Dr. Karel Petrak
Business ConsultantPJP Innovations Inc., USA
Highest Degree
D.Phil in Cancer and Chemistry from University of Sussex, London, UK
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PJP Innovations Inc., USA
Biography
Dr. Karel Petrak obtained his PhD degree in Cancer (breast cancer biomarkers) at University of Sussex (Brighton)/Imperial Cancer Research Fund, London, England. He is having 40 years experience in pharmaceutical industry, with a demonstrated success in pharmaceutical and biotechnology drug development, drug discovery and delivery of conventional drugs, proteins, and peptides, now seeking to apply industrial experience in basic and translational academic research. In past he worked as Scientist Research Centre, Polymer Synthesis Department, Research Area Head in Horsham, U.K., Project Leader in Ardsley New York , Special Assignment CIBA-Geigy Basel, Switzerland, Manager Suffern New York, Director responsible for research and development of oral and trans-dermal drug delivery products. Currently, he is working as Vice President, Research and Development at PJP INNOVATIONS, INC. Houston, Texas. He has published 47 research papers in journals as author/co-author.
Area of Interest:
Pharmacology and Toxicology
100%
Drug Discovery
62%
Drug Delivery
90%
Drug Analysis
75%
Drug Development
55%
Selected Publications
- Wolf, J.S., G. Li, A. Varadhachary, K. Petrak and M. Schneyer et al., 2007. Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo. Clin. Cancer Res., 13: 1601-1610.
CrossRef | Direct Link | - Petrak, K., 2006. Nanotechnology and site-targeted drug delivery. J. Biomat. Sci., 17: 1209-1219.
CrossRef | Direct Link | - Sherman, M.P. and K. Petrak, 2005. Lactoferrin-enhanced anoikis: A defense against neonatal necrotizing enterocolitis. Med. Hypoth., 65: 478-482.
CrossRef | Direct Link | - Petrak, K., 2005. Essential properties of drug-targeting delivery systems. Drug Discov. Today, 10: 1667-1667.
CrossRef | Direct Link | - Varadhachary, A., K. Petrak, J.S. Wolf, B.W. O'Malley, M. Spadaro, C. Curcio and F. Pericle, 2004. Oral recombinant human lactoferrin induces systemic immune responses and inhibits the growth of established tumors. Cancer Res., .
Direct Link | - Varadhachary, A., J.S. Wolf, , K. Petrak, B.W. O'Malley, M. Spadaro, C. Curcio and F. Pericle, 2004. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int. J. Cancer, 111: 398-403.
CrossRef | Direct Link | - Pillai, R., K. Petrak, P. Blezinger, D. Deshpande, V. Florack, B. Freimark and A. Rolland, 1998. Ultrasonic nebulization of cationic lipid-based gene delivery systems for airway administration. Pharm. Res., 15: 1743-1747.
CrossRef | Direct Link | - Freimark, B.D., H.P. Blezinger, V.J. Florack, J.L. Nordstrom, S.D. Long, D.S. Deshpande and K.L.Petrak, 1998. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes. J. Immunol., 160: 4580-4586.
Direct Link | - Petrak, K., 1994. Physico-chemical basis of specific interactions involving carbohydrates. Adv. Drug Delivery Rev. 13: 211-213.
CrossRef | Direct Link | - Petrak, K., 1993. Biocompatible particles based on block-copolymer aggregates for intravascular administration. J. Bioact. Compat. Polym., 8: 178-187.
CrossRef | Direct Link | - Rolland, A., J. O'mullane, P. Goddard, L. Brookman and K. Petrak, 1992. New macromolecular carriers for drugs. i. preparation and characterization of poly (oxyethylene-b-isoprene-b-oxyethylene) block copolymer aggregates. J. Appl. Polym. Sci., 44: 1195-1203.
CrossRef | Direct Link | - Goddard, P., I. Williamson, J. Brown, L.E. Hutchinson, Nicholls, J and K. Petrak, 1991. Soluble polymeric carriers for drug delivery-part 4: tissue autoradiography, and whole-body tissue distribution in mice, of n-(2-hydroxypropyl) methacrylamide copolymers following intravenous administration J. Bioact. Compatible Polym., 6: 4-24.
CrossRef | Direct Link | - Petrak, K., 1990. Polymers for use in drug delivery-property and structure requirements. Br. Polym. J., 22: 213-219.
CrossRef | Direct Link | - Morgan, P.J., S.E. Harding and K. Petrak, 1990. Hydrodynamic properties of a polyisoprene/pole(oxyethylene) block copolymer. Macromolecules, 23: 4461-4464.
CrossRef | Direct Link | - Artursson, P., L. Brown, J. Dix, P. Goddard and K. Petrak, 1990. Preparation of sterically stabilized nanoparticles by desolvation from graft copolymers. J. Polym. Sci., Part A: Polym. Chem., 28: 2651-2663.
CrossRef | Direct Link | - Petrak, K., 1989. The structure and properties of materials used in advanced drug delivery systems. Bull. Mater. Sci., 12: 41-47.
CrossRef | Direct Link | - Petrak, K., 1989. Pharmaceutical applications of functionalized polymers. React. Polym., 10: 231-237.
CrossRef | Direct Link | - Petrak, K. and P. Goddard, 1989. Transport of macromolecules across the capillary walls. Adv. Drug Delivery Rev., 3: 191-214.
CrossRef | Direct Link | - Goddard, P. and K. Petrak, 1989. Review: biodegradation of drug-modified polymers in drug delivery-a critical analysis. J. Bioact. Compat. Polymers., 4: 372-402.
CrossRef | Direct Link | - Boddy, A., L. Aarons and K. Petrak, 1989. Efficiency of drug targeting: steady-state considerations using a three-compartment model. Pharm. Res., 6: 367-372.
CrossRef | Direct Link | - Lohmann, D. and K. Petrak, 1988. Photoactivation and photocontrolled release of bioactive materials. Crit. Rev. Ther. Drug carrier Syst., 5: 263-320.
Direct Link | - Petrak, K., 1986. Polyelectrolyte complexes in biomedical applications. J. Bioact. Compat. Polymers., 1: 202-219.
CrossRef | Direct Link | - Petrak, K., 1984. Interactions between dyes and polyelectrolytes: effect of polymer-polymer interactions. J. Appl. Polym. Sci., 29: 3991-3998.
CrossRef | Direct Link | - Petrak, K. and R.V. Brooks, 1973. Methods for the quantitative estimation of nanogram and subnanogram amounts of steroids in blood and urine. Crit. Rev. Anal. Chem., 3: 421-453.
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