, Saarbrucken, Germany, ISBN-13: 978-3-639-71643-6, Pages: 180.
  21. Badila, E., A.M. Daraban, S. Ghiorghe, A. Georgescu, N. Alexandru, D. Bartos and C. Tirziu, 2014. Rethinking cardiovascular therapy-the effect of irbesartan on circulating microparticles and endothelial progenitor cells in patients with hypertension and dyslipidemia. Farmacia, 62: 93-106.
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  22. Andrei, E., N. Alexandru, E. Dragan and A. Georgescu, 2014. Flow cytometric analysis of circulating microparticles and endothelial progenitor cells in plasma; a research tool for atherosclerosis and therapy. Exp. Clin. Cardiol., 20: 1554-1563.
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  23. Alexandru, N., E. Badila and A. Georgescu, 2014. The role of endothelial progenitor cells in the cardiovascular disease pathogenesis. J. Stem Cells Res. Rev. Rep., Vol. 1, No. 2. .
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  24. Ton, B.H.T., Q. Chen, G. Gaina, C. Tucureanu and A. Georgescu et al., 2013. Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats. Acta Histochemica, 115: 840-850.
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  25. Georgescu, A., N. Alexandru, M. Nemecz, I. Titorencu and D. Popov, 2013. Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines. Eur. J. Pharmacol., 711: 27-35.
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  26. Alexandru, N., D. Popov, E. Dragan, E. Andrei and A. Georgescu, 2013. Circulating endothelial progenitor cell and platelet microparticle impact on platelet activation in hypertension associated with hypercholesterolemia. PloS One, Vol. 8. 10.1371/journal.pone.0052058.
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  27. Alexandru, N. and A. Georgescu, 2013. Circulating microparticles and microRNAs as players in atherosclerosis. World J. Hematol., 2: 16-19.
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  28. Titorencu, I., M.G. Albu, F. Anton, A. Georgescu and V.V. Jinga, 2012. Collagen-dexamethasone and collagen-D3 scaffolds for bone tissue engineering. Mol. Cryst. Liquid Cryst., 555: 208-217.
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  29. Stancu, C.S., A. Georgescu, L. Toma, G.M. Sanda and A.V. Sima, 2012. Glycated low density lipoproteins alter vascular reactivity in hyperlipidemic hyperglycemic hamsters. Ann. Roman. Soc. Cell Biol., 17: 9-15.
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  30. Georgescu, A., N. Alexandru, E. Andrei, I. Titorencu and E. Dragan et al., 2012. Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan. J. Thromb. Haemost., 10: 680-691.
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  31. Alexandru, N., D. Popov and A. Georgescu, 2012. Platelet dysfunction in vascular pathologies and how can it be treated. Thromb. Res., 129: 116-126.
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  32. Lupu, M., M. Khalil, E. Andrei, F. Iordache and K. Pfannkuche et al., 2011. Integration properties of Wharton's jelly-derived novel mesenchymal stem cells into ventricular slices of murine hearts. Cell. Physiol. Biochem., 28: 63-76.
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  33. Georgescu, A., N. Alexandru, M. Nemecz, I. Titorencu and D. Popov, 2011. Enoxaparin reduces adrenergic contraction of resistance arterioles in aging and in aging associated with diabetes via engagement of MAP kinase pathway. Blood Coagul. Fibrinol., 22: 310-316.
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  34. Georgescu, A., N. Alexandru, A. Constantinescu, I. Titorencu and D. Popov, 2011. The promise of EPC-based therapies on vascular dysfunction in diabetes. Eur. J. Pharmacol., 669: 1-6.
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  35. Georgescu, A., N. Alexandru and D. Popov, 2011. Ongoing Data on Vascular Endothelial Cell Dysfunction: An Update. In: From Vascular Cell Biology to Cardiovascular Medicine, Georgescu, A. and F. Antohe (Eds.). Kerala, India, ISBN: 978-81-7895-503-2, pp: 125-141.
  36. Georgescu, A., D. Popov, A. Constantin, M. Nemecz, N. Alexandru, D. Cochior and A. Tudor, 2011. Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes. Clin. Sci., 120: 463-472.
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  37. Georgescu, A., 2011. Vascular dysfunction in diabetes: The endothelial progenitor cells as new therapeutic strategy. World J. Diabetes, 2: 92-97.
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  38. Georgescu, A. and F. Antohe, 2011. Editor of the International Monograph from Vascular Cell Biology to Cardiovascular Medicine. In: Research Signpost Transworld Research Network, De Gortari, P. (Ed.). Kerala, India.
  39. Alexandru, N., D. Popov, E. Dragan, E. Andrei and A. Georgescu, 2011. Platelet activation in hypertension associated with hypercholesterolemia: Effects of irbesartan. J. Thromb. Haemost., 9: 173-184.
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  40. Alexandru, N., A. Georgescu, M. Amuzescu, C. Zamfir, A. Badila and D. Popov, 2011. Platelet reactivity in chronic venous insufficiency. Clin. Lab., 57: 527-534.
    PubMed  |  
  41. Nemecz, M., D. Popov and A. Georgescu, 2010. Phosphorylation/dephosphorylation signaling events in the aorta of streptozotocin-injected Golden Syrian Hamsters. Ann. RSCB, 25: 28-34.
  42. Chahed, S., A.S. Leroyer, M. Benzerroug, D. Gaucher and A. Georgescu et al., 2010. Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation. Diabetes, 59: 694-701.
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  43. Alexandru, N., D. Popov and A. Georgescu, 2010. Intraplatelet oxidative/nitrative stress: Inductors, consequences and control. Trends Cardiovasc. Med., 20: 232-238.
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  44. Popov, D., M. Nemecz, M. Dumitrescu, A. Georgescu and F.D. Bohmer, 2009. Long-term high glucose concentration influences Akt, ERK1/2 and PTP1B protein expression in human aortic smooth muscle cells. Biochem. Biophys. Res. Commun., 388: 51-55.
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  45. Georgescu, A., N. Alexandru, D. Popov, M. Amuzescu and E. Andrei et al., 2009. Chronic venous insufficiency is associated with elevated level of circulating microparticles. J. Thromb. Haemost., 7: 1566-1575.
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  46. Georgescu, A., F. Pluteanu, M.L. Flonta, E. Badila, M. Dorobantu and D. Popov, 2007. Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology, 81: 110-117.
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  47. Georgescu, A., D. Popov, N. Alexandru, A. Tudor and M. Simionescu, 2007. Structural and functional assessment of small arteries in obesity and type II diabetes. Proceedings of the 76th Congress of the European Atherosclerosis Society , Volume 8, June 10-13, 2007, Helsinki, Finland, pp: 229-229.
  48. Georgescu, A., D. Popov, E. Dragan, E. Dragomir and E. Badila, 2007. Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. Eur. J. Pharmacol., 570: 149-158.
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  49. Schneider, M., A. Georgescu, C. Bidmon, M. Tutsch, E.H. Fleischmann, D. Popov and M. Pischetsrieder, 2006. Detection of DNA-bound advanced glycation end‐products by immunoaffinity chromatography coupled to HPLC-diode array detection. Mol. Nutr. Food Res., 50: 424-429.
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  50. Georgescu, A., N. Alexandru, E. Constantinescu and D. Popov, 2006. Effect of gap junction uncoupler heptanol on resistance arteries reactivity in experimental models of diabetes, hyperlipemia and hyperlipemia-diabetes. Vasc. Pharmacol., 44: 513-518.
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  51. Georgescu, A., F. Safciuc and E. Constantinescu, 2006. The effect of aging on the vasomotor function of rat basilar artery. Proc. Roman. Acad. Ser. B., 1: 13-17.
  52. Georgescu, A., D. Popov, E. Dragomir, E. Dragan and M. Simionescu, 2006. Nebivolol protects and reverses endothelial dysfunction in diabetes associated with hypertension: Molecular mechanisms involved. Proceedings of the 24th Conference of the European Society for Microcirculation, August 30-September 2, 2006, Amsterdam, Netherlands, pp: 81-81.
  53. Georgescu, A., F. Pluteanu, M.L. Flonta, E. Badila, M. Dorobantu and D. Popov, 2005. The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery. Eur. J. Pharmacol., 508: 159-166.
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  54. Voinea, M., A. Georgescu, A. Manea, E. Dragomir, I. Manduteanu, D. Popov and M. Simionescu, 2004. Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. Eur. J. Pharmacol., 484: 111-118.
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  55. Radu, D.L., A. Georgescu, C. Stavaru, A. Carale and D. Popov, 2004. Double transgenic mice with type 1 diabetes mellitus develop somatic, metabolic and vascular disorders. J. Cell. Mol. Med., 8: 349-358.
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  56. Georgescu, A., D. Popov, M. Capraru and M. Simionescu, 2003. Enoxaparin: A low molecular weight heparin, restores the altered vascular reactivity of resistance arteries in aged and aged-diabetic hamsters. Vasc. Pharmacol., 40: 167-174.
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  57. Georgescu, A. and D. Popov, 2003. The contractile response of the mesenteric resistance arteries to prostaglandin F; effects of simultaneous hyperlipemia-diabetes. Fundam. Clin. Pharmacol., 17: 683-689.
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  58. Radu, L., C. Stavaru, A. Georgescu, D. Popov and C. Coman, 2002. Transgenic mouse model of type 1 diabetes. Proc. Jpn. Soc. Immunol., 32: 11-16.
  59. Popov, D., G. Costache, A. Georgescu and M. Enache, 2002. Beneficial effects of L-arginine supplementation in experimental hyperlipemia-hyperglycemia in the hamster. Cell Tissue Res., 308: 109-120.
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  60. Popov, D., G. Costache and A. Georgescu, 2001. Altered Vascular Reactivity of the Resistance Arteries: Lessons from the Hyperlipemic-Hyperglycemic Hamster Model. In: New Insights into Experimental Diabetes, Cheta, D.M. (Ed.). The Publishing House of the Romanian Academy, Rome, ISBN: 9789732708712, pp: 211-222.
  61. Georgescu, A., D. Popov and M. Simionescu, 2001. Mechanisms of impeded brady kinininduced vasodilation in experimental hyperlipemia-hyperglycemia: Contribution of nitric oxide and Ca2+ activated K+ channels. Fundam. Clin. Pharmacol., 15: 335-342.
  62. Georgescu, A., D. Popov and L. Vladimirescu, 2001. Effect of blocking the intercellular communication junctions on the contractile response of the resistance arteries. Curr. Problems Tech. Cell. Mol. Biol., 6: 85-90.
  63. Georgescu, A. and D. Popov, 2001. Vascular reactivity of the resistance arteries to potassium in combined hyperlipemia-hyperglycemia. Proc. Roman. Acad. Ser. B., 1: 111-117.
  64. Popov, D., G. Costache, A. Georgescu, M. Enache and M. Simionescu, 2000. Mechanisms of the impeded relaxation of the resistance arteries in hyperlipemia-hyperglycemia. Proceedings of the 5th Annual Meeting of the European Council for Blood Pressure and Cardiovascular Research, October 13-15, 2000, Noordwijkerhout, Netherlands -.
  65. Georgescu, A. and D. Popov, 2000. Age-dependent accumulation of advanced glycation endproducts is accelerated in combined hyperlipidemia and hyperglycemia, a process attenuated by L-arginine. J. Am. Aging Assoc., 23: 33-40.
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  66. Costache, G., D. Popov, A. Georgescu, M. Cenuse, V.V. Jinga and M. Simionescu, 2000. The effects of simultaneous hyperlipemia-hyperglycemia on the resistance arteries, myocardium and kidney glomeruli. J. Submicroscop. Cytol. Pathol., 32: 47-58.
    PubMed  |  
  67. Costahe, G., D. Popov, A. Georgescu and M. Simionescu, 1999. Functional-structural alterations of the resistance arteries in experimental hyperlipemia or hypergliycemia. Proc. Roman. Acad. Ser. B., 1: 33-37.
  68. Popov, D., G. Costache, A. Georgescu, M. Cenuse and M. Simionescu, 1998. In hyperlipemichyperglycemic hamsters the micro and macroangiopathic alterations are accompanied by modifications that may lead to an increased blood pressure. Proceedings of the 3rd European Research Conference on Blood Pressure and Cardiovascular Disease, October 16-18, 1998, Netherlands -.
  69. Georgescu, A., G. Costache, D. Popov and M. Simionescu, 1998. The abnormal responses to PGF2 and potassium of the mesenteric resistance arteries in hyperlipemic- hyperglycemic hamsters. Proceedings of the 3rd European Research Conference on Blood Pressure and Cardiovascular Disease, October 16-18, 1998, Netherlands -.
  70. Georgescu, A., D. Popov and G. Costache, 1998. Vascular reactivity of resistance arteries of hyperlipemic-hyperglycemic hamsters in the presence of vasoconstrictor agents. Curr. Problems Tech. Cell. Mol. Biol., 3: 124-129.
  71. Georgescu, A. and D. Popov, 1998. Influence of experimental diabetes on the cells of vascular wall. Studii si Cercetari de Biochimie, 41: 107-117.
  72. Costache, G., A. Georgescu, M. Cenuse, D. Popov and M. Simionescu, 1998. Alterations of resistance vessels and capillaries in hyperlipemic-hyperglycemic hamsters. Proceedings of the 70th EAS Congress, September 6-9, 1998, Geneva -.
  73. Georgescu, A., D. Popov and M. Hasu, 1997. Quantitative fluorimetric analysis of advanced glycosylation end products in mesenteric arteries and lens crystallin of hyperlipemic and simultaneously hyperlipemic and hyperglycemic hamsters. Curr. Problems Tech. Cell. Mol. Biol., 2: 65-68.
  74. Costache, G., M. Hasu, D. Popov and A. Georgescu, 1997. The use of the myograph technique for the investigation of the vascular reactivity: A review. Curr. Problems Tech. Cell. Mol. Biol., 2: 38-43.