Dr. Hassan Tawhid Hassan

Dr. Hassan Tawhid Hassan

Head of Academic Department/Faculty
Lancashire School of PG Medicine, UK


Highest Degree
M.D. in Leukemia Treatment from Berlin Senate Administration for Education, Science and Research, Berlin, Germany

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Area of Interest:

Molecular Sciences
100%
Haematology
62%
Oncology
90%
Leukemia
75%
Lymphoma
55%

Selected Publications

  1. Hassan, H.T., 2010. Embryonic genes expression in human adult normal and malignant stem cells: Opportunities and risks. Curr. Stem Cell Res. Treat., 2: 321-326.
  2. Hassan, H.T., 2009. c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implications. Leukemia Res., 33: 5-10.
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  3. Hassan, H.T., X. Zhai and J.A. Goodacre, 2008. CD133 stem cells in adult human brain. J. Neuro-Oncol., 89: 247-248.
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  4. Lu, C. and H.T. Hassan, 2006. Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells. Leukemia Res., 30: 296-302.
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  5. Sammons, J., N. Ahmed, M. El-Sheemy and H.T. Hassan, 2004. The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: Effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D3. Stem cells Dev., 13: 273-280.
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  6. Hassan, H.T., and M. El-Sheemy, 2004. Adult bone-marrow stem cells and their potential in medicine. J. Royal Soc. Med., 97: 465-471.
    PubMed  |  Direct Link  |  
  7. Hassan, H.T., 2004. Ajoene (natural garlic compound): A new anti-leukaemia agent for AML therapy. Leukemia Res., 28: 667-671.
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  8. Murphy, P.T., N. Ahmed and H.T. Hassan, 2002. Chronic myeloid leukemia and acromegaly in POEMS syndrome. Leukemia Res., 26: 1135-1137.
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  9. Murphy, P., N. Ahmed and H.T. Hassan, 2002. Increased serum levels of vascular endothelial growth factor correlate with splenomegaly in polycythemia vera. Leuk Res., 26: 1007-1010.
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  10. Begemann, P.G., H.T. Hassan, N. Kroger, W. Kruger, H. Kabisch and.AR. Zander, 2002. Correlation of time to platelet engraftment with amount of transplanted CD34+CD41+ cells after allogeneic bone marrow transplantation. J. Hematother Stem Cell Res., 11: 321-326.
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  11. Hassan, H.T., 2001. Transplantation Immunology. In: The Biology of Disease, Phillips, J., J. Phillips, P. Murray, P. Murray and P.R. Kirk, (Eds.). 2nd Edn., Blackwell Science Ltd., Oxford, pp: 115-123.
  12. Ahmed, N., L. Laverick, J. Sammons, H. Zhang, D.J. Maslin and H.T. Hassan, 2001. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res., 21: 3519-3523.
    PubMed  |  
  13. Ahmed, N., J. Sammons, R.J. Carson, M.A. Khokher and H.T. Hassan, 2001. Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma. Cell Biol. Int., 25: 429-435.
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  14. Sammons, J., N. Ahmed, M.A. Khokher and H.T. Hassan, 2000. Mechanisms mediating the inhibitory effect of all-trans retinoic acid on primitive hematopoietic stem cells in human long-term bone marrow culture. Stem Cells, 18: 214-219.
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  15. Leyden, D., N. Ahmed and H.T. Hassan, 2000. Hydroxyurea and trimidox enhance the radiation effect in human pancreatic adenocarcinoma cells. Anticancer Res., 20: 133-138.
    PubMed  |  
  16. Clausen, J., M. Stockschläder, N. Fehse, H.T. Hassan, C. Gabl and A.R. Zander, 2000. Blood-derived macrophage layers in the presence of hydrocortisone support myeloid progenitors in long-term cultures of CD34+ cord blood and bone marrow cells. Ann. Hematol., 79: 59-65.
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  17. Ahmed, N., M.A. Khokher and H.T. Hassan, 2000. Synthetic cytokines containing interleukin-3 exert potent megakaryopoietic activity. Haematologia, 30: 167-176.
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  18. Ahmed, N., J. Sammons, M.A. Khokher and H.T. Hassan, 2000. Retinoic acid suppresses interleukin 6 production in normal human osteoblasts. Cytokine, 12: 289-293.
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  19. Murray, P.G., L.J. Billingham, H.T. Hassan, J.R. Flavell and P.N. Nelson et al., 1999. Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease. Blood, 94: 442-447.
    PubMed  |  Direct Link  |  
  20. Kroger, N., W. Zeller, H.T. Hassan, W. Kruger and H. Renges et al., 1999. Steady-state mobilization of peripheral blood progenitor cells by cytokines alone in patients with solid tumors or hematological malignancies. Infusion Ther. Transfusion Med., 26: 85-90.
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  21. Kroger, N., C. Rauhoft, W. Zeller, H. Renges and H.T. Hassan et al., 1999. Efficacy of further attempts to mobilize CD34+ peripheral stem cells with alternative procedures after primary failure. Acta Haematol., 102: 144-147.
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  22. Kroger N., W. Zeller, H.T. Hassan, W. Kruger, C. Loliger and A.R. Zander, 1999. Stem cell mobilization with g-csf alone in breast cancer patients: Higher progenitor cell yield by delivering divided doses (2 ` 5 µg/kg) compared to a single dose (1 ` 10 µg/kg). Bone Marrow Transplantation, 23: 125-129.
    PubMed  |  Direct Link  |  
  23. Hassan, H.T., T. Hinz, N. Kroger, W. Zeller and A.R. Zander, 1999. Factors influencing platelet recovery after autologous transplantation of G-CSF-mobilized peripheral blood stem/progenitor cells following myeloablative therapy in 50 heavily pretreated lymphoma patients. Clin. Lab. Haematol., 21: 21-27.
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  24. Ahmed, N., M.A. Khokher and H.T. Hassan, 1999. Cytokine-induced expansion of human CD34+ stem/progenitor and CD34+CD41+ early megakaryocytic marrow cells cultured on normal osteoblasts. Stem Cells, 17: 92-99.
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  25. Ahmed, N., L. Laverick, J. Sammons, K. Baumforth and H.T. Hassan, 1999. Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bc1-2 in human myeloid leukaemia CD34 positive cells. Leukemia Res., 23: 741-749.
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  26. Ahmed, N., J. Sammons and H.T. Hassan, 1999. Bcl-2 protein in human myeloid leukaemia cells and its down-regulation during chemotherapy-induced apoptosis. Oncol. Reports, 6: 403-410.
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  27. Kroger, N., W. Zeller, N. Fehse, H.T. Hassan and W. Kruger et al., 1998. Mobilizing peripheral blood stem cells with high-dose G-CSF alone is as effective as with Dexa-BEAM plus G-CSF in lymphoma patients. Br. J. Haematol., 102: 1101-1106.
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  28. Kroger, N., W. Zeller, H.T. Hassan, W. Kruger, C. Loliger and A.R. Zander, 1998. Schedule-dependency of Granulocyte colony-stimulating factor in peripheral blood progenitor cell mobilization in breast cancer patients. Blood, 91: 1828-1829.
    Direct Link  |  
  29. Kroger, N., W. Zeller, H.T. Hassan, W. Kruger and H. Renges et al., 1998. Successful mobilization of peripheral blood stem cells in heavily pretreated myeloma patients with G-CSF alone. Ann. Hematol., 76: 257-262.
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  30. Kroger, N., W. Zeller, H.T. Hassan, J. Dierlamm and A.R. Zander, 1998. Difference between expression of adhesion molecules on CD34+ cells from bone marrow and G-CSF-stimulated peripheral blood. Stem Cells, 16: 49-53.
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  31. Hassan, H.T., K. Gutensohn, A.R. Zander and P. Kuhnl, 1998. CD34 Positive Cell Sorting and Enrichment: Applications in Bloodbanking and Transplantation. In: Cell Separation: Methods and Applications, Recktenwald, D. and A. Radbruch (Eds.). Marcel Dekker Inc., New York, USA., pp: 283-292.
  32. Al-Alami, O., J. Sammons, J. Martin and H.T. Hassan, 1998. Divergent effect of taxol on the proliferation, apoptosis and nitric oxide production in MHH225 CD34 positive and U937 CD34 negative human leukaemia cells. Leukemia Res., 22: 939-945.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Stockschlader, M., H.T. Hassan, W. Zeller, W. Kruger and J. Clausen et al., 1997. Allogeneic transplantation with CD34 positive selected cells. Leukemia Lymphoma, 25: 145-151.
  34. Stockschlader, M., H.T. Hassan, C. Krog, W. Kruger and C. Loliger et al., 1997. Long-term follow-up of leukaemia patients after related cryopreserved allogeneic bone marrow transplantation. Br. J. Haematol., 96: 382-386.
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  35. Meier-Tackmann, D., D.P. Agarwal, W. Kruger, C. Dereskewitz, H.T. Hassan and A.R. Zander, 1997. Changes in aldehyde dehydrogenase isozymes expression in long-term cultures of human hematopoietic progenitor cells. Adv. Exp. Med. Biol., 414: 47-57.
    PubMed  |  
  36. Hassan, H.T., E.Y. Sadovinkova, N.J. Drize, A.R. Zander and R.D. Neth, 1997. Fibronectin increases both non-adherent cells and CFU-GM while collagen increases adherent cells in human normal long-term bone marrow cultures. Haematologia, 28: 77-84.
    PubMed  |  
  37. Hassan, H.T., D. Plantholz and A.R. Zander, 1997. Weekly feeding with stem cell factor plus interleukin-3 plus interleukin-11 expands LT-CIC in Cord Blood CD34 positive cells cultured for five weeks on human bone marrow stroma. Exp. Hematol., 25: 826-827.
  38. Hassan, H.T., C. Krog, M. Stockschlader, W. Kruger and B. Schleimer et al., 1997. Factors influencing haematological recovery after allogeneic bone marrow transplantation in leukaemia patients treated with methotrexate-containing GVHD prophylaxis. Supportive Care Cancer, 5: 299-306.
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  39. Hassan, H.T. and A.R. Zander, 1997. Haematopoietic cytokines in the biology and treatment of acute myeloid leukaemia. Oncol. Rep., 4: 1141-1149.
    Direct Link  |  
  40. Stockschlader, M., H.T. Hassan, W. Kruger, H. Kabisch and A.R. Zander, 1996. Comparison of haematological recovery kinetics after myeloablative therapy between sibling allogeneic bone marrow and peripheral blood progenitor cell transplantation in the same adult acute lymphoblastic leukaemia patient. Leukemia Res., 20: 993-996.
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  41. Stockschlader, M., H.T. Hassan, C. Loliger and A.R. Zander, 1996. Long-term remission of CML following allogeneic transplantation of peripheral blood progenitor cells in fourth chronic phase after failing previous bone marrow transplantation and donor leucocyte transfusion. Acta Haematol., 96: 262-263.
  42. Kruger, W., M. Stockschlader, H.T. Hassan and A.R. Zander, 1996. Purging in bone marrow and stem cell transplantation. J. Lab. Med., 20: 210-220.
  43. Hassan, H.T., W. Zeller, M. Stockschlader, W. Kruger, M.M. Hoffknecht and A.R. Zander, 1996. Comparison between bone marrow and G-CSF-mobilized peripheral blood allografts undergoing clinical scale CD34+ cell selection. Stem Cells, 14: 419-429.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Hassan, H.T., S. Grell, U. Borrmann-Danso and M. Freund, 1996. Interferon-alpha enhances the cytotoxic and cytostatic activities of chemotherapeutic drugs in human myeloid leukemia cells. J. Interferon Cytokine Res., 16: 139-146.
    PubMed  |  
  45. Hassan, H.T., P. Begeman and A.R. Zander, 1996. The delayed platelet recovery after allogeneic cord blood transplantation could be due to an inadequate number of CD34+CD41+ cells in allografts. Exp. Hematol., 24: 1072-1073.
  46. Hassan, H.T., N.J. Drize, E.Y. Sadovinkova, O.I. Gan, S. Schrum, S. Gohla and R.D. Neth, 1996. TPSg, an anti-human immunodeficiency virus (HIV-1) agent, isolated from the Cupressaceae Thuja occidentale L. (Arborvitae) enhances in vivo hemopoietic progenitor cells recovery in sublethally irradiated mice. Immunol. Lett., 50: 119-122.
    PubMed  |  
  47. Hassan, H.T., M. Stockschlader, W. Kruger, M.M. Hoffknecht and A.R. Zander, 1996. G-CSF administration following peripheral blood selected CD34-positive cells autologous transplantation accelerates haematological recovery after myeloablative therapy. Br. J. Haematol., 92: 1027-1029.
    PubMed  |  
  48. Hassan, H.T., M. Stockschlader, B. Schleimer, W. Kruger and A.R. Zander, 1996. Comparison of the content and subpopulations of CD3 and CD34 positive cells in bone marrow harvests and G-CSF-mobilized peripheral blood leukapheresis products from healthy adult donors. Transplant Immunol., 4: 319-323.
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  49. Hassan, H.T., B. Biermann and A.R. Zander, 1996. Maintenance and expansion of erythropoiesis in human long-term bone marrow cultures in presence of erythropoietin plus stem cell factor and interleukin-3 or Interleukin-11. Eur. Cytokine Network, 7: 129-136.
    PubMed  |  
  50. Hassan, H.T. and A.R. Zander, 1996. Thrombocytopenia after high-dose chemotherapy and autologous stem cell transplantation: An unresolved problem and possible approaches to resolve it. J. Hematother. Stem Cell Res., 5: 407-414.
    PubMed  |  
  51. Hassan, H.T. and A.R. Zander, 1996. Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis. Acta Haematol., 95: 257-262.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Hassan, H.T., S. Grell, U. Borrmann-Danso and M. Freund, 1995. Effect of recombinant human interferons in inducing differentiation of acute megakaryoblastic leukaemia blast cells. Leukemia Lymphoma, 16: 329-333.
    PubMed  |  Direct Link  |  
  53. Hassan, H.T., E. Petershofen, E. Lux, C. Fonatsch, G. Heil and M. Freund, 1995. Establishment and characterization of a novel CD34-positive human myeloid leukemia cell line: MHH225 growing in serum-free culture. Ann. Hematol., 71: 111-117.
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  54. Hassan, H.T., A.R. Hanauske, E. Lux, H.D. Kleine and M. Freund, 1995. A new fibroblast growth stimulating activity from the human megakaryoblastic leukaemia cell line ELF-153: In vitro and in vivo findings. Int. J. Exp. Pathol., 76: 361-367.
    PubMed  |  
  55. Hassan, H.T., 1995. Efficacy of hydroxyurea in treatment of Egyptian patients with Thalassaemia: Preliminary results. In: Sickle cell disease and Thalassaemias: New trends in therapy. Colloque Inserm, 234: 232-240.
  56. Hassan, H.T. and M. Freund, 1995. Human stem cell factor protects CD34 positive human myeloid leukaemia cells from chemotherapy-induced apoptosis. Eur. J. Cancer, 31: 1883-1884.
    PubMed  |  Direct Link  |  
  57. Hassan, H.T. and M. Freund, 1995. Characteristic biological features of human megakaryoblastic leukaemia cell lines. Leukemia Res., 19: 589-594.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Hassan, H.T. and H.G. Drexler, 1995. Interleukins and colony stimulating factors in human myeloid leukemia cell lines. Leukemia Lymphoma, 20: 1-15.
    CrossRef  |  PubMed  |  Direct Link  |  
  59. Hassan, H.T. and A.R. Zander, 1995. Human normal and Leukemic Megakaryocytopoiesis. Cancer J., 8: 170-172.
  60. Hassan, H.T., S. Grell, U. Borrmann-Danso and M. Freund, 1994. Interleukin-4 inhibits proliferation of human leukemic megakaryoblast cell line MHH 225. Hematolog. Oncol., 12: 61-66.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Hassan, H.T., 1994. Mafosfamide enhances Interleukin-2-generated human effector cell cytotoxic activity against K562 myeloid leukaemia cells. Med. Oncol., 11: 135-136.
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  62. Maurer, H.R. and H.T. Hassan, 1993. Agar capillary clonogenic microassays for cellular immunocytotoxic activities in human leukaemia and lymphoma. Leukemia Lymphoma, 9: 305-313.
    PubMed  |  Direct Link  |  
  63. Hassan, H.T., 1993. Synergism Between Differentiation Agents: Preclinical and Clinical Studies in Myeloid Leukaemia. In: The Pharmacology of Cell Differentiation, Rifkind, R.A. (Ed.), Elsevier, Amsterdam, pp: 277-294.
  64. Hassan, H.T. and L.E. Zyada, 1993. Treatment with recombinant human interferon-alpha plus low dose cytarabine with or without hydroxyurea for children with acute monoblastic leukaemia. Hematol. Rev. Commun., 7: 125-131.
  65. Maurer, H.R., H.T. Hassan, C. Tsiriyotis and D.A. Spandidos, 1992. Recombinant human interferons alpha, beta and gamma reduce the antiproliferative action of cytarabine in K562 human myeloid leukaemia clonogenic cells. J. Cancer Res. Clin. Oncol., 118: 329-333.
    PubMed  |  
  66. Hassan, H.T., V. Heinemann and U. Jehn, 1992. Age and the biology of acute myeloid leukemia. Ann. Hematol., 64: 157-159.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Hassan, H.T., C. Tsiriyotis, H.R. Maurer and D. Spandidos, 1992. Recombinant human Interleukin-3 opposes the effects of vitamins A and D on HL-60 human myeloid leukaemia cells. Anticancer Res., 12: 821-825.
    PubMed  |  
  68. Hassan, H.T., A. Eliopoulos, H.R. Maurer and D. Spandidos, 1992. Recombinant human GM-CSF enhances the anti-proliferative activity of vitamin D in MCF-7 human breast cancer clonogenic cells. Eur. J. Cancer, 28: 1588-1589.
    PubMed  |  
  69. Hassan, H.T. and H.R. Maurer, 1992. Synergism between interferon-alpha and carboplatin in inhibiting K562 human myeloid leukaemia clonogenic cells: New potential therapeutic development. Leukemia Res., 16: 419-420.
    PubMed  |  
  70. Hassan, H.T., L.E. Zyada, M.H. Ragab and J.K.H. Rees, 1991. Synergistic interactions between recombinant human Interleukin-3, GM-CSF and G-CSF in normal human marrow granulocyte-macrophage colony formation. Cell Biol. Int., 15: 211-219.
    CrossRef  |  PubMed  |  Direct Link  |  
  71. Hassan, H.T., L.E. Zyada, M.H. Ragab and J.K.H. Rees, 1991. A biological hypothesis for the FAB classification of acute myeloid leukaemias. Med. Hypotheses, 35: 73-76.
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  72. Hassan, H.T., L.E. Zyada, M.H. Ragab and J.K. Rees, 1991. Impaired in vitro granulocytic differentiation of normal human myeloid marrow precursor cells from elderly adults. J. Clin. Exp. Gerontol., 13: 17-23.
  73. Hassan, H.T., H. Sharshira, L.E. Zyada and M.H. Ragab, 1991. Relation between leukaemia cell differentiation and count in acute myeloid Leukaemia. Med. Sci. Res., 19: 587-588.
  74. Hassan, H.T., A.F. Veit and H.R. Maurer, 1991. Synergistic interactions between differentiation-inducing agents in inhibiting the proliferation of HL-60 human myeloid leukaemia cells in clonogenic micro assays. J. Cancer Res. Clin. Oncol., 117: 227-231.
    CrossRef  |  PubMed  |  Direct Link  |  
  75. Hassan, H.T., A.F. VEIT and H.R. Maurer, 1991. Recombinant human GM-CSF significantly enhances the cytostatic activity of cell cycle specific anti-leukaemic drugs in HL-60 human myeloid leukaemia clonogenic cells in a capillary clonogenic micro-assay. Anticancer Res., 11: 481-485.
    PubMed  |  
  76. Hassan, H.T., 1991. Recombinant human Interleukin-6 enhances the antiproliferation and differentiation inducing effects of retinoic acid in HL-60 human myeloid leukaemic cells. Clin. Exp. Pharmacol. Physiol., 18: 847-851.
    CrossRef  |  PubMed  |  Direct Link  |  
  77. Hassan, H.T., 1991. In vitro interaction between retinoids and cytokines in human myeloid leukemia cells. Eur. J. Cancer, 27: 1182-1183.
    PubMed  |  
  78. Hassan, H.T. and H.R. Maurer, 1991. Synergistic combinations for differentiation therapy of myeloid leukaemia patients. Med. Sci. Res., 19: 195-198.
  79. Hassan, H.T. and H.R. Maurer, 1991. Preclinical screening of in vivo interactions between myelopoietic growth factors and antitumour drugs for therapy of myeloid Leukaemia patients (review). In Vivo, 5: 307-311.
    PubMed  |  
  80. Hassan, H.T. and H.R. Maurer, 1991. Effects of recombinant human cytokines on cytarabine activity in K562 human myeloid leukaemia cells. Chemotherapy, 37: 441-448.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Hassan H.T., L.E. Zyada, M.H. Ragab and J.K.H. Rees, 1991. New synergistic combinations of differentiation inducing agents in the treatment of acute myeloid leukaemia. Eur. J. Clin. Pharmacol., 41: 531-536.
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  82. Zyada, L.E., H.T. Hassan, M.H. Ragab and J.K.H. Rees, 1990. The relation between hypo-cholesterolaemia and degree of maturation in acute myeloid leukaemia. Hematolog. Oncol., 8: 65-69.
  83. Hassan, H.T., L.E. Zyada, J.K. Rees and M.H. Ragab, 1990. The effect of monocytic involvement of hyperaldolasaemia in patients with acute myelogenous leukaemia. Haematologia, 23: 73-77.
    PubMed  |  
  84. Hassan, H.T., E.C. Pearson and J.K. Rees, 1990. Retinoic acid induces granulocytic differentiation of myeloid progenitors in congenital agranulocytosis bone marrow cells. Cell Biol. Int., 14: 247-254.
    CrossRef  |  PubMed  |  Direct Link  |  
  85. Hassan, H.T. and J.K. Rees, 1990. Triple combination of retinoic acid, low concentration of cytarabine and dimethylformamide induces differentiation of human acute myeloid leukaemic blasts. Chemotherapy, 36: 51-57.
    PubMed  |  
  86. Hassan, H.T. and J.K. Rees, 1990. Triple combination of retinoic acid plus actinomycin D plus dimethylformamide induces differentiation of human acute myeloid leukaemic blasts in primary culture. Cancer Chemoth. Pharmacol., 26: 26-30.
    PubMed  |  
  87. Hassan, H.T. and J.K. Rees, 1990. Relation between age and blast cell differentiation in acute myeloid leukaemia patients. Oncology, 47: 439-442.
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  88. Hassan, H.T. and J.K. Rees, 1990. Myeloid Leukaemogenesis and its reversal by combined differentiation therapy: A complementary model. Med. Sci. Res., 18: 47-52.
  89. Hassan, H.T. and J.K. Rees, 1990. Effect of acute myeloid leukaemia serum on normal myeloid cell differentiation and hexamethylene bisacetamide-induced granulocytic differentiation of HL-60 human promyelocytic leukaemia cell line. Folia Haematolog., 17: 151-159.
  90. Hassan, H.T. and J.K. Rees, 1990. Auer bodies in acute myeloid leukaemia patients. Pathol. Practice Res., 186: 293-295.
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  91. Hassan, H.T., W. Labastide, C. Barker and J.K.H. Rees, 1989. Cooperative effects of human recombinant Granulocyte-macrophage colony stimulating factor and human recombinant erythropoietin in inducing differentiation of the human erythroleukaemic cell line K562 clonogenic cells. Leukemia Res., 13: 127-130.
  92. Hassan, H.T. and J.K. Rees, 1989. Triple combination of retinoic acid+aclacinomycin A+ dimethylformamide induces differentiation of human acute myeloid leukaemic blasts in primary culture. Anticancer Res., 9: 647-652.
    PubMed  |  
  93. Hassan, H.T. and J.K. Rees, 1989. Triple combination of retinoic acid + low concentration of cytosine arabinoside + hexamethylene bisacetamide induces differentiation of human AML blasts in primary culture. Hematolog. Oncol., 7: 429-440.
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  94. Hassan, H.T. and J.K. Rees, 1989. Triple combination of retinoic acid + 6-thioguanine + hexamethylene bisacetamide induces differentiation of human AML blasts in primary culture. Leukemia Res., 14: 109-117.
    CrossRef  |  PubMed  |  Direct Link  |  
  95. Hassan, H.T. and J.K. Rees, 1989. The effect of human recombinant granulocyte-macrophage colony stimulating factor on the proliferation and differentiation of myeloid progenitors in congenital agranulocytosis marrow cells. Haematologica, 22: 233-238.
    PubMed  |  
  96. Hassan, H.T. and J.K. Rees, 1989. Low concentrations of cytosine arabinoside, 6-thioguanine, actinomycin-D and aclacinomycin A stimulates the differentiation of normal human marrow myeloid progenitor cells. Med. Oncol. Tumour Pharmacoth., 6: 213-217.
    CrossRef  |  PubMed  |  Direct Link  |  
  97. Hassan, H.T. and J.K. Rees, 1989. Effect of polar-planar compounds on the differentiation of normal human myeloid immature marrow cells. Cancer Lett., 46: 37-41.
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  98. Hassan, H.T. and J.K. Rees, 1989. Differentiation induction therapy of myelodysplastic syndromes. Leukemia Res., 13: 633-637.
    CrossRef  |  PubMed  |  Direct Link  |  
  99. Hassan, H.T., 1988. Differentiation induction therapy: An alternative for the treatment of elderly patients with acute myeloid leukaemia. J. Clin. Exp. Gerontol., 10: 63-73.
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