Dr. Karel  Petrak

Dr. Karel Petrak

Business Consultant
PJP Innovations Inc., USA


Highest Degree
D.Phil in Cancer and Chemistry from University of Sussex, London, UK

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Biography

Dr. Karel Petrak obtained his PhD degree in Cancer (breast cancer biomarkers) at University of Sussex (Brighton)/Imperial Cancer Research Fund, London, England. He is having 40 years experience in pharmaceutical industry, with a demonstrated success in pharmaceutical and biotechnology drug development, drug discovery and delivery of conventional drugs, proteins, and peptides, now seeking to apply industrial experience in basic and translational academic research. In past he worked as Scientist Research Centre, Polymer Synthesis Department, Research Area Head in Horsham, U.K., Project Leader in Ardsley New York , Special Assignment CIBA-Geigy Basel, Switzerland, Manager Suffern New York, Director responsible for research and development of oral and trans-dermal drug delivery products. Currently, he is working as Vice President, Research and Development at PJP INNOVATIONS, INC. Houston, Texas. He has published 47 research papers in journals as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Drug Discovery
62%
Drug Delivery
90%
Drug Analysis
75%
Drug Development
55%

Selected Publications

  1. Wolf, J.S., G. Li, A. Varadhachary, K. Petrak and M. Schneyer et al., 2007. Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo. Clin. Cancer Res., 13: 1601-1610.
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  2. Petrak, K., 2006. Nanotechnology and site-targeted drug delivery. J. Biomat. Sci., 17: 1209-1219.
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  3. Sherman, M.P. and K. Petrak, 2005. Lactoferrin-enhanced anoikis: A defense against neonatal necrotizing enterocolitis. Med. Hypoth., 65: 478-482.
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  4. Petrak, K., 2005. Essential properties of drug-targeting delivery systems. Drug Discov. Today, 10: 1667-1667.
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  5. Varadhachary, A., K. Petrak, J.S. Wolf, B.W. O'Malley, M. Spadaro, C. Curcio and F. Pericle, 2004. Oral recombinant human lactoferrin induces systemic immune responses and inhibits the growth of established tumors. Cancer Res., .
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  6. Varadhachary, A., J.S. Wolf, , K. Petrak, B.W. O'Malley, M. Spadaro, C. Curcio and F. Pericle, 2004. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int. J. Cancer, 111: 398-403.
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  7. Pillai, R., K. Petrak, P. Blezinger, D. Deshpande, V. Florack, B. Freimark and A. Rolland, 1998. Ultrasonic nebulization of cationic lipid-based gene delivery systems for airway administration. Pharm. Res., 15: 1743-1747.
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  8. Freimark, B.D., H.P. Blezinger, V.J. Florack, J.L. Nordstrom, S.D. Long, D.S. Deshpande and K.L.Petrak, 1998. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes. J. Immunol., 160: 4580-4586.
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  9. Petrak, K., 1994. Physico-chemical basis of specific interactions involving carbohydrates. Adv. Drug Delivery Rev. 13: 211-213.
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  10. Petrak, K., 1993. Biocompatible particles based on block-copolymer aggregates for intravascular administration. J. Bioact. Compat. Polym., 8: 178-187.
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  11. Rolland, A., J. O'mullane, P. Goddard, L. Brookman and K. Petrak, 1992. New macromolecular carriers for drugs. i. preparation and characterization of poly (oxyethylene-b-isoprene-b-oxyethylene) block copolymer aggregates. J. Appl. Polym. Sci., 44: 1195-1203.
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  12. Goddard, P., I. Williamson, J. Brown, L.E. Hutchinson, Nicholls, J and K. Petrak, 1991. Soluble polymeric carriers for drug delivery-part 4: tissue autoradiography, and whole-body tissue distribution in mice, of n-(2-hydroxypropyl) methacrylamide copolymers following intravenous administration J. Bioact. Compatible Polym., 6: 4-24.
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  13. Petrak, K., 1990. Polymers for use in drug delivery-property and structure requirements. Br. Polym. J., 22: 213-219.
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  14. Morgan, P.J., S.E. Harding and K. Petrak, 1990. Hydrodynamic properties of a polyisoprene/pole(oxyethylene) block copolymer. Macromolecules, 23: 4461-4464.
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  15. Artursson, P., L. Brown, J. Dix, P. Goddard and K. Petrak, 1990. Preparation of sterically stabilized nanoparticles by desolvation from graft copolymers. J. Polym. Sci., Part A: Polym. Chem., 28: 2651-2663.
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  16. Petrak, K., 1989. The structure and properties of materials used in advanced drug delivery systems. Bull. Mater. Sci., 12: 41-47.
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  17. Petrak, K., 1989. Pharmaceutical applications of functionalized polymers. React. Polym., 10: 231-237.
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  18. Petrak, K. and P. Goddard, 1989. Transport of macromolecules across the capillary walls. Adv. Drug Delivery Rev., 3: 191-214.
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  19. Goddard, P. and K. Petrak, 1989. Review: biodegradation of drug-modified polymers in drug delivery-a critical analysis. J. Bioact. Compat. Polymers., 4: 372-402.
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  20. Boddy, A., L. Aarons and K. Petrak, 1989. Efficiency of drug targeting: steady-state considerations using a three-compartment model. Pharm. Res., 6: 367-372.
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  21. Lohmann, D. and K. Petrak, 1988. Photoactivation and photocontrolled release of bioactive materials. Crit. Rev. Ther. Drug carrier Syst., 5: 263-320.
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  22. Petrak, K., 1986. Polyelectrolyte complexes in biomedical applications. J. Bioact. Compat. Polymers., 1: 202-219.
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  23. Petrak, K., 1984. Interactions between dyes and polyelectrolytes: effect of polymer-polymer interactions. J. Appl. Polym. Sci., 29: 3991-3998.
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  24. Petrak, K. and R.V. Brooks, 1973. Methods for the quantitative estimation of nanogram and subnanogram amounts of steroids in blood and urine. Crit. Rev. Anal. Chem., 3: 421-453.
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