Dr. Ralf   Weiskirchen
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Dr. Ralf Weiskirchen

Head of Institute
RWTH University Hospital, Germany


Highest Degree
Ph.D. in Biochemistry from University of Cologne, Germany

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Area of Interest:

Biomedical Sciences
100%
Cancer Chemotherapy
62%
Cell Signaling
90%
Liver Fibrosis
75%
Hepatology
55%

Research Publications in Numbers

Books
0
Chapters
5
Articles
406
Abstracts
9

Selected Publications

  1. Weiskirchen, S., C.G. Tag, S. Sauer-Lehnen, F. Tacke and R. Weiskirchen, 2017. Isolation and culture of primary murine hepatic stellate cells. Methods Mol. Biol., .
  2. Maywald, M., S.K. Meurer, R. Weiskirchen and L. Rink, 2017. Zinc supplementation augments TGF-β1 dependent regulatory T cell induction. Mol. Nutr. Food Res., .
  3. Ma, Y., A. Li, R. Weiskirchen, J. Grotzinger, W. Yu, M. Mercola, D. Stewart and R.J. Schwartz, 2017. The CSRP2BP histone acetyltransferase drives smooth muscle gene expression. Nucl. Acids Res., .
  4. Koch, A., R. Weiskirchen, S. Ludwig, L. Buendgens and J. Bruensing, et al., 2017. Relevance of serum sclerostin concentrations in critically ill patients. J. Crit. Care, 37: 38-44.
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  5. Dietzel, E., J. Floehr, E. Van de Leur, R. Weiskirchen and W. Jahnen-Dechent, 2017. The serum protein Fetuin-B increases in vitro fertilization rate in mice by inhibiting premature zona pellucida hardening. Mol. Hum. Reprod., .
  6. Weiskirchen, R. and I. Susnea, 2016. Trace metal imaging in hepatic metal overload and deficiency diseases. Mass Spectrom. Rev., 35: 666-686.
  7. Weiskirchen, R. and F. Tacke, 2016. New treatment options for liver fibrosis: From-bench-tobedside. Der Gastroenterologe, 11: 40-46.
  8. Weiskirchen, R. and F. Tacke, 2016. Liver Fibrosis: From Pathogenesis to Novel Therapies. Digestive Dis., 34: 410-422.
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  9. Van Helden, J. and R. Weiskirchen, 2016. Diagnostic value of the quantitative HBsAg determination in hepatitis B infections. Z. Fur Gastroenterol., 54: 319-326.
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  10. Uerlings, R., A. Matusch and R. Weiskirchen, 2016. Reconstruction of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) spatial distribution images in Microsoft Excel 2007. Int. J. Mass Spectrom., 395: 27-35.
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  11. Rose, M., V. Kloten, E. Noetzel, L. Gola and J. Ehling, et al., 2016. ITIH5 mediates epigenetic reprogramming of breast cancer cells. Mol. Cancer, .
  12. Moro, N., R. Sonntag, J.M. Bangen, Y.A. Nevzorova and D. Fahrenkamp, et al., 2016. Cyclin E1 is essential for initiation and progression of hepatocellular carcinoma in mice. Hepatol., .
  13. Meurer, S.K., M. NeB, S. Weiskirchen, P. Kim and C.G. Tag, et al., 2016. Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice. PloS one, .
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  14. Koppe, C., P. Verheugd, J. Gautheron, F. Reisinger and K. Kreggenwinkel, et al., 2016. IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1. Hepatol., 64: 1217-1231.
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  15. Iwasaki, J., M. Afify, C. Bleilevens, U. Klinge, R. Weiskirchen, K. Nagai, S. Yagi, S. Uemoto and R.H. Tolba, 2016. The effect of nitric oxide synthase inhibitor (L-NAME) on ischemia-reperfusion injury following Pringle maneuver in cholestatic liver induced by bile duct ligation in rats. Eur. Surg. Res., .
  16. Dietzel, E., S. Weiskirchen, J. Floehr, M. Horiguchi and V. Todorovic, et al., 2016. Latent TGF-β binding protein-1 deficiency decreases female fertility. Biochem. Biophys. Res. Commun., .
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  17. Buhl, E.M., S. Djudjaj, J. Babickova, B.M. Klinkhammer and E. Folestad, et al., 2016. The role of PDGF-D in healthy and fibrotic kidneys. Kidney Int., 89: 848-861.
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  18. Borkham-Kamphorst, E., B.T. Steffen, E. Van de Leur, U. Haas, L. Tihaa, S.L. Friedman and R. Weiskirchen, 2016. CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis. Cell. Signalling, 28: 34-42.
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  19. Borkham-Kamphorst, E., B.T. Steffen, E. Van de Leur, L. Tihaa and U. Haas, et al., 2016. Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response. Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1863: 2604-2612.
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  20. Borkham-Kamphorst, E. and R. Weiskirchen, 2016. The PDGF system and its antagonists in liver fibrosis. Cytokine Growth Factor Rev., 28: 53-61.
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  21. Asimakopoulou, A., E. Borkham Kamphorst, F. Tacke and R. Weiskirchen, 2016. Lipocalin‐2 (NGAL/LCN2), a help‐me signal in organ inflammation. Hepatol., 63: 669-671.
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  22. Asimakopoulou, A., A. Fulop, E. Borkham-Kamphorst, E. Van de Leur and N. Gassler, et al., 2016. Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis. BBA Mol. Bas. Dis., .
  23. van Helden, J. and R. Weiskirchen, 2015. Performance of the two new fully automated anti-Mullerian hormone immunoassays compared with the clinical standard assay. Hum. Reprod., 30: 1918-1926.
  24. van Helden, J. and R. Weiskirchen, 2015. Experience with the first fully automated chemiluminescence immunoassay for the quantification of 1α, 25-dihydroxy-vitamin D. Clin. Chem. Lab. Med., 53: 761-770.
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  25. Weiskirchen, R., A. Mahli, S. Weiskirchen and C. Hellerbrand, 2015. The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front. Physiol., 6: 140-140.
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  26. Weiskirchen, R., 2015. Hepatoprotective and Anti-fibrotic Agents: It`s Time to Take the Next Step. Front. Pharmacol., .
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  27. Weiskirchen, R., 2015. CCN1, a molecular switch that imposes a self-limiting control on inflammation and wound healing in a multitude of organs? Am. J. Physiol. Lung Cell. Mol. Physiol., 309: L747-L748.
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  28. Weiskirchen, R. and R. Uerlings, 2015. Laser Ablation Inductively Coupled Plasma Mass Spectrometry in Biomedicine and Clinical Diagnosis. Cell. Mol. Med. Open Access, .
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  29. Weiskirchen, R. and F. Tacke, 2015. Small heterodimer partner (SHP) links hepatitis C and liver fibrosis: a small protein on the big stage. Liver Int., 35: 2218-2221.
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  30. Wallace, M.C., K. Hamesch, M. Lunova, Y. Kim, R. Weiskirchen, P. Strnad and S.L. Friedman, 2015. Standard operating procedures in experimental liver research: thioacetamide model in mice and rats. Lab. Anim., 49: 21-29.
  31. Van Helden, J. and R. Weiskirchen, 2015. Analytical evaluation of the novel soluble fms-like tyrosine kinase 1 and placental growth factor assays for the diagnosis of preeclampsia. Clin. Biochem., 48: 1113-1119.
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  32. Tolba, R.H., B.M. Riederer and R. Weiskirchen, 2015. Standard Operating Procedures in Experimental Liver Research: Time to achieve uniformity. Lab. Anim., 49: 1-3.
  33. Tolba, R., T. Kraus, C. Liedtke, M. Schwarz and R. Weiskirchen, 2015. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab. Anim., 49: 59-69.
  34. Tag, C.G., S. Weiskirchen, K. Hittatiya, F. Tacke, R.H. Tolba and R. Weiskirchen, 2015. Induction of experimental obstructive cholestasis in mice. Lab. Anim., 49: 70-80.
  35. Tag, C.G., S. Sauer-Lehnen, S. Weiskirchen, E. Borkham-Kamphorst, R.H. Tolba, F. Tacke and R. Weiskirchen, 2015. Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J. Visualized Exp., 2015: e52438-e52438.
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  36. Scholten, D., J. Trebicka, C. Liedtke and R. Weiskirchen, 2015. The carbon tetrachloride model in mice. Lab. Anim., 49: 4-11.
  37. Ramadori, P., R. Weiskirchen, J. Trebicka and K. Streetz, 2015. Mouse models of metabolic liver injury. Lab. Anim., 49: 47-58.
  38. Nair, D.G., R. Weiskirchen and S.K. Al-Musharafi, 2015. The use of marine-derived bioactive compounds as potential hepatoprotective agents. Acta Pharmacol. Sinica, 36: 158-170.
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  39. Horiguchi, M., V. Todorovic, K. Hadjiolova, R. Weiskirchen and D.B. Rifkin, 2015. Abrogation of both short and long forms of Latent Transforming Growth Factor-β Binding Protein-1 causes defective cardiovascular development and is perinatally lethal. Matrix Biol., 43: 61-70.
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  40. Heymann, F., K. Hamesch, R. Weiskirchen and F. Tacke, 2015. The concanavalin A model of acute hepatitis in mice. Lab. Anim., 49: 12-20.
  41. Hamesch, K., E. Borkham-Kamphorst, P. Strnad and R. Weiskirchen, 2015. Lipopolysaccharide-induced inflammatory liver injury in mice. Lab. Anim., 49: 37-46.
  42. Borkham-Kamphorst, E., S.K. Meurer, E. Van de Leur, U. Haas, L. Tihaa and R. Weiskirchen, 2015. PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β. Cell. Signalling, 27: 1305-1314.
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  43. Borkham-Kamphorst, E., P. Alexi, L. Tihaa, U. Haas and R. Weiskirchen, 2015. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities. Biochem. Biophys. Res. Commun., 457: 307-313.
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  44. Boaru, S.G., U. Merle, R. Uerlings, A. Zimmermann and C. Flechtenmacher, et al., 2015. Laser ablation inductively coupled plasma mass spectrometry imaging of metals in experimental and clinical Wilson`s disease. J. Cell. Mol. Med., 19: 806-814.
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  45. Boaru, S.G., E. Borkham Kamphorst, E. Van de Leur, E. Lehnen, C. Liedtke and R. Weiskirchen, 2015. NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes. Biochem. Biophys. Res. Commun., 458: 700-706.
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  46. Bartneck, M., K.T. Warzecha, C.G. Tag, S. Sauer-Lehnen and F. Heymann, et al., 2015. Isolation and time lapse microscopy of highly pure hepatic stellate cells. Anal. Cell. Pathol., .
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  47. Bartneck, M., F. Topuz, C.G. Tag, S. Sauer-Lehnen and K.T. Warzecha, et al., 2015. Molecular response of liver sinusoidal endothelial cells on hydrogels. Mater. Sci. Eng. C, 51: 64-72.
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  48. Asimakopoulou, A. and R. Weiskirchen, 2015. Lipocalin 2 in the pathogenesis of fatty liver disease and nonalcoholic steatohepatitis. Clin. Lipidology, 10: 47-67.
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  49. Winkler, S., E. Borkham Kamphorst, P. Stock, S. Bruckner and M. Dollinger, et al., 2014. Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model. Exp. Cell Res., 326: 230-239.
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  50. Weiskirchen, R. and F. Tacke, 2014. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg. Nutr., 3: 344-363.
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  51. Van Helden, J. and R. Weiskirchen, 2014. Hepatitis C diagnostics: clinical evaluation of the HCV-core antigen determination (Hepatitis C Diagnostik: Klinische Evaluierung der HCV-core Antigenbestimmung). Z. Gastroenterol., 52: 1160-1166.
  52. Tacke, F. and R. Weiskirchen, 2014. Liver immunology: new perspectives. Hepatobiliary Surg. Nutr., 3: 330-330.
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  53. Stocker, W., K. Karmilin, A. Hildebrand, H. Westphal and I. Yiallouros, et al., 2014. Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B. Biol. Chem., 395: 1195-1199.
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  54. Schon, H.T. and R. Weiskirchen, 2014. Immunomodulatory effects of transforming growth factor-β in the liver. Hepatobiliary Surg. Nutr., 3: 386-406.
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  55. Meurer, S.K., M. Alsamman, D. Scholten and R. Weiskirchen, 2014. Endoglin in liver fibrogenesis - Bridging basic science and clinical practice. World J. Biol. Chem., 5: 180-203.
  56. Martinez‐Palacian, A., S.M. Kanse and R. Weiskirchen, 2014. Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clin. Appl., 8: 438-446.
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  57. Koch, A., H.W. Zimmermann, N. Gassler, C. Jochum and R. Weiskirchen, et al., 2014. Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure. Liver Int., 34: 1330-1339.
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  58. Bultmann, C.A. and R. Weiskirchen, 2014. MAKERGAUL: an innovative MAK2-based model and software for real-time PCR quantification. Clin. Biochem., 47: 117-122.
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  59. Borkham-Kamphorst, E., C. Schaffrath, E. Van de Leur, U. Haas and L. Tihaa, et al., 2014. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling. Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1843: 902-914.
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  60. Boaru, S.G., U. Merle, R. Uerlings, A. Zimmermann and S. Weiskirchen, et al., 2014. Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson`s disease by laser ablation inductively coupled plasma mass spectrometry. BMC Neurosci., .
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  61. Asimakopoulou, A., E. Borkham-Kamphorst, M. Henning, E. Yagmur and N. Gassler, et al., 2014. Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. Biochim. Biophys. Acta (BBA) Mol. Cell Biol. Lipids, 1841: 1513-1524.
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  62. Abnaof, K., N. Mallela, G. Walenda, S.K. Meurer and K. Sere, et al., 2014. TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Syst. Biol., .
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  63. Yagmur, E., R. Weiskirchen, A. Schedel and P. Bugert, 2013. PTGS1 compound heterozygosity impairs gene expression and platelet aggregation and is associated with severe bleeding complications. Thrombosis Haemostasis, 110: 1083-1085.
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  64. Weiskirchen, R., J. Weimer, S.K. Meurer, A. Kron and B. Seipel, et al., 2013. Genetic characteristics of the human hepatic stellate cell line LX-2. PloS one, .
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  65. Weiskirchen, R. and S.K. Meurer, 2013. BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Front. Biosci., 18: 1435-1444.
  66. Walenda, G., K. Abnaof, S. Joussen, S.K. Meurer and B. Smeets, et al., 2013. TGF-β1 does not induce senescence of mesenchymal stromal cells and has similar effects in early and late passages. PLoS ONE, .
  67. Sahin, H., E. Borkham Kamphorst, M.L. Berres, M. Kaldenbach and P. Schmitz, et al., 2013. Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes. Hepatol., 57: 797-805.
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  68. Roderburg, C., M. Luedde, D.V. Cardenas, M. Vucur and T. Mollnow, et al., 2013. miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. J. Hepatol., 58: 736-742.
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  69. Pornwilard, M.M., U. Merle, R. Weiskirchen and J.S. Becker, 2013. Bioimaging of copper deposition in Wilson`s diseases mouse liver by laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI). Int. J. Mass Spectrom., 354: 281-287.
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  70. Pornwilard, M.M., R. Weiskirchen, N. Gassler, A.K. Bosserhoff and J.S. Becker, 2013. Novel bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry for diagnosis of fibrotic and cirrhotic liver disorders. PLoS One, .
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  71. Meurer, S.K., M. Alsamman, H. Sahin, H.E. Wasmuth and T. Kisseleva, et al., 2013. Overexpression of Endoglin modulates ALK/Smad signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One, .
  72. Martin, I.V., E. Borkham Kamphorst, S. Zok, C.R. van Roeyen and U. Eriksson, et al., 2013. Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis. Am. J. Pathol., 182: 107-117.
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  73. Liedtke, C., T. Luedde, T. Sauerbruch, D. Scholten and K. Streetz, et al., 2013. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Fibrogenesis Tissue Repair, .
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  74. Labbus, K., M. Henning, E. Borkham-Kamphorst, C. Geisler and T. Berger, et al., 2013. Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions. J. Proteomics, 78: 188-196.
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  75. Koch, A., R. Weiskirchen, J. Kunze, H. Duckers and J. Bruensing, et al., 2013. Elevated asymmetric dimethylarginine levels predict short-and long-term mortality risk in critically ill patients. J. Crit. Care, 28: 947-953.
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  76. Koch, A., R. Weiskirchen, J. Bruensing, H. Duckers and L. Buendgens, et al., 2013. Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis. Mediators Inflammation, .
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  77. Huss, S., C. Stellmacher, D. Goltz, I. Khlistunova and A.C. Adam, et al., 2013. Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC Gastroenterol., .
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  78. Dietzel, E., J. Wessling, J. Floehr, C. Schafer and S. Ensslen, et al., 2013. Fetuin-B, a liver-derived plasma protein is essential for fertilization. Dev. Cell, 25: 106-112.
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  79. Cubero, F.J., A. Singh, E. Borkham Kamphorst, Y.A. Nevzorova and M. Al Masaoudi, et al., 2013. TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model. Cell Death Differ., 20: 1580-1592.
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  80. Borkham-Kamphorst, E., H.W. Zimmermann, N. Gassler, U. Bissels and A. Bosio, et al., 2013. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J. Hepatol., 58: 104-111.
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  81. Borkham-Kamphorst, E., E. van de Leur, H.W. Zimmermann, K.R. Karlmark and L. Tihaa, et al., 2013. Protective effects of Lipocalin-2 (LCN2) in acute and chronic liver injury indicate a novel function in liver homeostasis. Z. Gastroenterologie, 1832: 660-673.
  82. Van Roeyen, C.R., P. Boor, E. Borkham-Kamphorst, S. Rong and R. Weiskirchen et al., 2012. A novel, dual role of CCN3 in experimental glomerulonephritis: Pro-angiogenic and anti-mesangioproliferative effects. Am. J. Pathol., 180: 1979-1990.
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  83. Tacke, F. and R. Weiskirchen, 2012. Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. Expert Rev. Gastroenterol. Hepatol., 6: 67-80.
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  84. Seidler, S., H.W. Zimmermann, R. Weiskirchen, C. Trautwein and F. Tacke, 2012. Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes. BMC Gastroenterol., 10.1186/1471-230X-12-38.
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  85. Sahin, H., E. Borkham-Kamphorst, C. Kuppe, M.M. Zaldivar and R. Weiskirchen, 2012. Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatol., 55: 1610-1619.
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  86. Reichenbach, V., G. Fernandez-Varo, G. Casals, D. Oro and R. Weiskirchen et al., 2012. Adenoviral dominantnegative soluble PDGFRbeta improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats. J. Hepatol., 57: 967-973.
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  87. Parahuleva, M.S., H. Holschermann, D. Zandt, J. Pons-Kuhnemann and R. Weiskirchen et al., 2012. Circulating Factor VII Activating Protease (FSAP) is associated with clinical outcome in acute coronary syndrome. Circulation J., 76: 2653-2661.
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  88. Oezdemir, R.F., N.T. Gaisa, K. Lindemann-Docter, R. Weiskirchen and M. Ahrens et al., 2012. Proteomic tissue profiling for improvement of grading of noninvasive papillary urothelial neoplasia. Clin. Biochem., 45: 7-11.
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  89. Nevzorova, Y.A., J.M. Bangen, R. Weiskirchen, U. Haas and W. Hu et al., 2012. Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice. Hepatol., 56: 1140-1149.
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  90. Meurer, S.K., M. Esser, L. Tihaa and R. Weiskirchen, 2012. BMP-7/TGF-β1 signalling in myoblasts: Components involved in signalling and BMP-7-dependent blockage of TGF-β-mediated CTGF expression. Eur. J. Cell Biol., 91: 450-463.
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  91. Kabgani, N., T. Grigoleit, K. Schulte, A. Sechi and R. Weiskirchen et al., 2012. Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS One, 10.1371/journal.pone.0034907.
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  92. Jansen, J., E. Rosenkranz, S. Overbeck, S. Warmuth and R. Weiskirchen, 2012. Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc. J. Nutr. Biochem., 23: 1458-1466.
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  93. Borkham-Kamphorst, E., S. Huss, L.E. Van De, U. Haas and R. Weiskirchen, 2012. Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liver Internat., 32: 1342-1353.
    CrossRef  |  Direct Link  |  
  94. Borkham-Kamphorst, E., C.R. Van Roeyen, J. Floege and R. Weiskirchen, 2012. CCN3/NOV small interfering RNA enhances fibrogenic gene expression in hepatic stellate cells and cirrhotic fat storing cell line CFSC. J. Cell Commun. Signal, 6: 11-25.
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  95. Boaru, S.G., E. Borkham Kamphorst, L. Tihaa, U. Haas and R. Weiskirchen, 2012. Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. J. Inflammation, .
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  96. Bergmann, C. and R. Weiskirchen, 2012. It`s not all in the cilium, but on the road to it: Genetic interaction network in polycystic kidney and liver diseases and how trafficking and quality control matter. J. Hepatol., 56: 1201-1203.
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  97. Weiskirchen, R., 2011. CCN proteins in liver health and disease. Front. Biosci., 16: 1939-1961.
  98. Scholten, D. and R. Weiskirchen, 2011. Questioning the challenging role of epithelial‐to‐mesenchymal transition in liver injury. Hepatol., 53: 1049-1051.
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  99. Rauen, T., R. Weiskirchen and J. Floege, 2011. In search of early events in the development of chronic kidney disease: the emerging role for lipocalin-2/NGAL. Nephrol. Dialysis Transplantation, 26: 445-447.
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  100. Pieper-Furst, U., R. Hall, S. Huss, H.P. Fischer and R. Weiskirchen et al., 2011. Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. BBA - Mol. Bas. Dis., 1812: 1640-1648.
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  101. Meurer, S.K., W.N. Vreden, L. Tihaa and R. Weiskirchen, 2011. Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Cell Signal, 23: 683-699.
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  102. Kammerer, E., A. Peuscher, A. Reinartz, C. Liedtke, R. Weiskirchen, J. Kopitz and N. Gassler, 2011. Human acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C. World J. Gastroenterol., 17: 4883-4889.
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  103. Henkel, C., K. Schwamborn, H.W. Zimmermann, F. Tacke and R. Weiskirchen et al., 2011. From proteomic multimarker rofiling to interesting proteins: Thymosin-β4 and Kininogen-1 as new potential biomarkers for inflammatory hepatic lesions. J. Cell. Mol. Med., 15: 2176-2188.
    CrossRef  |  Direct Link  |  
  104. Hellerbrand, C. and R. Weiskirchen, 2011. Does it not only matter how much but also when we eat to induce fatty liver? Hepatol., 54: 1096-1099.
  105. Borkham-Kamphorst, E., F. Drews and R. Weiskirchen, 2011. Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κβ activation. Liver Inter., 31: 656-665.
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  106. Zimmermann, H.W., S. Seidler, J. Nattermann, N. Gassler and R. Weiskirchen et al., 2010. Unctional contribution of elevated circulating and hepatic non-classical CD14+CD16+ monocytes to inflammation and human liver fibrosis. PLoS One, 10.1371/journal.pone.0011049.
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  107. Zaldivar, M.M., K. Pauels, P. Von Hundelshausen, M.L. Berres and R. Weiskirchen et al., 2010. CXC chemokine ligand 4 (CXCL4) is a plateletderived mediator of experimental liver fibrosis. Hepatol., 51: 1345-1353.
    CrossRef  |  Direct Link  |  
  108. Wasmuth, H.E. and R. Weiskirchen, 2010. Personalized medicine in hepatitis C: From genome‐wide association studies to clinical practice. Hepatol., 51: 2223-2225.
    Direct Link  |  
  109. Wasmuth, H.E. and R. Weiskirchen, 2010. Pathogenesis of liver fibrosis: modulation of stellate cells by chemokines. Z. Gastroenterol., 48: 38-45.
    Direct Link  |  
  110. Tacke, F. and R. Weiskirchen, 2010. Liver fibrosis-pathogenesis and novel therapeutic approaches. Der Internist, 51: 21-29.
    Direct Link  |  
  111. Schoenherr, C., R. Weiskirchen and S. Haan, 2010. Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription-1-dependent responses. Cell Commun. Signal., 10.1186/1478-811X-8-19.
    CrossRef  |  Direct Link  |  
  112. Reinartz, A., J. Ehling, A. Leue, C. Liedtke and R. Weiskirchen et al., 2010. Lipid-induced upregulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. BBA - Mol. Cell Biol. Lipids, 1801: 1025-1035.
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  113. Koch, A., R. Weiskirchen, H.W. Zimmermann, E. Sanson, C. Trautwein and F. Tacke, 2010. Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediat. Inflamm., 10.1155/2010/473540.
    CrossRef  |  Direct Link  |  
  114. Koch, A., R. Weiskirchen, E. Sanson, H.W. Zimmermann and S. Voigt et al., 2010. Circulating retinol binding protein 4 concentrations in critically ill patients before specific treatment: Prognostic impact and correlation with organ function, metabolism and inflammation. Crit. Care, 10.1186/cc9285.
    CrossRef  |  Direct Link  |  
  115. Kaemmerer, E., P. Plum, C. Klaus, R. Weiskirchen and C. Liedtke, et al., 2010. Fatty acid binding receptors in intestinal physiology and pathophysiology. World J. Gastrointest Pathophysiol., 1: 147-153.
  116. Huss, S., J. Schmitz, D. Goltz, H.P. Fischer, R. Buttner and R. Weiskirchen, 2010. Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. BMC Fibrogenesis Tissue Repair, 10.1186/1755-1536-3-10.
    CrossRef  |  Direct Link  |  
  117. Bomble, M., F. Tacke, L. Rink, E. Kovalenko and R. Weiskirchen, 2010. Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem. Biophys. Res. Commun., 396: 342-347.
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  118. Bohr, W., M. Kupper, K. Hoffmann and R. Weiskirchen, 2010. Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein. PLoS One, 10.1371/journal.pone.0016000.
    CrossRef  |  Direct Link  |  
  119. Bettermann, K., M. Vucur, J. Haybaeck, C. Koppe and R. Weiskirchen et al., 2010. TAK1 suppresses a NEMO-dependent but NF-kB-independent pathway to liver cancer. Cancer Cell, 17: 481-496.
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  120. Berres, M.L., R.R. Koenen, A. Rueland, M.M. Zaldivar and R. Weiskirchen et al., 2010. Antagonism of the chemokine CCL5 ameliorates experimental liver fibrosis in mice. J. Clin. Invest., 120: 4129-4140.
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  121. Weiskirchen, R., S.K. Meurer, O.A. Gressner, J. Herrmann, E.B. Kamphorst and M. Gressner, 2009. BMP-7 as antagonist of organ fibrosis. Frontiers Biosci., 14: 4992-5012.
  122. Weiskirchen, R., C. Liedtke and C. Trautwein, 2009. When sleeping beauty wakes up and jumps into a cancer‐minded environment. Hepatol., 49: 2122-2124.
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  123. Weiskirchen, R. and H.E. Wasmuth, 2009. The genes that underlie fatty liver disease: the harvest has begun. Hepatol., 49: 692-694.
    Direct Link  |  
  124. Wasmuth, H.E., F. Lammert, M.M. Zaldivar, R. Weiskirchen and C. Hellerbrand et al., 2009. Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterol., 137: 309-319.
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  125. Wasmuth, H.E., C.G. Tag, E.V. De Leur, C. Hellerbrand and R. Weiskirchen et al., 2009. The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB. Hepatol., 49: 775-780.
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  126. Schwamborn, K., R.C. Krieg, J. Grosse, N. Reulen and R. Weiskirchen et al., 2009. Serum proteomic profiling in patients with bladder cancer. Eur. Urol., 56: 989-997.
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  127. Roderfeld, M., R. Weiskirchen, S. Atanasova, A.M. Gressner, K.T. Preissner, E. Roeb and S.M. Kanse, 2009. Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells. Liver Int., 29: 686-691.
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  128. Oppen, N.V., A. Schurich, S. Hegenbarth, D. Stabenow and R. Weiskirchen et al., 2009. Systemic antigen crosspresented by liver sinusoidal endothelial cells induces liver-specific CD8 T cell retention and tolerization. Hepatol., 49: 1664-1672.
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  129. Nevzorova, Y.A., D. Tschaharganeh, N. Gassler, Y. Geng and R. Weiskirchen et al., 2009. Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Gastroenterol., 137: 691-703.
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  130. Mohren, S and R. Weiskirchen, 2009. Non-synonymous gene polymorphisms in the secretory signal peptide of human TGF-β1 affect cellular synthesis but not secretion of TGF-β1. Biochem. Biophys. Res. Commun., 379: 1015-1020.
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  131. Kovalenko, E., F. Tacke, O.A. Gressner, H. Zimmermann and R. Weiskirchen et al., 2009. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J. Viral Hepatitis, 16: 612-620.
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  132. Karlmark, K.R., R. Weiskirchen, H.W. Zimmermann, N. Gassler and F. Ginhoux et al., 2009. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatol., 50: 261-274.
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  133. Gressner, O.A., B. Lahme, M. Siluschek, K. Rehbein, R. Weiskirchen, A.M. Gressner, 2009. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes - but without modulating bone morphogenetic protein 7 signaling. Hepatol., 49: 2021-2030.
    CrossRef  |  Direct Link  |  
  134. Berres, M.L., S. Papen, K. Pauels, P. Schmitz and R. Weiskirchen et al., 2009. A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection. J. Hepatol., 50: 370-376.
    CrossRef  |  Direct Link  |  
  135. Bender, H., M.Y. Wiesinger, C. Nordhoff, C. Schoenherr and R. Weiskirchen et al., 2009. Interleukin-27 displays interferon γ-like functions in human hepatoma cells and hepatocytes. Hepatol., 50: 585-591.
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  136. Weiskirchen, R. and F. Lammert, 2008. A yellow bullet against the drivers of hepatic fibrogenesis. Hepatol., 48: 683-685.
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  137. Weiskirchen, R. E. Borkham-Kamphorst, S.K. Meurer, F. Drews and S. Mohren, et al., 2008. A complex network of intra- and intercellular mediators regulate cellular activation and transdifferentiation of hepatic stellate cells. In: Liver Cirrhosis: From Pathophysiology to Disease Management. Bosch, J., A.K. Burroughs, F. Lammert, D. Lebrec, T. Sauerbruch, (Ed.). Springer-Verlag, Germany, pp: 45-69.
  138. Wasmuth, H.E., M.M. Zaldivar, M.L. Berres, A. Werth and R. Weiskirchen et al., 2008. The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection. J. Hepatol., 48: 208-215.
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  139. Wang, H., Y.P. Zhao, C.F. Gao, Q. Ji and R. Weiskirchen et al., 2008. Transforming growth factor β1 gene variants increase transcription and are associated with liver cirrhosis in Chinese. Cytokine, 43: 20-25.
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  140. Tag, C.G., C. Oberkanins, G. Kriegshauser, C.J.E. Ingram and R. Weiskirchen et al., 2008. Evaluation of a novel reverse-hybridization StripAssay for genotyping DNA variants useful in diagnosis of adult-type hypolactasia. Clin. Chim. Acta, 392: 58-62.
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  141. Tag, C.G., A.M. Gressner and R. Weiskirchen, 2008. Rapid FSAP genotyping of the E393Q (Marburg II) and G534E (Marburg I) polymorphisms on the LightCycler in a multiplex PCR using two fluorescently labeled probe sets. Open Clin. Chem. J., 1: 42-46.
    Direct Link  |  
  142. Tacke, F., R. Weiskirchen and C. Trautwein, 2008. Liver function critically determines serum retinol-binding protein 4 (RBP4) levels in patients with chronic liver disease and cirrhosis. Hepatol., 48: 1724-1725.
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  143. Sagave, J.F., M. Moser, E. Ehler, S. Weiskirchen and R. Weiskirchen et al., 2008. Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure. BMC Dev. Biol., 10.1186/1471-213X-8-80.
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  144. Muetze, S., B. Leeners, J.R. Ortlepp, S. Kuse and R. Weiskirchen et al., 2008. Maternal factor v leiden mutation is associated with hellp syndrome in caucasian women. Acta Obstet. Gyn. Scan., 87: 635-642.
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  145. Gressner, O.A., M.S. Rizk, E. Kovalenko, R. Weiskirchen and A.M. Gressner, 2008. Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go? J. Gastroenterol. Hepatol., 23: 1024-1035.
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  146. Gressner, O.A., B. Lahme, M. Siluschek, K. Rehbein, R. Weiskirchen and A.M. Gressner, 2008. Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression. Liver Int., 28: 1207-1216.
    CrossRef  |  Direct Link  |  
  147. Gressner, O.A., B. Lahme, M. Siluschek, K. Rehbein, J. Herrmann, R. Weiskirchen and A.M. Gressner, 2008. Activation of TGF-β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J. Cell Mol. Med., 6: 2717-2730.
    CrossRef  |  Direct Link  |  
  148. Gressner, O.A., B. Lahme, K. Rehbein, M. Siluschek, R. Weiskirchen and A.M. Gressner, 2008. Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor expression in hepatocytes via PPARβ and Smad2/3- dependent pathways. J. Hepatol., 49: 758-767.
    CrossRef  |  Direct Link  |  
  149. Drews, F., S. Knobel, M. Moser, K.G. Muhlack and and R. Weiskirchen et al., 2008. Disruption of the latent transforming growth factor-β binding protein-1 gene causes alteration in facial structure and influences TGF- β bioavailability. BBA Mol. Cell Res., 1783: 34-48.
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  150. Borkham-Kamphorst, E., E. Kovalenko, C.R.C. Van Roeyen, N. Gassler and R. Weiskirchen et al., 2008. Platelet-derived growth factor isoform expression in carbon tetrachloride- induced chronic liver injury. Lab. Invest., 88: 1090-1100.
    CrossRef  |  Direct Link  |  
  151. Yagmur, E., R. Weiskirchen, A.M. Gressner, C. Trautwein and F. Tacke, 2007. Insulin resistance in liver cirrhosis is not associated with circulating retinol binding protein 4. Diabetes Care, 30: 1168-1172.
    CrossRef  |  Direct Link  |  
  152. Winau, F., G. Hegasy, R. Weiskirchen, S. Weber and C. Cassan et al., 2007. Ito cells are novel antigen presenting cells. Immunity, 26: 117-129.
  153. Weiskirchen, R., C.G. Tag, S. Mengsteab, A.M. Gressner, C.J.E. Ingram and D.M. Swallow, 2007. Pitfalls in LightCycler diagnosis of the Single-Nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. Clin. Chim. Acta, 384: 93-98.
    CrossRef  |  Direct Link  |  
  154. Weiskirchen, R. and S. Meurer, 2007. BMP-7 in focus: A member of the transforming growth factor- superfamily is implicated in the maintenance of liver healt. Hepatol., 45: 1324-1325.
  155. Tag, C.G., S. Mengsteab, S.M. Kanse and R. Weiskirchen, 2007. Rapid genotyping of the G534E polymorphism (Marburg I) of the gene encoding the factor VII-activating protease (FSAP) by LightCycler PCR. Clin. Biochem., 40: 1063-1064.
    CrossRef  |  Direct Link  |  
  156. Tag, C.G., M.C. Schifflers, M. Mohnen, A.M. Gressner and R. Weiskirchen, 2007. A novel proximal -13914G>A base replacement in the vicinity of the common -13910T/C lactase gene variation results in an atypical LightCycler melting curve in testing with the MutaREAL lactase test. Clin. Chem., 53: 146-148.
  157. Scherner, O., S.K. Meurer, L. Tihaa, A.M. Gressner and R. Weiskirchen, 2007. Endoglin differentially modulates antagonistic TGF-β and BMP-7 signaling. J. Biol. Chem., 282: 13934-13943.
    CrossRef  |  Direct Link  |  
  158. Palacios, R.S., M. Roderfeld, S. Hemmann, T. Rath and R. Weiskirchen et al., 2007. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab. Invest., 88: 1192-1203.
    CrossRef  |  Direct Link  |  
  159. Herrmann, J., U. Haas, A.M. Gressner and R. Weiskirchen, 2007. TGF-β up-regulates serum response factor in activated hepatic stellate cells. BBA Mol. Bas. Dis., 1772: 1250-1257.
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  160. Herrmann, J., A.M. Gressner and R. Weiskirchen, 2007. Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function? J. Cell. Mol. Med., 11: 704-722.
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  161. Gressner, O.A., R. Weiskirchen and A.M. Gressner, 2007. New pathogenetic concepts of liver fibrosis with options for therapy and diagnostics. Vet. Comp. Orthopaedics Traumatology, 58: 613-620.
    Direct Link  |  
  162. Gressner, O.A., R. Weiskirchen and A.M. Gressner, 2007. Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options. Comp. Hepatol., .
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  163. Gressner, O.A., R. Weiskirchen and A.M. Gressner, 2007. Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests. Clin. Chim. Acta, 381: 107-113.
    Direct Link  |  
  164. Gressner, O.A., R. Weiskirchen and A.M. Gressner, 2007. Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre‐disposition pending between fiction and reality. J. Cell. Mol. Med., 11: 1031-1051.
    Direct Link  |  
  165. Gressner, O.A., B. Lahme, I. Demirci, A.M. Gressner and R. Weiskirchen, 2007. Differential effects of TGF-β on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J. Hepatol., 47: 699-710.
    CrossRef  |  Direct Link  |  
  166. Borkham-Kamphorst, E., C.R. Van Roeyen, T. Ostendorf, J. Floege, A.M. Gressner and R. Weiskirchen, 2007. Pro-fibrogenic potential of PDGF-D in liver fibrosis. J. Hepatol., 46: 1064-1074.
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  167. Wang, H., Z.X. Yang, C.F. Gao, L.L. Xu and R. Weiskirchen et al., 2006. The association of transforming growth factor- β1 and its gene polymorphisms with multiple myeloma. Chin. J. Immunol., 22: 650-653.
  168. Roderfeld, M., R. Weiskirchen, S. Wagner, M.L. Berres and C. Henkel et al., 2006. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J., 20: 444-454.
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  169. Neyzen, S., V.E. De Leur, E. Borkham-Kamphorst, J. Herrmann, G. Hollweg, A.M. Gressner and R. Weiskirchen, 2006. Cryopreservation of hepatic stellate cells. J. Hepatol., 44: 910-917.
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  170. Kruit, A., J.C. Grutters, H.J.T. Ruven, R. Weiskirchen, S. Mengsteab, V. Den, Bosch and M.M. Jules, 2006. Transforming growth factor -β gene polymorphisms are associated with increased risk for developing pulmonary fibrosis. Chest, 129: 1584-1591.
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  171. Herrmann, J., E. Borkham-Kamphorst, U. Haas, V.E. De Leur and R. Weiskirchen et al., 2006. The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-β in smooth muscle and hepatic stellate cells. Biochem. Biophys. Res. Commun., 345: 1526-1535.
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  172. Henkel, C., M. Roderfeld, R. Weiskirchen, M.L. Berres and S. Hillebrandt et al., 2006. Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis. Proteomics, 6: 6538-6548.
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  173. Gressner, A.M., B. Lahme, S.K. Meurer, O. Gressner and R. Weiskirchen, 2006. Variable expression of Cystatin C in cultured transdifferentiating rat hepatic stellate cells. World J. Gastroenterol., 12: 731-738.
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  174. Gressner, A.M. and R. Weiskirchen, 2006. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets. J. Cell. Mol. Med., 10: 76-99.
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  175. Blondin, D., A. Donner, A.M. Gressner and R. Weiskirchen, 2006. Diagnostische Methode. In: Hamochromatosen - Hamsiderosen. Erhardt, H.A. and D. Haussinger, (Ed.). UNIMED Verlag AG, Bremen, London, Boston, pp: 55-72.
  176. Bandapalli, O.R., M. Geheeb, D. Kobelt, K. Kuhnle and R. Weiskirchen et al., 2006. Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases. Int. J. Cancer, 118: 74-89.
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  177. Antoine, M., M. Mavituna, R. Weiskirchen, A.M. Gressner and P. Kiefer, 2006. Plasma TGF- as a diagnostic and prognostic marker. In: Liver Diseases: Biochemical mechanisms and new therapeutic insights. Mann, D.A., S.L. Friedman and S. Ali, (Ed.). M/s Sc Pub Inc/Oxford & IBH Co, USA, pp: 511-517.
  178. Wang, H., S. Mengsteab, C.G. Tag, C.F. Gao and R. Weiskirchen et al., 2005. Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection. World J. Gastroenterol., 11: 1929-1936.
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  179. Tag, C.G., M.C. Schifflers, M. Mohnen, A.M. Gressner and R. Weiskirchen, 2005. Atypical melting curve resulting from genetic variation in the 3’ untranslated region at position 20218 in the prothrombin gene analyzed with the LightCycler Factor II (Prothrombin) G20210A assay. Clin. Chem., 51: 1560-1561.
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  180. Stockbrink, G., C. Stoll, D. Riediger, R. Weiskirchen and A.M. Gressner, 2005. Polymorphismen im TGF-1-Gen bei Lippen-Kiefer-Gaumenspalten. Rheinisches Zahnarzteblatt, 48: 408-409.
  181. Poser, I., T. Rothhammer, S. Dooley, R. Weiskirchen and A.K. Bosserhoff, 2005. Characterization of Sno expression in malignant melanoma. Int. J. Oncol., 26: 1411-1417.
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  182. Meurer, S.K., L. Tihaa, B. Lahme, A.M. Gressner and R. Weiskirchen, 2005. Identification of endoglin in rat hepatic stellate cells: New insights into transforming growth factor β receptor signaling. J. Biol. Chem., 280: 3078-3087.
    CrossRef  |  Direct Link  |  
  183. Meurer, S.K., B. Lahme, L. Tihaa, R. Weiskirchen and A.M. Gressner, 2005. Nacetyl-L-cysteine suppresses TGF-β signaling at distinct molecular steps: The biochemical and biological efficacy of a multifunctional, antifibrotic drug. Biochem. Pharmacol., 70: 1026-1034.
    CrossRef  |  Direct Link  |  
  184. Hillebrandt, S., H.E. Wasmuth, R. Weiskirchen, C. Hellerbrand and H. Keppeler et al., 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nature Genet., 37: 835-843.
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  185. Henkel, C., M. Roderfeld, R. Weiskirchen, B. Scheibe, S. Matern and E. Roeb, 2005. Identification of fibrosis-relevant proteins using DIGE (Difference in Gel Electrophoresis) in different models of hepatic fibrosis. Z. Gastroenterol., 43: 23-29.
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  186. Geier, A., C. Gartung, I. Theuri, H. Zoller and R. Weiskirchen et al., 2005. Occult celiac disease prevents the penetrance of hemochromatosis. World J. Gastroenterol., 11: 3323-3326.
    CrossRef  |  Direct Link  |  
  187. Borkham-Kamphorst, E., S.K. Meurer, A.M. Gressner and R. Weiskirchen, 2005. Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells. Biochem. Biophys. Res. Commun., 338: 1711-1718.
    CrossRef  |  Direct Link  |  
  188. Wang, H., Z.X. Yang, C.F. Gao, M.B. Wand, X.J. Wang, S. Mengsteab, A.M. Gressner and R. Weiskirchen, 2004. Transforming growth factor-β1 gene polymorphisms in Caucasians and Asians with post hepatitis fibrosis. Acad. J. Sec. Mil. Med. Univ., 25: 1284-1287.
  189. Stoll, C., S. Mengsteab, D. Stoll, D. Riediger, A.M. Gressner and R. Weiskirchen, 2004. Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med. Genet., 10.1186/1471-2350-5-15.
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  190. Janoschek, N., V.E. De Leur, A.M. Gressner and R. Weiskirchen, 2004. Induction of cell death in activated hepatic stellate cells by target gene expression of the thymidine kinase/Ganciclovir system. Biochem. Biophys. Res. Commun., 316: 1107-1115.
    CrossRef  |  Direct Link  |  
  191. Herrmann, J., M. Arias, V.E. De Leur, A.M. Gressner and R. Weiskirchen, 2004. CSRP2, TIMP-1 and SM22&aalpha; promoter fragments direct hepatic stellate cell-specific transgene expression in vitro, but not in vivo. Liver Int., 24: 69-79.
    CrossRef  |  Direct Link  |  
  192. Herrmann, J., B. Abriss, E.V. De Leur, S. Weiskirchen, A.M. Gressner and R. Weiskirchen, 2004. Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver. Arch. Virol., 149: 1611-1617.
    CrossRef  |  Direct Link  |  
  193. Geier, A., M. Reugels, R. Weiskirchen, H.E. Wasmuth and C.G. Dietrich et al., 2004. Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C. Liver Int., 24: 285-294.
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  194. Borkham-Kamphorst, E., J. Herrmann, D. Stoll, J. Treptau, A.M. Gressner and R. Weiskirchen, 2004. Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab. Invest., 84: 766-777.
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  195. Borkham-Kamphorst, E., D. Stoll, A.M. Gressner and R. Weiskirchen, 2004. Inhibitory effect of soluble PDGF-β receptor in culture-activated hepatic stellate cells. Biochem. Biophys. Res. Commun., 317: 451-462.
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  196. Borkham-Kamphorst, E., D. Stoll, A.M. Gressner and R. Weiskirchen, 2004. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Biochem. Biophys. Res. Commun., 321: 413-423.
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  197. Weiskirchen, R., M. Moser, K. Gunther, S. Weiskirchen and A.M. Gressner, 2003. The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22. Gene, 308: 43-52.
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  198. Weiskirchen, R. and K. Gunther, 2003. The CRP/MLP/TLP family of LIM domain proteins: acting by connecting. Bioessays, 25: 152-162.
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  199. Tag, C.G., S. Mengsteab, C. Hellerbrand, F. Lammert, A.M. Gressner and R. Weiskirchen, 2003. Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection. Cytokine, 24: 173-181.
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  200. Gunther, K., D. Stoll, G. Jakse, A.M. Gressner and R. Weiskirchen, 2003. Rapid detection of CSRP2 mRNA in mouse, rat and human using LightCycler-based quantitative real-time polymerase chain reaction. Anal. Biochem., 314: 144-148.
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  201. Gressner, A.M. and R. Weiskirchen, 2003. The tightrope of therapeutic suppression of active transforming growth factor-β: high enough to fall deeply? J. Hepatol., 39: 856-859.
  202. Arias, M., S. Sauer-Lehnen, J. Treptau, N. Janoschek and I. Theuerkauf et al., 2003. Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats. BMC Gastroenterol., 10.1186/1471-230X-3-29.
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  203. Abriss, B., G. Hollweg, A.M. Gressner and R. Weiskirchen, 2003. Adenoviral-mediated transfer of p53 or retinoblastoma protein blocks cell proliferation and induces apoptosis in culture-activated hepatic stellate cells. J. Hepatol., 38: 169-178.
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  204. Gressner, A.M., R. Weiskirchen, K. Breitkopf and S. Dooley, 2002. Roles of TGF-beta in hepatic fibrosis. Front Biosci., 7: d793-d807.
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  205. De Leur, E.V., K. Gunther, A.M. Gressner and R. Weiskirchen, 2002. Increasing the biological safety during intravenous injection into mice tail vein using a modified plastic syringe. Baltic J. Lab. Anim. Sci., 12: 248-249.
  206. Arias, M., B. Lahme, E.V. De Leur, A.M. Gressner and R. Weiskirchen, 2002. Adenoviral delivery of an antisense RNA complementary to the 3’ coding sequence of transforming growth factor-β1 inhibits fibrogenic activities of hepatic stellate cells. Cell Growth Differ., 13: 265-273.
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  207. Weiskirchen, R., M. Moser, S. Weiskirchen, M. Erdel, S. Dahmen, R. Buettner and A.M. Gressner, 2001. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. Biochem. J., 359: 485-496.
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  208. Tag, C.G., A.M. Gressner, R. Weiskirchen, 2001. An unusual melting curve profile in Light Cycler multiplex genotyping of the hemochromatosis H63D/C282Y gene mutations. Clin. Biochem., 34: 511-515.
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  209. Gao, C.F., X.T. Kong, A.M. Gressner and R. Weiskirchen, 2001. The expression and antigenicity identification of recombinant rat TGF-β1 in bacteria. Cell Res., 11: 95-100.
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  210. Fehrenbach, H., R. Weiskirchen, M. Kasper and A.M. Gressner, 2001. Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatol., 34: 943-952.
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  211. Weiskirchen, R., J. Kneifel, S. Weiskirchen, L.E. Van De, D. Kunz and A.M. Gressner, 2000. Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts. BMC Cell Biol., 10.1186/1471-2121-1-4.
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  212. Weiskirchen, R and A.M. Gressner, 2000. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Biochem. Biophys. Res. Commun., 274: 655-663.
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