Dr. Mark George Rae

Dr. Mark George Rae

Research Scientist
University College Cork, Ireland


Highest Degree
Ph.D. in Pharmacology from University of Glasgow, UK

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Biography

Dr. Mark George Rae is currently holds a position of Principal Investigator and Lecturer at Department of Physiology, University College Cork, Ireland. He has completed his Ph.D. in Pharmacology from University of Glasgow, UK. Previously he was appointed as Post-Doctoral Fellow at University of Strathclyde, and Department Physiology & Pharmacology, University of Nevada, University of Aberdeen, and Senior Post-Doctoral Fellow at University of Dundee, Research Electrophysiologist at Ionix Pharmaceuticals Ltd., Cambridge, Senior Research Fellow at Molecular Nociception Group, University College London, Senior Research Fellow at Astellas CNS in Edinburgh (ACE), Edinburgh University and Laboratory Coordinator at Department of Physiology, University College Cork. He is, or has been, an active member of several professional bodies in his career, presenting at numerous conferences as a member of the following professional bodies: The Physiological Society, Neuroscience Ireland, The Biochemical Society, International Society to Advance Alzheimer’s Research & Treatment, The British Neuroscience Association, Society for Neuroscience, The British Pharmacological Society, American Gastrointestinal Association, Scottish Neuroscience Group and American Gastrointestinal Association. He has acted as an expert reviewer for a number of journals including: British Journal of Pharmacology, The Journal of Physiology, The Journal of Endocrinology, Toxicology Letters, Brain Research Bulletin, and Scholarship of Teaching and Learning. He has published 20 research articles in journals contributed as author/co-author. He supervised 2 MSc students thesis and currently supervising 2 PhD and 1 MSc student thesis.

Area of Interest:

Pharmacology and Toxicology
100%
Physiology
62%
Pharmacology
90%
Neuroscience
75%
Neuropharmacology
55%

Selected Publications

  1. Rae, M.G. and M. McCarthy, 2017. The impact of vodcast utilisation upon student learning in the physiology component of a first year graduate to entry medicine module. J. Scholarship Teach. Learn., 17: 1-23.

  2. Rae, M.G. and D. O’Malley, 2017. Using an online student response system, socrative, to facilitate active learning of physiology by first year graduate entry to medicine students: A feasibility study. Res. Med. Educ. 10.15694/mep.2017.000004.
    CrossRef  |  Direct Link  |  

  3. Rae, M.G. and D. O’Malley, 2017. Student attitudes towards semi-flipped classroom teaching in a pre-clinical graduate entry to medicine physiology module. Res. Med. Educ. 10.15694/mep.2017.000009.
    CrossRef  |  Direct Link  |  

  4. Rae, M.G. and D. O’Malley, 2017. Do prerecorded lecture VODcasts affect lecture attendance of first-yearpre-clinical graduate entry to medicine students? Med. Teacher, 39: 250-254.
    CrossRef  |  Direct Link  |  

  5. Kaar, A., S.J. Morley and M.G. Rae, 2017. An efficient and cost-effective method of generating postnatal (P2-5) mouse primary hippocampal neuronal cultures. J. Neurosci. Methods, 286: 69-77.
    CrossRef  |  Direct Link  |  

  6. Ahmeda, A.F., M.G. Rae, M.F. Al Otaibi, L.M. Anweigi and E.J. Johns, 2017. Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats. J. Physiol. Biochem., 73: 207-214.
    CrossRef  |  Direct Link  |  

  7. Rae, M.G. and D. O’Malley, 2016. Cognitive dysfunction in Duchenne muscular dystrophy: A possible role for neuromodulatory immune molecules. J. Neurophys., 116: 1304-1315.
    CrossRef  |  

  8. Buckley, M.M., R.O`brien, M. Devlin, A. Creed, M.G. Rae, N.P. Hyland, D.P. Mckernan, E.M.M. Quigley and D. O`malley, 2016. Leptin modifies the pro-secretory and pro-kinetic effects of the inflammatory cytokine, interleukin-6 on colonic function in Sprague Dawley rats. Exp. Physiol., 10.1113/EP085917.
    CrossRef  |  Direct Link  |  

  9. Kaar, A. and M.G. Rae, 2015. Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling. Biochem. Soc. Trans., 43: 405-409.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Buckley, M.M., K.D. O'Halloran, M.G. Rae, T.G. Dinan and D. O'Malley, 2014. Modulation of enteric neurons by interleukin-6 and corticotrophin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome. J. Physiol., 592: 5235-5250.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Ahmeda, A.F., M.G. Rae and E.J. Johns, 2013. Effect of reactive oxygen species and nitric oxide in the neural control of intrarenal haemodynamics in anaesthetized normotensive rats. Acta Physiol., 209: 156-166.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Rae, M.G., J. Hilton and J. Sharkey, 2012. Putative TRP channel antagonists, SKF 96365, flufenamic acid and 2-APB, are non-competitive antagonists at recombinant human α1β2γ2 GABA(A) receptors. Neurochem. Int., 60: 543-554.
    CrossRef  |  

  13. Ruane-O'Hora, T., M.G. Rae and F. Markos, 2011. Effect of clazosentan, a selective endothelin a receptor antagonist and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig. Clin. Exp. Pharmacol. Physiol., 38: 515-520.
    CrossRef  |  

  14. Munro, G., H.K. Erichsen, M.G. Rae and N.R. Mirza, 2011. A question of balance-positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain. Neuropharmacology, 61: 121-132.
    CrossRef  |  

  15. Rae, M.G. and A.J. Irving, 2004. Both mGluR1 and mGluR5 mediate Ca2+ release and inward currents in hippocampal CA1 pyramidal neurons. Neuropharmacology, 46: 1057-1069.
    CrossRef  |  

  16. Shanley, L.J., A.J. Irving, M.G. Rae, M.L. Ashford and J. Harvey, 2002. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat. Neurosci., 5: 299-300.
    Direct Link  |  

  17. Irving, A.J., M.G. Rae and A.A. Coutts, 2002. Cannabinoids on the brain. Sci. World J., 2: 632-648.

  18. Rae, M.G., D.J. Martin, G.L. Collingridge and A.J. Irving, 2000. Role of Ca2+ stores in mGlu receptor-mediated supralinear Ca2+ signaling in rat hippocampal neurons. J. Neurosci., 20: 8628-8636.
    Direct Link  |  

  19. Irving, A.J., A.A. Coutts, J. Harvey, M.G. Rae, K. Mackie, G.S. Bewick and R.G. Pertwee, 2000. Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons. Neuroscience, 98: 253-262.
    CrossRef  |  

  20. Rae, M.G., N. Fleming, D.B. McGregor, K.M. Sanders and K.D. Keef, 1998. Control of motility patterns in the human colonic circular muscle layer by pacemaker activity. J. Physiol., 510: 309-320.
    Direct Link  |  

  21. Rae, M.G., M.A. Khoyi and K.D. Keef, 1998. Modulation of cholinergic neuromuscular transmission by nitric oxide in canine colonic circular smooth muscle. Am. J. Physiol., 275: 1324-1332.
    Direct Link  |  

  22. Rae, M.G., E.G. Rowan and C. Kennedy, 1998. Characterisation of P2X3-receptors present in neurones of rat dorsal root ganglia. Br. J. Pharmacol., 124: 176-180.

  23. Koh, S.D., K.K. Bradley, M.G. Rae, K.D. Keef, B. Horowitz and K.M. Sanders, 1998. Basal activation of ATP-sensitive potassium channels in murine colonic smooth muscle cell. Biophys. J., 75: 1793-1800.
    Direct Link  |  

  24. Robertson, S.J., M.G. Rae, E.G. Rowan and C. Kennedy, 1996. Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. Br. J. Pharmacol., 118: 951-956.
    Direct Link  |  

  25. Rae, M.G. and T.C. Muir, 1996. Neuronal mediators of inhibitory junction potentials and relaxation in the guinea-pig internal anal sphincter. J. Physiol., 493: 517-527.
    Direct Link  |  

  26. Rae, M.G., D. Rotondo, A.S. Milton and A.K. Dutta-Roy, 1992. Interleukin-1 inhibits PGE2 binding to macrophage-like P388D1 cells by a cyclic AMP-independent process. Biochim. Biophys. Acta, 1138: 75-79.
    Direct Link  |  

  27. Rae, M.G., D. Rotondo and A.K. Dutta-Roy, 1992. Regulation of prostaglandin E2 binding to a murine macrophage cell line, P388D1, by insulin. Biochim. Biophys. Acta, 1135: 343-348.
    Direct Link  |  

  28. Dutta-Roy, A.K., M.G. Rae, A.S. Milton and D. Rotondo, 1991. Stimulation of prostaglandin E2 binding to a murine macrophage cell line (P388D1) by insulin. Biochem. Soc. Trans., 19: 358-358.